Cited by 834PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase SignalingMetabolism, Diabetes, and Cancer

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Phosphorylation and Activation of p70 s6k by PDK1

Pullen, Nicholas, Dennis, Patrick B., Andjelkovic, Mirjana, Dufner, Almut, Kozma, Sara C., Hemmings, Brian A., Thomas, George·1998·Science

DOI 10.1126/science.279.5351.707

Open this paper in CoChat — free account

Abstract

Activation of the protein p70 s6k by mitogens leads to increased translation of a family of messenger RNAs that encode essential components of the protein synthetic apparatus. Activation of the kinase requires hierarchical phosphorylation at multiple sites, culminating in the phosphorylation of the threonine in position 229 (Thr 229 ), in the catalytic domain. The homologous site in protein kinase B (PKB), Thr 308 , has been shown to be phosphorylated by the phosphoinositide-dependent protein kinase PDK1. A regulatory link between p70 s6k and PKB was demonstrated, as PDK1 was found to selectively phosphorylate p70 s6k at Thr 229 . More importantly, PDK1 activated p70 s6k in vitro and in vivo, whereas the catalytically inactive PDK1 blocked insulin-induced activation of p70 s6k .

Integrity signals

Registry

Crossref · 10.1126/science.279.5351.707

Cites

13 of 13 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244
Self-citation
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα
Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R. J., Reese, C. B., & Cohen, P. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00122-9 · Cited by 2,874
Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B
Stokoe, D., Stephens, L. R., Copeland, T., Gaffney, P. R. J., Reese, C. B., Painter, G. F., Holmes, A. B., McCormick, F. P., & Hawkins, P. T. (1997) · Science · doi:10.1126/science.277.5325.567 · Cited by 1,216
Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6k
Jefferies, H. B. J., Fumagalli, S., Dennis, P. B., Reinhard, C., Pearson, R. B., & Thomas, G. (1997) · The EMBO Journal · doi:10.1093/emboj/16.12.3693 · Cited by 934
Self-citation
3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase
Alessi, D. R., Deák, M., Casamayor, A., Caudwell, F. B., MORRICE, N. A., Norman, D. G., Gaffney, P. R. J., Reese, C. B., MacDougall, C. N., Harbison, D., et al. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00336-8 · Cited by 754
PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase
Chung, J., Grammar, T. C., Lemon, K. P., Kazlauskas, A., & Blenis, J. (1994) · Nature · doi:10.1038/370071a0 · Cited by 712
The modular phosphorylation and activation of p70 s6k
Pullen, N., & Thomas, G. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00323-2 · Cited by 550
Self-citation
Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors.
Andjelković, M., Jakubowicz, T., Cron, P. D., Ming, X., Han, J. W., & Hemmings, B. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.5699 · Cited by 497
Self-citation
The principal target of rapamycin‐induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.
Pearson, R. B., Dennis, P. B., Han, J. W., Williamson, N. A., Kozma, S. C., Wettenhall, R. E., & Thomas, G. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00212.x · Cited by 443
Self-citation
The Principal Rapamycin-Sensitive p70s6k Phosphorylation Sites, T-229 and T-389, Are Differentially Regulated by Rapamycin-Insensitive Kinase Kinases
Dennis, P. B., Pullen, N., Kozma, S. C., & Thomas, G. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.11.6242 · Cited by 253
Self-citation

Show all 13 references

Research works printed but not linked: 3

O. Meyuhas D. Avni S. Shama in Translational Control J. W. B. Hershey M. B. Mathews N. Sonenberg Eds. (Cold Spring Harbor Laboratory Press Cold Spring Harbor NY 1996).
Ming X. F., et al., ibid. 371, 426 (1994).
S. K. Hanks and T. Hunter in The Protein Kinase Facts Book: Protein-Serine Kinases G. Hardie and S. Hanks Eds. (Academic Press London 1995).

