Phosphorylation and Activation of p70 s6k by PDK1

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R. J., Reese, C. B., & Cohen, P. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00122-9 · Cited by 2,874

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

Stokoe, D., Stephens, L. R., Copeland, T., Gaffney, P. R. J., Reese, C. B., Painter, G. F., Holmes, A. B., McCormick, F. P., & Hawkins, P. T. (1997) · Science · doi:10.1126/science.277.5325.567 · Cited by 1,216

Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6k

Jefferies, H. B. J., Fumagalli, S., Dennis, P. B., Reinhard, C., Pearson, R. B., & Thomas, G. (1997) · The EMBO Journal · doi:10.1093/emboj/16.12.3693 · Cited by 934

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

Alessi, D. R., Deák, M., Casamayor, A., Caudwell, F. B., MORRICE, N. A., Norman, D. G., Gaffney, P. R. J., Reese, C. B., MacDougall, C. N., Harbison, D., et al. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00336-8 · Cited by 754

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

Chung, J., Grammar, T. C., Lemon, K. P., Kazlauskas, A., & Blenis, J. (1994) · Nature · doi:10.1038/370071a0 · Cited by 712

The modular phosphorylation and activation of p70 s6k

Pullen, N., & Thomas, G. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00323-2 · Cited by 550

Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors.

Andjelković, M., Jakubowicz, T., Cron, P. D., Ming, X., Han, J. W., & Hemmings, B. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.5699 · Cited by 497

The principal target of rapamycin‐induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.

Pearson, R. B., Dennis, P. B., Han, J. W., Williamson, N. A., Kozma, S. C., Wettenhall, R. E., & Thomas, G. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00212.x · Cited by 443

The Principal Rapamycin-Sensitive p70s6k Phosphorylation Sites, T-229 and T-389, Are Differentially Regulated by Rapamycin-Insensitive Kinase Kinases

Dennis, P. B., Pullen, N., Kozma, S. C., & Thomas, G. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.11.6242 · Cited by 253

Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K

Kozma, S. C., & Thomas, G. (2002) · BioEssays · doi:10.1002/bies.10031 · Cited by 289

Activation of protein kinase B β and γ isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B α

Walker, K. S., Deák, M., PATERSON, A., Hudson, K., Cohen, P., & Alessi, D. R. (1998) · Biochemical Journal · doi:10.1042/bj3310299 · Cited by 282

Epstein-Barr Virus LMP2A Transforms Epithelial Cells, Inhibits Cell Differentiation, and Activates Akt

Scholle, F., Bendt, K. M., & Raab‐Traub, N. (2000) · Journal of Virology · doi:10.1128/jvi.74.22.10681-10689.2000 · Cited by 278

Detecting activation of ribosomal protein S6 kinase by complementary DNA and tissue microarray analysis.

Bärlund, M., Forozan, F., Kononen, J., Bubendorf, L., Chen, Y.-D., Bittner, M. L., Torhorst, J., Haas, P., Bucher, C., Sauter, G., et al. (2000) · Journal of the National Cancer Institute · doi:10.1093/jnci/92.15.1252 · Cited by 305

A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation

Frödin, M., Antal, T. L., Dümmler, B. A., Jensen, C. J., Deak, M., Gammeltoft, S., & Biondi, R. M. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf551 · Cited by 275

Replicative senescence: a critical review

Cristofalo, V. J., Lorenzini, A., Allen, R. G., Torres, C. A., & Tresini, M. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.07.010 · Cited by 285

Phosphoprotein Analysis Using Antibodies Broadly Reactive against Phosphorylated Motifs

Zhang, H., Zha, X., Tan, Y., Hornbeck, P. V., Mastrangelo, A. J., Alessi, D. R., Polakiewicz, R. D., & Comb, M. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206399200 · Cited by 268

Role of mTOR Signaling in Tumor Cell Motility, Invasion and Metastasis

Huang, S., & Zhou, H. (2011) · Current Protein and Peptide Science · doi:10.2174/138920311795659407 · Cited by 270

