Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., & Müller-Hill, B. (1987) · Nature · doi:10.1038/325733a0 · Cited by 4,619

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4245 · Cited by 4,431

The establishment of polarity by hippocampal neurons in culture.

Dotti, C., Sullivan, C., & Banker, G. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-04-01454.1988 · Cited by 1,862

Glutamate neurotoxicity in cortical cell culture

Choi, D. W., Maulucci-Gedde, M., & Kriegstein, A. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-02-00357.1987 · Cited by 1,506

Rat hippocampal neurons in dispersed cell culture.

Banker, G. A., & Cowan, W. M. (1977) · Brain Research · doi:10.1016/0006-8993(77)90594-7 · Cited by 1,110

Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels.

Masters, C. L., Multhaup, G., Simms, G., Pottgiesser, J., Martins, R. N., & Beyreuther, K. T. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb04000.x · Cited by 1,048

Neurotoxicity of a Fragment of the Amyloid Precursor Associated with Alzheimer's Disease

Yankner, B. A., Dawes, L. R., Fisher, S., Villa-Komaroff, L., Oster-Granite, M. L., & Neve, R. L. (1989) · Science · doi:10.1126/science.2474201 · Cited by 907

Outgrowth-regulating actions of glutamate in isolated hippocampal pyramidal neurons

Mattson, M. P., Dou, P., & Kater, S. B. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-06-02087.1988 · Cited by 557

Tachykinins

Maggio, J. E. (1988) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.11.030188.000305 · Cited by 550

Involvement of astroglial ceramide in palmitic acid‐induced Alzheimer‐like changes in primary neurons

Patil, S. P., Melrose, J., & Chan, C. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05797.x · Cited by 129

Neurofibrillary tangles and β-amyloid deposits in Alzheimer's disease

Goedert, M., Sisodia, S. S., & Price, D. L. (1991) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(91)90067-h · Cited by 128

Amyloid β peptide alters intracellular vesicle trafficking and cholesterol homeostasis

Liu, Y., Peterson, D. A., & Schubert, D. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13266 · Cited by 128

α-lipoic acid protects rat cortical neurons against cell death induced by amyloid and hydrogen peroxide through the Akt signalling pathway

Zhang, L., Xing, G. Q., Barker, J. L., Chang, Y. H., Maric, D., Ma, W., Li, B., & Rubinow, D. R. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02205-4 · Cited by 128

An interaction of β‐amyloid with aluminium in vitro

Exley, C., Price, N. C., Kelly, S. M., & Birchall, J. D. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80137-j · Cited by 128

Transient receptor potential channels in Alzheimer's disease

Yamamoto, S., Wajima, T., Hara, Y., Nishida, M., & Mori, Y. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2007.03.006 · Cited by 127

Increased antioxidant enzyme activity in amyloid beta protein-resistant cells

Sagara, Y., Dargusch, R., Klier, F. G., Schubert, D. A., & Behl, C. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-02-00497.1996 · Cited by 127

Ionic effects of the Alzheimer's disease β-amyloid precursor protein and its metabolic fragments

Fraser, S. P., Suh, Y.-H., & Djamgoz, M. B. A. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10079-5 · Cited by 127

Lack of alzheimer pathology after β-amyloid protein injections in rat brain

Games, D., Khan, K., Soriano, F., Keim, P. S., Davis, D. L., Bryant, K., & Lieberburg, I. M. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90057-5 · Cited by 127

Hormetic effect of amyloid-beta peptide in synaptic plasticity and memory.

