Phosphorylation and Activation of p70 s6k by PDK1

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

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Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

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Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6k

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3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

Alessi, D. R., Deák, M., Casamayor, A., Caudwell, F. B., MORRICE, N. A., Norman, D. G., Gaffney, P. R. J., Reese, C. B., MacDougall, C. N., Harbison, D., et al. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00336-8 · Cited by 754

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

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The modular phosphorylation and activation of p70 s6k

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Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors.

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The principal target of rapamycin‐induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.

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The Principal Rapamycin-Sensitive p70s6k Phosphorylation Sites, T-229 and T-389, Are Differentially Regulated by Rapamycin-Insensitive Kinase Kinases

Dennis, P. B., Pullen, N., Kozma, S. C., & Thomas, G. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.11.6242 · Cited by 253

Fluoromicroscopic detection of myc-tagged GLUT4 on the cell surface. Co-localization of the translocated GLUT4 with rearranged actin by insulin treatment in CHO cells and L6 myotubes.

Asahi, Y., Hayashi, H., Wang, L., & Ebina, Y. (1999) · PubMed · doi:10.11501/3167839 · Cited by 19

Statins up-regulate SmgGDS through β1-integrin/Akt1 pathway in endothelial cells

Minami, T., Satoh, K., Nogi, M., Kudo, S., Miyata, S., Tanaka, S.-I., & Shimokawa, H. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv253 · Cited by 18

Ro 31‐6045, the inactive analogue of the protein kinase C inhibitor Ro 31‐8220, blocks in vivo activation of p70s6k/p85s6k: implications for the analysis of S6K signalling

Marmy-Conus, N., Hannan, K. M., & Pearson, R. B. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02738-2 · Cited by 18

Signaling pathways of D3-phosphoinositide-binding kinases in T cells and their regulation by PTEN.

Seminario, M., & Wange, R. (2002) · Seminars in Immunology · doi:10.1006/smim.2001.0339 · Cited by 20

mTOR regulates GPVI-mediated platelet activation

Wang, L., Liu, G., Wu, N., Dai, B., Han, S., Liu, Q., Huang, F., Chen, Z., Xu, W., Xia, D., et al. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02756-y · Cited by 17

Akt mediates insulin rescue from apoptosis in brown adipocytes: effect of ceramide

Navarro, P., Valverde, Á. M., Rohn, J. L., Benito, M., & Lorenzo, M. (2000) · Growth Hormone & IGF Research · doi:10.1054/ghir.2000.0165 · Cited by 17

Bradykinin-stimulated protein synthesis by myocytes is dependent on the MAP kinase pathway and p70S6K

Ritchie, R. H., Marsh, J. D., & SCHIEBINGER, R. J. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.276.4.h1393 · Cited by 17

Chemical manipulation of the mTORC1 pathway in industrially relevant CHOK1 cells enhances production of therapeutic proteins

Dadehbeigi, N., & Dickson, A. J. (2015) · Biotechnology Journal · doi:10.1002/biot.201500075 · Cited by 16

eIF4E-Overexpression imparts perillyl alcohol and rapamycin-mediated regulation of telomerase reverse transcriptase

Sundin, T., Peffley, D. M., & Hentosh, P. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.05.029 · Cited by 16

Crystal structures of the S6K1 kinase domain in complexes with inhibitors

Niwa, H., Mikuni, J., Sasaki, S., Tomabechi, Y., Honda, K., Ikeda, M., Ohsawa, N., Wakiyama, M., Handa, N., Shirouzu, M., et al. (2014) · Journal of Structural and Functional Genomics · doi:10.1007/s10969-014-9188-8 · Cited by 18

Amino acids require glucose to enhance, through phosphoinositide-dependent protein kinase 1, the insulin-activated protein kinase B cascade in insulin-resistant rat adipocytes

Hinault, C., Mothe‐Satney, I., Gautier, N., & OBBERGHEN, E. V. (2006) · Diabetologia · doi:10.1007/s00125-006-0201-z · Cited by 16