Sorted by citations

Items 201–300 of 834

The Complexes of Mammalian Target of Rapamycin
Zhou, H., & Huang, S. (2010) · Current Protein and Peptide Science · doi:10.2174/138920310791824093 · Cited by 153
Induction of Metaphase Arrest in Cleaving Xenopus Embryos by the Protein Kinase p90 Rsk
Gross, S. D., Schwab, M. S., Lewellyn, A. L., & Maller, J. L. (1999) · Science · doi:10.1126/science.286.5443.1365 · Cited by 146
Amino-acid-dependent signal transduction
SLUIJTERS, D. A. V., Dubbelhuis, P. F., Blommaart, E. F. C., & Meijer, A. J. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3510545 · Cited by 144
Autophagy is essential to support skeletal muscle plasticity in response to endurance exercise
Sanchez, A. M. J., Bernardi, H., Py, G., & Candau, R. B. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00187.2014 · Cited by 125
Human skeletal muscle atrophy in amyotrophic lateral sclerosis reveals a reduction in Akt and an increase in atrogin‐1
Léger, B., Vergani, L., Sorarú, G., Hespel, P., Derave, W., Gobelet, C., D'Ascenzio, C., Angelini, C. I., & Russell, A. P. (2006) · The FASEB Journal · doi:10.1096/fj.05-5249fje · Cited by 147
Targeting PDK1 in Cancer
Raimondi, C., & Falasca, M. (2011) · Current Medicinal Chemistry · doi:10.2174/092986711796011238 · Cited by 141
Okadaic-Acid-Induced Inhibition of Protein Phosphatase 2A Produces Activation of Mitogen-Activated Protein Kinases ERK1/2, MEK1/2, and p70 S6, Similar to That in Alzheimer's Disease
Pei, J.-J., Gong, C., An, W., Winblad, B. G., Cowburn, R. F., Grundke, I., & Iqbal, K. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63445-1 · Cited by 142
Phosphorylation Sites in the Autoinhibitory Domain Participate in p70s6k Activation Loop Phosphorylation
Dennis, P. B., Pullen, N., Pearson, R. B., Kozma, S. C., & Thomas, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.24.14845 · Cited by 142
Self-citation
Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK
Richards, S. A., Fu, J., Romanelli, A., Shimamura, A., & Blenis, J. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80364-9 · Cited by 142
RETRACTED: Downstream effectors of oncogenic ras in multiple myeloma cells
Hu, L., Shi, Y., Hsu, J.-H., Gera, J., Ness, B. V., & Lichtenstein, A. K. (2003) · Blood · doi:10.1182/blood-2002-08-2640 · Cited by 141
Retracted
Phosphorylation of TNF-α converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation
Zhang, Q. H., Thomas, S. M., Lui, V. W. Y., Xi, S., Siegfried, J. M., Fan, H., Smithgall, T. E., Mills, G. B., & Grandis, J. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509719103 · Cited by 141
Transcriptomic analyses reveal rhythmic and CLOCK-driven pathways in human skeletal muscle
Perrin, L., Loizides-Mangold, U., Chanon, S., Gobet, C., Hulo, N., Isenegger, L., Weger, B. D., Migliavacca, E., Charpagne, A., Betts, J. A., et al. (2018) · eLife · doi:10.7554/elife.34114 · Cited by 139
Insulin-stimulated Protein Kinase B Phosphorylation on Ser-473 Is Independent of Its Activity and Occurs through a Staurosporine-insensitive Kinase
Hill, M. M. C., Andjelković, M., Brazil, D. P., Ferrari, S. M., Fabbro, D., & Hemmings, B. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100174200 · Cited by 139
Self-citation
PDK1 Homologs Activate the Pkc1–Mitogen-Activated Protein Kinase Pathway in Yeast
Inagaki, M., Schmelzle, T., Yamaguchi, T., Irie, K., Hall, M. N., & Matsumoto, K. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.12.8344 · Cited by 138
Evolution of the TOR Pathway
van Dam, T. J. P., Zwartkruis, F. J. T., Bos, J. L., & Snel, ‎. (2011) · Journal of Molecular Evolution · doi:10.1007/s00239-011-9469-9 · Cited by 147
The Role of mTORC1 in Regulating Protein Synthesis and Skeletal Muscle Mass in Response to Various Mechanical Stimuli
Goodman, C. A. (2013) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2013_17 · Cited by 145
Schizosaccharomyces pombe AGC family kinase Gad8p forms a conserved signaling module with TOR and PDK1‐like kinases
Matsuo, T., Kubo, Y., Watanabe, Y., & Yamamoto, M. P. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg298 · Cited by 135