Puzzo, D., Privitera, L., & Palmeri, A. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.12.020 · Cited by 95

Sex, Hormones, and Alzheimer's Disease

Baum, L. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.6.736 · Cited by 127

Amyloid β Peptide–Induced Cerebral Endothelial Cell Death Involves Mitochondrial Dysfunction and Caspase Activation

Xu, J., Chen, S., Ku, G., Ahmed, S. H., Xu, J., Chen, H., & Hsu, C. Y. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200106000-00008 · Cited by 125

β‐Amyloid peptide induces ultrastructural changes in synaptosomes and potentiates mitochondrial dysfunction in the presence of ryanodine

Mungarro‐Menchaca, X., Ferrera, P., Morán, J., & Arias, C. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10193 · Cited by 125

Rat Brain Glyceraldehyde‐3‐Phosphate Dehydrogenase Interacts with the Recombinant Cytoplasmic Domain of Alzheimer's β‐Amyloid Precursor Protein

Schulze, H., Schuler, A., Stüber, D., Döbeli, H., Langen, H., & Huber, G. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb13420.x · Cited by 125

A chemical approach to elucidate tin mechanism of transthyretin and β-protein amyloid fibril formation

Kelly, J. W., & Lansbury, P. T. (1994) · Amyloid · doi:10.3109/13506129409148451 · Cited by 125

Mechanisms of Neuronal Cell Death in Wernicke's Encephalopathy

Hazell, A. S., Todd, K. G., & Butterworth, R. F. (1998) · Metabolic Brain Disease · doi:10.1023/a:1020657129593 · Cited by 124

Aβ25–35 induces rapid lysis of red blood cells: contrast with Aβ1–42 and examination of underlying mechanisms

Mattson, M. P., Begley, J. G., Mark, R. J., & Furukawa, K. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00824-x · Cited by 124

Galantamine modulates nicotinic receptor and blocks Aβ-enhanced glutamate toxicity

Kihara, T., Sawada, H., Nakamizo, T., Kanki, R., Yamashita, H., Maelicke, A., & Shimohama, S. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.10.132 · Cited by 124

Deregulated Cdk5 promotes oxidative stress and mitochondrial dysfunction

Sun, K., de Pablo, Y., Vincent, F., & Shah, K. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05616.x · Cited by 124

β-amyloid peptide decreases membrane fluidity

Müller, W. E., Koch, S., Eckert, A., Hartmann, H., & Scheuer, K. (1995) · Brain Research · doi:10.1016/0006-8993(94)01463-r · Cited by 124

Neurotoxicity of Human Amylin in Rat Primary Hippocampal Cultures: Similarity to Alzheimer's Disease Amyloid‐β Neurotoxicity

May, P. C., Boggs, L. N., & Fuson, K. S. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb07480.x · Cited by 124

Alzheimer’s disease due to loss of function: A new synthesis of the available data

Kepp, K. P. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.06.004 · Cited by 123

Exploring ER stress response in cellular aging and neuroinflammation in Alzheimer's disease

Uddin, M. S., Yu, W. S., & Lim, L. W. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101417 · Cited by 123

Increased expression and subcellular translocation of the mitogen activated protein kinase kinase and mitogen-activated protein kinase in Alzheimer's disease

Arendt, T., Holzer, M., Grossmann, A., Zedlick, D., & Brückner, M. K. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00146-a · Cited by 123

Oligodendroglial progenitors labeled with the O4 antibody persist in the adult rat cerebral cortex in vivo

Reynolds, R., & Hardy, R. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19970301)47:5 · Cited by 261

Impairments of long-term potentiation in hippocampal slices of β-amyloid-infused rats

Itoh, A., Akaike, T., Sokabe, M., Nitta, A., Iida, R., Olariu, A., Yamada, K., & Nabeshima, T. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00601-9 · Cited by 122

Human and rodent Alzheimer β‐amyloid peptides acquire distinct conformations in membrane‐mimicking solvents

Ötvös, L., Szendrei, G. I., Lee, V. M.-Y., & Mantsch, H. H. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb19893.x · Cited by 122

Beta-amyloid peptide blocks the fast-inactivating K+ current in rat hippocampal neurons

Good, T. A., Smith, D. O., & Murphy, R. M. (1996) · Biophysical Journal · doi:10.1016/s0006-3495(96)79570-x · Cited by 122

Viruses and neurodegeneration

Zhou, L., Saksena, M. M., & Saksena, N. K. (2013) · Virology Journal · doi:10.1186/1743-422x-10-172 · Cited by 121

