Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

Chiang, C. C., Litingtung, Y., Lee, E., Young, K. E., Corden, J. L., Westphal, H., & Beachy, P. A. (1996) · Nature · doi:10.1038/383407a0 · Cited by 3,062

Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants

Goodrich, L. V., Milenković, L., Higgins, K. M., & Scott, M. P. (1997) · Science · doi:10.1126/science.277.5329.1109 · Cited by 1,696

Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development

Porter, J. A., Young, K. E., & Beachy, P. A. (1996) · Science · doi:10.1126/science.274.5285.255 · Cited by 1,360

Niemann-Pick C1 Disease Gene: Homology to Mediators of Cholesterol Homeostasis

Carstea, E. D., Morris, J. A., Coleman, K. G., Loftus, S. K., Zhang, D., Cummings, C., Gu, J., Rosenfeld, M. A., Pavan, W. J., Krizman, D. B., et al. (1997) · Science · doi:10.1126/science.277.5323.228 · Cited by 1,293

Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

Roelink, H., Porter, J. A., Chiang, C. C., Tanabe, Y., Chang, D. T., Beachy, P. A., & Jessell, T. M. (1995) · Cell · doi:10.1016/0092-8674(95)90397-6 · Cited by 888

Two Critical Periods of Sonic Hedgehog Signaling Required for the Specification of Motor Neuron Identity

Ericson, J., Brenner‐Morton, S., Kawakami, A., Roelink, H., & Jessell, T. M. (1996) · Cell · doi:10.1016/s0092-8674(00)81386-0 · Cited by 870

Defective cholesterol biosynthesis associated with the Smith-Lemli-Opitz syndrome

Tint, G. S., Irons, M., Elias, E. R., Batta, A. K., Frieden, R., Chen, T. S., & Salen, G. (1994) · New England Journal of Medicine · doi:10.1056/nejm199401133300205 · Cited by 798

Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly

Belloni, E., Muenke, M., Roessler, E., Traverse, G., Siegel-Bartelt, J., Frumkin, A., Mitchell, H. F., Donis-Keller, H., Helms, C. A., Hing, A. V., et al. (1996) · Nature Genetics · doi:10.1038/ng1196-353 · Cited by 643

Early Stages of Motor Neuron Differentiation Revealed by Expression of Homeobox Gene Islet-1

Ericson, J., Thor, S., Edlund, T., Jessell, T. M., & Yamada, T. (1992) · Science · doi:10.1126/science.1350865 · Cited by 620

Autoproteolysis in hedgehog protein biogenesis

Lee, J., Ekker, S. C., von Kessler, D. P., Porter, J. A., Sun, B. I., & Beachy, P. A. (1994) · Science · doi:10.1126/science.7985023 · Cited by 547

FGF signaling controls Shh-dependent oligodendroglial fate specification in the ventral spinal cord

Farreny, M.-A., Agius, E., Bel-Vialar, S., Escalas, N., Khouri‐Farah, N., Soukkarieh, C., Danesin, C., Pituello, F., Cochard, P., & Soula, C. (2018) · Neural Development · doi:10.1186/s13064-018-0100-2 · Cited by 30

Identification and Characterization of Several Dietary Alkaloids as Weak Inhibitors of Hedgehog Signaling

Lipinski, R. J., Dengler, E., Kiehn, M. W., Peterson, R. E., & BUSHMAN, W. A. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm222 · Cited by 30

The Inseparable Relationship Between Cholesterol and Hedgehog Signaling

Siebold, C., & Rohatgi, R. (2023) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-052521-040313 · Cited by 37

Recent Developments in β-Cell Differentiation of Pluripotent Stem Cells Induced by Small and Large Molecules

Kumar, S. S., Alarfaj, A. A., Munusamy, M. A., Singh, A. K., Peng, I.-C., Priya, S. P., Hamat, R. A., & Higuchi, A. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151223418 · Cited by 29

Inhibiting Hedgehog: An Update on Pharmacological Compounds and Targeting Strategies

Galperin, I., Dempwolff, L., Diederich, W. E., & Lauth, M. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b00188 · Cited by 29

Hedgehog signaling pathway and ovarian cancer.

