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Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis
Open accessAbstract
To characterize cell surface molecules involved in control of growth of malignant lymphocytes, monoclonal antibodies were raised against the human B lymphoblast cell line SKW6.4. One monoclonal antibody, anti-APO-1, reacted with a 52-kilodalton antigen (APO-1) on a set of activated human lymphocytes, on malignant human lymphocyte lines, and on some patient-derived leukemic cells. Nanogram quantities of anti-APO-1 completely blocked proliferation of cells bearing APO-1 in vitro in a manner characteristic of a process called programmed cell death or apoptosis. Cell death was preceded by changes in cell morphology and fragmentation of DNA. This process was distinct from antibody- and complement-dependent cell lysis and was mediated by the antibody alone. A single intravenous injection of anti-APO-1 into nu / nu mice carrying a xenotransplant of a human B cell tumor induced regression of this tumor within a few days. Histological thin sections of the regressing tumor showed that anti-APO-1 was able to induce apoptosis in vivo. Thus, induction of apoptosis as a consequence of a signal mediated through cell surface molecules like APO-1 may be a useful therapeutic approach in treatment of malignancy.
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Metadata
- Authors
- Trauth, B. C., Klas, C., Peters, A. M. J., Matzku, S., Möller, P., Falk, W., Debatin, K.-M., & Krammer, P. H.
- Venue
- Science
- Published
- 1989-07-21
- Volume
- 245
- Issue
- 4915
- Pages
- 301-305
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1976692354
- Cited by
- 1,716
- References
- 1
- FWCI
- 9.79
- Type
- journal article
- Language
- en
- Open access
- green
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