Phosphorylation and Activation of p70 s6k by PDK1

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The principal target of rapamycin‐induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.

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Carcinogenic metals and NF-κB activation

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Downstream the mTOR: S6 Kinases between Divergence and Redundancy

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S6 Kinase: A Compelling Prospect for Therapeutic Interventions

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Fused protein of δPKC activation loop and PDK1‐interacting fragment (δAL‐PIF) functions as a pseudosubstrate and an inhibitory molecule for PDK1 when expressed in cells

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Inhibitors of PKA and Related Protein Kinases

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A minimal cytoplasmic subdomain of the erythropoietin receptor mediates p70 S6 kinase phosphorylation

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Estrogen regulates PDPK1 to promote cell proliferation in epithelial ovarian cancer

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CHANGE OF THE MTOR PATHWAY IN TISSUES OF OVERFED GEESE

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S6K1 acts through FOXO to regulate juvenile hormone biosynthesis in the red flour beetle, Tribolium castaneum

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A Drosophila genetic screen for suppressors of S6kinase-dependent growth identifies the F-box subunit Archipelago/FBXW7

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Cardioprotective Effects of 3-Phosphoinositide-Dependent Protein Kinase-1 on Hypoxic Injury in Cultured Neonatal Rat Cardiomyocytes and Myocardium in a Rat Myocardial Infarct Model

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p-p70S6K (Thr 389) Expression in nodular sclerosing hodgkin's disease as evidence for receptor tyrosine kinase signaling.

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p53 modulates the effect of ribosomal protein S6 kinase1 (S6K1) on cisplatin toxicity in chronic myeloid leukemia cells

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Assays for monitoring p70 S6 kinase and RSK activation

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Electroconvulsive Seizure Normalizes Motor Deficits and Induces Autophagy Signaling in the MPTP-Induced Parkinson Disease Mouse Model

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Insulin signaling and pharmacology in humans and in corals

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IGF-I regulated phosphorylation and translocation of PDK-1 in neurons

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Signaling Pathways Induced by G-protein-coupled Receptors

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The 3-Phosphoinositide-Dependent Protein Kinase 1 Inhibits Rod Photoreceptor Development

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Nutrient Availability Dictates Cancer Metabolism–Based Therapeutic Responses to Nononcology Drugs

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Continuous ethanol exposure inhibits agonist-stimulated phosphorylation of p70S6 kinase and ribosomal S6 protein in cultured rat astrocytes

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Molecular Characterization and Expression Analysis of S6K1 in Cashmere Goats (Capra hircus)

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Plasminogen deficiency exacerbates skeletal muscle loss during mechanical unloading in developing mice

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Altered PI3K/AKT/mTOR Signaling Pathway and Cancer Stem Cells

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The Role of Serine-Threonine Kinase Receptor-Associated Protein (STRAP) Signaling in Cancer

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Growth Factor Signaling Pathways in Cancer

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Combined 3D QSAR Based Virtual Screening and Molecular Docking Study of Some Selected PDK-1 Kinase Inhibitors

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N-(methylamino)isobutyric acid inhibits proliferation of CFSC-2C hepatic stellate cells

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Serine 389 phosphorylation of 3-phosphoinositide-dependent kinase 1 by UNC-51-like kinase 1 affects its ability to regulate Akt and p70 S6kinase

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Three-Dimensional Migration of Human Amniotic Fluid Stem Cells Involves Mesenchymal and Amoeboid Modes and is Regulated by mTORC1

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mTORC1: Upstream and Downstream

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Requirement of the Serine-Threonine Kinase Akt for Heat Treatment-Induced Activation of p70 S6 Kinase

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Role of Inflammation in the Pathogenesis of Insulin Resistance in Obesity: Specific Role of Reactive Oxygen and Reactive Nitrogen Species

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The Regulation of Mammalian Target of Rapamycin

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The nuts‐and‐bolts of ribosomal protein s6 kinase 1 regulation: A shared responsibility for mTOR complexes 1 and 2

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Anabolic signalling in skeletal muscle : impact of diet and disease

