Finding the Intersection of Neuroplasticity, Stroke Recovery, and Learning: Scope and Contributions to Stroke Rehabilitation
Open accessAbstract
Aim. Neural plastic changes are experience and learning dependent, yet exploiting this knowledge to enhance clinical outcomes after stroke is in its infancy. Our aim was to search the available evidence for the core concepts of neuroplasticity, stroke recovery, and learning; identify links between these concepts; and identify and review the themes that best characterise the intersection of these three concepts. Methods. We developed a novel approach to identify the common research topics among the three areas: neuroplasticity, stroke recovery, and learning. A concept map was created a priori, and separate searches were conducted for each concept. The methodology involved three main phases: data collection and filtering, development of a clinical vocabulary, and the development of an automatic clinical text processing engine to aid the process and identify the unique and common topics. The common themes from the intersection of the three concepts were identified. These were then reviewed, with particular reference to the top 30 articles identified as intersecting these concepts. Results. The search of the three concepts separately yielded 405,636 publications. Publications were filtered to include only human studies, generating 263,751 publications related to the concepts of neuroplasticity ( n=6,498 ), stroke recovery ( n=79,060 ), and learning ( n=178,193 ). A cluster concept map (network graph) was generated from the results; indicating the concept nodes, strength of link between nodes, and the intersection between all three concepts. We identified 23 common themes (topics) and the top 30 articles that best represent the intersecting themes. A time-linked pattern emerged. Discussion and Conclusions. Our novel approach developed for this review allowed the identification of the common themes/topics that intersect the concepts of neuroplasticity, stroke recovery, and learning. These may be synthesised to advance a neuroscience-informed approach to stroke rehabilitation. We also identified gaps in available literature using this approach. These may help guide future targeted research.
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Physical activity improves patients' functioning, especially during the early post-stroke window of enhanced neuroplasticity, but also at a later time.
“Physical activity (PA), i.a., by stimulating neuroplasticity improves patients functioning (especially during the window of enhanced neuroplasticity early after stroke, but also at a later time [5]) [6,7].”
From Physical Activity, Psychological and Functional Outcomes in Non-Ambulatory Stroke Patients during Rehabilitation—A Pilot Study (2022) · cites this paper as [7]
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- Authors
- Carey, L., Walsh, A., Adikari, A., Goodin, P., Alahakoon, D., De Silva, D., Ong, K.-L., Nilsson, M., & Boyd, L.
- Affiliations
- La Trobe University (AU)
- The Royal Melbourne Hospital (AU)
- Research Centre for Data Analytics and Cognition, La Trobe University, Bundoora, VIC 3086, Australia
- Nanyang Technological University (SG)
- University of British Columbia (CA)
- Corresponding author
- Carey, Leeanne
- Nilsson, Michael
- Boyd, Lara
- ORCID
- Venue
- Neural Plasticity
- Publisher
- Wiley
- Published
- 2019-05-02
- Volume
- 2019
- Pages
- 1-15
- ISSN
- 1687-5443 (ISSN-L)
- 2090-5904
- PMC
- PMC6525913
- OpenAlex
- W2942517527
- Cited by
- 68
- References
- 68
- Citations by year
- 2026: 3 · 2025: 19 · 2024: 11 · 2023: 12 · 2022: 7 · 2021: 8 · 2020: 8
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Neural Plasticity (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DR-NTU (Nanyang Technological University) (submittedVersion, cc-by)
- Figshare (submittedVersion, cc-by)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- NOVA (University of Newcastle Australia) (submittedVersion, cc-by)
- Funders
- National Health and Medical Research Council (1134495, 1077898, 307905, 1022694, 220020413)
- James S. McDonnell Foundation (1134495, 1077898, 307905, 1022694, 220020413)
- Topics
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Keywords
- neuroplasticity, stroke recovery, learning, stroke rehabilitation, concept mapping, research gaps
- MeSH terms
- Stroke Rehabilitation, Brain, Humans, Learning, Neuronal Plasticity, Neurons, Recovery of Function, Stroke
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