Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

Chiang, C. C., Litingtung, Y., Lee, E., Young, K. E., Corden, J. L., Westphal, H., & Beachy, P. A. (1996) · Nature · doi:10.1038/383407a0 · Cited by 3,062

Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants

Goodrich, L. V., Milenković, L., Higgins, K. M., & Scott, M. P. (1997) · Science · doi:10.1126/science.277.5329.1109 · Cited by 1,696

Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development

Porter, J. A., Young, K. E., & Beachy, P. A. (1996) · Science · doi:10.1126/science.274.5285.255 · Cited by 1,360

Niemann-Pick C1 Disease Gene: Homology to Mediators of Cholesterol Homeostasis

Carstea, E. D., Morris, J. A., Coleman, K. G., Loftus, S. K., Zhang, D., Cummings, C., Gu, J., Rosenfeld, M. A., Pavan, W. J., Krizman, D. B., et al. (1997) · Science · doi:10.1126/science.277.5323.228 · Cited by 1,293

Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

Roelink, H., Porter, J. A., Chiang, C. C., Tanabe, Y., Chang, D. T., Beachy, P. A., & Jessell, T. M. (1995) · Cell · doi:10.1016/0092-8674(95)90397-6 · Cited by 888

Two Critical Periods of Sonic Hedgehog Signaling Required for the Specification of Motor Neuron Identity

Ericson, J., Brenner‐Morton, S., Kawakami, A., Roelink, H., & Jessell, T. M. (1996) · Cell · doi:10.1016/s0092-8674(00)81386-0 · Cited by 870

Defective cholesterol biosynthesis associated with the Smith-Lemli-Opitz syndrome

Tint, G. S., Irons, M., Elias, E. R., Batta, A. K., Frieden, R., Chen, T. S., & Salen, G. (1994) · New England Journal of Medicine · doi:10.1056/nejm199401133300205 · Cited by 798

Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly

Belloni, E., Muenke, M., Roessler, E., Traverse, G., Siegel-Bartelt, J., Frumkin, A., Mitchell, H. F., Donis-Keller, H., Helms, C. A., Hing, A. V., et al. (1996) · Nature Genetics · doi:10.1038/ng1196-353 · Cited by 643

Early Stages of Motor Neuron Differentiation Revealed by Expression of Homeobox Gene Islet-1

Ericson, J., Thor, S., Edlund, T., Jessell, T. M., & Yamada, T. (1992) · Science · doi:10.1126/science.1350865 · Cited by 620

Autoproteolysis in hedgehog protein biogenesis

Lee, J., Ekker, S. C., von Kessler, D. P., Porter, J. A., Sun, B. I., & Beachy, P. A. (1994) · Science · doi:10.1126/science.7985023 · Cited by 547

EUROPEAN SCHOOL OF MOLECULAR MEDICINE

Napoli, S. D. (2010)

The primary cilium as a regulator of cellular senescence in human fibroblasts

Breslin, L. (2014) · ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) · doi:10.13025/17764

Gli2 Accelerates Cardiac Progenitor Gene Expression During Mouse Embryonic Stem Cell Differentiation

Fair, J. (2014) · uO Research (University of Ottawa) · doi:10.20381/ruor-4281

Targeting Key Stemness-Related Pathways in Human Cancers

Coyle, K. M., Thomas, M. L., Sultan, M., & Marcato, P. (2015) · Springer eBooks · doi:10.1007/978-3-319-21030-8_15

Signaling Cross-Talk of Oncogenic KRAS and Hedgehog Pathways in Pancreatic Cancer

Cheng, X. (2011) · Springer eBooks · doi:10.1007/978-1-4419-8435-7_5

Repressing the Hedgehog Signalling Pathway Functional Analysis of the Tumour Suppressors Patched1 and Suppressor of Fused

Svärd, J. (2007)

zebrafish Calcitonin receptor-like receptor guides arterial differentiation in

Nicoli, S., Tobia, C., Gualandi, L., Sena, G. D., & Presta, M. (2008)

Hedgehog Signaling in Gastrointestinal Morphogenesis and Morphostasis

Westendorp, B. F., van Dop, W. A., & van den Brink, G. R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809954-4.00004-9

Überprüfung neuer Therapieansätze für Patched- assoziierte Tumoren im Mausmodell

der Fakultät, V., & der Naturwissenschaften, D. (2008)

The role of Hedgehog acyltransferase in Sonic hedgehog signalling

Jovanović, B. (2012) · Spiral (Imperial College London) · doi:10.25560/14486

Mapping the Shh regulatory landscape

Anderson, E. S. (2015) · ERA

Detection of Smo, Gli2 and Gli3 Among Basal Cell Carcinoma Patients in Sulaimani Province.

Khidhir, K. G. (2017) · Journal of Zankoy Sulaimani - Part A · doi:10.17656/jzs.10605

Involvement and Targeted Intervention of Deregulated Hedgehog Pathway in Osteosarcoma

Lo, W. W. (2012) · TSpace (University of Toronto)

Chemotherapy for Medulloblastoma in Adults

Moots, P. L., & Cooper, M. K. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812100-9.00036-x

General and Specific Receptor Tyrosine Kinase Signaling Mechanisms Revealed by Analysis of Chimeric EGFR and IR Family Receptors

McCabe, J. M. (2015)

Early Skeletal Morphogenesis in Embryonic Development

Yang, Y. (2018) · Primer on the metabolic bone diseases and disorders of mineral metabolism · doi:10.1002/9781119266594.ch1

Hedgehog Signaling Pathway Inhibitors for Basal Cell Carcinoma

Chen, L., Silapunt, S., & Migden, M. R. (2019) · Springer eBooks · doi:10.1007/978-3-030-26887-9_13

Effect of mutations on drug resistance of smoothened receptor toward inhibitors probed by molecular modeling

Gao, Z., Bao, J., Shi, S., Zhang, X., Gao, Y., & Zhu, T. (2020) · Chemical Physics Letters · doi:10.1016/j.cplett.2020.137126

Hedgehog Signaling in Gastrointestinal Morphogenesis and Morphostasis

van den Brink, G. R., Peppelenbosch, M. P., & Roberts, D. J. (2006) · Elsevier eBooks · doi:10.1016/b978-012088394-3/50012-x

Lkb1 controls expansion and folding of the cerebellar cortex

Ryan, K. E. (2014)

Medulloblastoma Model

Lau, J., & Weiss, W. A. (2012) · Neuromethods · doi:10.1007/7657_2012_37

Basalzellnävussyndrom

Hahn, H. (2001) · Springer eBooks · doi:10.1007/978-3-642-56889-3_5

Metastasis Initiation

Faingold, D., Bakalian, S., & Russell-Hermanns, D. S. (2013) · Springer eBooks · doi:10.1007/978-1-4614-3685-0_28

Bioactivity Assessment of Veratrum californicum Alkaloids

Dirks, M. L. (2021) · doi:10.18122/td/1897/boisestate

Disorders of Cholesterol Biosynthesis, Genetics of

Phillipi, C. A., & Steiner, R. D. (2008) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0020223

Experimental approaches to evaluate mechanisms of developmental toxicity

Faustman, E. M., Gohlke, J. M., Ponce, R. A., Lewandowski, T. A., Seeley, M. R., Whittaker, S. G., & Griffith, W. C. (2011) · Informa Healthcare eBooks · doi:10.3109/9781841848211.002

Alobar holoprosencephaly with cyclopia

Schroeder, E., & Allen, M. (2012) · Applied Radiology · doi:10.37549/ar1886

Comparative transcriptome analysis of Veratrum maackii and Veratrum nigrum reveals multiple candidate genes involved in steroidal alkaloid biosynthesis

Wang, D., Yu, Z., Guan, M., Cai, Q., Jia, W. P., Ma, P., Xue, Z., Ma, R., Oksman‐Caldentey, K., & Rischer, H. (2023) · Scientific Reports · doi:10.1038/s41598-023-35429-5

Cyclopamin und die Lämmer

Giannis, A. (2023) · Springer eBooks · doi:10.1007/978-3-662-67510-6_10

An optimized in situ hybridization protocol to study early developmental patterns and signaling pathways in paradise fish (Macropodus opercularis)

Szabó, N., Fodor, E., Szabó, K. S., Tarcsa, V., Gyulai, Z., Jakab, S., Gelei, E., Czimer, D., Miklósi, Á., & Varga, M. (2025) · Biologia Futura · doi:10.1007/s42977-025-00290-2

Common forms of basal cell carcinoma of the skin: The first experience with sonidegib in the B-SURE observational study in Russia

Орлова, К. В., Nazarova, V. V., Petenko, N. N., & Демидов, Л. В. (2025) · Journal of Modern Oncology · doi:10.26442/18151434.2025.3.203495

Modeling Cancer Progression on the Pathway Level

Edelman, E. J. (2008) · DukeSpace (Duke University)

The 129S1 / SvImJ Mouse Strain Is Resistant to the Effects of Early Embryonic Alcohol and Other Sonic Hedgehog Inhibitors

Lapham, R. L., Fish, E. W., & Parnell, S. E. (2026) · Birth Defects Research · doi:10.1002/bdr2.70020

Hedgehog signaling pathway dysregulation in different cancers, potential molecular biomarkers, and therapeutic implications

Hassan, T., Ali, T., & Jan, I. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-23908-3.00015-0

Chemotherapy for medulloblastoma in adults

Tobin, G., & Peñas-Prado, M. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-27356-8.00029-2

Interaction entre la voie Hedgehog et les hormones stéroïdiennes dans les cellules normales et cancéreuses de la prostate

Sirab, N. (2010) · theses.fr (ABES) · doi:10.70675/61ce0590zc46az438dza4faz44d64acefe00

Genomic Profiling of Pediatric Low-Grade Gliomas

Bergthold, G. (2015) · theses.fr (ABES) · doi:10.70675/bc221d41z5934z4e2fzb4fezdfbff39bda19

Régulation du développement des cellules musculaires lisses de l'estomac chez l'embryon de poulet

McKey, J. (2014) · theses.fr (ABES) · doi:10.70675/2abfa796za204z42ffz97abz7375af675e4a

Role of Ataxin-7 in the development of vertebrate eye and its impact in the understanding of human eye pathologies and spinocerebellar ataxia type 7

Carrillo-Rosas, S. (2017) · theses.fr (ABES) · doi:10.70675/1eb79839z7959z4c32z8399z2bbfeb4e9025

Patched as a new target for adrenocortical carcinoma treatment

Hasanovic, A. (2018) · theses.fr (ABES) · doi:10.70675/e4759414z32e1z4e77zbb6fz743df9c365d0

Etude du rôle de la voie Sonic Hedgehog sur la transmission et la séquence développementale GABAergique

Delmotte, Q. (2020) · theses.fr (ABES) · doi:10.70675/794730a2zf055z435fz924fze60feeefde5c

Rôle de la voie de signalisation Sonic Hedgehog dans les cellules Glast positives du cerveau de souris adulte

Tirou, L. (2020) · theses.fr (ABES) · doi:10.70675/5a9de569zf953z4f2cz9ccaz89ba17ab8490

Identification et caractérisation de nouveaux régulateurs de la voie Hedgehog dans l’homéostasie pulmonaire et la BPCO

Petit, L. (2024) · theses.fr (ABES) · doi:10.70675/1f5d1e7bz6b9dz463czb061zb3a1132b176a

Steroidal alkaloids as multi-target therapeutics for the treatment of endometriosis

Shirodkar, S., & Doshi, G. (2026) · Steroids · doi:10.1016/j.steroids.2026.109827

BindingDB Entry 50018814: Current approaches and strategies to identify Hedgehog signaling pathway inhibitors for cancer therapy.

BindingDB (2024) · UC San Diego · doi:10.7270/q2m049qv

BindingDB Entry 50037518: Discovery of high-affinity ligands of sigma1 receptor, ERG2, and emopamil binding protein by pharmacophore modeling and virtual screening.

BindingDB (2012) · UC San Diego · doi:10.7270/q2639qhb

BindingDB Entry 50044332: Scaffold hopping approach to a new series of smoothened antagonists.

BindingDB (2015) · UC San Diego · doi:10.7270/q2jw8gf6

BindingDB Entry 50047997: Design, Synthesis, and Pharmacological Evaluation of 2-(2,5-Dimethyl-5,6,7,8-tetrahydroquinolin-8-yl)-N-aryl Propanamides as Novel Smoothened (Smo) Antagonists.

