Phosphorylation and Activation of p70 s6k by PDK1

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R. J., Reese, C. B., & Cohen, P. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00122-9 · Cited by 2,874

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

Stokoe, D., Stephens, L. R., Copeland, T., Gaffney, P. R. J., Reese, C. B., Painter, G. F., Holmes, A. B., McCormick, F. P., & Hawkins, P. T. (1997) · Science · doi:10.1126/science.277.5325.567 · Cited by 1,216

Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6k

Jefferies, H. B. J., Fumagalli, S., Dennis, P. B., Reinhard, C., Pearson, R. B., & Thomas, G. (1997) · The EMBO Journal · doi:10.1093/emboj/16.12.3693 · Cited by 934

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

Alessi, D. R., Deák, M., Casamayor, A., Caudwell, F. B., MORRICE, N. A., Norman, D. G., Gaffney, P. R. J., Reese, C. B., MacDougall, C. N., Harbison, D., et al. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00336-8 · Cited by 754

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

Chung, J., Grammar, T. C., Lemon, K. P., Kazlauskas, A., & Blenis, J. (1994) · Nature · doi:10.1038/370071a0 · Cited by 712

The modular phosphorylation and activation of p70 s6k

Pullen, N., & Thomas, G. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00323-2 · Cited by 550

Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors.

Andjelković, M., Jakubowicz, T., Cron, P. D., Ming, X., Han, J. W., & Hemmings, B. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.5699 · Cited by 497

The principal target of rapamycin‐induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.

Pearson, R. B., Dennis, P. B., Han, J. W., Williamson, N. A., Kozma, S. C., Wettenhall, R. E., & Thomas, G. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00212.x · Cited by 443

The Principal Rapamycin-Sensitive p70s6k Phosphorylation Sites, T-229 and T-389, Are Differentially Regulated by Rapamycin-Insensitive Kinase Kinases

Dennis, P. B., Pullen, N., Kozma, S. C., & Thomas, G. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.11.6242 · Cited by 253

Hepatocyte‐specific deletion of Cdc42 results in delayed liver regeneration after partial hepatectomy in mice†

Yuan, H., Zhang, H., Wu, X., Zhang, Z., Du, D., Zhou, W., Zhou, S., Brakebusch, C., & Chen, Z. (2008) · Hepatology · doi:10.1002/hep.22610 · Cited by 34

Phosphorylation and degradation of S6K1 (p70S6K1) in response to persistent JNK1 Activation

Zhang, J., Gao, Z., & Ye, J. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.06.013 · Cited by 37

Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells

Xu, J., Jia, Y., Tapadar, S., Weaver, J. D., Raji, I. O., Pithadia, D. J., Javeed, N., García, A. J., Choi, D., Matveyenko, A. V., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-33875-0 · Cited by 35

Akt-Dependent Cell Size Regulation by the Adhesion Molecule on Glia Occurs Independently of Phosphatidylinositol 3-Kinase and Rheb Signaling

Scheidenhelm, D. K., Cresswell, J. R., Haipek, C. A., Fleming, T. P., Mercer, R. W., & Gutmann, D. H. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.8.3151-3162.2005 · Cited by 34

Nutrient sensing of mTORC1 signaling in cancer and aging

Jiang, C., Tan, X., Liu, N., Yan, P., Hou, T., & Wei, W. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.08.001 · Cited by 35

Pharmacologic inhibition of LAT1 predominantly suppresses transport of large neutral amino acids and downregulates global translation in cancer cells

Nishikubo, K., Ohgaki, R., Okanishi, H., Okuda, S., Xu, M., Endou, H., & Kanai, Y. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17553 · Cited by 33

Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells

Tamgüney, T., Zhang, C., Fiedler, D., Shokat, K. M., & Stokoe, D. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.04.006 · Cited by 33

PDPK1 regulates autophagosome biogenesis by binding to PIK3C3

Hu, B., Zhang, Y., Deng, T., Gu, J., Liu, J., Yang, H. M., Xu, Y., Yan, Y., Yang, F., Zhang, H., et al. (2020) · Autophagy · doi:10.1080/15548627.2020.1817279 · Cited by 32