Mutant Presenilin-1 Induces Apoptosis and Downregulates Akt/PKB
Weihl, C. C., Ghadge, G. D., Kennedy, S. G., Hay, N., Miller, R. J., & Roos, R. P. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-13-05360.1999 · Cited by 137
Role of the p70S6K pathway in regulating the actin cytoskeleton and cell migration
Berven, L. A., Willard, F. S., & Crouch, M. F. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2003.12.032 · Cited by 137
Mechanisms of resistance to rapamycins
Huang, S., & Houghton, P. J. (2001) · Drug Resistance Updates · doi:10.1054/drup.2002.0227 · Cited by 143
Triptolide Restores Autophagy to Alleviate Diabetic Renal Fibrosis through the miR-141-3p/PTEN/Akt/mTOR Pathway
Li, X.-Y., Wang, S.-S., Han, Z., Han, F., Chang, Y.-P., Yang, Y., Xue, M., Sun, B., & Chen, L.-M. (2017) · Molecular Therapy - Nucleic Acids · doi:10.1016/j.omtn.2017.08.011 · Cited by 132
Mislocalization of the Cell Polarity Protein Scribble Promotes Mammary Tumorigenesis and Is Associated with Basal Breast Cancer
Feigin, M. E., Akshinthala, S. D., Araki, K., Rosenberg, A. Z., Muthuswamy, L. B., Martin, B., Lehmann, B. D., Berman, H. K., Pietenpol, J. A., Cardiff, R. D., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3415 · Cited by 135
Evidence That 3-Phosphoinositide-dependent Protein Kinase-1 Mediates Phosphorylation of p70 S6 Kinase in Vivoat Thr-412 as well as Thr-252
Balendran, A., Currie, R. A., Armstrong, C. G., Avruch, J., & Alessi, D. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.52.37400 · Cited by 135
Label-free Kinase Profiling Using Phosphate Affinity Polyacrylamide Gel Electrophoresis
Kinoshita‐Kikuta, E., Aoki, Y., Kinoshita, E., & Koike, T. (2006) · Molecular & Cellular Proteomics · doi:10.1074/mcp.t600044-mcp200 · Cited by 134
p53/p21(CIP1) cooperate in enforcing rapamycin-induced G(1) arrest and determine the cellular response to rapamycin.
Huang, S., Liu, L. N., Hosoi, H., Dilling, M. B., Shikata, T., & Houghton, P. J. (2001) · PubMed · Cited by 130
Mechanisms of Proliferation Synergy by Receptor Tyrosine Kinase and G Protein–Coupled Receptor Activation in Human Airway Smooth Muscle
Krymskaya, V. P., Orsini, M. J., Eszterhas, A. J., Brodbeck, K. C., Benovic, J., Panettieri, R. A., & Penn, R. B. (2000) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.23.4.4115 · Cited by 131
PI3-kinase and TOR: PIKTORing cell growth
Richardson, C. J., Schalm, S. S., & Blenis, J. (2004) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2003.12.023 · Cited by 130
Octreotide and the mTOR Inhibitor RAD001 (Everolimus) Block Proliferation and Interact with the Akt-mTOR-p70S6K Pathway in a Neuro-Endocrine Tumour Cell Line
Grozinsky‐Glasberg, S., Franchi, G. M., Teng, M. J., Leontiou, C. A., de Oliveira, A. R., Ciaramella, P. D., Salahuddin, N., Korbonits, M., & Grossman, A. B. (2007) · Neuroendocrinology · doi:10.1159/000111501 · Cited by 130
Cross-talk between the ERK and p70 S6 Kinase (S6K) Signaling Pathways
Wang, L., Gout, I. T., & Proud, C. G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102776200 · Cited by 130
Sli2 (Ypk1), a Homologue of Mammalian Protein Kinase SGK, Is a Downstream Kinase in the Sphingolipid-Mediated Signaling Pathway of Yeast
Sun, Y., 谷口, 律., Tanoue, D., Yamaji, T., Takematsu, H., Mori, K., Fujita, T., Kawasaki, T., & Kozutsumi, Y. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.12.4411-4419.2000 · Cited by 130
Kinase phosphorylation: Keeping it all in the family
Peterson, R. T., & Schreiber, S. L. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80326-1 · Cited by 130
Effect of Phosphoinositide-Dependent Kinase 1 on Protein Kinase B Translocation and Its Subsequent Activation
Filippa, N., Sable, C. L., Hemmings, B. A., & OBBERGHEN, E. V. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.15.5712-5721.2000 · Cited by 130
Self-citation
Transformation by v-Src: Ras-MAPK and PI3K-mTOR Mediate Parallel Pathways
Penuel, E. M., & Martin, G. S. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.6.1693 · Cited by 131
Early Events in M-CSF Receptor Signaling
