The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function
Abstract
Lymphocyte-specific interferon regulatory factor (LSIRF) (now called IRF4) is a transcription factor expressed only in lymphocytes. Mice deficient in IRF4 showed normal distribution of B and T lymphocyes at 4 to 5 weeks of age but developed progressive generalized lymphadenopathy. IRF4-deficient mice exhibited a profound reduction in serum immunoglobulin concentrations and did not mount detectable antibody responses. T lymphocyte function was also impaired in vivo; these mice could not generate cytotoxic or antitumor responses. Thus, IRF4 is essential for the function and homeostasis of both mature B and mature T lymphocytes.
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In the citing paper
“Pip-deficient animals develop normal numbers of B cells (including λ-expressors) which cannot undergo activation”
From Assembly requirements of PU.1–Pip (IRF‐4) activator complexes: inhibiting function in vivo using fused dimers (1999) · cites this paper as Mittrucker et al., 1997
In the citing paper
“whereas PIP function is necessary for maturation of B and T lymphocytes (34”
From AKT Induces Transcriptional Activity of PU.1 through Phosphorylation-mediated Modifications within Its Transactivation Domain (2001) · cites this paper as [34]
In the citing paper
“whereas PIP−/− animals exhibit a block in peripheral maturation of B cells and fail to produce antibodies in response to antigenic stimulation.”
From AKT Induces Transcriptional Activity of PU.1 through Phosphorylation-mediated Modifications within Its Transactivation Domain (2001) · cites this paper as [34]
In the citing paper
“Similarly, T cells of the mutant animals (PIP−/−) lack proliferative and cytotoxic responses (34”
From AKT Induces Transcriptional Activity of PU.1 through Phosphorylation-mediated Modifications within Its Transactivation Domain (2001) · cites this paper as [34]
In the citing paper
“IRF-4 2 / 2 mice develop progressive generalized lymphadenopathy and have severe defects in B and T lymphocyte function. (65)”
From Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells (2002) · cites this paper as [65]
In the citing paper
“IRF-4 2 / 2 mice develop progressive generalized lymphadenopathy and have severe defects in B and T lymphocyte function. (65)”
From Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells (2002) · cites this paper as [65]
Citations
Cites
Differential T Cell Costimulatory Requirements in CD28-Deficient Mice
Shahinian, A., Pfeffer, K., Lee, K. P., Kündig, T. M., Kishihara, K., Wakeham, A. C., Kawai, K., Ohashi, P. S., Thompson, C. B., & Mak, T. W. (1993) · Science · doi:10.1126/science.7688139 · Cited by 1,258
Self-citationInterleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment
Willerford, D. M., Chen, J., Ferry, J. A., Davidson, L., Ma, A. I., & Alt, F. W. (1995) · Immunity · doi:10.1016/1074-7613(95)90180-9 · Cited by 1,079
Requirement for Transcription Factor IRF-1 in NO Synthase Induction in Macrophages
Kamijo, R., Harada, H., Matsuyama, T., Bosland, M. C., Gerecitano, J. F., Shapiro, D., Le, J., Koh, S. I., Kimura, T., Green, S. J., et al. (1994) · Science · doi:10.1126/science.7510419 · Cited by 843
Self-citationTanaka, N., Ishihara, M., Kitagawa, M., Harada, H., Kimura, T., Matsuyama, T., Lamphier, M. S., Aizawa, S., Mak, T. W., & Taniguchi, T. (1994) · Cell · doi:10.1016/0092-8674(94)90132-5 · Cited by 491
Self-citationPip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.
Eisenbeis, C. F., Singh, H., & Storb, U. (1995) · Genes & Development · doi:10.1101/gad.9.11.1377 · Cited by 447
An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes
Tamura, T., Ishihara, M., Lamphier, M. S., Tanaka, N., Oishi, I., Aizawa, S., Matsuyama, T., Mak, T. W., Taki, S., & Taniguchi, T. (1995) · Nature · doi:10.1038/376596a0 · Cited by 431
Self-citationBetz, A. G., Milstein, C., González‐Fernández, Á., Pannell, R., Larson, T., & Neuberger, M. S. (1994) · Cell · doi:10.1016/0092-8674(94)90316-6 · Cited by 379
An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes
石原, 正. (1997) · Cited by 366
Transitional B cells are the target of negative selection in the B cell compartment.
Carsetti, R., Köhler, G., & Lamers, M. C. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.6.2129 · Cited by 358
Interferon-Induced Antiviral Actions and Their Regulation
Sen, G. C., & Ransohoff, R. M. (1993) · Advances in virus research · doi:10.1016/s0065-3527(08)60083-4 · Cited by 334
Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage
Tanaka, N., Ishihara, M., Lamphier, M. S., Nozawa, H., Matsuyama, T., Mak, T. W., Aizawa, S., Tokino, T., Oren, M., & Taniguchi, T. (1996) · Nature · doi:10.1038/382816a0 · Cited by 324
Self-citationFunctional analysis of T lymphocyte subsets in antiviral host defense.