Design and synthesis of benzoazepin-2-one analogs as allosteric binders targeting the PIF pocket of PDK1

Wei, L., Gao, X., Warne, R. L., Hao, X., Bussiere, D. E., Gu, X.-J., Uno, T., & Liu, Y. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.05.019 · Cited by 32

Blockade of ataxia telangiectasia mutated sensitizes hepatoma cell lines to sorafenib by interfering with Akt signaling

Fujimaki, S., Matsuda, Y., Wakai, T., Sanpei, A., Kubota, M., Takamura, M., Yamagiwa, S., Yano, M., Ohkoshi, S., & Aoyagi, Y. (2012) · Cancer Letters · doi:10.1016/j.canlet.2011.12.043 · Cited by 32

Cyclic AMP inhibits translation of cyclin D3 in T lymphocytes at the level of elongation by inducing eEF2-phosphorylation

Gützkow, K. B., Låhne, H. U., Naderi, S., Torgersen, K. M., Skålhegg, B. S., Koketsu, M., Uehara, Y., & Blomhoff, H. K. (2003) · Cellular Signalling · doi:10.1016/s0898-6568(03)00038-x · Cited by 32

Efficacy of dual PI-3K and mTOR inhibitors in vitro and in vivo in acute lymphoblastic leukemia

Wong, J., Welschinger, R., Hewson, J. W., Bradstock, K. F., & Bendall, L. J. (2014) · Oncotarget · doi:10.18632/oncotarget.2260 · Cited by 30

Alcohol and Indinavir Adversely Affect Protein Synthesis and Phosphorylation of MAPK and mTOR Signaling Pathways in C2C12 Myocytes

Hong‐Brown, L. Q., Brown, C. R., Huber, D. S., & Lang, C. H. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00157.x · Cited by 31

Inhibition of Mammalian Target of Rapamycin Signaling by 2-(Morpholin-1-yl)pyrimido[2,1-α]isoquinolin-4-one

Ballou, L. M., Selinger, E. S., Choi, J. Y., Drueckhammer, D. G., & Lin, R. Z. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704741200 · Cited by 31

Translational Control of Protein Synthesis in Pancreatic Acinar Cells

Sans, M. D., & Williams, J. A. (2002) · International Journal of Gastrointestinal Cancer · doi:10.1385/ijgc:31:1-3:107 · Cited by 31

Morphoproteomic and pharmacoproteomic rationale for mTOR effectors as therapeutic targets in head and neck squamous cell carcinoma.

Brown, R. E., Zhang, P. L., Lun, M., Zhu, S., Pellitteri, P. K., Riefkohl, W., Law, A. W., Wood, G. C., & Kennedy, T. L. (2006) · PubMed · Cited by 31

Differential control of the NIMA-related kinases, Nek6 and Nek7, by serum stimulation.

Minoguchi, S., Minoguchi, M., & Yoshimura, A. (2003) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/s0006-291x(03)00049-4 · Cited by 32

Farnesylthiosalicylic acid blocks mammalian target of rapamycin signaling in breast cancer cells

Yue, W., Wang, J., Li, Y., Fan, P., & Santen, R. J. (2005) · International Journal of Cancer · doi:10.1002/ijc.21222 · Cited by 31

Phenotypic analysis of human glioma cells expressing the MMAC1 tumor suppressor phosphatase

Morimoto, A. M., Berson, A. E., Fujii, G. H., Teng, D. H. ‐., Tavtigian, S. V., Bookstein, R., Steck, P. A., & Bolen, J. B. (1999) · Oncogene · doi:10.1038/sj.onc.1202441 · Cited by 31

Peridinin, a carotenoid, inhibits proliferation and survival of HTLV-1-infected T-cell lines

Ishikawa, C., Jomori, T., Tanaka, J., Senba, M., & Mori, N. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3648 · Cited by 30