Bourette, R. P., & Rohrschneider, L. R. (2000) · Growth Factors · doi:10.3109/08977190009001065 · Cited by 125
Withdrawal of Essential Amino Acids Increases Autophagy by a Pathway Involving Ca2+/Calmodulin-dependent Kinase Kinase-β (CaMKK-β)
Ghislat, G., Patrón, M., Rizzuto, R., & Knecht, E. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.365767 · Cited by 130
Rho GTPase Control of Protein Kinase C-related Protein Kinase Activation by 3-Phosphoinositide-dependent Protein Kinase
Flynn, P., Mellor, H., Casamassima, A., & Parker, P. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.15.11064 · Cited by 126
Tsc2 Null Murine Neuroepithelial Cells Are a Model for Human Tuber Giant Cells, and Show Activation of an mTOR Pathway
Onda, H. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2002.1184 · Cited by 126
Carboxyl-terminal Phosphorylation Regulates the Function and Subcellular Localization of Protein Kinase C βII
Edwards, A., Faux, M. C., Scott, J. D., & Newton, A. C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.10.6461 · Cited by 126
The Multifaceted Role of Nutrient Sensing and mTORC1 Signaling in Physiology and Aging
Fernandes, S., & Demetriades, C. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.707372 · Cited by 131
Crosstalk Between Protein Kinase A and Growth Factor Receptor Signaling Pathways in Arterial Smooth Muscle
Bornfeldt, K., & Krebs, E. G. (1999) · Cellular Signalling · doi:10.1016/s0898-6568(99)00020-0 · Cited by 125
Modulation of cellular apoptotic potential: contributions to oncogenesis
Stambolic, V., Mak, T. W., & Woodgett, J. R. (1999) · Oncogene · doi:10.1038/sj.onc.1203126 · Cited by 125
Small‐Molecule Inhibitors of PDK1
Peifer, C., & Alessi, D. R. (2008) · ChemMedChem · doi:10.1002/cmdc.200800195 · Cited by 124
Activation of the p70 S6 Kinase and Phosphorylation of the 4E-BP1 Repressor of mRNA Translation by Type I Interferons
Lekmine, F., Shahab Uddin, M. S., Sassano, A., Parmar, S., Brachmann, S. M., Majchrzak, B., Sonenberg, N., Hay, N., Fish, E. N., & Platanias, L. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301364200 · Cited by 125
Phosphatidylinositol 3-kinase mediates mitogen-induced human airway smooth muscle cell proliferation
Krymskaya, V. P., Penn, R. B., Orsini, M. J., Scott, P., Plevin, R. J., Walker, T. R., Eszterhas, A. J., Amrani, Y., Chilvers, E. R., & Panettieri, R. A. (1999) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1999.277.1.l65 · Cited by 123
Identification of Tyrosine Phosphorylation Sites on 3-Phosphoinositide-dependent Protein Kinase-1 and Their Role in Regulating Kinase Activity
Park, J., Hill, M. M. C., Heß, D., Brazil, D. P., Hofsteenge, J., & Hemmings, B. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105916200 · Cited by 123
Self-citation
The camKK2/camKIV relay is an essential regulator of hepatic cancer
Lin, F., Marcelo, K. L., Rajapakshe, K., Coarfa, C., Dean, A. M., Wilganowski, N. L., Robinson, H., Sevick, E., Bissig, K., Goldie, L. C., et al. (2015) · Hepatology · doi:10.1002/hep.27832 · Cited by 121
Phosphoinositide-Regulated Kinases and Phosphoinositide Phosphatases
Leslie, N. R., Biondi, R. M., & Alessi, D. R. (2001) · Chemical Reviews · doi:10.1021/cr000091i · Cited by 121
Distinct Phosphatidylinositol 3-Kinase Lipid Products Accumulate upon Oxidative and Osmotic Stress and Lead to Different Cellular Responses
KAAY, J. V. D., Beck, M., Gray, A., & Downes, C. P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.50.35963 · Cited by 120
Key factors in mTOR regulation
Bai, X., & Jiang, Y. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0163-7 · Cited by 123
P70 S6 kinase mediates tau phosphorylation and synthesis
Pei, J.-J., An, W., Zhou, X., Nishimura, T., Norberg, J., Benedikz, E., Götz, J., & Winblad, B. G. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.11.059 · Cited by 121
mTOR-Mediated Activation of p70 S6K Induces Differentiation of Pluripotent Human Embryonic Stem Cells
Easley, C. A., Ben‐Yehudah, A., Redinger, C. J., Oliver, S. L., Varum, S., Eisinger, V. M., Carlisle, D. L., Donovan, P. J., & Schatten, G. P. (2010) · Cellular Reprogramming · doi:10.1089/cell.2010.0011 · Cited by 122
