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Cited by 1,148

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Range of Messenger Action of Calcium Ion and Inositol 1,4,5-Trisphosphate

Allbritton, Nancy L., Meyer, Tobias, Stryer, Lubert·1992·Science
DOI 10.1126/science.1465619
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Abstract

The range of messenger action of a point source of Ca 2+ or inositol 1,4,5-trisphosphate (IP 3 ) was determined from measurements of their diffusion coefficients in a cytosolic extract from Xenopus laevis oocytes. The diffusion coefficient ( D ) of [ 3 H]IP 3 injected into an extract was 283 μm 2 /s. D for Ca 2+ increased from 13 to 65 μm 2 /s when the free calcium concentration was raised from about 90 nM to 1 μm. The slow diffusion of Ca 2+ in the physiologic concentration range results from its binding to slowly mobile or immobile buffers. The calculated effective ranges of free Ca 2+ before it is buffered, buffered Ca 2+ , and IP 3 determined from their diffusion coefficients and lifetimes were 0.1 μm, 5 μm, and 24 μm, respectively. Thus, for a transient point source of messenger in cells smaller than 20 μm, IP 3 is a global messenger, whereas Ca 2+ acts in restricted domains.

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Metadata

Authors
Allbritton, N. L., Meyer, T., & Stryer, L.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1992-12-11
Volume
258
Issue
5089
Pages
1812-1815
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.1465619
OpenAlex
W2007263885
Cited by
1,148
References
1
FWCI
27.18
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Range of Messenger Action of Calcium Ion and Inositol 1,4,5-Trisphosphate. https://app.cochat.ai/papers/10.1126/science.1465619
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Allbritton, N. L., Meyer, T., & Stryer, L. (1992). Range of Messenger Action of Calcium Ion and Inositol 1,4,5-Trisphosphate. Science. https://doi.org/10.1126/science.1465619

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