The Phosphoinositide 3-Kinase Pathway in Human Cancer: Genetic Alterations and Therapeutic Implications

Arcaro, A., & Stücklin, A. G. (2007) · Current Genomics · doi:10.2174/138920207782446160 · Cited by 274

Mechanisms maintaining the dormancy and survival of mammalian primordial follicles

Reddy, P., Zheng, W., & Liu, K. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.10.001 · Cited by 276

Invited Review: Intracellular signaling in contracting skeletal muscle

Sakamoto, K., & Goodyear, L. J. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00167.2002 · Cited by 260

90-kDa Ribosomal S6 Kinase Is Phosphorylated and Activated by 3-Phosphoinositide-dependent Protein Kinase-1

Jensen, C. J., Buch, M.-B., Krag, T. O. B., Hemmings, B. A., Gammeltoft, S., & Frödin, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.38.27168 · Cited by 263

From the Cyclooxygenase-2 Inhibitor Celecoxib to a Novel Class of 3-Phosphoinositide-Dependent Protein Kinase-1 Inhibitors

Zhu, J., Huang, J., Tseng, P., Yang, Y.-T. C., Fowble, J. W., Shiau, C., Shaw, Y., Kulp, S. K., & Chen, C. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-4063 · Cited by 258

Activation of Phosphatidylinositol 3-Kinase Is Sufficient for Cell Cycle Entry and Promotes Cellular Changes Characteristic of Oncogenic Transformation

Klippel, A., Escobedo, M.-A., Wachowicz, M. S., Apell, G., Brown, T. W., Giedlin, M. A., Kavanaugh, W. M., & Williams, L. T. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.10.5699 · Cited by 255

Stimulus-Dependent Regulation of Serum and Glucocorticoid Inducible Protein Kinase (SGK) Transcription, Subcellular Localization and Enzymatic Activity

Firestone, G. L., Giampaolo, J. R., & O'Keeffe, B. A. (2003) · Cellular Physiology and Biochemistry · doi:10.1159/000070244 · Cited by 255

A Novel mTOR-Regulated Phosphorylation Site in Elongation Factor 2 Kinase Modulates the Activity of the Kinase and Its Binding to Calmodulin

Browne, G. J., & Proud, C. G. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.7.2986-2997.2004 · Cited by 256

Rapamycin: an anti-cancer immunosuppressant?

Law, B. K. (2005) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2004.09.009 · Cited by 252

3-Phosphoinositide-Dependent Protein Kinase-1/Akt Signaling Represents a Major Cyclooxygenase-2-Independent Target for Celecoxib in Prostate Cancer Cells

Kulp, S. K., Yang, Y.-T. C., Hung, C., Chen, K., Lai, J.-P., Tseng, P., Fowble, J. W., Ward, P. J., & Chen, C. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2396 · Cited by 252

Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast

Casamayor, A., Torrance, P. D., Kobayashi, T., Thorner, J. W., & Alessi, D. R. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80088-8 · Cited by 245

Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase

Cheng, X., Ma, Y., Moore, M. J., Hemmings, B. A., & Taylor, S. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.9849 · Cited by 248

Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function

Jastrzebski, K., Hannan, K. M., Tchoubrieva, E. B., Hannan, R. D., & Pearson, R. B. (2007) · Growth Factors · doi:10.1080/08977190701779101 · Cited by 240

Alterations of insulin signaling in type 2 diabetes: A review of the current evidence from humans

Fröjdö, S., Vidal, H., & Pirola, L. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.10.019 · Cited by 247

Expression of the Serum- and Glucocorticoid-inducible Protein Kinase, Sgk, Is a Cell Survival Response to Multiple Types of Environmental Stress Stimuli in Mammary Epithelial Cells*

Leong, M., Maiyar, A. C., Kim, B., O'Keeffe, B. A., & Firestone, G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211649200 · Cited by 254

The S6K protein family in health and disease

Tavares, M. R., Pavan, I. C. B., do Amaral, C. L., Meneguello, L., Luchessi, A. D., & Simabuco, F. M. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.03.001 · Cited by 252

Insulin Receptor Substrate-1 and Phosphoinositide-Dependent Kinase-1 Are Required for Insulin-Stimulated Production of Nitric Oxide in Endothelial Cells

Montagnani, M., Ravichandran, L. V., Chen, H., Esposito, D. L., & Quon, M. J. (2002) · Molecular Endocrinology · doi:10.1210/me.2002-0074 · Cited by 235

The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module

Kannan, N., Haste, N. M., Taylor, S. S., & Neuwald, A. F. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610251104 · Cited by 236

p21-activated Kinase (PAK1) Is Phosphorylated and Activated by 3-Phosphoinositide-dependent Kinase-1 (PDK1)

King, C. C., Gardiner, E. M. M., Zenke, F. T., Bohl, B. P., Newton, A. C., Hemmings, B. A., & Bokoch, G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006553200 · Cited by 235

TOR Signaling

Harris, T. E., & Lawrence, J. C. (2003) · Science s STKE · doi:10.1126/stke.2122003re15 · Cited by 239

Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779.

Shi, Y., Gera, J., Hu, L., Hsu, J.-H., Bookstein, R., Li, W., & Lichtenstein, A. K. (2002) · PubMed · Cited by 231

Novel Small Molecule Inhibitors of 3-Phosphoinositide-dependent Kinase-1*

Feldman, R., Wu, J. M., Polokoff, M., Kochanny, M., Dinter, H., Zhu, D.-G., Biroc, S., Alicke, B., Bryant, J., Yuan, S., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501367200 · Cited by 218

Signal perception and transduction: the role of protein kinases

Schenk, P. W., & Snaar-Jagalska, E. B. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(98)00178-5 · Cited by 232

Insulin-Mediated Stimulation of Protein Kinase Akt

Hermann, C., Aßmus, B., Urbich, C., Zeiher, A. M., & Dimmeler, S. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.2.402 · Cited by 233

Akt Protein Kinase Inhibits Rac1-GTP Binding through Phosphorylation at Serine 71 of Rac1

Kwon, T., Kwon, D. Y., Chun, J., Kim, J., & Kang, S. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.423 · Cited by 225

Tyrosine 1101 of Tie2 Is the Major Site of Association of p85 and Is Required for Activation of Phosphatidylinositol 3-Kinase and Akt

Kontos, C. D., Stauffer, T. P., Yang, W.-P., York, J. D., Huang, L., Blanar, M. A., Meyer, T., & Peters, K. G. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.4131 · Cited by 222

The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling

Vázquez, F., & Sellers, W. R. (2000) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(99)00032-3 · Cited by 226

TGF-β inhibits p70 S6 kinase via protein phosphatase 2A to induce G1 arrest

Petritsch, C., Beug, H., Balmain, A., & Oft, M. (2000) · Genes & Development · doi:10.1101/gad.854200 · Cited by 223

Intracellular signalling: PDK1 – a kinase at the hub of things

BELHAM, C. M., Wu, S., & Avruch, J. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80058-x · Cited by 221

Phosphoinositides and signal transduction

Toker, A. (2002) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-002-8465-z · Cited by 222

The role of PI 3-kinase in insulin action

Alessi, D. R., & Downes, C. P. (1998) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s0005-2760(98)00133-7 · Cited by 216

The Inositol Phosphatase SHIP Inhibits Akt/PKB Activation in B Cells

Aman, M. J., Lamkin, T. D., Okada, H., Kurosaki, T., & Ravichandran, K. S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.51.33922 · Cited by 162

Luteolin Inhibits Vascular Endothelial Growth Factor-Induced Angiogenesis; Inhibition of Endothelial Cell Survival and Proliferation by Targeting Phosphatidylinositol 3′-Kinase Activity

Bagli, E., Stefaniotou, M. I., Morbidelli, L., Ziche, M., Psilas, K. G., Murphy, C., & Fotsis, T. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3104 · Cited by 215

Role of PI3K and AKT specific isoforms in ovarian cancer cell migration, invasion and proliferation through the p70S6K1 pathway

Meng, Q., Xia, C., Fang, J. S., Rojanasakul, Y., & Jiang, B. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.05.019 · Cited by 212

Compensatory PI3-kinase/Akt/mTor activation regulates imatinib resistance development

Burchert, A., Wang, Y., Cai, D., von Bubnoff, N. C. C., Paschka, P., Müller‐Brüsselbach, S., Ottmann, O. G., Duyster, J., Hochhaus, A., & Neubauer, A. (2005) · Leukemia · doi:10.1038/sj.leu.2403898 · Cited by 215

Differential contributions of ERK and PI3-kinase to the regulation of cyclin D1 expression and to the control of the G1/S transition in mouse embryonic stem cells

Jirmanova, L., Afanassieff, M., Gobert, S., Markossian, S., & Savatier, P. (2002) · Oncogene · doi:10.1038/sj.onc.1205728 · Cited by 216

MAP kinases, phosphatidylinositol 3-kinase, and p70 S6 kinase mediate the mitogenic response of human endothelial cells to vascular endothelial growth factor

Yu, Y., & Sato, J. D. (1999) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199902)178:2 · Cited by 210

SGK integrates insulin and mineralocorticoid regulation of epithelial sodium transport

Wang, J., Barbry, P., Maiyar, A. C., Rozansky, D. J., Bhargava, A., Leong, M. L. L., Firestone, G. L., & Pearce, D. (2001) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2001.280.2.f303 · Cited by 210

Mammalian target of rapamycin inhibition as therapy for hematologic malignancies

Panwalkar, A. W., Verstovšek, S., & Giles, F. J. (2004) · Cancer · doi:10.1002/cncr.20026 · Cited by 206

Tuberous sclerosis complex tumor suppressor–mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

Jaeschke, A., Hartkamp, J., Saitoh, M., Roworth, W., Nobukuni, T., Hodges, A., Sampson, J. R., Thomas, G., & Lamb, R. F. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.jcb.200206108 · Cited by 208

S6K1 Plays a Critical Role in Early Adipocyte Differentiation

Carnevalli, L. S., Masuda, K., Frigerio, F., Bacquer, O. L., Um, S. H., Gandin, V., Topisirović, I., Sonenberg, N., Thomas, G., & Kozma, S. C. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.02.018 · Cited by 212

A Human Protein Kinase Bγ with Regulatory Phosphorylation Sites in the Activation Loop and in the C-terminal Hydrophobic Domain

Brodbeck, D., Cron, P. D., & Hemmings, B. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.14.9133 · Cited by 204

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site

Biondi, R. M., Komander, D., Thomas, C. C., Lizcano, J. M., Deak, M., Alessi, D. R., & van Aalten, D. M. F. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf437 · Cited by 207

PRR5, a Novel Component of mTOR Complex 2, Regulates Platelet-derived Growth Factor Receptor β Expression and Signaling

Woo, S.-Y., Kim, D., Jun, C., Kim, Y. M., Haar, E. V., Lee, S.-I., Hegg, J. W., Bandhakavi, S., Griffin, T. J., & Kim, D. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704343200 · Cited by 206

Amino Acid-dependent Control of p70s6k

Iiboshi, Y., Papst, P. J., Kawasome, H., Hosoi, H., Abraham, R. T., Houghton, P. J., & Terada, N. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.2.1092 · Cited by 201

ErbB2 Increases Vascular Endothelial Growth Factor Protein Synthesis via Activation of Mammalian Target of Rapamycin/p70S6K Leading to Increased Angiogenesis and Spontaneous Metastasis of Human Breast Cancer Cells

Klos, K. S., Wyszomierski, S. L., Sun, M., Tan, M., Zhou, X., Li, P., Yang, W., Yin, G., Hittelman, W. N., & Yu, D. (2006) · Cancer Research · doi:10.1158/0008-5472.can-04-4559 · Cited by 201

Regulation of Translational Effectors by Amino Acid and Mammalian Target of Rapamycin Signaling Pathways

Shigemitsu, K., Tsujishita, Y., Hara, K., Nanahoshi, M., Avruch, J., & Yonezawa, K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.2.1058 · Cited by 199

Signal Transduction Pathways That Regulate Eukaryotic Protein Synthesis

Rhoads, R. E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.43.30337 · Cited by 201

Coordinate regulation of translation by the PI 3-kinase and mTOR pathways

Martin, K. A., & Blenis, J. (2002) · Advances in cancer research · doi:10.1016/s0065-230x(02)86001-8 · Cited by 204

Lipid-Regulated Kinases: Some Common Themes at Last

Downward, J. (1998) · Science · doi:10.1126/science.279.5351.673 · Cited by 198

When translation meets transformation: the mTOR story

Avérous, J., & Proud, C. G. (2006) · Oncogene · doi:10.1038/sj.onc.1209887 · Cited by 197

PDK1: At the crossroad of cancer signaling pathways

Gagliardi, P. A., Puliafito, A., & Primo, L. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.04.014 · Cited by 196

dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1

Radimerski, T., Montagne, J., Rintelen, F., Stocker, H., KAAY, J. V. D., Downes, C. P., Hafen, E., & Thomas, G. (2002) · Nature Cell Biology · doi:10.1038/ncb763 · Cited by 190

Exercise and insulin cause GLUT-4 translocation in human skeletal muscle

Thorell, A., Hirshman, M. F., Nygren, J., Jorfeldt, L., Wojtaszewski, J. F. P., Dufresne, S. D., Horton, E. S., Ljungqvist, O. H., & Goodyear, L. J. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.4.e733 · Cited by 193

mTOR Signaling in Protein Translation Regulation: Implications in Cancer Genesis and Therapeutic Interventions

Showkat, M., Beigh, M. A., & Andrabi, K. I. (2014) · Molecular Biology International · doi:10.1155/2014/686984 · Cited by 196

μ-Opioid Receptor Activates Signaling Pathways Implicated in Cell Survival and Translational Control

Polakiewicz, R. D., Schieferl, S. M., Gingras, A., Sonenberg, N., & Comb, M. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.36.23534 · Cited by 190

Role of S6 phosphorylation and S6 kinase in cell growth.

Volarević, S., & Thomas, G. (2001) · Progress in Nucleic Acid Research and Molecular Biology · doi:10.1016/s0079-6603(00)65003-1 · Cited by 200

TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity

Yang, Q., Inoki, K., Kim, E., & Guan, K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602282103 · Cited by 183

A 3-Phosphoinositide-dependent Protein Kinase-1 (PDK1) Docking Site Is Required for the Phosphorylation of Protein Kinase Cζ (PKCζ) and PKC-related Kinase 2 by PDK1

Balendran, A., Biondi, R. M., Cheung, P., Casamayor, A., Deák, M., & Alessi, D. R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000421200 · Cited by 183

Cyclin D1 Expression Mediated by Phosphatidylinositol 3-Kinase through mTOR-p70S6K-Independent Signaling in Growth Factor-Stimulated NIH 3T3 Fibroblasts

Takuwa, N., Fukui, Y., & Takuwa, Y. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.1346 · Cited by 180

p70 S6 Kinase Is Regulated by Protein Kinase Cζ and Participates in a Phosphoinositide 3-Kinase-Regulated Signalling Complex

Romanelli, A., Martin, K. A., Toker, A., & Blenis, J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2921 · Cited by 180

Molecular Cloning and Characterization of the Human Protein Kinase D2

Sturany, S., Lint, J. V., Müller, F., Wilda, M., Hameister, H., Höcker, M. R., Brey, A., Gern, U., Vandenheede, J. R., Gress, T. M., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008719200 · Cited by 185

HMGB1 Is Phosphorylated by Classical Protein Kinase C and Is Secreted by a Calcium-Dependent Mechanism

Oh, Y. J., Youn, J. H., Ji, Y., Lee, S. E., Lim, K. J., Choi, J. E., & Shin, J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0801873 · Cited by 180

Regulation of an Activated S6 Kinase 1 Variant Reveals a Novel Mammalian Target of Rapamycin Phosphorylation Site

Saitoh, M., Pullen, N., Brennan, P., Cantrell, D. A., Dennis, P. B., & Thomas, G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201745200 · Cited by 177

The p70 S6 Kinase Integrates Nutrient and Growth Signals to Control Translational Capacity

Avruch, J., BELHAM, C. M., Weng, Q. P., Hara, K., & Yonezawa, K. (2001) · Progress in molecular and subcellular biology · doi:10.1007/978-3-642-56688-2_5 · Cited by 181

The Structure and Function of PKN, a Protein Kinase Having a Catalytic Domain Homologous to That of PKC

Mukai, H. (2003) · The Journal of Biochemistry · doi:10.1093/jb/mvg019 · Cited by 173

Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast

Friant, S., Lombardi, R., Schmelzle, T., Hall, M. N., & Riezman, H. (2001) · The EMBO Journal · doi:10.1093/emboj/20.23.6783 · Cited by 173

Studies on the Mechanism of Resistance to Rapamycin in Human Cancer Cells

Hosoi, H., Dilling, M. B., Liu, L. N., Danks, M. K., Shikata, T., Sekulic, A., Abraham, R. T., Lawrence, J. C., & Houghton, P. J. (1998) · Molecular Pharmacology · doi:10.1124/mol.54.5.815 · Cited by 173

Protein Kinase B Localization and Activation Differentially Affect S6 Kinase 1 Activity and Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 Phosphorylation

Dufner, A., Andjelković, M., Burgering, B. M. T., Hemmings, B. A., & Thomas, G. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.6.4525 · Cited by 169

Inactivation and dephosphorylation of protein kinase Bα (PKBα) promoted by hyperosmotic stress

Meier, R., Thelen, M., & Hemmings, B. A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.24.7294 · Cited by 169

PDK1 regulates growth through Akt and S6K in Drosophila

Rintelen, F., Stocker, H., Thomas, G., & Hafen, E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.011318098 · Cited by 170

Signaling control of mRNA translation in cancer pathogenesis

Holland, E. C., Sonenberg, N., Pandolfi, P. P., & Thomas, G. (2004) · Oncogene · doi:10.1038/sj.onc.1207590 · Cited by 171

The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression

Kim, S. K., & NOVAK, R. F. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.07.004 · Cited by 167

Lysosomal Dysfunction in Down Syndrome Is APP-Dependent and Mediated by APP-βCTF (C99)

Jiang, Y., Sato, Y., Im, E., Berg, M., Bordi, M., Darji, S., Kumar, A., Mohan, P. S., Bandyopadhyay, U., Diaz, A., et al. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.0578-19.2019 · Cited by 166

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Eguchi, S., Iwasaki, H., Ueno, H., Frank, G. D., Motley, E. D., Eguchi, K., Marumo, F., Hirata, Y., & Inagami, T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.52.36843 · Cited by 163

Maximal lengthening contractions increase p70 S6 kinase phosphorylation in human skeletal muscle in the absence of nutritional supply

Eliasson, J., Brink-Elfegoun, T., Nilsson, J. E., Köhnke, R., Ekblom, B. T., & Blomstrand, E. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00141.2006 · Cited by 163

SHP-1 Regulates Lck-induced Phosphatidylinositol 3-Kinase Phosphorylation and Activity

Cuevas, B. D., Lu, Y., Watt, S., Kumar, R., Zhang, J., Siminovitch, K. A., & Mills, G. B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.39.27583 · Cited by 164

Control of p70 ribosomal protein S6 kinase and acetyl‐CoA carboxylase by AMP‐activated protein kinase and protein phosphatases in isolated hepatocytes

Krause, U., Bertrand, L., & Hue, L. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.03074.x · Cited by 162

Characterization of S6K2, a novel kinase homologous to S6K1

Lee-Fruman, K. K., Kuo, C. J., Lippincott, J., Terada, N., & Blenis, J. (1999) · Oncogene · doi:10.1038/sj.onc.1202894 · Cited by 162

Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing

Blandino-Rosano, M., Barbaresso, R., Jiménez-Palomares, M., Bozadjieva-Kramer, N., Werneck‐de‐Castro, J. P., Hatanaka, M., Mirmira, R. G., Sonenberg, N., Liu, M. R., Rüegg, M. A., et al. (2017) · Nature Communications · doi:10.1038/ncomms16014 · Cited by 161

Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs

Blalock, W. L., Oppenheimer, C. W., Chang, F., Hoyle, P., Wang, X. Y., Algate, P. A., Franklin, R. A., Oberhaus, S. M., Steelman, L. S., & McCubrey, J. A. (1999) · Leukemia · doi:10.1038/sj.leu.2401493 · Cited by 160

Translation control: Connecting mitogens and the ribosome

Peterson, R. T., & Schreiber, S. L. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70152-6 · Cited by 156

Hyperosmotic Stress Stimulates Promoter Activity and Regulates Cellular Utilization of the Serum- and Glucocorticoid-inducible Protein Kinase (Sgk) by a p38 MAPK-dependent Pathway*

Bell, L. M., Leong, M., Kim, B., Wang, E., Park, J., Hemmings, B., & Firestone, G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002076200 · Cited by 164

Mechanotransduction in skeletal muscle

Thomas, J. F. (2006) · Frontiers in bioscience · doi:10.2741/2057 · Cited by 159

Heregulin-dependent Activation of Phosphoinositide 3-Kinase and Akt via the ErbB2/ErbB3 Co-receptor

Hellyer, N. J., Kim, M.-S., & Koland, J. G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102079200 · Cited by 156

c-Raf/MEK/ERK Pathway Controls Protein Kinase C-mediated p70S6K Activation in Adult Cardiac Muscle Cells*

Iijima, Y., Laser, M., Shiraishi, H., Willey, C., Sundaravadivel, B., Xu, L., McDermott, P., & Kuppuswamy, D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200328200 · Cited by 155

A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells

Martelli, A. M., Tazzari, P. L., Tabellini, G., Bortul, R., Billi, A. M., Manzoli, L., Ruggeri, A., Conte, R., & Cocco, L. (2003) · Leukemia · doi:10.1038/sj.leu.2403044 · Cited by 155

A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells

Matsuoka, Y., Nagahara, Y., Ikekita, M., & Shinomiya, T. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705182 · Cited by 152

Hydrogen Peroxide Activates p70S6k Signaling Pathway

Bae, G., Seo, D. W., Kwon, H.-K., Lee, H. Y., Hong, S., Lee, Z., Ha, K., Lee, H. W., & Han, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.46.32596 · Cited by 149

Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer

Lin, H.-J., Hsieh, F.-C., Song, H., & Lin, J. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602862 · Cited by 153

PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle

Dong, L., & Liu, F. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00011.2005 · Cited by 149

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Loffing, J., Flores, S. Y., & Staub, O. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040104.131654 · Cited by 149

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

Alessi, D. R., Kozlowski, M. T., Weng, Q.-P., MORRICE, N. A., & Avruch, J. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70037-5 · Cited by 574

Evidence That 3-Phosphoinositide-dependent Protein Kinase-1 Mediates Phosphorylation of p70 S6 Kinase in Vivoat Thr-412 as well as Thr-252

Balendran, A., Currie, R. A., Armstrong, C. G., Avruch, J., & Alessi, D. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.52.37400 · Cited by 135

Mechanism of PDK1-catalyzed Thr-229 Phosphorylation of the S6K1 Protein Kinase

Keshwani, M. M., Gao, X., & Harris, T. K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.032177 · Cited by 15

The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB

Biondi, R. M., Kieloch, A., Currie, R. A., Deak, M., & Alessi, D. R. (2001) · The EMBO Journal · doi:10.1093/emboj/20.16.4380 · Cited by 377

p70S6 Kinase

(2006) · Springer eBooks · doi:10.1007/3-540-29832-0_1202