Chen, Q., Gao, G., & Luo, S. (2013) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.1000-9604.2013.06.04 · Cited by 29

The Hedgehog signalling pathway as a therapeutic target in early breast cancer development

O'Toole, S. A., Swarbrick, A., & Sutherland, R. L. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220903130612 · Cited by 29

From Drosophila segmentation to human cancer therapy

Ingham, P. W. (2018) · Development · doi:10.1242/dev.168898 · Cited by 29

New frameshift mutation in the 5α‐reductase type 2 gene in a Brazilian patient with 5α‐reductase deficiency

Ferraz, L. F. C., Baptista, M. T. M., Maciel‐Guerra, A. T., Guerra‐Júnior, G., & Hackel, C. (1999) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19991126)87:3 · Cited by 24

Holoprosencephaly: recent advances and new insights

Kinsman, S. L., Plawner, L. L., & Hahn, J. S. (2000) · Current Opinion in Neurology · doi:10.1097/00019052-200004000-00003 · Cited by 29

Recent advances in the efficient synthesis of steroid natural products: emerging methods and strategies

Wang, Y., & Gui, J. (2025) · Chemical Society Reviews · doi:10.1039/d3cs01150j · Cited by 28

The origin of the vertebrate jaw: Intersection between developmental biology-based model and fossil evidence

Gai, Z., & Zhu, M. (2012) · Chinese Science Bulletin · doi:10.1007/s11434-012-5372-z · Cited by 28

Sphingosine-1-Phosphate Receptor-1 Controls Venous Endothelial Barrier Integrity in Zebrafish

Tobia, C., Chiodelli, P., Nicoli, S., Dell’Era, P., Buraschi, S., Mitola, S. M. F., Foglia, E. A., van Loenen, P. B., Alewijnse, A. E., & Presta, M. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.250035 · Cited by 28

NODAL and SHH dose-dependent double inhibition promotes an HPE-like phenotype in chick embryos

Mercier, S., David, V., Ratié, L., Gicquel, I., Odent, S., & Dupé, V. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.010132 · Cited by 28

Sonic Hedgehog Expression and Its Role in Form-Deprivation Myopia in Mice

Qian, Y., Chu, R., Hu, M., & Hoffman, M. R. (2009) · Current Eye Research · doi:10.1080/02713680903003492 · Cited by 28

Chemical technologies for probing embryonic development

Shestopalov, I. A., & Chen, J. (2008) · Chemical Society Reviews · doi:10.1039/b703023c · Cited by 28

The role of maternal toxicity in lovastatin‐induced developmental toxicity

Lankas, G. R., Cukierski, M. A., & Wise, L. D. (2004) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.20005 · Cited by 28

Role of morphogens in brain growth

Tannahill, D., Harris, L. W., & Keynes, R. J. (2005) · Journal of Neurobiology · doi:10.1002/neu.20163 · Cited by 28

Expression of sonic hedgehog downstream genes is modified in rat embryos exposed in utero to a distal inhibitor of cholesterol biosynthesis

Gofflot, F., Gaoua, W., Bourguignon, L., Roux, C., & Picard, J. J. (2001) · Developmental Dynamics · doi:10.1002/1097-0177(2000)9999:9999 · Cited by 27

Sonidegib, a novel smoothened inhibitor for the treatment of advanced basal cell carcinoma

Doan, H. Q., Silapunt, S., & Migden, M. R. (2016) · OncoTargets and Therapy · doi:10.2147/ott.s108171 · Cited by 27

Applying a weight of evidence approach to the evaluation of developmental toxicity of biopharmaceuticals

Rocca, M. S., Morford, L. L., Blanset, D. L., Halpern, W., Cavagnaro, J. A., & Bowman, C. (2018) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2018.07.006 · Cited by 30

High-Risk Recurrence Basal Cell Carcinoma: Focus on Hedgehog Pathway Inhibitors and Review of the Literature

Campione, E., Prete, M. D., Lozzi, F., Lanna, C., Spallone, G., Mazzeo, M., Cosio, T., Rapanotti, C., Dika, E., Gaziano, R., et al. (2020) · Chemotherapy · doi:10.1159/000509156 · Cited by 27

Sonic Hedgehog Pathway Modulation Normalizes Expression of Olig2 in Rostrally Patterned NPCs With Trisomy 21

Klein, J. A., Li, Z., Rampam, S., Cardini, J., Ayoub, A., Shaw, P., Rachubinski, A. L., Espinosa, J. M., Zeldich, E., & Haydar, T. F. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.794675 · Cited by 27

Antagonistic interactions of hedgehog, Bmp and retinoic acid signals control zebrafish endocrine pancreas development

Tehrani, Z., & Lin, S. (2011) · Development · doi:10.1242/dev.050450 · Cited by 27

Discovery of potent and novel smoothened antagonists via structure-based virtual screening and biological assays

Lu, W., Zhang, D., Ma, H., Tian, S., Zheng, J., Wang, Q. L., Luo, L., & Zhang, X. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.05.035 · Cited by 27

Congenital eye anomalies: More mosaic than thought?

