Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

Chiang, C. C., Litingtung, Y., Lee, E., Young, K. E., Corden, J. L., Westphal, H., & Beachy, P. A. (1996) · Nature · doi:10.1038/383407a0 · Cited by 3,062

Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants

Goodrich, L. V., Milenković, L., Higgins, K. M., & Scott, M. P. (1997) · Science · doi:10.1126/science.277.5329.1109 · Cited by 1,696

Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development

Porter, J. A., Young, K. E., & Beachy, P. A. (1996) · Science · doi:10.1126/science.274.5285.255 · Cited by 1,360

Niemann-Pick C1 Disease Gene: Homology to Mediators of Cholesterol Homeostasis

Carstea, E. D., Morris, J. A., Coleman, K. G., Loftus, S. K., Zhang, D., Cummings, C., Gu, J., Rosenfeld, M. A., Pavan, W. J., Krizman, D. B., et al. (1997) · Science · doi:10.1126/science.277.5323.228 · Cited by 1,293

Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

Roelink, H., Porter, J. A., Chiang, C. C., Tanabe, Y., Chang, D. T., Beachy, P. A., & Jessell, T. M. (1995) · Cell · doi:10.1016/0092-8674(95)90397-6 · Cited by 888

Two Critical Periods of Sonic Hedgehog Signaling Required for the Specification of Motor Neuron Identity

Ericson, J., Brenner‐Morton, S., Kawakami, A., Roelink, H., & Jessell, T. M. (1996) · Cell · doi:10.1016/s0092-8674(00)81386-0 · Cited by 870

Defective cholesterol biosynthesis associated with the Smith-Lemli-Opitz syndrome

Tint, G. S., Irons, M., Elias, E. R., Batta, A. K., Frieden, R., Chen, T. S., & Salen, G. (1994) · New England Journal of Medicine · doi:10.1056/nejm199401133300205 · Cited by 798

Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly

Belloni, E., Muenke, M., Roessler, E., Traverse, G., Siegel-Bartelt, J., Frumkin, A., Mitchell, H. F., Donis-Keller, H., Helms, C. A., Hing, A. V., et al. (1996) · Nature Genetics · doi:10.1038/ng1196-353 · Cited by 643

Early Stages of Motor Neuron Differentiation Revealed by Expression of Homeobox Gene Islet-1

Ericson, J., Thor, S., Edlund, T., Jessell, T. M., & Yamada, T. (1992) · Science · doi:10.1126/science.1350865 · Cited by 620

Autoproteolysis in hedgehog protein biogenesis

Lee, J., Ekker, S. C., von Kessler, D. P., Porter, J. A., Sun, B. I., & Beachy, P. A. (1994) · Science · doi:10.1126/science.7985023 · Cited by 547

The role of cholesterol in Shh signaling and teratogen-induced holoprosencephaly

Incardona, J. P., & Roelink, H. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000653 · Cited by 76

Brain as a paradigm of organ growth: Hedgehog–Gli signaling in neural stem cells and brain tumors

Stecca, B. A., & Altaba, A. R. I. (2005) · Journal of Neurobiology · doi:10.1002/neu.20160 · Cited by 76

Sending and Receiving Hedgehog Signals

Petrov, K. O., Wierbowski, B. M., & Salic, A. N. (2017) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100616-060847 · Cited by 76

Transport of maternal cholesterol to the fetus is affected by maternal plasma cholesterol concentrations in the Golden Syrian hamster

Burke, K. T., Colvin, P. L., Myatt, L., Graf, G. A., Schroeder, F., & Woollett, L. A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800538-jlr200 · Cited by 75

Chemistry and bioactivities of natural steroidal alkaloids

Xiang, M.-L., Hu, B., Qi, Z., Wang, X., Xie, T., Wang, Z., Ma, D.-Y., Zeng, Q., & Luo, X. (2022) · Natural Products and Bioprospecting · doi:10.1007/s13659-022-00345-0 · Cited by 73

Current perspectives in zebrafish reverse genetics: Moving forward

Skromne, I., & Prince, V. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21484 · Cited by 74

Snail and Sonic Hedgehog activation in neuroendocrine tumors of the ileum

Fendrich, V., Waldmann, J., Esni, F., Ramaswamy, A., Mullendore, M. E., Buchholz, M., Maitra, A., & Feldmann, G. (2007) · Endocrine Related Cancer · doi:10.1677/erc-07-0108 · Cited by 73

A Small‐Molecule Antagonist of the Hedgehog Signaling Pathway

Lee, J., Wu, X., di Magliano, M. P., Peters, E. C., Wang, Y., Hong, J., Hebrok, M., Ding, S., Cho, C. Y., & Schultz, P. G. (2007) · ChemBioChem · doi:10.1002/cbic.200700403 · Cited by 73

Molecular Pathways Regulating Pro-migratory Effects of Hedgehog Signaling

Hochman, E., Castiel, A., Jacob‐Hirsch, J., Amariglio, N., & Izraeli, S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605905200 · Cited by 72

Hypomorphic Temperature-Sensitive Alleles of NSDHL Cause CK Syndrome

McLarren, K. W., Severson, T., du Souich, C., Stockton, D. W., Kratz, L. E., Cunningham, D., Hendson, G., Morin, R. D., Wu, D., Paul, J. E., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.11.004 · Cited by 74

How a Hedgehog might see holoprosencephaly

Roessler, E. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg058 · Cited by 73

DHCR24 Gene Knockout Mice Demonstrate Lethal Dermopathy with Differentiation and Maturation Defects in the Epidermis

Mirza, R., Hayasaka, S., Takagishi, Y., Kambe, F., Ohmori, S., Maki, K., Yamamoto, M., Murakami, K., Kaji, T., ZADWORNY, D., et al. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700111 · Cited by 71

Pathophysiology of phenylketonuria

Dyer, C. A. (1999) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/(sici)1098-2779(1999)5:2 · Cited by 71

The Hedgehog Signaling Pathway: Where Did It Come From?

Hausmann, G., von Mering, C., & Basler, K. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000146 · Cited by 71

Hedgehog signaling is directly required for the development of zebrafish dorsal root ganglia neurons

Ungos, J. M., Karlstrom, R. O., & Raible, D. W. (2003) · Development · doi:10.1242/dev.00722 · Cited by 70

CHOLESTEROL AND DEVELOPMENT: THE RSH ("SMITH-LEMLI-OPITZ") SYNDROME AND RELATED CONDITIONS

Opitz, J. M., Gilbert‐Barness, E., Ackerman, J., & Lowichik, A. (2002) · Fetal and Pediatric Pathology · doi:10.1080/15227950252852078 · Cited by 70

RSH/Smith-Lemli-Opitz Syndrome: Mutations and Metabolic Morphogenesis

Kelley, R. I. (1998) · The American Journal of Human Genetics · doi:10.1086/301987 · Cited by 70

Negative regulation of Hedgehog signaling by the cholesterogenic enzyme 7-dehydrocholesterol reductase

Koide, T., Hayata, T., & Cho, K. W. Y. (2006) · Development · doi:10.1242/dev.02393 · Cited by 69

Role of the Hedgehog pathway in hepatocellular carcinoma (Review)

Zheng, X. M., Zeng, W., Gai, X., Xu, Q., Li, C., Liang, Z., Tuo, H., & Liu, Q. (2013) · Oncology Reports · doi:10.3892/or.2013.2690 · Cited by 69

The calcium pump of the endoplasmic reticulum plays a role in midline signaling during early zebrafish development

Créton, R. (2004) · Developmental Brain Research · doi:10.1016/j.devbrainres.2004.03.016 · Cited by 69

Congenital abnormalities of body patterning: embryology revisited

Goodman, F. R. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14187-6 · Cited by 69

Cholesterol supplementation with egg yolk increases plasma cholesterol and decreases plasma 7-dehydrocholesterol in Smith-Lemli-Opitz syndrome

Linck, L. M., Lin, D. S., Flavell, D. P., CONNOR, W. E., & Steiner, R. D. (2000) · American Journal of Medical Genetics · doi:10.1002/1096-8628(20000828)93:5 · Cited by 66

Basal Cell Carcinoma: From the Molecular Understanding of the Pathogenesis to Targeted Therapy of Progressive Disease

Göppner, D., & Leverkus, M. (2010) · Journal of Skin Cancer · doi:10.1155/2011/650258 · Cited by 67

RCAS-RNAi: A loss-of-function method for the developing chick retina

Harpavat, S., & Cepko, C. L. (2006) · BMC Developmental Biology · doi:10.1186/1471-213x-6-2 · Cited by 67

The patched polymorphism Pro1315Leu (C3944T) may modulate the association between use of oral contraceptives and breast cancer risk

Chang‐Claude, J., Dunning, A. M., Schnitzbauer, U., Galmbacher, P., Tee, L. J., Wjst, M., Chalmers, J., Zemzoum, I., Harbeck, N., Pharoah, P. D. P., et al. (2002) · International Journal of Cancer · doi:10.1002/ijc.10889 · Cited by 67

Inhibition of sonic hedgehog autoprocessing in cultured mammalian cells by sterol deprivation

Guy, R. K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.13.7307 · Cited by 67

Developmental signaling pathways in brain tumor‐derived stem‐like cells

Clark, P. A., Treisman, D. M., Ebben, J. D., & Kuo, J. S. (2007) · Developmental Dynamics · doi:10.1002/dvdy.21381 · Cited by 65

Hedgehog Signaling Regulation of Homeodomain Protein Islet Duodenum Homeobox-1 Expression in Pancreatic β-Cells*

Thomas, M. K., Lee, J. H., Rastalsky, N., & Habener, J. F. (2001) · Endocrinology · doi:10.1210/endo.142.3.8007 · Cited by 66

Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates

Byrne, E. F. X., Luchetti, G., Rohatgi, R., & Siebold, C. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.10.004 · Cited by 64

Contact-Mediated Inhibition Between Oligodendrocyte Progenitor Cells and Motor Exit Point Glia Establishes the Spinal Cord Transition Zone

Smith, C. J., Morris, A. D., Welsh, T. G., & Kucenas, S. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001961 · Cited by 64

Hedgehog and adipogenesis: Fat and fiction

Cousin, W., Fontaine, C., Dani, C., & Peraldi, P. (2007) · Biochimie · doi:10.1016/j.biochi.2007.08.012 · Cited by 64

Structural basis of SUFU–GLI interaction in human Hedgehog signalling regulation

Cherry, A. L., Finta, C., Karlström, M., Jin, Q., Schwend, T., Astorga‐Wells, J., Zubarev, R. A., Campo, M. D., Criswell, A. R., de Sanctis, D., et al. (2013) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444913028473 · Cited by 66

Region-specific requirement for cholesterol modification of sonic hedgehog in patterning the telencephalon and spinal cord

Huang, X., Litingtung, Y., & Chiang, C. C. (2007) · Development · doi:10.1242/dev.000729 · Cited by 64

Hedgehog interacting protein in the mature brain: membrane-associated and soluble forms

Coulombe, J. N., Traiffort, É., Loulier, K., Faure, H., & Ruat, M. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2003.10.024 · Cited by 64

Itraconazole induces apoptosis and cell cycle arrest via inhibiting Hedgehog signaling in gastric cancer cells

Hu, Q., Hou, Y.-C., Huang, J., Fang, J.-Y., & Xiong, H. (2017) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-017-0526-0 · Cited by 63

The Hedgehog-GLI pathway in embryonic development and cancer: implications for pulmonary oncology therapy

Armas‐López, L., Zúñiga, J., Arrieta, O. G., & Ávila‐Moreno, F. (2017) · Oncotarget · doi:10.18632/oncotarget.19527 · Cited by 63

Cyclopamine induces digit loss in regenerating axolotl limbs

Roy, S., & Gardiner, D. M. (2002) · Journal of Experimental Zoology · doi:10.1002/jez.10110 · Cited by 62

Hedgehog Signaling Pathway and Lung Cancer

Velcheti, V., & Govindan, R. (2007) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e31802c0276 · Cited by 62

Selective elimination of leukemia stem cells: Hitting a moving target

Crews, L. A., & Jamieson, C. H. M. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.08.006 · Cited by 63

Biology‐Oriented Synthesis of a Withanolide‐Inspired Compound Collection Reveals Novel Modulators of Hedgehog Signaling

Švenda, J., Sheremet, M., Kremer, L., Maier, L., Bauer, J. O., Carsten Strohmann, B., Ziegler, S., Kumar, K., & Waldmann, H. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201500112 · Cited by 62

Hedgehog Signaling

Choy, S. W., & Cheng, S. H. (2012) · Vitamins and hormones · doi:10.1016/b978-0-12-394622-5.00001-8 · Cited by 62

Chemical Genetics

Yeh, J.-R. J., & Crews, C. M. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00200-4 · Cited by 63

Cholesterol metabolism: the main pathway acting downstream of cytochrome P450 oxidoreductase in skeletal development of the limb

Schmidt, K., Hughes, C., Chudek, J. A., Goodyear, S. R., Aspden, R. M., Talbot, R., Gundersen, T. E., Blomhoff, R., Henderson, C., Wolf, C. R., et al. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01638-08 · Cited by 61

The SHH/GLI signaling pathway: a therapeutic target for medulloblastoma

Lospinoso Severini, L., Ghirga, F., Bufalieri, F., Quaglio, D., Infante, P., & Di Marcotullio, L. (2020) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2020.1823967 · Cited by 61

Hedgehog signaling in cancer stem cells: a focus on hematological cancers

Campbell, V. L., & Copland, M. (2015) · Stem Cells and Cloning Advances and Applications · doi:10.2147/sccaa.s58613 · Cited by 62

Terpenoids and a Flavonoid Glycoside from Acacia pennata Leaves as Hedgehog/GLI-Mediated Transcriptional Inhibitors

Rifai, Y., Arai, M. A., Koyano, T., Kowithayakorn, T., & Ishibashi, M. (2010) · Journal of Natural Products · doi:10.1021/np1000818 · Cited by 61

Converse Conformational Control of Smoothened Activity by Structurally Related Small Molecules

Yang, H., Xiang, J., Wang, N., Zhao, Y., Hyman, J. M., Li, S., Jiang, J., Chen, J., Yang, Z., & Lin, S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m807648200 · Cited by 61

Zebrafish con/disp1 reveals multiple spatiotemporal requirements for Hedgehog-signaling in craniofacial development

Schwend, T., & Ahlgren, S. C. (2009) · BMC Developmental Biology · doi:10.1186/1471-213x-9-59 · Cited by 61

Posaconazole, a Second-Generation Triazole Antifungal Drug, Inhibits the Hedgehog Signaling Pathway and Progression of Basal Cell Carcinoma

Chen, B., Trang, V., Lee, A. G., Williams, N. S., Wilson, A. N., Epstein, E. H., Tang, J. Y., & Kim, J. (2016) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0729-t · Cited by 61

Design and Evolution of a Macrocyclic Peptide Inhibitor of the Sonic Hedgehog/Patched Interaction

Owens, A. E., de Paola, I., Hansen, W. A., Liu, Y., Khare, S. D., & Fasan, R. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b06087 · Cited by 61

Targeting the Hedgehog Pathway in Cancer: Current Evidence and Future Perspectives

Girardi, D. M., Barrichello, A. P. D. C., Fernandes, G. D. S., & Pereira, A. A. L. (2019) · Cells · doi:10.3390/cells8020153 · Cited by 61

Sonic Hedgehog and Bone Morphogenetic Protein Regulate Interneuron Development from Dorsal Telencephalic ProgenitorsIn Vitro

Gulácsi, A., & Lillien, L. E. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-30-09862.2003 · Cited by 60

Zebrafish blowout provides genetic evidence for Patched1-mediated negative regulation of Hedgehog signaling within the proximal optic vesicle of the vertebrate eye

Lee, J., Willer, J. R., Willer, G. B., Smith, K. E., Gregg, R. G., & Gross, J. M. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.03.035 · Cited by 60

A novel role of the hedgehog pathway in lens regeneration

Tsonis, P. A., Vergara, M. N., Spence, J. R., Madhavan, M., Kramer, E. L., Call, M. K., Santiago, W. G., Vallance, J. E., Robbins, D. J., & Rio‐Tsonis, K. D. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2003.12.005 · Cited by 60

Lipid metabolism fattens up hedgehog signaling

Blassberg, R. A., & Jacob, J. (2017) · BMC Biology · doi:10.1186/s12915-017-0442-y · Cited by 63

Isolation of a Novel Platelet-Derived Growth Factor-Responsive Precursor from the Embryonic Ventral Forebrain

Chojnacki, A., & Weiss, S. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3302-04.2004 · Cited by 64

Cholesterol Biosynthesis from Lanosterol

Kim, J.-H., Lee, J. N., & Paik, Y. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101661200 · Cited by 60

Palmitoylation of Hedgehog Proteins

Buglino, J. A., & Resh, M. D. (2012) · Vitamins and hormones · doi:10.1016/b978-0-12-394622-5.00010-9 · Cited by 59

Hedgehog Signaling Pathway in Ovarian Cancer

Szkandera, J., Kiesslich, T., Haybaeck, J., Gerger, A., & Pichler, M. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14011179 · Cited by 59

Medicinal history of North American Veratrum

Chandler, C. M., & McDougal, O. M. (2013) · Phytochemistry Reviews · doi:10.1007/s11101-013-9328-y · Cited by 59

Hedgehog/Gli supports androgen signaling in androgen deprived and androgen independent prostate cancer cells

Chen, M., Feuerstein, M. A., Levina, E. M., Baghel, P. S., Carkner, R. D., Tanner, M. J., Shtutman, M. S., Vacherot, F., Terry, S., TAILLE, A. D. L., et al. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-89 · Cited by 59

Sonic hedgehog, Wnt, and brain‐derived neurotrophic factor cell signaling pathway crosstalk: potential therapy for depression

Tayyab, M., Shahi, M. H., Farheen, S., M., M. M. P., Khanam, N., Castresana, J. S., & Hossain, M. S. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24104 · Cited by 59

X-Linked dominant disorders of cholesterol biosynthesis in man and mouse

Herman, G. E. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00160-8 · Cited by 59

Digging a hole under Hedgehog: downstream inhibition as an emerging anticancer strategy

Magno, L. D., Coni, S., Marcotullio, L. D., & Canettieri, G. (2015) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2015.06.003 · Cited by 60

Sterol balance in the Smith-Lemli-Opitz syndrome: reduction in whole body cholesterol synthesis and normal bile acid production

Steiner, R. D., Linck, L. M., Flavell, D. P., Lin, D. S., & Connor, W. E. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33456-8 · Cited by 58

Developmental Pathways: Sonic Hedgehog-Patched-GLI

Walterhouse, D. O., Yoon, J., & Iannaccone, P. M. (1999) · Environmental Health Perspectives · doi:10.1289/ehp.99107167 · Cited by 58

Cholesterol deficit but not accumulation of aberrant sterols is the major cause of the teratogenic activity in the Smith-Lemli-Opitz syndrome animal model

Gaoua, W., Wolf, C., Chevy, F., Ilien, F., & Roux, C. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32412-3 · Cited by 58

Shh Maintains Nkx2.1 in the MGE by a Gli3-Independent Mechanism

Gulácsi, A., & Anderson, S. A. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhk018 · Cited by 57

Precision Oncology, Signaling, and Anticancer Agents in Cancer Therapeutics

Advani, D., Sharma, S., Kumari, S., Ambasta, R. K., & Kumar, P. (2021) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520621666210308101029 · Cited by 63

Cyclopamine‐induced synophthalmia in sheep: defining a critical window and toxicokinetic evaluation

Welch, K. D., Panter, K. E., Lee, S. T., Gardner, D. R., Stegelmeier, B. L., & Cook, D. (2009) · Journal of Applied Toxicology · doi:10.1002/jat.1427 · Cited by 56

Activation of Hedgehog Signaling by the Environmental Toxicant Arsenic May Contribute to the Etiology of Arsenic-Induced Tumors

Fei, D. L., Li, H., Kozul, C. D., Black, K. E., Singh, S., Gosse, J. A., DiRenzo, J., Martin, K. A., Wang, B., Hamilton, J. W., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2898 · Cited by 55

Emerging Roles for Hedgehog-Patched-Gli Signal Transduction in Reproduction1

Walterhouse, D. O., Lamm, M. L. G., Villavicencio, E. H., & Iannaccone, P. M. (2003) · Biology of Reproduction · doi:10.1095/biolreprod.103.015941 · Cited by 56

Genetic evidence that Sil is required for the sonic hedgehog response pathway

Izraeli, S., Lowe, L. A., Bertness, V. L., Campaner, S., Hahn, H., Kirsch, I. R., & Kuehn, M. R. (2001) · genesis · doi:10.1002/gene.10004 · Cited by 55

Angiogenesis within the developing mouse neural tube is dependent on sonic hedgehog signaling: possible roles of motor neurons

Nagase, T., Nagase, M., Yoshimura, K., Fujita, T., & Koshima, I. (2005) · Genes to Cells · doi:10.1111/j.1365-2443.2005.00861.x · Cited by 58

Cell Confluence-dependent Remodeling of Endothelial Membranes Mediated by Cholesterol

Corvera, S., DiBonaventura, C., & Shpetner, H. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001708200 · Cited by 55

Sonic Hedgehog-responsive Genes in the Fetal Prostate

Yu, M., Gipp, J. J., Yoon, J. W., Iannaccone, P., Walterhouse, D. O., & BUSHMAN, W. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m809172200 · Cited by 54

A Chemical Genomic Approach Identifies Matrix Metalloproteinases as Playing an Essential and Specific Role in Xenopus Melanophore Migration

Tomlinson, M. L., Guan, P., Morris, R. J., Fidock, M. D., Rejzek, M., García‐Morales, C., Field, R. A., & Wheeler, G. N. (2009) · Chemistry & Biology · doi:10.1016/j.chembiol.2008.12.005 · Cited by 54

Ahedgehoghomolog regulates gut formation in leech(Helobdella)

Kang, D., Huang, F. Z., Li, D., Shankland, M., Gaffield, W., & Weisblat, D. A. (2003) · Development · doi:10.1242/dev.00395 · Cited by 55

Generating pancreatic β-cells from embryonic stem cells by manipulating signaling pathways

Tsaniras, S. C., & Jones, P. M. (2010) · Journal of Endocrinology · doi:10.1677/joe-10-0073 · Cited by 54

Targeting the Hedgehog Pathway in Pediatric Medulloblastoma

Huang, S., & Yang, J. (2015) · Cancers · doi:10.3390/cancers7040880 · Cited by 53

Statins activate the canonical hedgehog-signaling and aggravate non-cirrhotic portal hypertension, but inhibit the non-canonical hedgehog signaling and cirrhotic portal hypertension

Uschner, F. E., Ranabhat, G., Choi, S. S., Granzow, M., Klein, S., Schierwagen, R., Raskopf, E., Gautsch, S., van der Ven, P. F. M., Fürst, D. O., et al. (2015) · Scientific Reports · doi:10.1038/srep14573 · Cited by 53

Design and Synthesis of Inhibitors of Hedgehog Signaling Based on the Alkaloid Cyclopamine

Winkler, J. D., Isaacs, A. K., Holderbaum, L., Tatard-Leitman, V. M., & Dahmane, N. (2009) · Organic Letters · doi:10.1021/ol900974u · Cited by 53

Distribution of Indian hedgehog and its receptors patched and smoothened in human chronic pancreatitis

Kayed, H., Kleeff, J. H., Keleg, S., Büchler, M., & Frieß, H. (2003) · Journal of Endocrinology · doi:10.1677/joe.0.1780467 · Cited by 53

Smith-Lemli-Opitz Syndrome: The First Malformation Syndrome Associated with Defective Cholesterol Synthesis

Battaile, K. P., & Steiner, R. D. (2000) · Molecular Genetics and Metabolism · doi:10.1006/mgme.2000.3020 · Cited by 53

Squalene synthase: Structure and regulation

Tansey, T. R., & Shechter, I. (2000) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(00)65005-5 · Cited by 52

Cholesterol Metabolism Is Required for Intracellular Hedgehog Signal Transduction In Vivo

Stottmann, R. W., Turbé-Doan, A., Tran, P. V., Kratz, L. E., Moran, J. L., Kelley, R. I., & Beier, D. R. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002224 · Cited by 53

Hedgehog and Notch Signaling Regulate Self-Renewal of Undifferentiated Pleomorphic Sarcomas

Wang, C. Y. Y., Wei, Q., Han, I., Sato, S., Ghanbari-Azarnier, R., Whetstone, H., Poon, R. W. M., Hu, J., Zheng, F., Zhang, P., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-2531 · Cited by 52

Migration of Founder Epithelial Cells Drives Proper Molar Tooth Positioning and Morphogenesis

Procházka, J., Procházková, M., Du, W., Špoutil, F., Turečková, J., Hoch, R. V., Shimogori, T., Sedláček, R., Rubenstein, J. L. R., Wittmann, T., et al. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.11.025 · Cited by 52

A SHH-FOXF1-BMP4 signaling axis regulating growth and differentiation of epithelial and mesenchymal tissues in ureter development

Bohnenpoll, T., Wittern, A. B., Mamo, T. M., Weiss, A., Rudat, C., Kleppa, M., Schuster-Gossler, K., Wojahn, I., Lüdtke, T. H., Trowe, M., et al. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006951 · Cited by 51

The hedgehog pathway in nonalcoholic fatty liver disease

Machado, M. V., & Diehl, A. M. (2018) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2018.1448752 · Cited by 52

Easy and Rapid Differentiation of Embryonic Stem Cells into Functional Motoneurons Using Sonic Hedgehog‐Producing Cells

Soundararajan, P., Lindsey, B. W., Leopold, C., & Rafuse, V. F. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0654 · Cited by 52

Inhibition of Ocular Neovascularization by Hedgehog Blockade

Surace, E. M., Balaggan, K. S., Tessitore, A., Mussolino, C., Cotugno, G., Bonetti, C., Vitale, A., Ali, R. R., & Auricchio, A. (2005) · Molecular Therapy · doi:10.1016/j.ymthe.2005.10.010 · Cited by 52

Cholesterol storage defect in RSH/Smith–Lemli–Opitz syndrome fibroblasts

Wassif, C. A., Vied, D., Tsokos, M., Connor, W. E., Steiner, R. D., & Porter, F. D. (2002) · Molecular Genetics and Metabolism · doi:10.1016/s1096-7192(02)00010-0 · Cited by 52

Loss of Mevalonate/Cholesterol Homeostasis in the Brain: A Focus on Autism Spectrum Disorder and Rett Syndrome

Segatto, M., Tonini, C., Pfrieger, F. W., Trezza, V., & Pallottini, V. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133317 · Cited by 51

Aberrant Heparan Sulfate Proteoglycan Localization, Despite Normal Exostosin, in Central Chondrosarcoma

Schrage, Y. M., Hameetman, L., Szuhai, K., Cleton-Jansen, A., Taminiau, A. H. M., Hogendoorn, P. C. W., & Bovée, J. V. M. G. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080623 · Cited by 52

Hedgehog signaling is required for the differentiation of ES cells into neurectoderm

Maye, P. F., Becker, S., Siemen, H., Thorne, J. T., Byrd, N. A., Carpentino, J. E., & Grabel, L. B. (2003) · Developmental Biology · doi:10.1016/j.ydbio.2003.09.027 · Cited by 51

Patterning, Regionalization, and Cell Differentiation in the Forebrain

Marín, Ó., & Rubenstein, J. L. R. (2002) · Elsevier eBooks · doi:10.1016/b978-012597951-1/50007-x · Cited by 50

The Full-length Unprocessed Hedgehog Protein Is an Active Signaling Molecule

Tokhunts, R. A., Singh, S., Chu, T., D’Angelo, G., Baubet, V., Goetz, J. A., Huang, Z. J., Yuan, Z., Ascano, M., Zavros, Y. L., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.078626 · Cited by 50

Chapter 3 Murine Models of Holoprosencephaly

Schachter, K. A., & Krauss, R. S. (2008) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)00603-0 · Cited by 50

Inherited disorders of cholesterol biosynthesis

Waterham, H. R. (2002) · Clinical Genetics · doi:10.1034/j.1399-0004.2002.610601.x · Cited by 50

From Teratogens to Potential Therapeutics: Natural Inhibitors of the Hedgehog Signaling Network Come of Age

Hovhannisyan, A., Matz‐Soja, M., & Gebhardt, R. (2009) · Planta Medica · doi:10.1055/s-0029-1185979 · Cited by 22

Mechanistic Investigation of Veratrum Alkaloid-Induced Mammalian Teratogenesis

Gaffield, W., Incardona, J. P., Kapur, R. P., & Roelink, H. (1999) · ACS symposium series · doi:10.1021/bk-2000-0745.ch012

The teratogenic Veratrum alkaloid cyclopamine inhibits Sonic hedgehog signal transduction

Incardona, J. P., Gaffield, W., Kapur, R. P., & Roelink, H. (1998) · Development · doi:10.1242/dev.125.18.3553 · Cited by 654

A teratogen inhibiting cholesterol biosynthesis phenocopies Sonic Hedgehog developmental gene mutation in rat embryos

Kolf‐Clauw, M., Clotmarr, F., Roux, C., & Picard, J. (1998) · Toxicology Letters · doi:10.1016/s0378-4274(98)80829-1

The role of cholesterol in Shh signaling and teratogen-induced holoprosencephaly

Incardona, J. P., & Roelink, H. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000653 · Cited by 76