Targeting the Phosphatidylinositol 3-Kinase Pathway in Airway Smooth Muscle

Krymskaya, V. P. (2007) · BioDrugs · doi:10.2165/00063030-200721020-00003 · Cited by 30

Quantification of the effect of amino acids on an integrated mTOR and insulinsignaling pathway

Vinod, P. K. U., & Venkatesh, K. V. (2009) · Molecular BioSystems · doi:10.1039/b816965a · Cited by 30

An immunohistochemical perspective of PPARβ and one of its putative targets PDK1 in normal ovaries, benign and malignant ovarian tumours

Ahmed, N., Riley, C. B., & Quinn, M. A. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604306 · Cited by 30

The Activated Glucocorticoid Receptor Modulates Presumptive Autoregulation of Ribosomal Protein S6 Protein Kinase, p70 S6K

Shah, O. J., Iñiguez-Lluhı́, J. A., Romanelli, A., Kimball, S. R., & Jefferson, L. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m105935200 · Cited by 30

The class I PI3K/Akt pathway is critical for cancer cell survival in dogs and offers an opportunity for therapeutic intervention

Chen, Y., Tan, K. A. L., Pang, L. Y., & Argyle, D. J. (2012) · BMC Veterinary Research · doi:10.1186/1746-6148-8-73 · Cited by 30

mTOR Signaling as a Target of Amino Acid Treatment of the Age-Related Sarcopenia

D’Antona, G., & Nisoli, E. (2010) · Interdisciplinary topics in gerontology and geriatrics · doi:10.1159/000319998 · Cited by 29

Mitogen-Independent Phosphorylation of S6K1 and Decreased Ribosomal S6 Phosphorylation in Senescent Human Fibroblasts

Zhang, H., Hoff, H. B., Marinucci, T., Cristofalo, V. J., & Sell, C. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4965 · Cited by 29

A Phosphatidylinositol 3-Kinase/p70 Ribosomal S6 Protein Kinase Pathway Is Required for the Regulation by Insulin of the p85α Regulatory Subunit of Phosphatidylinositol 3-Kinase Gene Expression in Human Muscle Cells

Roques, M., & Vidal, H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.48.34005 · Cited by 29

Suboptimal Cross-linking of Antigen Receptor Induces Syk-dependent Activation of p70S6 Kinase through Protein Kinase C and Phosphoinositol 3-Kinase*

Li, H.-L., Davis, W., & Puré, E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.14.9812 · Cited by 36

Conditional and domain‐specific inactivation of the Tsc2 gene in neural progenitor cells

Fu, C., & Ess, K. C. (2013) · genesis · doi:10.1002/dvg.22377 · Cited by 27

Phosphoinositide dependent protein kinase 1 is required for exercise-induced cardiac hypertrophy but not the associated mitochondrial adaptations

Noh, J., Wende, A. R., Olsen, C. D., Kim, B. J., Bevins, J., Zhu, Y., Zhang, Q., Riehle, C., & Abel, E. D. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.10.015 · Cited by 28

Morphoproteomic confirmation of constitutively activated mTOR, ERK, and NF-kappaB pathways in high risk neuro-blastoma, with cell cycle and protein analyte correlates.

Brown, R. E., Tan, D., Taylor, J. S., Miller, M., Prichard, J. W., & Kott, M. M. (2007) · PubMed · Cited by 27

Microscopic Modes and Free Energies of 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Binding with Celecoxib and Other Inhibitors

AbdulHameed, M. D. M., Hamza, A., & Zhan, C. (2006) · The Journal of Physical Chemistry B · doi:10.1021/jp065207e · Cited by 27

Targeting the Mammalian Target of Rapamycin in Lung Cancer

Vicary, G. W., & Roman, J. (2016) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2016.08.014 · Cited by 27

PI3-Kinase Is Involved in Mitogenic Signaling by the Oncogenic Receptor Tyrosine Kinase Xiphophorus Melanoma Receptor Kinase in Fish Melanoma

Wellbrock, C., Fischer, P., & Schartl, M. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4580 · Cited by 27

Fes Mediates the IL-4 Activation of Insulin Receptor Substrate-2 and Cellular Proliferation