Mechanism of PDK1-catalyzed Thr-229 Phosphorylation of the S6K1 Protein Kinase

Keshwani, M. M., Gao, X., & Harris, T. K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.032177 · Cited by 15

Regulation of Hematopoietic Stem Cell Self-Renewal and Leukemia Maintenance by the PI3K-mTORC1 Pathway

Ghosh, J., & Kapur, R. (2016) · Current Stem Cell Reports · doi:10.1007/s40778-016-0067-z · Cited by 15

The overview of Mitogen-activated extracellular signal-regulated kinase (MEK)-based dual inhibitor in the treatment of cancers

Wang, H., Chi, L., Yu, F., Dai, H., Si, X., Gao, C., Wang, Z., Liu, L., Zheng, J., Ke, Y., et al. (2022) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2022.116922 · Cited by 15

Differential activation of the PI 3-kinase effectors AKT/PKB and p70 S6 kinase by compound 48/80 is mediated by PKCα

Byrne, R. D., Rosivatz, E., Parsons, M., Larijani, B., Parker, P. J., Ng, T., & Woscholski, R. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.07.004 · Cited by 15

Indinavir impairs protein synthesis and phosphorylations of MAPKs in mouse C2C12 myocytes.

Hong-Brown, L., Brown, C. R., & Lang, C. H. (2004) · American Journal of Physiology - Cell Physiology · doi:10.1152/ajpcell.00038.2004 · Cited by 15

Recent progress in insulin signal transduction

Hei, Y.-J. (1998) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/s1056-8719(98)00051-3 · Cited by 15

Insulin‐Like Growth Factor I Prevents the Development of Sensitivity to Kainate Neurotoxicity in Cerebellar Granule Cells

Leski, M. L., Valentine, S. L., Baer, J. D., & Coyle, J. T. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751548.x · Cited by 15

The Src-family tyrosine kinase inhibitor PP1 interferes with the activation of ribosomal protein S6 kinases.

Shah, O., Kimball, S., & Jefferson, L. (2002) · Biochemical Journal · doi:10.1042/bj20020198 · Cited by 17

Nitric Oxide Donors Selectively Potentiate Thrombin-Stimulated p70S6k Activity and Morphological Changes in Swiss 3T3 Cells

Berven, L. A., Frew, I. J., & Crouch, M. F. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1833 · Cited by 15

Impact of Src Homology 2-Containing Inositol 5′-Phosphatase 2 on the Regulation of Insulin Signaling Leading to Protein Synthesis in 3T3-L1 Adipocytes Cultured with Excess Amino Acids

Murakami, S., Sasaoka, T., Wada, T., Fukui, K., Nagira, K., Ishihara, H., Usui, I., & Kobayashi, M. (2004) · Endocrinology · doi:10.1210/en.2003-1574 · Cited by 15

Cytoreductive effects of farnesyl transferase inhibitors on multiple myeloma tumor cells.

Shi, Y., Gera, J., Hsu, J.-H., Ness, B. G. V., & Lichtenstein, A. K. (2003) · PubMed · Cited by 15

Helicobacter pylori modulates host cell survival regulation through the serine-threonine kinase, 3-phosphoinositide dependent kinase 1 (PDK-1)

King, C. C., & Obonyo, M. (2015) · BMC Microbiology · doi:10.1186/s12866-015-0543-0 · Cited by 14

Cell cycle control by the insulin-like growth factor signal: at the crossroad between cell growth and mitotic regulation

Scalia, P., Williams, S. J., Fujita‐Yamaguchi, Y., & Giordano, A. (2022) · Cell Cycle · doi:10.1080/15384101.2022.2108117 · Cited by 17

The immunosuppressive drug cyclosporin A has an immunostimulatory function in CD8 + T cells

Wißfeld, J., Hering, M., ten Bosch, N., & Cui, G. (2024) · European Journal of Immunology · doi:10.1002/eji.202350825 · Cited by 14