Leist, T. P., Cobbold, S. P., Waldmann, H., Aguet, M., & Zinkernagel, R. M. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.138.7.2278 · Cited by 233
Kneitz, B., Herrmann, T., Yonehara, S., & Schimpl, A. (1995) · European Journal of Immunology · doi:10.1002/eji.1830250925 · Cited by 229
Matsuyama, T., Grossman, A., Mittrücker, H.-W., Siderovski, D. P., Kiefer, F., Kawakami, T., Richardson, C. D., Taniguchi, T., Yoshinaga, S. K., & Mak, T. W. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.12.2127 · Cited by 196
Self-citationYamagata, T., Nishida, J., Tanaka, T., Sakai, R., Mitani, K., Yoshida, M., Taniguchi, T., Yazaki, Y., & Hirai, H. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.4.1283 · Cited by 196
Peripheral lymphoid development and function in TCR mutant mice
Mombaerts, P., Mizoguchi, E., Ljunggren, H., lacomini, J., Ishikawa, H., Wang, L., Grusby, M. J., Gilmcher, L. H., Winn, H. J., Bhan, A. K., et al. (1994) · International Immunology · doi:10.1093/intimm/6.7.1061 · Cited by 96
Immunoglobulin-mediated signal transduction in B cells from CD45-deficient mice.
Benatar, T., Carsetti, R., Furlonger, C. L., Kamalia, N., Mak, T. W., & Paige, C. J. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.1.329 · Cited by 91
Self-citationThe importance of the 3′-enhancer region in immunoglobulinxgene expression
Meyer, K. B., Sharpe, M. J., Surani, M. A., & Neuberger, M. S. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.19.5609 · Cited by 81
Mittrücker, H., Shahinian, A., Bouchard, D., Kündig, T. M., & Mak, T. W. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2481 · Cited by 77
Self-citationGrossman, A., Mittrücker, H.-W., Nicholl, J., Suzuki, A., Chung, S., Antonio, L., Suggs, S., Sutherland, G. R., Siderovski, D. P., & Mak, T. W. (1996) · Genomics · doi:10.1006/geno.1996.0547 · Cited by 60
Self-citationMoskophidis, D., & Lehmann-Grube, F. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.9.3291 · Cited by 55
Flagged first, then by citations
Research works printed but not linked: 4
- Lamphier M., Taniguchi T., Immunologist 2, 167 (1994);
- Vaughan P. S., et al., ibid. 377, 362 (1995);
- Schmits R., et al., ibid., p. 1415.
- Healthy 5- to 7-week-old mice were used for all experiments. Mice were maintained according to the guidelines of the Canadian Council of Animal Care. H.-W.M. is a recipient of a grant from the Deutsche Forschungsgemeinschaft. The authors thank M. Bachmann G. Boehmelt G. Duncan D. Ferrick C. Furlonger D. Kägi F. Kiefer L. Marengere C. Paige J. Penninger M. Saunders R. Schmits D. Siderovski D. Speiser S. Yoshinaga and P. Waterhouse for providing reagents and for helpful comments.
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Honda, K., & Taniguchi, T. (2006) · Nature reviews. Immunology · doi:10.1038/nri1900 · Cited by 1,716
IRF Family of Transcription Factors as Regulators of Host Defense
Taniguchi, T., Ogasawara, K., Takaoka, A., & Tanaka, N. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.623 · Cited by 1,658
Plasma cell differentiation requires the transcription factor XBP-1
Reimold, A., Iwakoshi, N., Manis, J., Vallabhajosyula, P., Szomolanyi-Tsuda, E., Gravallese, E., Friend, D., Grusby, M., Alt, F., & Glimcher, L. (2001) · Nature · doi:10.1038/35085509 · Cited by 1,371
The IRF Family Transcription Factors in Immunity and Oncogenesis
Tamura, T., Yanai, H., Savitsky, D., & Taniguchi, T. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090400 · Cited by 1,259
Metadata
- Authors
- Mittrücker, H.-W., Matsuyama, T., Grossman, A., Kündig, T. M., Potter, J., Shahinian, A., Wakeham, A., Patterson, B., Ohashi, P. S., & Mak, T. W.
- Affiliations
- University of Toronto (CA)
- Nagasaki University (JP)
- B. Patterson, Department of Oncologic Pathology, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, M5G 2C1, Canada.
- Venue
- Science
- Published
- 1997-01-24
- Volume
- 275
- Issue
- 5299
- Pages
- 540-543
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2022687427
- Cited by
- 583
- References
- 21
- Citations by year
- 2026: 7 · 2025: 15 · 2024: 12 · 2023: 20 · 2022: 23 · 2021: 23 · 2020: 17 · 2019: 15 · 2018: 16 · 2017: 20 · 2016: 15 · 2015: 18 · 2014: 25 · 2013: 32 · 2012: 20
- FWCI
- 8.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Keywords
- IRF4, transcription factors, B cells, T cells, lymphocyte homeostasis, lymphadenopathy, antibody deficiency, antibody response, cytotoxic T lymphocytes, antitumor immunity
- MeSH terms
- Lymphadenopathy, Interferon Regulatory Factor-4, Animals, Antibody Formation, B-Lymphocytes, Cell Differentiation, Cells, Cultured, Homeostasis, Mice, Inbred BALB C, T-Lymphocytes, Cytotoxic, Transcription, Genetic, Mice, SCID, Mice, Knockout, Cell Proliferation, Interferon Regulatory Factors, Mice
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