Cited by 349Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationAxon Guidance and Neuronal Signaling

Early Neocortical Regionalization in the Absence of Thalamic Innervation

Miyashita-Lin, Emily M., Hevner, Robert, Wassarman, Karen Montzka, Martinez, Salvador, Rubenstein, John L. R.·1999·Science

Abstract

There is a long-standing controversy regarding the mechanisms that generate the functional subdivisions of the cerebral neocortex. One model proposes that thalamic axonal input specifies these subdivisions; the competing model postulates that patterning mechanisms intrinsic to the dorsal telencephalon generate neocortical regions. Gbx-2 mutant mice, whose thalamic differentiation is disrupted, were investigated. Despite the lack of cortical innervation by thalamic axons, neocortical region–specific gene expression ( Cadherin-6 , EphA-7 , Id-2 , and RZR-beta ) developed normally. This provides evidence that patterning mechanisms intrinsic to the neocortex specify the basic organization of its functional subdivisions.

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Crossref · 10.1126/science.285.5429.906

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31 of 31 references verified0 citation errors · 0 not checkable

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  • Differential gene expression and gradients of signaling molecules across the embryonic brain generate prospective subdivisions of the neocortex.

    “More specifically, it is well documented that differential gene expression and the gradients of signaling molecules across the embryonic brain generate prospective subdivisions of the neocortex [24–29].”

    From Development of prefrontal cortex (2022) · cites this paper as [28]

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Authors
Miyashita-Lin, E. M., Hevner, R., Wassarman, K. M., Martinez, S., & Rubenstein, J. L. R.
Affiliations
  • University of California, San Francisco (US)
  • Department of Morphological Sciences, Faculty of Medicine, University of Murcia, Institute of Neurosciences, University Miguel Hernandez, Alicante, Spain.
Corresponding author
  • Miyashita-Lin, Emily M.
  • Hevner, Robert
  • Wassarman, Karen Montzka
  • Rubenstein, John L. R.
Venue
Science
Published
1999-08-06
Volume
285
Issue
5429
Pages
906-909
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2071596650
Cited by
349
References
31
Citations by year
2026: 2 · 2025: 6 · 2024: 4 · 2023: 7 · 2022: 6 · 2021: 6 · 2020: 5 · 2019: 28 · 2018: 4 · 2017: 7 · 2016: 3 · 2015: 9 · 2014: 7 · 2013: 13 · 2012: 17
FWCI
5.67
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Funders
  • National Institutes of Health (2r01mh051561-04a1)
  • National Institute of Mental Health (R01 MH4942801, R01MH049428, R01MH51561-01A1)
  • National Institute of Neurological Disorders and Stroke (R01NS034661, NS34661-01A1)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Keywords
thalamocortical connections, cortical patterning, dorsal telencephalon, Id2, CDH6
MeSH terms
Animals, Axons, Carbocyanines, DNA-Binding Proteins, Immunohistochemistry, Mutation, Nerve Fibers, Proteins, Receptors, Cell Surface, Steroid 17-alpha-Hydroxylase, Telencephalon, Thalamus, Transcription Factors, Cadherins, Gene Expression, In Situ Hybridization, Receptors, Cytoplasmic and Nuclear, Homeodomain Proteins, Neocortex, Receptors, Melatonin, Mice, Inhibitor of Differentiation Proteins, Lymphoid Enhancer-Binding Factor 1, S100 Calcium Binding Protein G, Calbindin 2

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