Cited by 1,975Alzheimer's disease research and treatmentsNeuropeptides and Animal PhysiologyNeuroinflammation and Neurodegeneration Mechanisms

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Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

Yankner, Bruce A., Duffy, Lawrence K., Kirschner, Daniel A.·1990·Science

DOI 10.1126/science.2218531

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Abstract

The amyloid β protein is deposited in the brains of patients with Alzheimer's disease but its pathogenic role is unknown. In culture, the amyloid β protein was neurotrophic to undifferentiated hippocampal neurons at low concentrations and neurotoxic to mature neurons at higher concentrations. In differentiated neurons, amyloid β protein caused dendritic and axonal retraction followed by neuronal death. A portion of the amyloid β protein (amino acids 25 to 35) mediated both the trophic and toxic effects and was homologous to the tachykinin neuropeptide family. The effects of the amyloid β protein were mimicked by tachykinin antagonists and completely reversed by specific tachykinin agonists. Thus, the amyloid β protein could function as a neurotrophic factor for differentiating neurons, but at high concentrations in mature neurons, as in Alzheimer's disease, could cause neuronal degeneration.

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Authors: Yankner, B. A., Duffy, L. K., & Kirschner, D. A.
Affiliations: Boston Children's Hospital (US)
University of Alaska Fairbanks (US)
ORCID: Yankner, Bruce A.
Duffy, Lawrence K.
Kirschner, Daniel A.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1990-10-12
Volume: 250
Issue: 4978
Pages: 279-282
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.2218531
OpenAlex: W2059214757
Cited by: 1,975
References: 31
Citations by year: 2026: 9 · 2025: 17 · 2024: 15 · 2023: 22 · 2022: 14 · 2021: 29 · 2020: 19 · 2019: 29 · 2018: 32 · 2017: 27 · 2016: 37 · 2015: 44 · 2014: 46 · 2013: 40 · 2012: 40
FWCI: 64.80
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG08572, R01AG008572)
National Institute of Neurological Disorders and Stroke (NS01240, K08NS001240)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: amyloid-beta, Alzheimer's disease, neurotoxicity, neurotrophic effects, tachykinin antagonists, hippocampal neurons, neuronal differentiation, neuronal cell death, dendritic retraction, axonal retraction, neurotrophic factors
MeSH terms: Amino Acid Sequence, Animals, Cells, Cultured, Embryo, Mammalian, Hippocampus, Molecular Sequence Data, Neurons, Neurotoxins, Peptide Fragments, Tachykinins, Amyloid beta-Peptides, Rats

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Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

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