BindingDB (2018) · UC San Diego · doi:10.7270/q2tq63g3

BindingDB Entry 50032117: Purmorphamine activates the Hedgehog pathway by targeting Smoothened.

BindingDB (2011) · UC San Diego · doi:10.7270/q2736r40

BindingDB Entry 50031842: Design of 1-piperazinyl-4-arylphthalazines as potent Smoothened antagonists.

BindingDB (2010) · UC San Diego · doi:10.7270/q2wq03zq

BindingDB Entry 50030749: Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway.

BindingDB (2010) · UC San Diego · doi:10.7270/q2sj1kpn

BindingDB Entry 50006997: Inhibiting Hedgehog: An Update on Pharmacological Compounds and Targeting Strategies.

BindingDB (2021) · UC San Diego · doi:10.7270/q2r214np

BindingDB Entry 50008982: Structural optimization on a virtual screening hit of smoothened receptor.

BindingDB (2021) · UC San Diego · doi:10.7270/q2ns0z92

BindingDB Entry 50001863: Discovery of potent and novel smoothened antagonists via structure-based virtual screening and biological assays.

BindingDB (2020) · UC San Diego · doi:10.7270/q2bv7k6q

BindingDB Entry 50033579: Synthesis and biological evaluation of desmethylveramiline, a micromolar Hedgehog inhibitor.

BindingDB (2012) · UC San Diego · doi:10.7270/q28c9wm4

BindingDB Entry 50010060: Piperazic acid derivatives inhibit Gli1 in Hedgehog signaling pathway.

BindingDB (2021) · UC San Diego · doi:10.7270/q22j6gcr

BindingDB Entry 50030823: GDC-0449-a potent inhibitor of the hedgehog pathway.

BindingDB (2010) · UC San Diego · doi:10.7270/q21r6qmj

BindingDB Entry 50038863: Hedgehog-Gli signaling pathway inhibitors as anticancer agents.

BindingDB (2012) · UC San Diego · doi:10.7270/q22n536m

Molecular Mechanisms of Fetal Alcohol Syndrome: Shh-signaling S.C.A. wishes to thank Marianne Bronner-Fraser for her long-term help and support, and Sarah Mahoney and Vijaya Thakur for technical help. Portions of this articles are adapted from Ahlgren et al., 2002. S.C.A. is supported by March of Dimes grant number FY02–134 and National Institutes of Health Grant 7 R21 AA013596–02. S.C.A. is the Crown Family Research Scholar in Developmental Systems Biology.

Ahlgren, S. (2005) · Elsevier eBooks · doi:10.1016/b978-012564370-2/50075-1

CHAPTER 253 – Hedgehog Signaling and Embryonic Development

Merchant, M., Ye, W.-L., & de Sauvage, F. D. (2003) · Elsevier eBooks · doi:10.1016/b978-012124546-7/50614-8

From Teratogens to Potential Therapeutics: Natural Inhibitors of the Hedgehog Signaling Network Come of Age

Hovhannisyan, A., Matz‐Soja, M., & Gebhardt, R. (2009) · Planta Medica · doi:10.1055/s-0029-1185979 · Cited by 22

Mechanistic Investigation of Veratrum Alkaloid-Induced Mammalian Teratogenesis

Gaffield, W., Incardona, J. P., Kapur, R. P., & Roelink, H. (1999) · ACS symposium series · doi:10.1021/bk-2000-0745.ch012

The teratogenic Veratrum alkaloid cyclopamine inhibits Sonic hedgehog signal transduction

Incardona, J. P., Gaffield, W., Kapur, R. P., & Roelink, H. (1998) · Development · doi:10.1242/dev.125.18.3553 · Cited by 654

A teratogen inhibiting cholesterol biosynthesis phenocopies Sonic Hedgehog developmental gene mutation in rat embryos

Kolf‐Clauw, M., Clotmarr, F., Roux, C., & Picard, J. (1998) · Toxicology Letters · doi:10.1016/s0378-4274(98)80829-1

The role of cholesterol in Shh signaling and teratogen-induced holoprosencephaly

Incardona, J. P., & Roelink, H. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000653 · Cited by 76