Cited by 58

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Cellular signalling by lipoprotein receptors

Herz, Joachim, Gotthardt, Michael, Willnow, Thomas E.·2000·Current Opinion in Lipidology

Abstract

Lipoprotein receptors are commonly thought merely to mediate the internalization of lipoprotein particles or the exchange of lipids at the cell surface. Recent findings have now implicated these multifunctional receptors in cellular signalling mechanisms that extend beyond simple ligand endocytosis. By mediating the cellular uptake of lipophilic vitamins and hormones, megalin, a member of the LDL receptor gene family, regulates critical hormonal and metabolic processes. Other members of the LDL receptor family interact with cytoplasmic adaptor and scaffold proteins, which allows them to transmit signals directly across the plasma membrane of the target cell. This sheds a new light on the emerging roles of lipoprotein receptors in pathologic disease processes such as Alzheimer's disease.

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Crossref · 10.1097/00041433-200004000-00009

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3 of 3 references verified0 citation errors · 0 not checkable

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  • LDL receptor family members contain NPXY motif(s) specifically recognized by Dab2.

    “The members of the LDL (low density lipoprotein) receptor family contain the NPXY motif(s) specifically recognized by Dab2”

    From Endocytosis and Physiology: Insights from Disabled-2 Deficient Mice (2016) · cites this paper as Herz et al., 2000

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Metadata

Authors
Herz, J., Gotthardt, M., & Willnow, T. E.
Venue
Current Opinion in Lipidology
Published
2000-04
Volume
11
Issue
2
Pages
161-166
ISSN
0957-9672
Cited by
58
References
3
Language
en

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