Role of mTOR Signalling in the Control of Translation Initiation and Elongation by Nutrients
Proud, C. G. (2004) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-18930-2_13 · Cited by 121
Interleukin-8 Signaling Promotes Translational Regulation of Cyclin D in Androgen-Independent Prostate Cancer Cells
MacManus, C. F., Pettigrew, J., Seaton, A., Wilson, C., Maxwell, P. J., Berlingeri, S., Purcell, C., McGurk, M., Johnston, P. G., & Waugh, D. J. J. (2007) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-07-0032 · Cited by 118
Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition
Komander, D., Kular, G. S., Jennifer, B. A. I. N., Elliott, M., Alessi, D. R., & van Aalten, D. M. F. (2003) · Biochemical Journal · doi:10.1042/bj20031119 · Cited by 117
mTOR Signaling Pathway and mTOR Inhibitors in Cancer Therapy
Gómez-Pinillos, A., & Ferrari, A. C. (2012) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2012.02.014 · Cited by 119
The role of AMP-activated protein kinase in the coordination of skeletal muscle turnover and energy homeostasis
Sanchez, A. M. J., Candau, R. B., Csibi, A., Pagano, A. F., Raibon, A., & Bernardi, H. (2012) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00125.2012 · Cited by 122
Phytohormones Participate in an S6 Kinase Signal Transduction Pathway in Arabidopsis1
Turck, F., Zilbermann, F., Kozma, S., Thomas, G., & Nagy, F. (2004) · Plant Physiology · doi:10.1104/pp.103.035873 · Cited by 118
Self-citation
Phosphorylation of the Catalytic Subunit of Protein Kinase A
Moore, M. J., Kanter, J. R., Jones, K., & Taylor, S. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204970200 · Cited by 116
A liaison between mTOR signaling, ribosome biogenesis and cancer
Gentilella, A., Kozma, S. C., & Thomas, G. (2015) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2015.02.005 · Cited by 120
Self-citation
Extracellular Zinc Activates p70 S6 Kinase through the Phosphatidylinositol 3-Kinase Signaling Pathway
Kim, S., Jung, Y.-S., Kim, D., Koh, H., & Chung, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001975200 · Cited by 115
Activation of Mitogenic Pathways by Albumin in Kidney Proximal Tubule Epithelial Cells
Dixon, R. C., & Brunskill, N. J. (1999) · Journal of the American Society of Nephrology · doi:10.1681/asn.v1071487 · Cited by 113
Semaphorin 7A Is a Negative Regulator of T Cell Responses
Czopik, A. K., Bynoe, M. S., Palm, N. W., Raine, C. S., & Medzhitov, R. M. (2006) · Immunity · doi:10.1016/j.immuni.2006.03.013 · Cited by 112
Mechanism of Protein Kinase B Activation by Insulin/Insulin-Like Growth Factor-1 Revealed by Specific Inhibitors of Phosphoinositide 3-Kinase—Significance for Diabetes and Cancer
Galetić, I., Andjelković, M., Meier, R., Brodbeck, D., Park, J., & Hemmings, B. A. (1999) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(98)00071-0 · Cited by 112
Self-citation
Domain Swapping Used To Investigate the Mechanism of Protein Kinase B Regulation by 3-Phosphoinositide-Dependent Protein Kinase 1 and Ser473 Kinase
Andjelković, M., Maira, S.-M., Cron, P. D., Parker, P. J., & Hemmings, B. A. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.7.5061 · Cited by 111
Self-citation
S6K1-Mediated Disassembly of Mitochondrial URI/PP1γ Complexes Activates a Negative Feedback Program that Counters S6K1 Survival Signaling
Djouder, N., Metzler, S. C., Schmidt, A., Wirbelauer, C., Gstaiger, M., Aebersold, R. H., Heß, D., & Krek, W. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.08.010 · Cited by 107
Involvement of the PI 3-kinase signaling pathway in progression of colon adenocarcinoma.
Khaleghpour, K., Li, Y., Banville, D., Yu, Z.-B., & Shen, S.-H. (2003) · Carcinogenesis · doi:10.1093/carcin/bgg195 · Cited by 123
Growth Hormone Induces Cellular Insulin Resistance by Uncoupling Phosphatidylinositol 3-Kinase and Its Downstream Signals in 3T3-L1 Adipocytes
Takano, A., Haruta, T., Iwata, M., Usui, I., Uno, T., Kawahara, J., Ueno, E., Sasaoka, T., & Kobayashi, M. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1891 · Cited by 109
mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif
Baffi, T. R., Lordén, G., Wozniak, J. M., Feichtner, A., Yeung, W., Kornev, A. P., King, C. C., Rio, J. C. D., Limaye, A. J., Bogomolovas, J., et al. (2021) · Science Signaling · doi:10.1126/scisignal.abe4509 · Cited by 116
Signal Pathways Involved in Activation of p70S6K and Phosphorylation of 4E-BP1 following Exposure of Multiple Myeloma Tumor Cells to Interleukin-6*
Shi, Y.-J., Hsu, J.-H., Hu, L.-P., Gera, J., & Lichtenstein, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200043200 · Cited by 133
Phosphoinositide-dependent protein kinase 1, a sensor of protein conformation
Biondi, R. M. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.01.005 · Cited by 109
Differential roles of PDK1- and PDK2-phosphorylation sites in the yeast AGC kinases Ypk1, Pkc1 and Sch9
Roelants, F. M. (2004) · Microbiology · doi:10.1099/mic.0.27286-0 · Cited by 107
Inhibition of Vascular Smooth Muscle Cell Proliferation, Migration, and Survival by the Tumor Suppressor Protein PTEN
Huang, J.-H., & Kontos, C. (2002) · Arteriosclerosis, Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000016358.05294.8d · Cited by 111
PDK1: The Major Transducer of PI 3-Kinase Actions
Bayascas, J. R. (2010) · Current topics in microbiology and immunology · doi:10.1007/82_2010_43 · Cited by 110
Intracellular network of phosphatidylinositol 3-kinase, mammalian target of the rapamycin/70 kDa ribosomal S6 kinase 1, and mitogen-activated protein kinases pathways for regulating mycobacteria-induced IL-23 expression in human macrophages
Yang, C., Song, C., Lee, J., Jung, S.-B., Oh, J.-H., Park, J., Kim, H., Park, J., Paik, T.-H., & Jo, E. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00699.x · Cited by 107
Akt Activation Induced by Lysophosphatidic Acid and Sphingosine-1-phosphate Requires Both Mitogen-Activated Protein Kinase Kinase and p38 Mitogen-Activated Protein Kinase and Is Cell-Line Specific
Baudhuin, L. M., Cristina, K. L., Lü, J., & Xu, Y. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.3.660 · Cited by 108
The Carboxyl Terminus of Protein Kinase C Provides a Switch to Regulate Its Interaction with the Phosphoinositide-dependent Kinase, PDK-1
Gao, T., Toker, A., & Newton, A. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101357200 · Cited by 108
Heat stress activates the A kt/m TOR signalling pathway in rat skeletal muscle
Yoshihara, T., Naıto, H., Kakigi, R., Ichinoseki‐Sekine, N., Ogura, Y., Sugiura, T., & Katamoto, S. (2012) · Acta Physiologica · doi:10.1111/apha.12040 · Cited by 117
Enhancing Repair of the Mammalian Heart
Santini, M. P., Tsao, L., Monassier, L., Theodoropoulos, C., Carter, J., Lara‐Pezzi, E., Slonimsky, E., Salimova, E., Delafontaine, P., Song, Y., et al. (2007) · Circulation Research · doi:10.1161/circresaha.107.148791 · Cited by 106
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1
DeAngelis, A. M., Heinrich, G., Dai, T., Bowman, T. A., Patel, P. R., Lee, S. J., Hong, E., Jung, D. Y., Aßmann, A., Kulkarni, R. N., et al. (2008) · Diabetes · doi:10.2337/db08-0379 · Cited by 106
Confocal imaging of the subcellular distribution of phosphatidylinositol 3,4,5-trisphosphate in insulin- and PDGF-stimulated 3T3-L1 adipocytes
Oatey, P. B., Kanamarlapudi, V., WILLIAMS, A. G., Fletcher, L. M., Foulstone, E. J., Cullen, P. J., & Tavaré, J. M. (1999) · Biochemical Journal · doi:10.1042/bj3440511 · Cited by 106
Mechanism of zinc‐induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3β in SH‐SY5Y neuroblastoma cells
An, W., Björkdahl, C., Liu, R., Cowburn, R. F., Winblad, B. G., & Pei, J.-J. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02948.x · Cited by 107
From Preadipocyte to Adipocyte: Differentiation-Directed Signals of Insulin from the Cell Surface to the Nucleus
Sorisky, A. (1999) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408369991239169 · Cited by 106
Phospholipase D2‐derived phosphatidic acid binds to and activates ribosomal p70 S6 kinase independently of mTOR
Lehman, N., Ledford, B., Fulvio, M. D., Frondorf, K. A., McPhail, L. C., & Gómez-Cambronero, J. (2007) · The FASEB Journal · doi:10.1096/fj.06-6652com · Cited by 109