Ohuchi, H., Sato, K., Habuta, M., Fujita, H., & Bando, T. (2018) · Congenital Anomalies · doi:10.1111/cga.12304 · Cited by 28

Alterations in Gene Expression Induced in Day-9 Mouse Embryos Exposed to Hyperthermia (HS) or 4-Hydroperoxycyclophosphamide (4CP): Analysis Using cDNA Microarrays

Mikheeva, S. A. (2004) · Toxicological Sciences · doi:10.1093/toxsci/kfh080 · Cited by 27

Lipid domains in the endocytic pathway

Kobayashi, T., Yamaji‐Hasegawa, A., & Kiyokawa, E. (2001) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.2000.0234 · Cited by 27

The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway.

Stecca, B. A., & Altaba, A. R. I. (2002) · Journal of Biology · doi:10.1186/1475-4924-1-9 · Cited by 27

ABCG2 is required to control the sonic hedgehog pathway in side population cells with stem‐like properties

Balbuena, J., Pachón, G., Lopez‐Torrents, G., Aran, J. M., Castresana, J. S., & Pétriz, J. (2011) · Cytometry Part A · doi:10.1002/cyto.a.21103 · Cited by 26

A new role for Hedgehogs in juxtacrine signaling

Pettigrew, C. A., Asp, E., & Emerson, C. P. (2013) · Mechanisms of Development · doi:10.1016/j.mod.2013.12.002 · Cited by 26

Tandem Metathesis Reactions of Oxabicyclo[2.2.1]heptenes: Studies on the Spirocyclic Core of Cyclopamine

Oblak, E. Z., G-Dayanandan, N., & Wright, D. L. (2011) · Organic Letters · doi:10.1021/ol200706f · Cited by 26

Limb malformations of rat fetuses exposed to a distal inhibitor of cholesterol biosynthesis

Chevy, F., Illien, F., Wolf, C., & Roux, C. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m200082-jlr200 · Cited by 26

Critical time window of hedgehog-dependent angiogenesis in murine yolk sac

Nagase, M., Nagase, T., Koshima, I., & Fujita, T. (2006) · Microvascular Research · doi:10.1016/j.mvr.2005.11.006 · Cited by 26

Removal of Pax6 Partially Rescues the Loss of Ventral Structures in Shh Null Mice

Fuccillo, M. V., Rutlin, M. L., & Fishell, G. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhk023 · Cited by 25

Roughing up Smoothened: chemical modulators of hedgehog signaling.

King, R. W. (2002) · Journal of Biology · doi:10.1186/1475-4924-1-8 · Cited by 26

Surfaceome Profiling Reveals Regulators of Neural Stem Cell Function

DeVeale, B., Bausch‐Fluck, D., Seaberg, R. M., Runciman, S. B., Akbarian, V., Karpowicz, P. A., Yoon, C., Song, H., Leeder, R., Zandstra, P. W., et al. (2013) · Stem Cells · doi:10.1002/stem.1550 · Cited by 25

Enhancement of Cyclopamine via Conjugation with Nonmetabolic Sugars

Goff, R. D., & Thorson, J. S. (2012) · Organic Letters · doi:10.1021/ol300703z · Cited by 25

Sulfation of Glycosaminoglycan Hydrogels Instructs Cell Fate and Chondral versus Endochondral Lineage Decision of Skeletal Stem Cells In Vivo

Chasan, S., Hesse, E., Atallah, P., Gerstner, M., Diederichs, S., Schenker, A., Grobe, K., Werner, C., & Richter, W. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202109176 · Cited by 25

Role of Sonic hedgehog signaling in epithelial and mesenchymal development of hair follicles in an organ culture of embryonic mouse skin

Nanba, D., Nakanishi, Y., & Hieda, Y. (2003) · Development Growth & Differentiation · doi:10.1046/j.1524-4725.2003.691.x · Cited by 25