Jiang, H., Foltenyi, K., Kashiwada, M., Donahue, L., Vuong, B. Q., Hehn, B. T., & Rothman, P. B. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.4.2627 · Cited by 27

S6K1 controls pancreatic β cell size independently of intrauterine growth restriction

Um, S. H., Sticker-Jantscheff, M., Chau, G. C., Vintersten, K., Mueller, M., Gangloff, Y., Adams, R. H., Spetz, J.-F., Elghazi, L., Pfluger, P. T., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci77030 · Cited by 26

Antitumor Mechanisms of Targeting the PDK1 Pathway in Head and Neck Cancer

Bhola, N. E., Freilino, M. L., Joyce, S. C., Sen, M., Thomas, S. M., Sahu, A., Cassell, A., Chen, C., & Grandis, J. R. (2012) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-11-0936 · Cited by 26

The identification of 8,9-dimethoxy-5-(2-aminoalkoxy-pyridin-3-yl)-benzo[c][2,7]naphthyridin-4-ylamines as potent inhibitors of 3-phosphoinositide-dependent kinase-1 (PDK-1)

Nittoli, T., Dushin, R. G., Ingalls, C. L., Cheung, K., Floyd, M. B., Fraser, H. L., Olland, A. M., Hu, Y., Grosu, G. T., & Han, X. (2009) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2009.12.036 · Cited by 26

Distinct regulatory mechanism for p70 S6 kinase β from that for p70 S6 kinase α

Minami, T., Hara, K., Oshiro, N., Ueoku, S., Yoshino, K.-I., Tokunaga, C., Shirai, Y., Saito, N., Gout, I. T., & Yonezawa, K. (2001) · Genes to Cells · doi:10.1046/j.1365-2443.2001.00479.x · Cited by 26

Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1

Phin, S., Kupferwasser, D., Joseph, L. A. M., & Lee-Fruman, K. K. (2003) · Biochemical Journal · doi:10.1042/bj20021794 · Cited by 26

Proliferation of IL‐6‐independent multiple myeloma does not require the activity of extracellular signal‐regulated kinases (ERK1/2)

Zhang, B., & Fenton, R. G. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10148 · Cited by 24

P–S6K is associated with insect diapause via the ROS/AKT/ S6K/CREB/HIF-1 pathway in the cotton bollworm, Helicoverpa armigera

Wang, X.-X., Geng, S., Zhang, X., & Xu, W. (2020) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2019.103262 · Cited by 25

S6 kinase 1 at the central node of cell size and ageing

Fumagalli, S., & Pende, M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.949196 · Cited by 28

Engrailed2 modulates cerebellar granule neuron precursor proliferation, differentiation and insulin-like growth factor 1 signaling during postnatal development

Rossman, I. T., Lin, L., Morgan, K. M., DiGiovine, M. P., Buskirk, E. K. V., Kamdar, S., Millonig, J. H., & DiCicco-Bloom, E. M. (2014) · Molecular Autism · doi:10.1186/2040-2392-5-9 · Cited by 26

A link between protein translation and body weight

Rui, L. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31289 · Cited by 25

The Nuclear Receptor DHR3 Modulates dS6 Kinase–Dependent Growth in Drosophila

Montagne, J., Lecerf, C., Parvy, J.-P., Callister, J. B., Radimerski, T., Ruhf, M.-L., Zilbermann, F., Vouilloz, N., Stocker, H., Hafen, E., et al. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000937 · Cited by 27

Characterization of testis‐specific serine–threonine kinase 3 and its activation by phosphoinositide‐dependent kinase‐1‐dependent signalling

Bucko‐Justyna, M., Lipiński, L., Burgering, B. M. T., & Trzeciak, L. (2005) · FEBS Journal · doi:10.1111/j.1742-4658.2005.05018.x · Cited by 25

The mTOR pathway in Gliomas: From molecular insights to targeted therapies

Pournajaf, S., & Pourgholami, M. H. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118237 · Cited by 27