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membrane localization SHIP inhibits Akt activation in B cells through regulation of Akt

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Downstream of mTOR: Translational Control of Cancer

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Systematic Interrogation of the Temperature Perturbation in the Insulin Signaling Pathway for Optogenetic Stimulation

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The PI3K Pathway in Colorectal Cancers

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Regulation of the mammalian target of rapamycin complex 2 (mTORC2)

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SRPK2 Phosphorylation by the AGC Kinases, and mTORC1 Regulation of Alternative Splicing

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Selective insulin signaling in the pancreatic beta-cell via the two insulin receptor isoforms

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Chemerin and Prohibitin in the Regulation of Ovarian Follicular Development and their Potential Involvement in Polycystic Ovarian Syndrome

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PI3-Kinases

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Ribosomal Protein S6 and S6 Kinases

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The roles of PDK1 and SGK1 in colorectal cancer

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The Molecular Basis of Insulin Action and Insulin Resistance

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Translational control : mTOR signalling and the use of next-generation sequencing methods

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PHOSPHOINOSITIDE 3-KINASE ENZYMES AS DOWNSTREAM TARGETS OF THE EGF RECEPTOR

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Cell-cycle control by protein kinase B

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Intracellular Signal Transduction Cascades

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The role of the PDK1/PKB kinases in regulating neuronal survival and differentiation: characterization of the PDK1 K465E knock-in mice

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Determining the Role of Autophagy in HER2/neu-Induced Mammary Tumor Dormancy and Recurrence

Dwyer, S. (2013) · Scholarly Commons (University of Pennsylvania)

Insulin Signalling and Regulation of Protein Kinase B in Adipocytes

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Role of C-Kit Receptor Tyrosine Kinase on INS-1 Cell VEGF-A Expression in Vitro

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Investigation of the mechanisms and therapeutic implications of crosstalk between G-protein-coupled receptors and the epidermal growth factor receptor in HNSCC

Bhola, N. E. (2009) · D-Scholarship@Pitt (University of Pittsburgh)

Mechanisms of Tim-3 Signal Transduction in the Modulation of Downstream TCR Signaling

Lee, J. (2013) · D-Scholarship@Pitt (University of Pittsburgh)

TOR Signaling and Cell Growth Control

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Mechanisms of KRAS-Mediated Pancreatic Tumor Formation and Progression: A Dissertation

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Mechanical Stretch and Electrical Stimulation in Mouse Skeletal Muscle in Vivo: Initiation of Hypertrophic Signaling

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Regulation of protein synthesis in human skeletal muscle : separate and combined effects of exercise and amino acids

Apró, W. (2014) · Diva portal (Dalarna University Library)

Regulation of Growth Factor and Nutrient Sensing Pathways by Human Papillomavirus E6 Proteins

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Molecular basis of L-DOPA-induced dyskinesia : Studies on striatal signaling

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SKAR: a novel target of S6 Kinase 1

Jülich, K. (2008) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-11918

Molecular dissection of the internalization step of endocytosis in "Saccharomyces cerevisiae" : Rvs167p and binding partners

Lombardi, R. (2001) · edoc (University of Basel) · doi:10.5451/unibas-002540561

Withdrawal of Essential Amino Acids Increases Autophagy by a Pathway Involving Ca 2 /Calmodulin-dependent Kinase

Ghislat, G., Patrón, M., Rizzuto, R., & Knecht, E. (2012)

Nierenfunktion Kinase-defizienter Mäuse

Sandulache, D. (2007)

Brief Comunication: p-p70S6K (r 389) Expression in Nodular Sclerosing Hodgkin’s Disease as Evidence for Receptor Tyrosine Kinase Signaling

Brown, R. E., & Kamal, N. R. (2015)

Molecular mechanisms of neuronal survival; Roles of kinases in ischemic cell death

Gotoh, Y. (2002) · Springer eBooks · doi:10.1007/978-4-431-68430-5_7

Functions of the P21-Activated Protein Kinases (Paks) in Neutrophils and their Regulation by Complex Lipids