Synthesis and biological evaluation of desmethylveramiline, a micromolar Hedgehog inhibitor

Guerlet, G., Spangenberg, T., Mann, A., Faure, H., & Ruat, M. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.04.103 · Cited by 25

Analysis of Nsdhl-deficient embryos reveals a role for Hedgehog signaling in early placental development

Jiang, F., & Herman, G. E. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl405 · Cited by 25

Differential role of Hedgehog signaling in human pancreatic (patho-) physiology: An up to date review

Klieser, E., Swierczynski, S., Mayr, C., Jäger, T., Schmidt, J., Neureiter, D., Kiesslich, T., & Illig, R. (2016) · World Journal of Gastrointestinal Pathophysiology · doi:10.4291/wjgp.v7.i2.199 · Cited by 25

Development of taladegib as a sonic hedgehog signaling pathway inhibitor

Jin, G., Sivaraman, A., & Lee, K. (2017) · Archives of Pharmacal Research · doi:10.1007/s12272-017-0987-x · Cited by 25

Dhcr24 activates the PI 3K/Akt/ HKII pathway and protects against dilated cardiomyopathy in mice

Dong, W., Guan, F., Zhang, X., Gao, S., Liu, N., Chen, W., Zhang, L., & Lü, D. (2018) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12007 · Cited by 25

Pathogenesis of medulloblastoma and current treatment outlook

Jóźwiak, J., Grajkowska, W., & Wlodarski, P. K. (2006) · Medicinal Research Reviews · doi:10.1002/med.20088 · Cited by 25

The Hedgehog signaling pathway – implications for drug targets in cancer and neurodegenerative disorders

Bak, M., Hansen, C., Tommerup, N., & Larsen, L. A. (2003) · Pharmacogenomics · doi:10.1517/phgs.4.4.411.22751 · Cited by 25

Semilobar Holoprosencephaly with Midline 'Seam': A Topologic and Morphogenetic Model Based Upon MRI Analysis

Takahashi, T. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg077 · Cited by 25

Hedgehog Signaling in Myeloid Malignancies

Abraham, A., & Matsui, W. H. (2021) · Cancers · doi:10.3390/cancers13194888 · Cited by 24

Gene-environment interactions in birth defect etiology: Challenges and opportunities

Lipinski, R. J., & Krauss, R. S. (2022) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2022.10.001 · Cited by 27

The Blockade of Mineralocorticoid Hormone Signaling Provokes Dramatic Teratogenesis in Cultured Rat Embryos

Mirshahi, M., AYANI, E., Nicolas, C., Golestaneh, N., Ferrari, P., Valamanesh, F., & Agarwal, M. K. (2002) · International Journal of Toxicology · doi:10.1080/10915810290096324 · Cited by 24

Matching mice to malignancy: molecular subgroups and models of medulloblastoma

Lau, J., Schmidt, C., Markant, S. L., Taylor, M. D., Wechsler‐Reya, R. J., & Weiss, W. A. (2012) · Child s Nervous System · doi:10.1007/s00381-012-1704-1 · Cited by 24

CDK7 inhibition suppresses aberrant hedgehog pathway and overcomes resistance to smoothened antagonists

Liu, F., Jiang, W., Sui, Y., Meng, W., Hou, L., Li, T., Li, M., Zhang, L., Mo, J., Wang, J., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1815780116 · Cited by 24

Sterol and oxysterol synthases near the ciliary base activate the Hedgehog pathway

Findakly, S., Daggubati, V., García, G., Lastella, S., Choudhury, A., Tran, C. K., Li, A., Tong, P., Garcia, J. Q., Puri, N., et al. (2020) · The Journal of Cell Biology · doi:10.1083/jcb.202002026 · Cited by 24

Expression of sax1/nkx1.2 and sax2/nkx1.1 in zebrafish

Bae, Y., Shimizu, T., Muraoka, O., Yabe, T., Hirata, T., Nojima, H., Hirano, T., & Hibi, M. (2004) · Gene Expression Patterns · doi:10.1016/j.modgep.2003.12.001 · Cited by 24

Protection from lipopolysaccharide-induced pulmonary microvascular endothelial cell injury by activation of hedgehog signaling pathway

Yu, Y., Li, Q., Deng, Z., Zhang, Z., Xu, J., Qian, G., & Wang, G. (2010) · Molecular Biology Reports · doi:10.1007/s11033-010-0473-8 · Cited by 24

