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Cited by 158Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental DisordersMemory and Neural Mechanisms

Postsynaptic signaling during plasticity of dendritic spines

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Murakoshi, Hideji, Yasuda, Ryohei·2012·Trends in Neurosciences
DOI 10.1016/j.tins.2011.12.002PMC PMC3306839
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Abstract

Dendritic spines, small bulbous postsynaptic compartments emanating from neuronal dendrites, have been thought to serve as basic units of memory storage. Despite their small size (~0.1 femtoliter), thousands of species of proteins exist in the spine, including receptors, channels, scaffolding proteins and signaling enzymes. Biochemical signaling mediated by these molecules leads to morphological and functional plasticity of dendritic spines, and ultimately learning and memory in the brain. Here, we review new insights into the mechanisms underlying spine plasticity brought about by recent advances in imaging techniques to monitor molecular events in single dendritic spines. The activity of each protein displays a specific spatiotemporal pattern, coordinating downstream events at different microdomains to change the function and morphology of dendritic spines.

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  • Spine growth is likely to be a multifaceted event involving regulated changes in cytoskeletal elements, membrane addition, and receptor trafficking under the control of multiple small GTPases.

    “Indeed spine growth is likely to be a multifaceted event involving regulated changes in cytoskeletal elements, membrane addition, and receptor trafficking under the control of multiple small GTPases”

    From Ral mediates activity‐dependent growth of postsynaptic membranes via recruitment of the exocyst (2013) · cites this paper as Murakoshi and Yasuda, 2012

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Authors
Murakoshi, H., & Yasuda, R.
Affiliations
  • Duke Medical Center (US)
  • Howard Hughes Medical Institute (US)
Corresponding author
Yasuda, Ryohei
ORCID
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2012-02
Volume
35
Issue
2
Pages
135-143
ISSN
0166-2236 (ISSN-L)
DOI
10.1016/j.tins.2011.12.002
PMC
PMC3306839
OpenAlex
W2074708994
Cited by
158
References
22
Citations by year
2026: 7 · 2025: 5 · 2024: 3 · 2023: 8 · 2022: 9 · 2021: 10 · 2020: 12 · 2019: 10 · 2018: 7 · 2017: 12 · 2016: 20 · 2015: 16 · 2014: 16 · 2013: 17 · 2012: 6
FWCI
1.87
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Howard Hughes Medical Institute
  • National Institutes of Health
  • National Institute of Mental Health (R01MH080047, R01MH095090)
  • National Institute on Drug Abuse (R01DA027807)
  • National Institute of Neurological Disorders and Stroke (R01NS068410)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
dendritic spines, postsynaptic signaling, synaptic plasticity, dendritic spine morphology, learning and memory, spatiotemporal signaling, scaffold proteins
MeSH terms
Animals, Cytoskeleton, Dendrites, Neuronal Plasticity, Synapses, Dendritic Spines

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