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Investigating the roles of two key negative regulators of the PI3K pathway in T cell-mediated autoimmunity

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ACTIVATION OF PI3-KINASE - A KEY REGULATOR OF PLATELET FUNCTION

Reséndiz, J. C. (2005) · Työväentutkimus Vuosikirja

Skeletal Muscle Atrophy and Hypertrophy

Glass, D. J. (2005) · CRC Press eBooks · doi:10.1201/9780849333798.ch3

The contribution of single Akt isoforms to neuronal survival: characterization of a new mechanim of Akt activation in the PDK1 K465E mice

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correlates with PRAS40 phosphorylation 2

Canedo, C. S., Demeulder, B., Ginion, A., José, R., Balligand, J., Alessi, D. R., Jean-Louis, Beauloye, C., Hue, L., & Bertrand, L. (2010)

Effect of α-lactalbumin and β-lactoglobulin hydrolysates on markers of metabolic syndrome

Lagace, M. (2012) · Mspace (University of Manitoba)

Modulation of the mTOR pathway in male Lewis rats after morphine self-administration and subsequent extinction trainingPreprint

Ucha, M., Coria, S. M., Núñez, A. E., Santos‐Toscano, R., Roura‐Martínez, D., Fernández‐Ruíz, J., Higuera‐Matas, A., & Ambrosio, E. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/276121

Clinical Management of Primary Ovarian Insufficiency

Okamura, Y. (2018) · Springer eBooks · doi:10.1007/978-981-10-7941-2_7

Role of mechanistic Target of Rapamycin (mTOR) signaling in the crustacean molting gland

Abuhagr, A. M., Mykles, D. L., Garrity, D. M., Reddy, A. N., & Curthoys, N. P. (2007) · Digital Collections of Colorado (Colorado State University) · doi:10.25675/3.020423

Role of PDK1 in Activating AGC Protein Kinase

Alessi, D. R. (2003) · Elsevier eBooks · doi:10.1016/b978-012124546-7/50447-2

mTOR under stress

Heberle, A. M. (2019) · University of Groningen research database (University of Groningen / Centre for Information Technology)

Deciphering the crosstalk of the mTORC1 and MAPK networks in cancer

Navas, P. R. (2020) · doi:10.33612/diss.123822961

Insulin Signaling Promotes Ras/MAPK Cascade Activity by Inhibiting the FOXO Transcription Factor DAF-16

Hall, M. (2014) · TSpace (University of Toronto)

Tissue-specific Stem Cells

Patra, S. S. (2020) · doi:10.37421/2168-9547.2020.09.250

Key factors in mTOR regulation

Jiang, X. B. (2010)

Regulation | mTOR and its Substrates

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EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) ACTIVATION BY GASTRIN RELEASING PEPTIDE (GRP) IN HEAD AND NECK CANCER: MECHANISMS AND CLINICAL IMPLICATIONS

Zhang, Q. H. (2005) · D-Scholarship@Pitt (University of Pittsburgh)

SHP-1 and PDK1 Form a Phosphotyrosine-Dependent Nucleo-Cytoplasmic Shuttling Complex: Implications for Differentiation

Sephton, C. F. (2007) · University Library - University of Saskatchewan (University of Saskatchewan)

Role of PDK1 in Activating AGC Protein Kinase

Alessi, D. R. (2003) · Elsevier eBooks · doi:10.1016/b978-012124546-7/50515-5

Skeletal Muscle Atrophy and Hypertrophy

Glass, D. J. (2005) · CRC Press eBooks · doi:10.1201/9781420048957.ch3

Dynamic Visualization of Expressed Gene Networks

Remy, I., & Michnick, S. W. (2003) · CRC Press eBooks · doi:10.1201/9780203911129.ch11

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

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Evidence That 3-Phosphoinositide-dependent Protein Kinase-1 Mediates Phosphorylation of p70 S6 Kinase in Vivoat Thr-412 as well as Thr-252

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Mechanism of PDK1-catalyzed Thr-229 Phosphorylation of the S6K1 Protein Kinase

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The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB

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p70S6 Kinase

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