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FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis
Abstract
FADD (also known as Mort-1) is a signal transducer downstream of cell death receptor CD95 (also called Fas). CD95, tumor necrosis factor receptor type 1 (TNFR-1), and death receptor 3 (DR3) did not induce apoptosis in FADD-deficient embryonic fibroblasts, whereas DR4, oncogenes E1A and c- myc , and chemotherapeutic agent adriamycin did. Mice with a deletion in the FADD gene did not survive beyond day 11.5 of embryogenesis; these mice showed signs of cardiac failure and abdominal hemorrhage. Chimeric embryos showing a high contribution of FADD null mutant cells to the heart reproduce the phenotype of FADD-deficient mutants. Thus, not only death receptors, but also receptors that couple to developmental programs, may use FADD for signaling.
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- We thank V. M. Dixit for DR3 and DR4 vectors and P. H. Krammer for agonistic antibody to Fas; H. Hsu L.-M. Boucher and members of T.W.M.'s laboratory for material and instructive discussions; I. del Barco Barrantes and B. Hum for technical assistance; M. Saunders for scientific editing; and I. Ng for administrative support. Supported in part by a grant from the National Cancer Institute of Canada (NCIC) and grant CA13106 from the National Cancer Institute and Medical Research Council of Canada.
Cited by
Death Receptors: Signaling and Modulation
Ashkenazi, A., & Dixit, V. M. (1998) · Science · doi:10.1126/science.281.5381.1305 · Cited by 5,866
Signal transduction by the JNK group of MAP kinases
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Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis
Earnshaw, W. C., Martins, L. M., & Kaufmann, S. H. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.383 · Cited by 2,760
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
Micheau, O., & Tschopp, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00521-x · Cited by 2,738
Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy
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Metadata
- Authors
- Yeh, W.-C., Pompa, J. L. D. L., McCurrach, M. E., Shu, H.-B., Elia, A. J., Shahinian, A., Ng, M., Wakeham, A., Khoo, W., Mitchell, K., El-Deiry, W. S., Lowe, S. W., Goeddel, D. V., & Mak, T. W.
- Venue
- Science
- Published
- 1998-03-20
- Volume
- 279
- Issue
- 5358
- Pages
- 1954-1958
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2122482353
- Cited by
- 893
- References
- 3
- FWCI
- 30.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yeh, W.-C., Pompa, J. L. D. L., McCurrach, M. E., Shu, H.-B., Elia, A. J., Shahinian, A., Ng, M., Wakeham, A., Khoo, W., Mitchell, K., El-Deiry, W. S., Lowe, S. W., Goeddel, D. V., & Mak, T. W. (1998). FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis. Science. https://doi.org/10.1126/science.279.5358.1954
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