Ndr Protein Kinase Is Regulated by Phosphorylation on Two Conserved Sequence Motifs
Millward, T. A., Heß, D., & Hemmings, B. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.48.33847 · Cited by 105
Self-citation
Changes in the phosphorylation of initiation factor eIF‐2α, elongation factor eEF‐2 and p70 S6 kinase after transient focal cerebral ischaemia in mice
Althausen, S., Mengesdorf, T., Mies, G., Oláh, L., Nairn, A. C., Proud, C. G., & Paschen, W. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00462.x · Cited by 105
Protein kinase C-α overexpression stimulates Akt activity and suppresses apoptosis induced by interleukin 3 withdrawal
Li, W., Zhang, J., Flechner, L., Hyun, T. S., Yam, A., Franke, T. F., & Pierce, J. H. (1999) · Oncogene · doi:10.1038/sj.onc.1203065 · Cited by 105
Phosphoinositide 3-kinases in T lymphocyte activation
Ward, S. G., & Cantrell, D. A. (2001) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00223-5 · Cited by 107
O‐linked N‐acetylglucosamine levels in cerebellar neurons respond reciprocally to pertubations of phosphorylation
Griffith, L. S., & Schmitz, B. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00439.x · Cited by 104
Visualization of biochemical networks in living cells
Remy, I., & Michnick, S. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.131216098 · Cited by 104
Sphingosine Is a Novel Activator of 3-Phosphoinositide-dependent Kinase 1
King, C. C., Zenke, F. T., Dawson, P. E., Sonnenburg, E. D., Newton, A. C., Hemmings, B. A., & Bokoch, G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909663199 · Cited by 103
Self-citation
Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex.
Ziegler, W., Parekh, D., Good, J. A. L., Whelan, R. D. H., Kelly, J., Frech, M., Hemmings, B., & Parker, P. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80236-x · Cited by 113
Self-citation
Mechanisms of acquired resistance to endocrine therapy in hormone-dependent breast cancer cells
Yue, W., Fan, P., Wang, J., Li, Y., & Santen, R. J. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.05.008 · Cited by 101
TRB3 is a PI 3-kinase dependent indicator for nutrient starvation
Schwarzer, R., Dames, S., Tondera, D., Klippel, A., & Kaufmann, J. (2005) · Cellular Signalling · doi:10.1016/j.cellsig.2005.08.002 · Cited by 104
The catalytic subunit of cAMP-dependent protein kinase: prototype for an extended network of communication
Smith, C. M., Radzio-Andzelm, E., Madhusudan, Akamine, P., & Taylor, S. S. (1999) · Progress in Biophysics and Molecular Biology · doi:10.1016/s0079-6107(98)00059-5 · Cited by 99
Inhibitory Mechanisms of Tea Polyphenols on the Ultraviolet B-activated Phosphatidylinositol 3-Kinase-dependent Pathway
Nomura, M., Kaji, A., He, Z., Ma, W.-Y., Miyamoto, K., Yang, C. S., & Dong, Z. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107897200 · Cited by 99
Cross-talk between Sirtuin and Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in the Regulation of S6 Kinase 1 (S6K1) Phosphorylation
Hong, S., Zhao, B., Lombard, D. B., Fingar, D. C., & Inoki, K. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.520734 · Cited by 101
Dual Role of Pseudosubstrate in the Coordinated Regulation of Protein Kinase C by Phosphorylation and Diacylglycerol
Sonnenburg, E. D., & Newton, A. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.14.10697 · Cited by 97
p70 Ribosomal protein S6 kinase ( Rps6kb1 ): an update
Bahrami-B, F., Ataie-Kachoie, P., Pourgholami, M. H., & Morris, D. L. (2014) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2014-202560 · Cited by 101
4E-binding Proteins, the Suppressors of Eukaryotic Initiation Factor 4E, Are Down-regulated in Cells with Acquired or Intrinsic Resistance to Rapamycin
Dilling, M. B., Germain, G. S., Dudkin, L., Jayaraman, A. L., Zhang, X., Harwood, F. C., & Houghton, P. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110782200 · Cited by 96
Nutrient sensing in the mTOR/S6K1 signalling pathway
Gulati, P., & Thomas, G. (2007) · Biochemical Society Transactions · doi:10.1042/bst0350236 · Cited by 99
Self-citation

