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The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE)

Matsuyama, Toshifumi, Grossman, Alex, Mittrücker, Hans-Willi, Siderovski, David P., Kiefer, Friedemann, Kawakami, Takatoshi, Richardson, Christopher D., Taniguchi, Tadatsugu, Yoshinaga, Steven K., Mak, Tak W.·1995·Nucleic Acids Research
DOI 10.1093/nar/23.12.2127
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Abstract

Interferon regulatory factor (IRF) genes encode a family of DNA-binding proteins that are involved in the transcriptional regulation of type-I interferon and/or interferon-inducible genes. We report here the characterization of LSIRF, a new member of the IRF gene family cloned from mouse spleen by the polymerase chain reaction using degenerate primers. LSIRF was found to encode a 51 kDa protein that shares a high degree of amino acid sequence homology in the DNA-binding domain with other IRF family members. LSIRF expression was detectable only in lymphoid cells. In contrast to other IRF genes, LSIRF expression was not induced by interferons, but rather by antigen-receptor mediated stimuli such as plant lectins, CD3 or IgM crosslinking. In in vitro DNA binding studies, LSIRF was able to bind to the interferon-stimulated response element (ISRE) of the MHC class I promoter. The expression pattern and DNA binding activities suggest that LSIRF plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells.

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Crossref · 10.1093/nar/23.12.2127

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Metadata

Authors
Matsuyama, T., Grossman, A., Mittrücker, H.-W., Siderovski, D. P., Kiefer, F., Kawakami, T., Richardson, C. D., Taniguchi, T., Yoshinaga, S. K., & Mak, T. W.
Venue
Nucleic Acids Research
Publisher
Oxford University Press (OUP)
Published
1995
Volume
23
Issue
12
Pages
2127-2136
ISSN
  • 0305-1048
  • 1362-4962
DOI
10.1093/nar/23.12.2127
Cited by
196
References
5
Language
en

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