Insulin augments serotonin-induced contraction via activation of the IR/PI3K/PDK1 pathway in the rat carotid artery

Watanabe, S., Matsumoto, T., Oda, M., Yamada, K., Takagi, J., Taguchi, K., & Kobayashi, T. (2015) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-015-1759-4 · Cited by 24

The choreography of protein kinase PDK1 and its diverse substrate dance partners

Leroux, A. E., & Biondi, R. M. (2023) · Biochemical Journal · doi:10.1042/bcj20220396 · Cited by 25

Steady-state Kinetic Mechanism of PDK1

Gao, X., & Harris, T. K. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602448200 · Cited by 24

Kinetic Mechanism of Fully Activated S6K1 Protein Kinase

Keshwani, M. M., & Harris, T. K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800114200 · Cited by 24

Dephosphorylation by Default, a Potential Mechanism for Regulation of Insulin Receptor Substrate-1/2, Akt, and ERK1/2

Zhande, R., Zhang, W., Zheng, Y., Pendleton, E., Li, Y., Polakiewicz, R. D., & Sun, X. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605251200 · Cited by 24

The full‐length isoform of the mouse pleckstrin homology domain‐interacting protein (PHIP) is required for postnatal growth

Li, S., Francisco, A. B., Han, C., Pattabiraman, S., Foote, M. R., Giesy, S. L., Wang, C., Schimenti, J. C., Boisclair, Y. R., & Long, Q. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.08.042 · Cited by 23

Regulation of insulin secretion by geniposide: possible involvement of phosphatidylinositol 3-phosphate kinase.

Lx, G., Liu, H., & Yin, F. (2014) · PubMed · Cited by 24

Aberrant regulation of the Akt signaling network by human cytomegalovirus allows for targeting of infected monocytes

Peppenelli, M. A., Miller, M. J., Altman, A. M., Cojohari, O., & Chan, G. C. T. (2018) · Antiviral Research · doi:10.1016/j.antiviral.2018.07.015 · Cited by 23

IKK-β mediates hydrogen peroxide induced cell death through p85 S6K1

Jia, C.-H., Li, M., Liu, J., Zhao, L., Lin, J., Lai, P.-L., Zhou, X., Zhang, Y., Chen, Z.-G., Li, H.-Y., et al. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.115 · Cited by 24

Signal Transduction and Post-Transcriptional Gene Expression

Wilson, K. F., & Cerione, R. (2000) · Biological chemistry · doi:10.1515/bc.2000.048 · Cited by 24

Lentivirus-AIMP2-DX2 shRNA Suppresses Cell Proliferation by Regulating Akt1 Signaling Pathway in the Lungs of AIMP2 +/– Mice

Hwang, S., Chang, S.-H., Minai‐Tehrani, A., Kim, Y.-S., & Cho, M. (2013) · Journal of Aerosol Medicine and Pulmonary Drug Delivery · doi:10.1089/jamp.2011.0959 · Cited by 23

T3 peptide, a fragment of tumstatin, stimulates proliferation and migration of cardiac fibroblasts through activation of Akt signaling pathway

Yasuda, J., Fukui, K., Okada, M., & Yamawaki, H. (2017) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-017-1413-0 · Cited by 23

Abnormalities of protein kinases in neurodegenerative diseases

Wagey, R. T. E., & Krieger, C. (1998) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8845-5_4 · Cited by 23

p70 ribosomal S6 kinase regulates subpleural fibrosis following transforming growth factor-α expression in the lung

Madala, S. K., Thomas, G., Edukulla, R., Davidson, C. R., Schmidt, S., Schehr, A., & Hardie, W. D. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00063.2015 · Cited by 24

Transcriptional Regulation of NK Cell Development by mTOR Complexes

Yang, C., & Malarkannan, S. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.566090 · Cited by 25

Protein Phosphorylation as a Key Mechanism of mTORC1/2 Signaling Pathways

Tchevkina, E. M., & Komelkov, A. V. (2012) · InTech eBooks · doi:10.5772/48274 · Cited by 26