Authors: Pullen, N., Dennis, P. B., Andjelkovic, M., Dufner, A., Kozma, S. C., Hemmings, B. A., & Thomas, G.
Affiliations: Friedrich Miescher Institute, Maulbeerstrasse 66, CH-4058, Basel, Switzerland.
Friedrich Miescher Institute (CH)
Corresponding author: Dennis, Patrick B.
Hemmings, Brian A.
Thomas, George
ORCID: Dennis, Patrick B.
Dufner, Almut
Thomas, George
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1998-01-30
Volume: 279
Issue: 5351
Pages: 707-710
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.279.5351.707
OpenAlex: W2041926656
Cited by: 826
References: 13
Citations by year: 2026: 3 · 2025: 6 · 2024: 13 · 2023: 11 · 2022: 14 · 2021: 20 · 2020: 12 · 2019: 12 · 2018: 10 · 2017: 13 · 2016: 12 · 2015: 21 · 2014: 22 · 2013: 29 · 2012: 29
FWCI: 28.89
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: p70S6K, PDK1, protein kinase A, protein kinase activation, protein synthesis regulation, insulin signaling, Akt, catalytic domain
MeSH terms: Wortmannin, Amino Acid Sequence, Androstadienes, Animals, Binding Sites, Catalysis, Cell Line, Enzyme Activation, Insulin, Insulin Antagonists, Molecular Sequence Data, Phosphorylation, Phosphothreonine, Polyenes, Proto-Oncogene Proteins, Recombinant Proteins, Protein Serine-Threonine Kinases, Calcium-Calmodulin-Dependent Protein Kinases, Ribosomal Protein S6 Kinases, Sirolimus, Proto-Oncogene Proteins c-akt, Calcium-Calmodulin-Dependent Protein Kinase Type 4, 3-Phosphoinositide-Dependent Protein Kinases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Phosphorylation and Activation of p70 s6k by PDK1

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks