The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Light-Independent Role of CRY1 and CRY2 in the Mammalian Circadian Clock
Abstract
Cryptochrome (CRY), a photoreceptor for the circadian clock in Drosophila , binds to the clock component TIM in a light-dependent fashion and blocks its function. In mammals, genetic evidence suggests a role for CRYs within the clock, distinct from hypothetical photoreceptor functions. Mammalian CRY1 and CRY2 are here shown to act as light-independent inhibitors of CLOCK-BMAL1, the activator driving Per1 transcription. CRY1 or CRY2 (or both) showed light-independent interactions with CLOCK and BMAL1, as well as with PER1, PER2, and TIM. Thus, mammalian CRYs act as light-independent components of the circadian clock and probably regulate Per1 transcriptional cycling by contacting both the activator and its feedback inhibitors.
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Cites
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Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms
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The cryb mutation identifies cryptochrome as a circadian photoreceptor in Drosophila
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A Differential Response of Two Putative Mammalian Circadian Regulators, mper1and mper2, to Light
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Putative Human Blue-Light Photoreceptors hCRY1 and hCRY2 Are Flavoproteins
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Cited by
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Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379
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Mop3 is an essential component of the master circadian pacemaker in mammals.
Bunger, M. K., Wilsbacher, L. D., Moran, S. M., Clendenin, C., Radcliffe, L. A., Hogenesch, J. B., Simon, M. C., Takahashi, J. S., & Bradfield, C. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00205-1 · Cited by 1,621
Transcriptional architecture and chromatin landscape of the core circadian clock in mammals
Koike, N., