Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

Chiang, C. C., Litingtung, Y., Lee, E., Young, K. E., Corden, J. L., Westphal, H., & Beachy, P. A. (1996) · Nature · doi:10.1038/383407a0 · Cited by 3,062

Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants

Goodrich, L. V., Milenković, L., Higgins, K. M., & Scott, M. P. (1997) · Science · doi:10.1126/science.277.5329.1109 · Cited by 1,696

Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development

Porter, J. A., Young, K. E., & Beachy, P. A. (1996) · Science · doi:10.1126/science.274.5285.255 · Cited by 1,360

Niemann-Pick C1 Disease Gene: Homology to Mediators of Cholesterol Homeostasis

Carstea, E. D., Morris, J. A., Coleman, K. G., Loftus, S. K., Zhang, D., Cummings, C., Gu, J., Rosenfeld, M. A., Pavan, W. J., Krizman, D. B., et al. (1997) · Science · doi:10.1126/science.277.5323.228 · Cited by 1,293

Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

Roelink, H., Porter, J. A., Chiang, C. C., Tanabe, Y., Chang, D. T., Beachy, P. A., & Jessell, T. M. (1995) · Cell · doi:10.1016/0092-8674(95)90397-6 · Cited by 888

Two Critical Periods of Sonic Hedgehog Signaling Required for the Specification of Motor Neuron Identity

Ericson, J., Brenner‐Morton, S., Kawakami, A., Roelink, H., & Jessell, T. M. (1996) · Cell · doi:10.1016/s0092-8674(00)81386-0 · Cited by 870

Defective cholesterol biosynthesis associated with the Smith-Lemli-Opitz syndrome

Tint, G. S., Irons, M., Elias, E. R., Batta, A. K., Frieden, R., Chen, T. S., & Salen, G. (1994) · New England Journal of Medicine · doi:10.1056/nejm199401133300205 · Cited by 798

Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly

Belloni, E., Muenke, M., Roessler, E., Traverse, G., Siegel-Bartelt, J., Frumkin, A., Mitchell, H. F., Donis-Keller, H., Helms, C. A., Hing, A. V., et al. (1996) · Nature Genetics · doi:10.1038/ng1196-353 · Cited by 643

Early Stages of Motor Neuron Differentiation Revealed by Expression of Homeobox Gene Islet-1

Ericson, J., Thor, S., Edlund, T., Jessell, T. M., & Yamada, T. (1992) · Science · doi:10.1126/science.1350865 · Cited by 620

Autoproteolysis in hedgehog protein biogenesis

Lee, J., Ekker, S. C., von Kessler, D. P., Porter, J. A., Sun, B. I., & Beachy, P. A. (1994) · Science · doi:10.1126/science.7985023 · Cited by 547

Xenopus as a model organism in developmental chemical genetic screens

Tomlinson, M. L., Field, R. A., & Wheeler, G. N. (2005) · Molecular BioSystems · doi:10.1039/b506103b · Cited by 49

Expression and Function of Sonic Hedgehog Pathway Components in Pituitary Adenomas: Evidence for a Direct Role in Hormone Secretion and Cell Proliferation

Vila, G., Theodoropoulou, M., Stalla, J., Tonn, J. C., Losa, M., Renner, U., Stalla, G. K., & Páez-Pereda, M. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1014 · Cited by 49

The sonic hedgehog-GLI1 signaling pathway in brain tumor development

Shahi, M. H., REY, J. A., & Castresana, J. S. (2012) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2012.720975 · Cited by 49

Hedgehog-Producing Cancer Cells Respond to and Require Autocrine Hedgehog Activity

Singh, S., Wang, Z., Fei, D. L., Black, K. E., Goetz, J. A., Tokhunts, R. A., Giambelli, C., Rodríguez‐Blanco, J., Long, J., Lee, E. N., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2313 · Cited by 49

Targeting human respiratory syncytial virus transcription anti-termination factor M2-1 to inhibit in vivo viral replication

Bailly, B., Richard, C.-A., Sharma, G., Wang, L., Johansen, L. M., Cao, J., Pendharkar, V. V., Sharma, D.-C., Galloux, M., Wang, Y., et al. (2016) · Scientific Reports · doi:10.1038/srep25806 · Cited by 49

The role of hedgehog signaling in gastric cancer: molecular mechanisms, clinical potential, and perspective

Xu, Y., Song, S., Wang, Z., & Ajani, J. A. (2019) · Cell Communication and Signaling · doi:10.1186/s12964-019-0479-3 · Cited by 49

Oxidized derivatives of 7-dehydrocholesterol induce growth retardation in cultured rat embryos: a model for antenatal growth retardation in the Smith-Lemli-Opitz syndrome

Gaoua, W., Chevy, F., Roux, C., & Wolf, C. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32450-0 · Cited by 49

Role of Sonic hedgehog signaling and the expression of its components in human embryonic stem cells

Wu, S. M., Choo, A. B. H., Yap, M. G. S., & Chan, K. K. (2009) · Stem Cell Research · doi:10.1016/j.scr.2009.09.002 · Cited by 48

Astrocytic Sonic Hedgehog Alleviates Intracerebral Hemorrhagic Brain Injury via Modulation of Blood-Brain Barrier Integrity

Xing, G., Zhao, T., Zhang, X., He, L., Li, X., Cui, P., Li, M., Li, D., Zhang, N., & Jiang, W. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.575690 · Cited by 49

Dysregulation of hedgehog signalling predisposes to synovial chondromatosis

Hopyan, S., Nadesan, P., Yu, C., Wunder, J. S., & Alman, B. A. (2005) · The Journal of Pathology · doi:10.1002/path.1761 · Cited by 48

Mechanisms of Smoothened Regulation in Hedgehog Signaling

Zhang, J., Liu, Z., & Jia, J. (2021) · Cells · doi:10.3390/cells10082138 · Cited by 47

Dynamics of Sonic hedgehog signaling in the ventral spinal cord are controlled by intrinsic changes in source cells requiring Sulfatase 1

Oustah, A. A., Danesin, C., Khouri‐Farah, N., Farreny, M.-A., Escalas, N., Cochard, P., Glise, B., & Soula, C. (2014) · Development · doi:10.1242/dev.101717 · Cited by 52

The chick embryo as a model for the effects of prenatal exposure to alcohol on craniofacial development

Kiecker, C. M. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.01.007 · Cited by 47

Hedgehog pathway inhibition in advanced basal cell carcinoma: latest evidence and clinical usefulness

Silapunt, S., Chen, L. L., & Migden, M. R. (2016) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758834016653605 · Cited by 47

Erythroid Differentiation in Vitro Is Blocked by Cyclopamine, an Inhibitor of Hedgehog Signaling

Detmer, K., Walker, A. N., Jenkins, T. M., Steele, T. A., & Dannawi, H. (2000) · Blood Cells Molecules and Diseases · doi:10.1006/bcmd.2000.0318 · Cited by 46

Regulation and function of Dbx genes in the zebrafish spinal cord

Gribble, S. L., Nikolaus, O. B., & Dorsky, R. I. (2007) · Developmental Dynamics · doi:10.1002/dvdy.21367 · Cited by 46

Targeting of the Sonic Hedgehog Pathway by Atractylenolides Promotes Chondrogenic Differentiation of Mesenchymal Stem Cells

Li, X., Wei, G., Wang, X., Liu, D., Deng, R., Li, H., Zhou, J.-H., Li, Y., Zeng, H., & Chen, D. (2012) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b12-00265 · Cited by 46

A critical role of Sonic Hedgehog signaling in maintaining the tumorigenicity of neuroblastoma cells

Mao, L., Xia, Y., Zhou, Y., Dai, R., Yang, X., Duan, S.-J., Qiao, X., Mei, Y., Hu, B., & Cui, H. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01262.x · Cited by 46

Left‐sided CHILD syndrome caused by a nonsense mutation in the NSDHL gene

Hummel, M., Cunningham, D., Mullett, C. J., Kelley, R. I., & Herman, G. E. (2003) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.20248 · Cited by 46

Calcitonin receptor-like receptor guides arterial differentiation in zebrafish

Nicoli, S., Tobia, C., Gualandi, L., Sena, G. D., & Presta, M. (2008) · Blood · doi:10.1182/blood-2007-10-118166 · Cited by 46

Late gestational lung hypoplasia in a mouse model of the Smith-Lemli-Opitz syndrome

Yu, H., Wessels, A., Chen, J., Phelps, A. L., Oatis, J. E., Tint, G. S., & Patel, S. B. (2004) · BMC Developmental Biology · doi:10.1186/1471-213x-4-1 · Cited by 46

Dual Roles of the Cardin-Weintraub Motif in Multimeric Sonic Hedgehog

Farshi, P., Ohlig, S., Pickhinke, U., Höing, S., Jochmann, K., Lawrence, R., Dreier, R., Dierker, T., & Grobe, K. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.206474 · Cited by 46

The Hedgehog processing pathway is required for NSCLC growth and survival

Rodríguez‐Blanco, J., Schilling, N. S., Tokhunts, R. A., Giambelli, C., Long, J., Fei, D. L., Singh, S., Black, K. E., Wang, Z., Galimberti, F., et al. (2012) · Oncogene · doi:10.1038/onc.2012.243 · Cited by 45

Targeting the Oncoprotein Smoothened by Small Molecules: Focus on Novel Acylguanidine Derivatives as Potent Smoothened Inhibitors

Pietrobono, S., & Stecca, B. A. (2018) · Cells · doi:10.3390/cells7120272 · Cited by 45

Acyltransferases for secreted signalling proteins (Review)

Chang, S., & Magee, A. I. (2009) · Molecular Membrane Biology · doi:10.1080/09687680802706432 · Cited by 46

Vsx2/Chx10 ensures the correct timing and magnitude of Hedgehog signaling in the mouse retina

Sigulinsky, C., Green, E. S., Clark, A. M., & Levine, E. M. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.02.055 · Cited by 45

Hedgehog Signaling

NAGASE, T., Nagase, M., Machida, M., & YAMAGISHI, M. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1389.029 · Cited by 45

Are we on the brink of nonsurgical treatment for ameloblastoma?

Sauk, J. J., Nikitakis, N. G., & Scheper, M. A. (2010) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1016/j.tripleo.2010.01.024 · Cited by 44

Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway

Büttner, A., Seifert, K., Cottin, T., Sarli, V., Tzagkaroulaki, L., Scholz, S., & Giannis, A. (2009) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2009.06.008 · Cited by 46

Salvianolic Acids for Injection (SAFI) promotes functional recovery and neurogenesis via sonic hedgehog pathway after stroke in mice

Zhang, Y., Zhang, X., Cui, L., Chen, R., Zhang, C., Li, Y., He, T., Zhu, X., Shen, Z., Dong, L., et al. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.09.001 · Cited by 43

Cyclopia (synophthalmia) in Smith–Lemli–Opitz syndrome: First reported case and consideration of mechanism

Weaver, D. D., Solomon, B. D., Akin, K. K., Kelley, R. I., & Muenke, M. (2010) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.30241 · Cited by 44

Hedgehog signaling in the murine melanoma microenvironment

Geng, L., Cuneo, K. C., Cooper, M. K., Wang, H., Sekhar, K. R., Fu, A., & Hallahan, D. E. (2007) · Angiogenesis · doi:10.1007/s10456-007-9078-9 · Cited by 44

The emerging roles of Hedgehog signaling in tumor immune microenvironment

Wang, J., Cui, B., Li, X., Zhao, X., Huang, T., & Ding, X. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1171418 · Cited by 43

Meckel’s Cartilage Differentiation Is Dependent on Hedgehog Signaling

Melnick, M., Witcher, D., Bringas, P., Carlsson, P., & Jaskoll, T. F. (2005) · Cells Tissues Organs · doi:10.1159/000085950 · Cited by 43

Molecular changes associated with teratogen‐induced cyclopia

Loucks, E. J., Schwend, T., & Ahlgren, S. C. (2007) · Birth Defects Research Part A Clinical and Molecular Teratology · doi:10.1002/bdra.20387 · Cited by 42

Potent Inhibitors of the Hedgehog Signaling Pathway

Brunton, S. A., Stibbard, J. H. A., Rubin, L. L., Kruse, L. I., Guicherit, O. M., Boyd, E. A., & Price, S. C. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm070694n · Cited by 43

Proteomic Changes during Disturbance of Cholesterol Metabolism by Azacoprostane Treatment in Caenorhabditis elegans

Choi, B.-K., Chitwood, D. J., & Paik, Y. (2003) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m300036-mcp200 · Cited by 43

Hedgehog Signaling and Pancreatic Tumor Development

Lauth, M., & Toftgård, R. (2011) · Advances in cancer research · doi:10.1016/b978-0-12-386469-7.00001-3 · Cited by 43

Sonic Hedgehog Signaling Drives Proliferation of Synoviocytes in Rheumatoid Arthritis: A Possible Novel Therapeutic Target

Wang, M., Zhu, S., Peng, W., Li, Q., Li, Z., Luo, M., Feng, X., Lin, Z., & Huang, J. (2014) · Journal of Immunology Research · doi:10.1155/2014/401903 · Cited by 42

Annexin-1 is abnormally expressed in Fragile X syndrome: Two-dimensional electrophoresis study in lymphocytes

Sun, H.-T., Cohen, S., & Kaufmann, W. E. (2001) · American Journal of Medical Genetics · doi:10.1002/1096-8628(20010915)103:1 · Cited by 24

Numb−/low Enriches a Castration-Resistant Prostate Cancer Cell Subpopulation Associated with Enhanced Notch and Hedgehog Signaling

Guo, Y., Zhang, K., Cheng, C., Ji, Z., Wang, X., Wang, M., Chu, M., Tang, D. G., Zhu, H. H., & Gao, W. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-0913 · Cited by 42

Convergent Total Synthesis of (−)-Cyclopamine

Sofiadis, M., Xu, D., Rodriguez, A. J., Nissl, B., Clementson, S., Petersen, N. N., & Baran, P. S. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c09085 · Cited by 41

Asymmetric Synthesis of Cyclopamine, a Hedgehog (Hh) Signaling Pathway Inhibitor

Shao, H., Liu, W., Liu, M., He, H., Zhou, Q., Zhu, S., & Gao, S. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c10362 · Cited by 41

Protease nexin 1 inhibits hedgehog signaling in prostate adenocarcinoma

McKee, C. M., Xu, D., Cao, Y., Kabraji, S. K., Allen, P. D., Kersemans, V., Beech, J. S., Smart, S., Hamdy, F. C., Ishkanian, A., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59348 · Cited by 41

Canonical Hedgehog Pathway and Noncanonical GLI Transcription Factor Activation in Cancer

Suchors, C., & Kim, J. (2022) · Cells · doi:10.3390/cells11162523 · Cited by 45

Discontinuous organization and specification of the lateral floor plate in zebrafish

Schäfer, M., Kinzel, D., & Winkler, C. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.09.018 · Cited by 41

Guidance of Postural Motoneurons Requires MAPK/ERK Signaling Downstream of Fibroblast Growth Factor Receptor 1

Soundararajan, P., Fawcett, J. P., & Rafuse, V. F. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4932-09.2010 · Cited by 40

The role of hedgehog signaling during gastric regeneration

Kang, D.-H., Han, M., Song, M.-H., Lee, Y.-S., Kim, E., Kim, H., Kim, G.-H., Kim, D., Yoon, S., Baek, S., et al. (2009) · Journal of Gastroenterology · doi:10.1007/s00535-009-0006-1 · Cited by 40

Heparan Sulfate and Transglutaminase Activity Are Required for the Formation of Covalently Cross-linked Hedgehog Oligomers

Dierker, T., Dreier, R., Migone, M., Hamer, S., & Grobe, K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.044867 · Cited by 41

Roles of Hedgehog pathway components and retinoic acid signalling in specifying zebrafish ventral spinal cord neurons

England, S. J., Batista, M. F., Mich, J. K., Chen, J., & Lewis, K. E. (2011) · Development · doi:10.1242/dev.066159 · Cited by 40

The Veratrum and Solanum Alkaloids

Heretsch, P. M., & Giannis, A. (2015) · The Alkaloids. Chemistry and biology/The alkaloids. Chemistry and biology · doi:10.1016/bs.alkal.2014.11.002 · Cited by 40

Visualization of Gli Activity in Craniofacial Tissues of Hedgehog-Pathway Reporter Transgenic Zebrafish

Schwend, T., Loucks, E. J., & Ahlgren, S. C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014396 · Cited by 39

Sonic hedgehog ligand partners with caveolin-1 for intracellular transport

Mao, H., Diehl, A. M., & Li, Y. (2009) · Laboratory Investigation · doi:10.1038/labinvest.2008.163 · Cited by 39

Signaling molecules derived from the cholesterol biosynthetic pathway: mechanisms of action and possible roles in human disease

Edwards, P. A., & Ericsson, J. (1998) · Current Opinion in Lipidology · doi:10.1097/00041433-199810000-00007 · Cited by 39

Rapid Clearance of Psoriatic Skin Lesions Induced by Topical Cyclopamine

Taş, S., & Avcı, O. (2004) · Dermatology · doi:10.1159/000079596 · Cited by 39

Sonic Hedgehog Pathway Contributes to Gastric Cancer Cell Growth and Proliferation

Wan, J., Zhou, J., Zhao, H., Wang, M., Wei, Z., Gao, H., Wang, Y., & Cui, H. (2014) · BioResearch open access · doi:10.1089/biores.2014.0001 · Cited by 38

Patched1 and Patched2 inhibit Smoothened non-cell autonomously

Roberts, B., Casillas, C., Alfaro, A. C., Jägers, C., & Roelink, H. (2016) · eLife · doi:10.7554/elife.17634 · Cited by 38

Craniofacial Anomalies of the Cultured Mouse Embryo Induced by Inhibition of Sonic Hedgehog Signaling: An Animal Model of Holoprosencephaly

Nagase, T., Nagase, M., Osumi, N., Fukuda, S., Nakamura, S., Ohsaki, K., Harii, K., Asato, H., & Yoshimura, K. (2005) · Journal of Craniofacial Surgery · doi:10.1097/00001665-200501000-00016 · Cited by 38

Four cholesterol-sensing proteins

Lange, Y., & Steck, T. L. (1998) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(98)80119-x · Cited by 38

Exo-Cyclopamine—a stable and potent inhibitor of hedgehog-signaling

Heretsch, P. M., Büttner, A., Tzagkaroulaki, L., Zahn, S., Kirchner, B., & Giannis, A. (2011) · Chemical Communications · doi:10.1039/c1cc11782c · Cited by 37

Molecular mechanisms underlying the action of carcinogens in gastric cancer with a glimpse into targeted therapy

Patrad, E., Khalighfard, S., Amiriani, T., Khori, V., & Alizadeh, A. M. (2022) · Cellular Oncology · doi:10.1007/s13402-022-00715-3 · Cited by 38

Sonic Hedgehog pathway is essential for neuroblastoma cell proliferation and tumor growth

Xu, L., Wang, X., Wan, J., Li, T., Gong, X., Zhang, K., Liang, Y., Xiang, Z., Xu, M., & Cui, H. (2012) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-1222-6 · Cited by 37

Rod Photoreceptor Responses in Children With Smith-Lemli-Opitz Syndrome

Elias, E. R. (2003) · Archives of Ophthalmology · doi:10.1001/archopht.121.12.1738 · Cited by 37

Gli3 mediates cell survival and sensitivity to cyclopamine in pancreatic cancer

Steg, A. D., Amm, H. M., Novák, Z., Frost, A. R., & Johnson, M. R. (2010) · Cancer Biology & Therapy · doi:10.4161/cbt.10.9.13252 · Cited by 37

Hedgehog signaling is required at multiple stages of zebrafish tooth development

Jackman, W. R., Yoo, J. J., & Stock, D. W. (2010) · BMC Developmental Biology · doi:10.1186/1471-213x-10-119 · Cited by 37

Marked alteration of sterol metabolism and composition without compromising retinal development or function.

Fliesler, S. J., Richards, M. J., Miller, C., & Peachey, N. S. (1999) · PubMed · Cited by 37

Deficiency of Patched 1-induced Gli1 signal transduction results in astrogenesis in Swedish mutated APP transgenic mice

He, P., Staufenbiel, M., Li, R., & Shen, Y. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu370 · Cited by 33

Metastatic basal cell carcinoma in the era of hedgehog signaling pathway inhibitors

Weiss, G. J., & Korn, R. L. (2012) · Cancer · doi:10.1002/cncr.27532 · Cited by 36

Small molecule inhibitors of the hedgehog signaling pathway for the treatment of cancer

Yun, J. I., Kim, H. R., Park, H., Kim, S. K., & Lee, J. (2012) · Archives of Pharmacal Research · doi:10.1007/s12272-012-0801-8 · Cited by 36

Primary cilium remodeling mediates a cell signaling switch in differentiating neurons

Toro-Tapia, G., & Das, R. M. (2020) · Science Advances · doi:10.1126/sciadv.abb0601 · Cited by 38

Patterning of the vertebrate ventral spinal cord

Poh, A. M., Karunaratne, A., Kolle, G., Huang, N., Smith, E., Starkey, J., Wen, D., Wilson, I. S., Yamada, T., & Hargrave, M. R. (2002) · The International Journal of Developmental Biology · doi:10.1387/ijdb.12141448 · Cited by 36

Cancer stem cells in glioma: challenges and opportunities.

Wang, J., Ma, Y., & Cooper, M. K. (2013) · PubMed · doi:10.3978/j.issn.2218-676x.2013.08.01 · Cited by 35

Gli2 Expression and Human Bladder Transitional Carcinoma Cell Invasiveness

Mechlin, C. W., Tanner, M. J., Chen, M., Buttyan, R., Levin, R. M., & Mian, B. M. (2010) · The Journal of Urology · doi:10.1016/j.juro.2010.03.007 · Cited by 35

Striking Alkenol Versus Allenol Reactivity: Metal‐Catalyzed Chemodifferentiating Oxycyclization of Enallenols

Alcaide, B., Almendros, P., del Campo, T. M., Redondo, M. C., & Fernández, I. (2011) · Chemistry - A European Journal · doi:10.1002/chem.201102100 · Cited by 35

Introduction of wild-type patched gene suppresses the oncogenic potential of human squamous cell carcinoma cell lines including A431

Koike, C., Mizutani, T., Ito, T., Shimizu, Y., Yamamichi, N., Kameda, T., Michimukai, E., Kitamura, N., Okamoto, T., & Iba, H. (2002) · Oncogene · doi:10.1038/sj.onc.1205370 · Cited by 35

Understanding Abnormal SMO-SHH Signaling in Autism Spectrum Disorder: Potential Drug Target and Therapeutic Goals

Rahi, S., & Mehan, S. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-01010-1 · Cited by 38

Hedgehog antagonist cyclopamine isomerizes to less potent forms when acidified

Wilson, S. R., Strand, M. F., Krapp, A., Rise, F., Petersen, D., & Krauss, S. J. K. (2010) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2010.02.017 · Cited by 35

Human limb malformations; an approach to the molecular basis of development

Grzeschik, K. (2002) · The International Journal of Developmental Biology · doi:10.1387/ijdb.12455638 · Cited by 34

Induction of neurogenin‐1 expression by sonic hedgehog: Its role in development of trigeminal sensory neurons

Ota, M., & Ito, K. (2003) · Developmental Dynamics · doi:10.1002/dvdy.10336 · Cited by 34

Molecular genetics of the Smith-Lemli-Opitz syndrome and postsqualene sterol metabolism

Fitzky, B. U., Glossmann, H. H., Utermann, G., & Moebius, F. F. (1999) · Current Opinion in Lipidology · doi:10.1097/00041433-199904000-00006 · Cited by 33

FoxD5 mediates anterior–posterior polarity through upstream modulator Fgf signaling during zebrafish somitogenesis

Lee, H., Tseng, W.-A., Lo, F.-Y., Liu, T., & Tsai, H. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.10.001 · Cited by 33

An ENU Mutagenesis Screen in Zebrafish for Visual System Mutants Identifies a Novel Splice-Acceptor Site Mutation in patched2 that Results in Colobomas

Lee, J., Cox, B. D., Daly, C. M. S., Lee, C., Nuckels, R. J., Tittle, R. K., Uribe, R. A., & Gross, J. M. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-11061 · Cited by 33

Hedgehog Pathway Inhibitors and Their Utility in Basal Cell Carcinoma: A Comprehensive Review of Current Evidence

Tay, E. Y., Teoh, Y.-L., & Yeo, M. S. (2018) · Dermatology and Therapy · doi:10.1007/s13555-018-0277-7 · Cited by 34

Sonic hedgehog distribution within mature hippocampal neurons

Petralia, R. S., Wang, Y., Mattson, M. P., & Yao, P. J. (2011) · Communicative & Integrative Biology · doi:10.4161/cib.17832 · Cited by 32

Developmental Pathways in Musculoskeletal Neoplasia: Involvement of the Indian Hedgehog-Parathyroid Hormone-Related Protein Pathway

Tiet, T. D., & Alman, B. A. (2003) · Pediatric Research · doi:10.1203/01.pdr.0000054688.93486.18 · Cited by 32

Chemical ‘Jekyll and Hyde’s: small-molecule inhibitors of developmental signaling pathways

Sakata, T., & Chen, J. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15019g · Cited by 33

Inositol hexakisphosphate kinase-2 acts as an effector of the vertebrate Hedgehog pathway

Sarmah, B., & Wente, S. R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1007256107 · Cited by 32

Antiandrogen Exposure in Utero Disrupts Expression of Desert Hedgehog and Insulin-Like Factor 3 in the Developing Fetal Rat Testis

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Embryogenesis of holoprosencephaly

Shiota, K., Yamada, S., Komada, M., & Ishibashi, M. (2007) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.32020 · Cited by 31

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Liu, H., Gu, D., & Xie, J. (2011) · 癌症：英文版 · doi:10.5732/cjc.010.10540 · Cited by 33

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Strand, M. F., Wilson, S. R., Dembinski, J. L., Holsworth, D. D., Khvat, A. V., Okun, I. M., Petersen, D., & Krauss, S. J. K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019904 · Cited by 30

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