Opposing and uncoupling effects of mTOR and S6K1 in the regulation of endothelial tissue factor expression

Ming, X., Rajapakse, A. G., Carvas, J. M., Ruffieux, J., & Yang, Z. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.11.030 · Cited by 14

Analysis of ribosomal protein S6 baseline phosphorylation and effect of tau pathology in the murine brain and human hippocampus

Klingebiel, M., Dinekov, M., & Köhler, C. N. (2017) · Brain Research · doi:10.1016/j.brainres.2017.01.016 · Cited by 15

A novelSOS1mutation in Costello/CFC syndrome affects signaling in both RAS and PI3K pathways

Tumurkhuu, M., Saitoh, M., Takita, J., Mizuno, Y., & Mizuguchi, M. (2013) · Journal of Receptors and Signal Transduction · doi:10.3109/10799893.2013.779279 · Cited by 14

Patient-Driven Discovery, Therapeutic Targeting, and Post-Clinical Validation of a Novel AKT1 Fusion–Driven Cancer

Slotkin, E. K., Diolaiti, D., Shukla, N. N., Cruz, F. S. D., Clark, J., Gundem, G., Yellapantula, V. D., Levine, M. F., You, D., Ma, P., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0953 · Cited by 16

Post-translational regulation of the mTORC1 pathway: A switch that regulates metabolism-related gene expression

Wang, Y., Engel, T., & Teng, X. (2024) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2024.195005 · Cited by 13

ELK1/MTOR/S6K1 Pathway Contributes to Acquired Resistance to Gefitinib in Non-Small Cell Lung Cancer

Zhao, L., Wang, Y., Sun, X., Zhang, X., Simone, N. L., & He, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042382 · Cited by 12

Synthesis and biological evaluation of 2-anilino-4-substituted-7H-pyrrolopyrimidines as PDK1 inhibitors

O’Brien, N. J., Brzozowski, M., Buskes, M. J., Deady, L. W., & Abbott, B. M. (2014) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2014.06.018 · Cited by 13

Diosmetin Induces Modulation of Igf-1 and Il-6 Levels to Alter Rictor-Akt-PKCα Cascade in Inhibition of Prostate Cancer

Pakradooni, R., Shukla, N., Gupta, K., Kumar, J., Isali, I., Khalifa, A., & Shukla, S. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10204741 · Cited by 14

Molecular Basis of the Mechanisms Controlling MASTL

Hermida, D., Mortuza, G. B., Pedersen, A.-K., Pozdnyakova, I., Nguyen, T. T. T. N., Maroto, M., Williamson, M., Ebersole, T. W., Cazzamali, G., Rand, K. D., et al. (2019) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra119.001879 · Cited by 12

Activation of phosphatidylinositol 3-kinase is required for transcriptional activity of F-type 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: assessment of the role of protein kinase B and p70 S6 kinase

de Mattos, S. F., Pinos, E. D. L., Joaquin, M., & Tauler, A. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3490059 · Cited by 13

Antigen receptor regulation of phosphoinositide‐dependent kinase 1 pathways during thymocyte development

Hinton, H. J., Clarke, R. G., & Cantrell, D. A. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.09.045 · Cited by 13

G-Protein βγ Subunit-Dependent Phosphorylation of 62-kDa Protein in the Early Signaling Pathway of Starfish Oocyte Maturation Induced by 1-Methyladenine

Nakano, T., Kontani, K., Kurosu, H., Katada, T., Hoshi, M., & Chiba, K. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9248 · Cited by 13

Differential control of ageing and lifespan by isoforms and splice variants across the mTOR network

Navas, P. R., & Thedieck, K. (2017) · Essays in Biochemistry · doi:10.1042/ebc20160086 · Cited by 13

Multifaceted control of mRNA translation machinery in cancer

Alboushi, L., Hackett, A. P., Naeli, P., Bakhti, M., & Jafarnejad, S. M. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.110037 · Cited by 13

Similar PDK1–AKT–mTOR pathway activation in balloon cells and dysmorphic neurons of type II focal cortical dysplasia with refractory epilepsy

Lin, Y., Lin, K., Kang, D., Liu, X., Wang, X., Zheng, S., Yu, L., & Lin, Z. (2015) · Epilepsy Research · doi:10.1016/j.eplepsyres.2015.02.002 · Cited by 12

Loss of PTEN expression does not contribute to PDK-1 activity and PKC activation-loop phosphorylation in Jurkat leukaemic T cells

Freeley, M., Park, J., Yang, K., Wange, R. L., Volkov, Y., Kelleher, D. P., & Long, A. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.07.020 · Cited by 12

Regulation of protein kinase Cδ downregulation by protein kinase Cε and mammalian target of rapamycin complex 2

Basu, A., Sridharan, S., & Persaud, S. D. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.07.006 · Cited by 12

Mitogen-Activated Signaling in Airway Smooth Muscle: A Central Role for Ras

Hershenson, M. B., & Abe, M. K. (1999) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.21.6.f168 · Cited by 12

Dynamic visualization of expressed gene networks

Remy, I., & Michnick, S. W. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10328 · Cited by 12

The subcellular localization of 3-phosphoinositide-dependent protein kinase is controlled by caveolin-1 binding

Chun, J., Kwon, T., Lee, E. J., Hyun, S. H., Hong, S., & Kang, S. S. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.10.208 · Cited by 12

Role of the p70 S6 kinase cascade in neutrophilic differentiation and proliferation of HL-60 cells—a study of transferrin receptor-positive and -negative cells obtained from dimethyl sulfoxide- or retinoic acid-treated HL-60 cells

Kanayasu‐Toyoda, T., Yamaguchi, T., Oshizawa, T., Kogi, M., Uchida, E., & Hayakawa, T. (2002) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(02)00330-2 · Cited by 12

The Dstpk61 locus of Drosophila produces multiple transcripts and protein isoforms, suggesting it is involved in multiple signalling pathways

Clyde, D., & Bownes, M. (2000) · Journal of Endocrinology · doi:10.1677/joe.0.1670391 · Cited by 12

NOP14-mediated ribosome biogenesis is required for mTORC2 activation and predicts rapamycin sensitivity

Xiao, Y., Kuang, B., Ma, S., Wang, R., Lin, J., Zeng, Y., Xie, X., & Feng, L. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.105681 · Cited by 11

Molecular Docking Studies of Myricetin and Its Analogues against Human PDK-1 Kinase as Candidate Drugs for Cancer

Singh, S., & Srivastava, P. (2015) · Computational Molecular Bioscience · doi:10.4236/cmb.2015.52004 · Cited by 11

Rapamycin inhibition of baculovirus recombinant (BVr) ribosomal protein S6 kinase (S6K1) is mediated by an event other than phosphorylation

Beigh, M. A., Showkat, M., Hussain, M. U., Latoo, S. A., Majeed, S. T., & Andrabi, K. I. (2012) · Cell Communication and Signaling · doi:10.1186/1478-811x-10-4 · Cited by 11

PI3Ks—Drug Targets in Inflammation and Cancer

Wymann, M. P. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-3012-0_5 · Cited by 11

p60-S6K1 represents a novel kinase active isoform with the mode of regulation distinct from p70/p85-S6K1 isoforms

Zaiets, I. V., Holiar, V. V., Sivchenko, A. S., Smialkovska, V. V., & Filonenko, V. V. (2019) · The Ukrainian Biochemical Journal · doi:10.15407/ubj91.04.017 · Cited by 11

Functional cross-talk between the cyclic AMP and Jak/STAT signaling pathways in vascular smooth muscle cells

Meloche, S., Pelletier, S. W., & Servant, M. J. (2000) · Springer eBooks · doi:10.1007/978-1-4615-4351-0_12 · Cited by 11

Activation of a PKC is required for vanadate-induced phosphorylation of protein kinase B (Akt), but not p70S6k in mouse epidermal JB6 cells