A requirement for hedgehog signaling in thyroid hormone-induced postembryonic intestinal remodeling

Wen, L., Hasebe, T., Miller, T. C. R., Ishizuya‐Oka, A., & Shi, Y. (2015) · Cell & Bioscience · doi:10.1186/s13578-015-0004-3 · Cited by 24

Interaction of phosphoinositolglycan(-peptides) with plasma membrane lipid rafts of rat adipocytes

Müller, G. A., Hanekop, N., Kramer, W., Bandlow, W., & Frick, W. (2002) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(02)00451-4 · Cited by 23

Cholesterylation: a tail of hedgehog

Ciepla, P., Magee, A. I., & Tate, E. W. (2015) · Biochemical Society Transactions · doi:10.1042/bst20150032 · Cited by 23

Sonidegib for the Treatment of Advanced Basal Cell Carcinoma: A Comprehensive Review of Sonidegib and the Bolt Trial with 12-Month Update

Chen, L. L., Silapunt, S., & Migden, M. R. (2016) · Future Oncology · doi:10.2217/fon-2016-0118 · Cited by 23

Activated hedgehog pathway is a potential target for pharmacological intervention in biliary tract cancer

Kiesslich, T., Mayr, C., Wachter, J., Bach, D., Fuereder, J., Wagner, A., Alinger, B., Pichler, M., Fazio, P. D., Ocker, M., et al. (2014) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-014-2161-9 · Cited by 23

Targeting the Hedgehog Pathway

Cohen, D. J. (2012) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2012.01.005 · Cited by 23

Sonic Hedgehog on Microparticles and Neovascularization

Soleti, R., & Martínez, M. C. (2012) · Vitamins and hormones · doi:10.1016/b978-0-12-394622-5.00018-3 · Cited by 23

Cyclopamine bioactivity by extraction method from Veratrum californicum

Turner, M. W., Cruz, R., Mattos, J., Baughman, N., Elwell, J., Fothergill, J. W., Nielsen, A., Brookhouse, J., Bartlett, A., Málek, P., et al. (2016) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2016.06.017 · Cited by 23

Development of anticancer agents targeting the Hedgehog signaling

Zhang, X., Tian, Y. E., Yang, Y., & Hao, J. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2497-x · Cited by 23

Functionally Distinctive Ptch Receptors Establish Multimodal Hedgehog Signaling in the Tooth Epithelial Stem Cell Niche

Binder, M., Chmielarz, P., McKinnon, P. J., Biggs, L. C., Thesleff, I., & Balic, A. (2019) · Stem Cells · doi:10.1002/stem.3042 · Cited by 23

Down-regulation of astrocytic sonic hedgehog by activation of endothelin ETB receptors: Involvement in traumatic brain injury-induced disruption of blood brain barrier in a mouse model

Michinaga, S., Inoue, A., Sonoda, K., Mizuguchi, H., & Kōyama, Y. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105042 · Cited by 23

A synthetic approach to C-nor-D-homosteroids based on a cascade of radical cyclisations from a vinylcyclopropane-substituted acyl radical precursor

Pattenden, G., Stoker, D. A., & Winne, J. M. (2009) · Tetrahedron · doi:10.1016/j.tet.2009.05.020 · Cited by 23

A hedgehog homolog is involved in muscle formation and organization of Sepia officinalis (mollusca) mantle

Grimaldi, A., Tettamanti, G., Acquati, F., Bossi, E., Guidali, M. L., Banfi, S., Monti, L., Valvassori, R., & de Eguileor, M. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21453 · Cited by 23

Role of p53 in DNA strand break-induced apoptosis in organotypic slice culture from the mouse cerebellum

Inamura, N., Araki, T., Enokido, Y., Nishio, C., Aizawa, S., & Hatanaka, H. (2000) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(20000515)60:4 · Cited by 33

Scaffold hopping approach to a new series of smoothened antagonists

Lu, W., Geng, D., Sun, Z., Yang, Z., Ma, H., Zheng, J., & Zhang, X. (2014) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2014.03.079 · Cited by 22

In vivo analysis of compound activity and mechanism of action using epistasis in Drosophila

Bangi, E., Garza, D., & Hild, M. (2010) · Journal of Chemical Biology · doi:10.1007/s12154-010-0051-5 · Cited by 22