In Vivo Activation of Protein Kinase A in Schizosaccharomyces pombe Requires Threonine Phosphorylation at Its Activation Loop and Is Dependent on PDK1

Tang, Y., & McLeod, M. (2004) · Genetics · doi:10.1534/genetics.104.032466 · Cited by 23

Critical Role of T-Loop and H-Motif Phosphorylation in the Regulation of S6 Kinase 1 by the Tuberous Sclerosis Complex

Shah, O. J., & Hunter, T. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400957200 · Cited by 23

Drosophila Activin signaling promotes muscle growth through InR/dTORC1 dependent and independent processes

Kim, M.-J., & O’Connor, M. B. (2020) · Development · doi:10.1242/dev.190868 · Cited by 21

Electroconvulsive seizure inhibits the mTOR signaling pathway via AMPK in the rat frontal cortex

Kim, S. H., Yu, H. S., Huh, S., Kang, U. G., & Kim, Y. S. (2021) · Psychopharmacology · doi:10.1007/s00213-021-06015-2 · Cited by 27

CKD712, (S)-1-(α-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, inhibits the lipopolysaccharide-stimulated secretion of HMGB1 by inhibiting PI3K and classical protein kinase C

Oh, Y. J., Youn, J. H., Min, H. J., Kim, D.-H., Lee, S.-S., Choi, I., & Shin, J. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.03.013 · Cited by 22

Nicotine Inhibits Memory CTL Programming

Sun, Z., Smyth, K., Garcia, K. Y., Mattson, E., Li, L., & Xiao, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068183 · Cited by 22

Possible Dual Regulatory Circuits Involving AtS6K1 in the Regulation of Plant Cell Cycle and Growth

Shin, Y.-J., Kim, S., Du, H. N., Choi, S.-Y., Verma, D. P. S., & Cheon, C.-I. (2012) · Molecules and Cells · doi:10.1007/s10059-012-2275-4 · Cited by 22

Rapamycin modulation of p70 S6 kinase signaling inhibits Rift Valley fever virus pathogenesis

Bell, T. M., Espina, V. A., Senina, S., Lehman, C. W., Brahms, A., Carey, B. D., Lin, S., Lundberg, L., Pinkham, C., Baer, A., et al. (2017) · Antiviral Research · doi:10.1016/j.antiviral.2017.04.011 · Cited by 22

Morphoproteomic confirmation of a constitutively activated mTOR pathway in high grade prostatic intraepithelial neoplasia and prostate cancer.

Brown, R. E., Zotalis, G., Zhang, P. L., & Zhao, B. (2008) · PubMed Central · Cited by 21

Involvement of the rapamycin-sensitive pathway in the insulin regulation of muscle protein synthesis in streptozotocin-diabetic rats

Grzelkowska, K., Dardevet, D. P., Balage, M., & Grizard, J. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1600137 · Cited by 22

Mapping of mTOR drug targets: Featured platforms for anti-cancer drug discovery

Shams, R. S., Ito, Y., & Miyatake, H. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.108012 · Cited by 22

Mechanisms for luteinizing hormone induction of growth hormone gene transcription in fish model: Crosstalk of the cAMP/PKA pathway with MAPK-and PI3K-dependent cascades

Sun, C., He, M., Ko, W. K. W., & Wong, A. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.10.017 · Cited by 21

p70 S6 kinase and actin dynamics

Ip, C. K. M., & Wong, A. S. T. (2012) · Spermatogenesis · doi:10.4161/spmg.19413 · Cited by 23

Mammalian target of rapamycin as a target in hematological malignancies

Kelly, K. R., Rowe, J. H., Padmanabhan, S., Nawrocki, S. T., & Carew, J. S. (2011) · Targeted Oncology · doi:10.1007/s11523-011-0175-8 · Cited by 21

S6K1 is acetylated at lysine 516 in response to growth factor stimulation

Fenton, T. R., Gwalter, J., Cramer, R., & Gout, I. T. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.06.081 · Cited by 21

Synthesis and biological evaluation of substituted 3-anilino-quinolin-2(1H)-ones as PDK1 inhibitors

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