Death Receptors: Signaling and Modulation

Caspases: Enemies Within

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The Bcl-2 Protein Family: Arbiters of Cell Survival

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Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.

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An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

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Identification and characterization of a new member of the TNF family that induces apoptosis

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Programmed Cell Death in Animal Development

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Mechanisms and Genes of Cellular Suicide

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FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

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A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

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IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

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The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

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TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

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Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

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The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

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The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

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Induction of Apoptosis by Apo-2 Ligand, a New Member of the Tumor Necrosis Factor Cytokine Family

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The Receptor for the Cytotoxic Ligand TRAIL

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A Matter of Life and Cell Death

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Molecular thanatopsis: a discourse on the BCL2 family and cell death

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Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

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A novel domain within the 55 kd TNF receptor signals cell death

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MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

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Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape

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IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

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Osteoprotegerin Is a Receptor for the Cytotoxic Ligand TRAIL

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TNF-Dependent Recruitment of the Protein Kinase RIP to the TNF Receptor-1 Signaling Complex

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Identification and Characterization of an IκB Kinase

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C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2

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TRAIL‐R2: a novel apoptosis‐mediating receptor for TRAIL

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KILLER/DR5 is a DNA damage–inducible p53–regulated death receptor gene

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Two TNF receptors

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An Induced Proximity Model for Caspase-8 Activation

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Lymphocyte apoptosis induced by CD95 (APO–1/Fas) ligand–expressing tumor cells — A mechanism of immune evasion?

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FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis

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Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis

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The Novel Receptor TRAIL-R4 Induces NF-κB and Protects against TRAIL-Mediated Apoptosis, yet Retains an Incomplete Death Domain

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Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice

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Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

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FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis

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Death Receptor 5, a New Member of the TNFR Family, and DR4 Induce FADD-Dependent Apoptosis and Activate the NF-κB Pathway

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TWEAK, a New Secreted Ligand in the Tumor Necrosis Factor Family That Weakly Induces Apoptosis

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A novel receptor for Apo2L/TRAIL contains a truncated death domain

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Signal Transduction by DR3, a Death Domain-Containing Receptor Related to TNFR-1 and CD95

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Cloning and Characterization of TRAIL-R3, a Novel Member of the Emerging TRAIL Receptor Family

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Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death

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Identification and Molecular Cloning of Two Novel Receptors for the Cytotoxic Ligand TRAIL

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RIP mediates tumor necrosis factor receptor 1 activation of NF‐kappaB but not Fas/APO‐1‐initiated apoptosis.

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RAIDD is a new 'death' adaptor molecule

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The CARD domain: a new apoptotic signalling motif

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A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

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Activation of SAPK/JNK by TNF Receptor 1 Through a Noncytotoxic TRAF2-Dependent Pathway

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The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex

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Casper Is a FADD- and Caspase-Related Inducer of Apoptosis

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Self-association of the “Death Domains” of the p55 Tumor Necrosis Factor (TNF) Receptor and Fas/APO1 Prompts Signaling for TNF and Fas/APO1 Effects

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I-FLICE, a Novel Inhibitor of Tumor Necrosis Factor Receptor-1- and CD-95-induced Apoptosis

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Early Activation of c-Jun N-terminal Kinase and p38 Kinase Regulate Cell Survival in Response to Tumor Necrosis Factor α

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A death-domain-containing receptor that mediates apoptosis

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TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL

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TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling

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Interaction between the C. elegans cell-death regulators CED-9 and CED-4

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NMR structure of the death domain of the p75 neurotrophin receptor

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Characterization of two receptors for TRAIL1

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TRAMP, a Novel Apoptosis-Mediating Receptor with Sequence Homology to Tumor Necrosis Factor Receptor 1 and Fas(Apo-1/CD95)

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Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-κB

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CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP.

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CAR1, a TNFR–Related Protein, Is a Cellular Receptor for Cytopathic Avian Leukosis–Sarcoma Viruses and Mediates Apoptosis

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LARD: A new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing

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Cell death: TRAIL and its receptors

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Role of CED-4 in the activation of CED-3

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Activation of apoptosis by Apo-2 ligand is independent of FADD but blocked by CrmA

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Identification of a ligand for the death-domain-containing receptor Apo3

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Caenorhabditis elegans CED-4 stimulates CED-3 processing and CED-3-induced

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Apoptosis and the maintenance of homoeostasis in the immune system

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Interleukin 1β-converting Enzyme Related Proteases/Caspases Are Involved in TRAIL-induced Apoptosis of Myeloma and Leukemia Cells

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A potential mechanism of "cross-talk" between the p55 tumor necrosis factor receptor and Fas/APO1: proteins binding to the death domains of the two receptors also bind to each other.

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p53-dependent impairment of T-cell proliferation in FADD dominant-negative transgenic mice

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Cutting Edge: Lymphocyte Inhibitor of TRAIL (TNF-Related Apoptosis-Inducing Ligand): A New Receptor Protecting Lymphocytes from the Death Ligand TRAIL

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Placing death under control

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Caspases: Enemies Within

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