Probing extracellular Sonic hedgehog in neurons

Eitan, E., Petralia, R. S., Wang, Y., Indig, F. E., Mattson, M. P., & Yao, P. J. (2016) · Biology Open · doi:10.1242/bio.019422 · Cited by 22

Progress toward a Convergent, Asymmetric Synthesis of Jervine

Zavesky, B. P., Cruz, P. D. J., & Johnson, J. S. (2020) · Organic Letters · doi:10.1021/acs.orglett.0c00972 · Cited by 22

From Teratogens to Potential Therapeutics: Natural Inhibitors of the Hedgehog Signaling Network Come of Age

Hovhannisyan, A., Matz‐Soja, M., & Gebhardt, R. (2009) · Planta Medica · doi:10.1055/s-0029-1185979 · Cited by 22

Circonstances cliniques du diagnostic du syndrome de Smith-Lemli-Opitz et tentatives de corrélation phénotype-génotype : à propos de 45 cas

Goldenberg, A., Chevy, F., Bernard, C., Wolf, C., & Cormier‐Daire, V. (2003) · Archives de Pédiatrie · doi:10.1016/s0929-693x(03)00214-8 · Cited by 22

In situ stem cell therapy: novel targets, familiar challenges

Agrawal, S., & Schaffer, D. V. (2004) · Trends in biotechnology · doi:10.1016/j.tibtech.2004.12.004 · Cited by 22

Plasma Membrane Rafts Complete Cholesterol Synthesis by Participating in Retrograde Movement of Precursor Sterols

Yamauchi, Y., Reid, P., Sperry, J. B., Furukawa, K., Takeya, M., Chang, C. C. Y., & Chang, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703653200 · Cited by 22

Vismodegib Resistance in Basal Cell Carcinoma: Not a Smooth Fit

Ridky, T. W., & Cotsarelis, G. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.02.009 · Cited by 21

Design of 1-piperazinyl-4-arylphthalazines as potent Smoothened antagonists

Lucas, B. S., Aaron, W. H., An, S. M., Austin, R. J., Brown, M. L., Chan, H. M., Chong, A., Hungate, R. W., Huang, T. H.-W., Jiang, B., et al. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.04.110 · Cited by 21

prdm12b specifies the p1 progenitor domain and reveals a role for V1 interneurons in swim movements

Zannino, D., Downes, G., & Sagerström, C. G. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2014.02.025 · Cited by 24

Selective Release of a Cyclopamine Glucuronide Prodrug toward Stem-like Cancer Cell Inhibition in Glioblastoma

Balbous, A., Renoux, B., Cortes, U., Milin, S., Guilloteau, K., Legigan, T., Rivet, P., Boissonnade, O., Martin, S., Tripiana, C., et al. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-1038 · Cited by 21

Development of an Enzyme-Linked Immunosorbent Assay for the Veratrum Plant Teratogens: Cyclopamine and Jervine

Lee, S. T., Panter, K. E., Gaffield, W., & Stegelmeier, B. L. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf020961s · Cited by 21

Smarcd3 Regulates the Timing of Zebrafish Myogenesis Onset

Ochi, H., Hans, S., & Westerfield, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m708594200 · Cited by 21

Lack of Evidence for Activation of the Hedgehog Pathway in Psoriasis

Gudjonsson, J. E., Aphale, A., Grachtchouk, M. A., Ding, J., Nair, R. P., Wang, T., Voorhees, J. J., Dlugosz, A. A., & Elder, J. T. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.266 · Cited by 21

Design, synthesis, and structure–activity-relationship of tetrahydrothiazolopyridine derivatives as potent smoothened antagonists

Ma, H., Lu, W., Sun, Z., Luo, L., Geng, D., Yang, Z., Li, E., Zheng, J., Wang, M., Zhang, H., et al. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.11.006 · Cited by 20

Drug Repurposing Flubendazole to Suppress Tumorigenicity via PCSK9-dependent Inhibition and Potentiate Lenvatinib Therapy for Hepatocellular Carcinoma

Jin, W., Yu, J., Su, Y., Lin, H., Liu, T., Chen, J., Ge, C., Zhao, F., Geng, Q., Mao, L., et al. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.81415 · Cited by 20

Anterior shift in gene expression precedes anteriormost digit formation in amniote limbs