Li, J., Dokka, S., Wang, L., Shi, X., Castranova, V., Yan, Y., Costa, M., & Huang, C. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000007277.90298.24 · Cited by 11

Perturbation of EGF-activated MEK1 and PKB signal pathways by TGF-?1 correlates with perturbation of EGF-induced cyclin D1 and DNA synthesis by TGF-?1 in C3H 10T1/2 cells

Yan, S., Krebs, S. J., Leister, K. J., & Wenner, C. E. (2000) · Journal of Cellular Physiology · doi:10.1002/1097-4652(200010)185:1 · Cited by 11

Effects of Streptozocin-Induced Diabetes and Islet Cell Transplantation on Insulin Signaling in Rat Skeletal Muscle

Markuns, J. F., Napoli, R., Hirshman, M. F., Davalli, A. M., Cheatham, B., & Goodyear, L. J. (1999) · Endocrinology · doi:10.1210/en.140.1.106 · Cited by 12

Role of phosphoinositide 3OH‐kinase in autocrine transformation by PDGF‐BB*

Rosenmüller, T., Rydh, K., & Nånberg, E. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.1126 · Cited by 11

Wortmannin inhibits translation of tumor necrosis factor-α in superantigen-activated T cells

Ramírez, M., Fernández-Troy, N., Buxadé, M., Casaroli-Marano, R. P., Benítez, D., Pérez-Maldonado, C., & Espel, E. (1999) · International Immunology · doi:10.1093/intimm/11.9.1479 · Cited by 11

Compartmentalization proteomics revealed endolysosomal protein network changes in a goat model of atrial fibrillation

Ayagama, T., Charles, P. D., Bose, S. J., Boland, B., Priestman, D. A., Aston, D., Berridge, G., Fischer, R., Cribbs, A. P., Song, Q., et al. (2024) · iScience · doi:10.1016/j.isci.2024.109609 · Cited by 8

The effects of ketone bodies and ketogenesis on the PI3K/AKT/mTOR signaling pathway: A systematic review

Matawali, A., Yeap, J. W., Sulaiman, S. F., & Tan, M. (2025) · Nutrition Research · doi:10.1016/j.nutres.2025.04.010 · Cited by 12

Phosphorylation of LKB1 by PDK1 Inhibits Cell Proliferation and Organ Growth by Decreased Activation of AMPK

Borkowsky, S., Gass, M., Alavizargar, A., Hanewinkel, J., Hallstein, I., Nedvetsky, P. I., Heuer, A., & Krahn, M. P. (2023) · Cells · doi:10.3390/cells12050812 · Cited by 10

Synthesis and biological evaluation of substituted 2-anilino-7H-pyrrolopyrimidines as PDK1 inhibitors

O’Brien, N. J., Brzozowski, M., Wilson, D. J. D., Deady, L. W., & Abbott, B. M. (2014) · Tetrahedron · doi:10.1016/j.tet.2014.05.033 · Cited by 10

Baculovirus-mediated expression, purification, and characterization of a fully activated catalytic kinase domain construct of the 70kDa 40S ribosomal protein S6 kinase-1 αII isoform (S6K1αII)

Keshwani, M. M., Ross, D. B., Ragan, T. J., & Harris, T. K. (2007) · Protein Expression and Purification · doi:10.1016/j.pep.2007.11.003 · Cited by 10

Distinct functions of erythropoietin and stem cell factor are linked to activation of mTOR kinase signaling pathway in human erythroid progenitors.