Global Effects of Mistranslation from an Editing Defect in Mammalian Cells

Nangle, L. A., Motta, C. M., & SCHIMMEL, P. R. (2006) · Chemistry & Biology · doi:10.1016/j.chembiol.2006.08.011 · Cited by 121

New clues to Alzheimer's disease: Unraveling the roles of amyloid and tau

Yanker, B. A. (1996) · Nature Medicine · doi:10.1038/nm0896-850 · Cited by 120

Preferential adsorption, internalization and resistance to degradation of the major isoform of the Alzheimer's amyloid peptide, Aβ1–42, in differentiated PC12 cells

Burdick, D., Kosmoski, J., Knauer, M. F., & Glabe, C. G. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01262-0 · Cited by 102

Interleukin-6 as a neurotrophic factor for promoting the survival of cultured catecholaminergic neurons in a chemically defined medium from fetal and postnatal rat midbrains

Kushima, Y., Hama, T., & Hatanaka, H. (1992) · Neuroscience Research · doi:10.1016/0168-0102(92)90039-f · Cited by 120

Expression of the low-affinity nerve growth factor receptor enhances beta-amyloid peptide toxicity.

Rabizadeh, S., Bitler, C. M., Butcher, L. L., & Bredesen, D. E. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10703 · Cited by 120

Axonal degeneration as a therapeutic target in the CNS

Lingor, P., Koch, J. C., Tönges, L., & Bähr, M. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1362-3 · Cited by 119

Amyloid β−Cu2+Complexes in both Monomeric and Fibrillar Forms Do Not Generate H2O2Catalytically but Quench Hydroxyl Radicals

Nadal, R. C., Rigby, S. E. J., & Viles, J. H. (2008) · Biochemistry · doi:10.1021/bi8011093 · Cited by 119

Alzheimer's Disease Related Markers, Cellular Toxicity and Behavioral Deficits Induced Six Weeks after Oligomeric Amyloid-β Peptide Injection in Rats

Zussy, C., Brureau, A., Keller, E., Marchal, S., Blayo, C., Delair, B., IXART, G., Maurice, T., & Givalois, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053117 · Cited by 118

Architecture of the Alzheimer?s A�P Ion Channel Pore

Arispe, N. J. (2004) · The Journal of Membrane Biology · doi:10.1007/s00232-003-0638-7 · Cited by 117

β‐Cyclodextrin interacts with the Alzheimer amyloid β‐A4 peptide

Camilleri, P., Haskins, N. J., & Hewlett, D. R. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)80467-2 · Cited by 117

Tauroursodeoxycholic Acid Prevents Amyloid-β Peptide-Induced Neuronal Death Via a Phosphatidylinositol 3-Kinase-Dependent Signaling Pathway

Solá, S., Castro, R. E., Laires, P. A., Steer, C. J., & Rodrigues, C. M. P. (2003) · Molecular Medicine · doi:10.2119/2003-00042.rodrigues · Cited by 117

β-amyloid peptide in vitro toxicity: Lot-to-lot variability

May, P. C., Gitter, B. D., Waters, D. C., Simmons, L. K., Becker, G. W., Small, J. S., & Robison, P. M. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90064-5 · Cited by 117

Anticonvulsants attenuate amyloid β-peptide neurotoxicity, Ca2+ deregulation, and cytoskeletal pathology

Mark, R. J., Ashford, J. W., Goodman, Y., & Mattson, M. P. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(94)00150-2 · Cited by 117

Neurodegeneration mediated by glutamate and β-amyloid peptide: a comparison and possible interaction

Gray, C. W., & Patel, A. J. (1995) · Brain Research · doi:10.1016/0006-8993(95)00669-h · Cited by 117

The keystone of Alzheimer pathogenesis might be sought in Aβ physiology

Puzzo, D., Gulisano, W., Arancio, O., & Palmeri, A. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.039 · Cited by 116

