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IRAK (Pelle) Family Member IRAK-2 and MyD88 as Proximal Mediators of IL-1 Signaling
Abstract
The interleukin-1 receptor (IL-1R) signaling pathway leads to nuclear factor kappa B (NF-κB) activation in mammals and is similar to the Toll pathway in Drosophila : the IL-1R–associated kinase (IRAK) is homologous to Pelle. Two additional proximal mediators were identified that are required for IL-1R–induced NF-κB activation: IRAK-2, a Pelle family member, and MyD88, a death domain–containing adapter molecule. Both associate with the IL-1R signaling complex. Dominant negative forms of either attenuate IL-1R–mediated NF-κB activation. Therefore, IRAK-2 and MyD88 may provide additional therapeutic targets for inhibiting IL-1–induced inflammation.
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Metadata
- Authors
- Muzio, M., Ni, J., Feng, P., & Dixit, V. M.
- Venue
- Science
- Published
- 1997-11-28
- Volume
- 278
- Issue
- 5343
- Pages
- 1612-1615
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1965971815
- Cited by
- 1,170
- References
- 0
- FWCI
- 19.78
- Type
- journal article
- Language
- en
- Open access
- closed
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