Geslain, R., Uddin, S., Liu, H., Jiang, H.-M., van Besien, K., Pan, T., & Wickrema, A. (2013) · Cytokine · doi:10.1016/j.cyto.2012.10.017 · Cited by 8

Involvement of Type I Protein Kinase A in the Differentiation of L6 Myoblast in Conjunction with Phosphatidylinositol 3-Kinase

Han, S. Y., Park, D. Y., Lee, G. H., Park, S. D., & Hong, S. H. (2002) · Molecules and Cells · doi:10.1016/s1016-8478(23)15075-8 · Cited by 10

Phosphoinositide-dependent Kinase Phosphorylation of Protein Kinase C Apl II Increases during Intermediate Facilitation inAplysia

Pepio, A. M., Thibault, G. L., & Sossin, W. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202264200 · Cited by 10

Functional cross-talk between the cyclic AMP and Jak/STAT signaling pathways in vascular smooth muscle cells

Meloche, S., Pelletier, S. W., & Servant, M. J. (2000) · Molecular and Cellular Biochemistry · doi:10.1023/a:1007140606333 · Cited by 10

The SZT2 Interactome Unravels New Functions of the KICSTOR Complex

Cattelani, C., Lesiak, D., Liebscher, G., Singer, I. I., Stasyk, T., Wallnöfer, M. H., Heberle, A. M., Corti, C., Hess, M. W., Pfaller, K., et al. (2021) · Cells · doi:10.3390/cells10102711 · Cited by 10

S6 protein kinase activates Juvenile Hormone and vitellogenin production in the cockroach B lattella germanica

Abrisqueta, M., Süren‐Castillo, S., & Maestro, J. L. (2016) · Physiological Entomology · doi:10.1111/phen.12156 · Cited by 9

Negative regulation of interleukin 1β expression in response to DnaK from Pseudomonas aeruginosa via the PI3K/PDK1/FoxO1 pathways

Lee, J., Jeon, J., Bai, F., Wu, W., & Ha, U. (2020) · Comparative Immunology Microbiology and Infectious Diseases · doi:10.1016/j.cimid.2020.101543 · Cited by 8

Regulation of eukaryotic protein kinases by Pin1, a peptidyl-prolyl isomerase

Chen, X., & Igumenova, T. I. (2022) · Advances in Biological Regulation · doi:10.1016/j.jbior.2022.100938 · Cited by 11

FilGAP regulates tumor growth in Glioma through the regulation of mTORC1 and mTORC2

Tsutsumi, K., Nohara, A., Tanaka, T., Murano, M., Miyagaki, Y., & Ohta, Y. (2023) · Scientific Reports · doi:10.1038/s41598-023-47892-1 · Cited by 8

Synthesis of substituted 4-(1H-indol-6-yl)-1H-indazoles as potential PDK1 inhibitors

Brzozowski, M., O’Brien, N. J., Wilson, D. J. D., & Abbott, B. M. (2013) · Tetrahedron · doi:10.1016/j.tet.2013.11.054 · Cited by 8

Genotype Directed Therapy in Murine Mismatch Repair Deficient Tumors

Kucherlapati, M. H., Esfahani, S. A., Habibollahi, P., Wang, J., Still, E., Bronson, R. T., Mahmood, U., & Kucherlapati, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068817 · Cited by 8

Phosphoproteomics Profiling Defines a Target Landscape of the Basophilic Protein Kinases AKT, S6K, and RSK in Skeletal Myotubes

Fricke, A. L., Mühlhäuser, W. W. D., Reimann, L., Zimmermann, J. P., Reichenbach, C., Knapp, B. L., Peikert, C. D., Heberle, A. M., Faessler, E., Schäuble, S., et al. (2023) · Journal of Proteome Research · doi:10.1021/acs.jproteome.2c00505 · Cited by 8

Signal transduction pathways as novel therapy targets in lung cancer.

Reinmuth, N., Mesters, R., Bieker, R., Hoffknecht, P., Berdel, W., & Thomas, M. (2004) · Lung Cancer · doi:10.1016/j.lungcan.2004.07.976 · Cited by 6

SP600125 Inhibits Cap-dependent Translation Independently of the c-Jun N-terminal Kinase Pathway

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Expression, purification, and characterization of a structurally disordered and functional C-terminal autoinhibitory domain (AID) of the 70kDa 40S ribosomal protein S6 kinase-1 (S6K1)

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p70S6 Kinase

(2006) · Springer eBooks · doi:10.1007/3-540-29832-0_1202