Uejima, A., Amano, T., Nomura, N., Noro, M., Yasue, T., Shiroishi, T., Ohta, K., Yokoyama, H., & Tamura, K. (2010) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2009.01161.x · Cited by 20

Basal Cell Carcinoma, Hedgehog Signaling, and Targeted Therapeutics: The Long and Winding Road

Wong, S. Y., & Dlugosz, A. A. (2014) · Journal of Investigative Dermatology · doi:10.1038/skinbio.2014.4 · Cited by 20

Arsenic Trioxide, Itraconazole, All-Trans Retinoic Acid and Nicotinamide: A Proof of Concept for Combined Treatments with Hedgehog Inhibitors in Advanced Basal Cell Carcinoma

Cosio, T., Prete, M. D., & Campione, E. (2020) · Biomedicines · doi:10.3390/biomedicines8060156 · Cited by 20

Vertebrate limb development: from Harrison?s limb disk transplantations to targeted disruption of Hox genes

Koussoulakos, S. L. (2004) · Anatomy and Embryology · doi:10.1007/s00429-004-0436-8 · Cited by 20

Central Nervous System Embryogenesis and Its Failures

Lacbawan, F. L., & Muenke, M. (2002) · Pediatric and Developmental Pathology · doi:10.1007/s10024-002-0003-3 · Cited by 20

Implications of hedgehog signaling antagonists for cancer therapy

Xie, J. (2008) · Acta Biochimica et Biophysica Sinica · doi:10.1111/j.1745-7270.2008.00431.x · Cited by 20

Embryonic expression of cholesterogenic genes is restricted to distinct domains and colocalizes with apoptotic regions in mice

Laubner, D., Rainer Breitling, A., & Adamski, J. (2003) · Molecular Brain Research · doi:10.1016/s0169-328x(03)00094-9 · Cited by 20

Divergent and gram-scale syntheses of (–)-veratramine and (–)-cyclopamine

Hou, W., Lin, H., Wu, Y., Li, C., Chen, J., Liu, X., & Qin, Y. (2024) · Nature Communications · doi:10.1038/s41467-024-49748-2 · Cited by 19

Targeting Cancer Stem Cells with Defined Compounds and Drugs

Naujokat, C., & Laufer, S. (2013) · Journal of cancer research updates · Cited by 19

Hedgehog targeting by cyclopamine suppresses head and neck squamous cell carcinoma and enhances chemotherapeutic effects.

Mozet, C., Stoehr, M., Dimitrova, K., Dietz, A., & Wichmann, G. (2013) · PubMed · Cited by 19

Habenular Neurogenesis in Zebrafish Is Regulated by a Hedgehog, Pax6 Proneural Gene Cascade

Halluin, C., Madelaine, R., Naye, F., Peers, B., Roussigné, M., & Blader, P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158210 · Cited by 19

Hedgehog signaling and cell cycle control in differentiating erythroid progenitors

Detmer, K., Thompson, A. J., Garner, R. E., Walker, A. M., Gaffield, W., & Dannawi, H. (2004) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2004.08.026 · Cited by 20

Non-melanoma skin cancer: pathogenesis and mechanisms

Lauth, M., Undén, A. B., & Toftgård, R. (2004) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2004.09.005 · Cited by 19

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Hovhannisyan, A., Matz‐Soja, M., & Gebhardt, R. (2009) · Planta Medica · doi:10.1055/s-0029-1185979 · Cited by 22

Mechanistic Investigation of Veratrum Alkaloid-Induced Mammalian Teratogenesis

Gaffield, W., Incardona, J. P., Kapur, R. P., & Roelink, H. (1999) · ACS symposium series · doi:10.1021/bk-2000-0745.ch012

The teratogenic Veratrum alkaloid cyclopamine inhibits Sonic hedgehog signal transduction

Incardona, J. P., Gaffield, W., Kapur, R. P., & Roelink, H. (1998) · Development · doi:10.1242/dev.125.18.3553 · Cited by 654

A teratogen inhibiting cholesterol biosynthesis phenocopies Sonic Hedgehog developmental gene mutation in rat embryos

Kolf‐Clauw, M., Clotmarr, F., Roux, C., & Picard, J. (1998) · Toxicology Letters · doi:10.1016/s0378-4274(98)80829-1

The role of cholesterol in Shh signaling and teratogen-induced holoprosencephaly

Incardona, J. P., & Roelink, H. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000653 · Cited by 76