A Novel Neurotrophic Drug for Cognitive Enhancement and Alzheimer's Disease

Chen, Q., Prior, M., Dargusch, R., Roberts, A. J., Riek, R., Eichmann, C., Chiruta, C., Akaishi, T., Abe, K., Maher, P. A., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027865 · Cited by 116

Promotion of axonal maturation and prevention of memory loss in mice by extracts of Astragalus mongholicus

Tohda, C., Tamura, T., Matsuyama, S., & Komatsu, K. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706865 · Cited by 116

Neurotoxicity and Oxidative Damage of Beta Amyloid 1–42 versus Beta Amyloid 1–40 in the Mouse Cerebral Cortex

Klein, A., Kowall, N. W., & Ferrante, R. J. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07845.x · Cited by 115

A broadly neuroprotective derivative of curcumin

Liu, Y., Dargusch, R., Maher, P. A., & Schubert, D. A. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05236.x · Cited by 115

Cofilin-mediated neurodegeneration in alzheimer’s disease and other amyloidopathies

Maloney, M. T., & Bamburg, J. R. (2007) · Molecular Neurobiology · doi:10.1007/bf02700622 · Cited by 115

Single intracerebroventricular administration of amyloid-beta (25–35) peptide induces impairment in short-term rather than long-term memory in rats

Stepanichev, M. Y., Moiseeva, Y. V., Лазарева, Н. А., Onufriev, M. V., & Gulyaeva, N. V. (2003) · Brain Research Bulletin · doi:10.1016/s0361-9230(03)00118-7 · Cited by 115

Intraneuronal β-Amyloid Expression Downregulates the Akt Survival Pathway and Blunts the Stress Response

Magrané, J., Rosen, K. M., Smith, R. C., Walsh, K. X., Gouras, G. K., & Querfurth, H. W. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1723-05.2005 · Cited by 115

Passage of human amyloid β-protein 1–40 across the murine blood-brain barrier

Maness, L. M., Banks, W. A., Podlisny, M. B., Selkoe, D. J., & Kastin, A. J. (1994) · Life Sciences · doi:10.1016/0024-3205(94)00331-9 · Cited by 97

Amyloid-β-Induced Ion Flux in Artificial Lipid Bilayers and Neuronal Cells: Resolving a Controversy

Capone, R. F., Quiroz, F. G., Prangkio, P., Saluja, I., Sauer, A., Bautista, M. R., Turner, R. S., Yang, J., & Mayer, M. (2009) · Neurotoxicity Research · doi:10.1007/s12640-009-9033-1 · Cited by 114

Expression analysis of glycogen synthase kinase‐3 in human tissues

Lau, K., Miller, C. C. J., Anderton, B. H., & Shaw, P. C. (1999) · Journal of Peptide Research · doi:10.1034/j.1399-3011.1999.00083.x · Cited by 114

Channel formation by serum amyloid A: a potential mechanism for amyloid pathogenesis and host defense

Hirakura, Y., Carreras, I., Sipe, J. D., & Kagan, B. L. (2002) · Amyloid · doi:10.3109/13506120209072440 · Cited by 114

Glutamate and Amyloid β-Protein Rapidly Inhibit Fast Axonal Transport in Cultured Rat Hippocampal Neurons by Different Mechanisms

Hiruma, H., Katakura, T., Takahashi, S., Ichikawa, T., & Kawakami, T. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-26-08967.2003 · Cited by 114

Aberrant Activation of Focal Adhesion Proteins Mediates Fibrillar Amyloid β-Induced Neuronal Dystrophy

Grace, E. A., & Busciglio, J. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-02-00493.2003 · Cited by 113

Stepwise dynamics of epitaxially growing single amyloid fibrils

Kellermayer, M., Karsai, Á., Benke, M., Soós, K., & Penke, B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704305105 · Cited by 113

Induction of immune system mediators in the hippocampal formation in Alzheimer's and Parkinson's diseases: Selective effects on specific interleukins and interleukin receptors

Araujo, D. M., & Lapchak, P. A. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90398-0 · Cited by 113

A POTENT INHIBITOR OF NEURITE OUTGROWTH THAT PREDOMINATES IN THE EXTRACELLULAR MATRIX OF REACTIVE ASTROCYTES

Canning, D. R., Höke, A., Malemud, C. J., & Silver, J. (1996) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(96)00004-4 · Cited by 113

Synaptic loss in cognitively impaired aged rats is ameliorated by chronic human nerve growth factor infusion

Chen, K. S., Masliah, E., Mallory, M. E., & Gage, F. H. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00099-5 · Cited by 113

Association between vascular basement membrane components and the lesions of Alzheimer's disease

Perlmutter, L. S., Barrón, E., Saperia, D., & Chui, H. C. (1991) · Journal of Neuroscience Research · doi:10.1002/jnr.490300411 · Cited by 113

Activation of nuclear factor-κB by β-amyloid peptides and interferon-γ in murine microglia

Bonaiuto, C., McDonald, P. P., Rossi, F., & Cassatella, M. A. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00054-4 · Cited by 112

The Antioxidant Vitamin E Modulates Amyloid β-Peptide-Induced Creatine Kinase Activity Inhibition and Increased Protein Oxidation: Implications for the Free Radical Hypothesis of Alzheimer's Disease

Yatin, S. M., Aksenov, M. Y., & Butterfield, D. A. (1999) · Neurochemical Research · doi:10.1023/a:1020997903147 · Cited by 112

β-Amyloid neurotoxicity: A discussion of in vitro findings

Cotman, C. W., Pike, C. J., & Copani, A. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90060-b · Cited by 112

Astroglia in Alzheimer's disease

Frederickson, R. C. A. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90036-w · Cited by 111

Local protective effects of nerve growth factor-secreting fibroblasts against excitotoxic lesions in the rat striatum

Frim, D. M., Short, M. P., Rosenberg, W. S., Simpson, J. R., Breakefield, X. O., & Ole Isacson, A. (1993) · Journal of neurosurgery · doi:10.3171/jns.1993.78.2.0267 · Cited by 111

Cupric–amyloid β peptide complex stimulates oxidation of ascorbate and generation of hydroxyl radical

Dikalov, S., Vitek, M. P., & Mason, R. P. (2003) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.11.004 · Cited by 110

Interaction of Alzheimer β-amyloid peptide with the human monocytic cell line THP-1 results in a protein kinase C-dependent secretion of tumor necrosis factor-α

Klegeris, A., Walker, D. G., & McGeer, P. L. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01229-2 · Cited by 110

Amyloid Beta-Induced Neuronal Death is Bax-Dependent but Caspase-Independent

Selznick, L. A., Zheng, T. S., Flavell, R. A., RAKIC, P. T., & Roth, K. A. (2000) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/59.4.271 · Cited by 110

Altered Calcium Signaling and Neuronal Injury: Stroke and Alzheimer's Disease as Examplesa

Mattson, M. P., Rydel, R. E., Lieberburg, I. M., & Smith‐Swintosky, V. L. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb18285.x · Cited by 110

The role of amyloid β in the pathogenesis of Alzheimer's disease

Gilbert, B. J. (2013) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2013-201515 · Cited by 109

β‐Amyloid protein oligomers induced by metal ions and acid pH are distinct from those generated by slow spontaneous ageing at neutral pH

Klug, G. M., Lošić, D., Supundi, Subasinghe, S., Aguilar, M., Martin, L. L., & Small, D. H. (2003) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2003.03815.x · Cited by 109

Characterizing the neuroprotective effects of alkaline extract of Lycium barbarum on β-amyloid peptide neurotoxicity

Ho, J. Y. S., Yu, M.-S., Lai, C. S.-W., So, K., Yuen, W.-H., & Chang, R. C. (2007) · Brain Research · doi:10.1016/j.brainres.2007.04.075 · Cited by 109

Modeling neurodegenerative disease pathophysiology in thiamine deficiency: Consequences of impaired oxidative metabolism

Jhala, S. S., & Hazell, A. S. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.11.019 · Cited by 109

Laminin and its neurite outgrowth‐promoting domain in the brain in Alzheimer's disease and Down's syndrome patients

Murtomäki, S., Risteli, J., Risteli, L., Koivisto, U., Johansson, S., & Liesi, P. (1992) · Journal of Neuroscience Research · doi:10.1002/jnr.490320216 · Cited by 109

Delineating the Mechanism of Alzheimer’s Disease Aβ Peptide Neurotoxicity

Cappai, R., & Barnham, K. J. (2008) · Neurochemical Research · doi:10.1007/s11064-007-9469-8 · Cited by 108

Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases

Cahill, C. M., Lahiri, D. K., Huang, X., & Rogers, J. T. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.12.001 · Cited by 108

Intracellular oligomeric amyloid-beta rapidly regulates GluA1 subunit of AMPA receptor in the hippocampus

Whitcomb, D. J., Hogg, E. L., Regan, P. L., Piers, T. M., Narayan, P. S., Whitehead, G., Winters, B. L., Kim, D.-H., Kim, E., George‐Hyslop, P. S., et al. (2015) · Scientific Reports · doi:10.1038/srep10934 · Cited by 108

The SEC receptor recognizes a pentapeptide neodomain of alpha 1-antitrypsin-protease complexes

Joslin, G., Fallon, R. J., Bullock, J., Adams, S. P., & Perlmutter, D. H. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99160-x · Cited by 108

Alzheimer Aβ neurotoxicity: Promotion by antichymotrypsin, ApoE4; inhibition by Aβ-related peptides

Ma, J., Brewer, H. B., & Potter, H. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00112-1 · Cited by 108

The cellular model for Alzheimer's disease research: PC12 cells

Xie, D., Deng, T., Zhai, Z., Sun, T., & Xu, Y. D. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1016559 · Cited by 107

β-Amyloid(Phe(SO3H)24)25–35 in rat nucleus basalis induces behavioral dysfunctions, impairs learning and memory and disrupts cortical cholinergic innervation

Harkany, T., O’Mahony, S. M., Kelly, J. P., Soós, K., Törõ, I., Penke, B., Luiten, P. G. M., Nyakas, C. J., Gulya, K., & Leonard, B. E. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00091-0 · Cited by 107

Trifluoroacetic acid pretreatment reproducibly disaggregates the amyloid β-peptide

Jao, S., Ma, K., Talafous, J., Orlando, R., & Zagorski, M. G. (1997) · Amyloid · doi:10.3109/13506129709003835 · Cited by 107

Modulation of beta-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family

Cam (2006) · Molecular Neurodegeneration · doi:10.1186/1750-1326-1-8 · Cited by 106

Alzheimer’s amyloid β-peptide (1–42) induces cell death in human neuroblastoma via bax/bcl-2 ratio increase: An intriguing role for methionine 35

Clementi, M. E., Pezzotti, M., Orsini, F., Sampaolese, B., Mezzogori, D., Grassi, C., Giardina, B., & Misiti, F. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.01.137 · Cited by 105

Is the Amyloid Hypothesis of Alzheimer's disease therapeutically relevant?

Teich, A. F., & Arancio, O. (2012) · Biochemical Journal · doi:10.1042/bj20120653 · Cited by 105

Novel Genetic Tools Reveal Cdk5's Major Role in Golgi Fragmentation in Alzheimer's Disease

Sun, K.-H., de Pablo, Y., Vincent, F., Johnson, E. O., Chavers, A. K., & Shah, K. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-11-1106 · Cited by 105

Neurovascular Pathways and Alzheimer Amyloid β-peptide

Zlokovic, B. V., Deane, R., Sallstrom, J., Chow, N., & Miano, J. M. (2006) · Brain Pathology · doi:10.1111/j.1750-3639.2005.tb00103.x · Cited by 104

Capillary cerebral amyloid angiopathy identifies a distinct APOE ε4-associated subtype of sporadic Alzheimer’s disease

Thal, D. R., Papassotiropoulos, A., Saido, T. C., Griffin, W. S. T., Mrak, R. E., Kölsch, H., Tredici, K. D., Attems, J., & Ghebremedhin, E. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0707-9 · Cited by 103

The amyloid‐β peptide and its role in Alzheimer's disease

Clippingdale, A. B., Wade, J. D., & Barrow, C. J. (2001) · Journal of Peptide Science · doi:10.1002/psc.324 · Cited by 103

HIV-1 Tat Activates Neuronal Ryanodine Receptors with Rapid Induction of the Unfolded Protein Response and Mitochondrial Hyperpolarization

Norman, J. P., Perry, S. W., Reynolds, H. M., Kiebala, M., Bentley, K. L. D. M., Trejo, M., Volsky, D. J., Maggirwar, S. B., Dewhurst, S., Masliah, E., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003731 · Cited by 103

Nicotinic receptor–mediated protection against β-amyloid neurotoxicity

Shimohama, S., & Kihara, T. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01100-8 · Cited by 103

Small heat shock proteins inhibit in vitro Aβ1–42 amyloidogenesis

Kudva, Y. C., Hiddinga, H. J., Butler, P. C., Mueske, C. S., & Eberhardt, N. L. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01180-0 · Cited by 103

Exploration of subsite binding specificity of human cathepsin D through kinetics and rule‐based molecular modeling

Scarborough, P. E., Dunn, B. M., Guruprasad, K., Topham, C. M., Blundell, T. L., Richo, G. R., & Conner, G. E. (1993) · Protein Science · doi:10.1002/pro.5560020215 · Cited by 103

Amyloid-beta peptide, substance P, and bombesin bind to the serpin-enzyme complex receptor.

Joslin, G., Krause, J. E., Hershey, A. D., Adams, S., Fallon, R. J., & Perlmutter, D. H. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54721-9 · Cited by 103

Anti-Amyloid Therapies for Alzheimer’s Disease and the Amyloid Cascade Hypothesis

Fedele, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914499 · Cited by 102

Neuronal Pentraxin 1 Contributes to the Neuronal Damage Evoked by Amyloid-β and Is Overexpressed in Dystrophic Neurites in Alzheimer's Brain

Abad, M. A., Enguita, M., DeGregorio-Rocasolano, N., Ferrer, I., & Trullas, R. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0575-06.2006 · Cited by 102

Stem cell delivery of therapies for brain disorders

Aleynik, A., Gernavage, K. M., Mourad, Y. S., Sherman, L. S., Liu, K. Y., Gubenko, Y. A., & Rameshwar, P. (2014) · Clinical and Translational Medicine · doi:10.1186/2001-1326-3-24 · Cited by 102

Back to the Future with Phenotypic Screening

Prior, M., Chiruta, C., Currais, A. J. M., Goldberg, J., Ramsey, J., Dargusch, R., Maher, P. A., & Schubert, D. A. (2014) · ACS Chemical Neuroscience · doi:10.1021/cn500051h · Cited by 102

Amyloid β Protein Enhances the Survival of Hippocampal Neurons in Vitro

Whitson, J. S., Selkoe, D. J., & Cotman, C. W. (1989) · Science · doi:10.1126/science.2928783 · Cited by 469

Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity.

Takashima, A., Noguchi, K., Sato, K., Hoshino, T., & Imahori, K. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.16.7789 · Cited by 385

Intracerebral /sB-amyloid(25–35) produces tissue damage: Is it neurotoxic?

Rush, D. K., Aschmies, S., & Merriman, M. C. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90061-2 · Cited by 72

An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P.

Kowall, N. W., Beal, M. F., Busciglio, J. A., Duffy, L. K., & Yankner, B. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.7247 · Cited by 529

Nerve growth factor potentiates the neurotoxicity of beta amyloid.

Yankner, B. A., Cáceres, A., & Duffy, L. K. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.22.9020 · Cited by 174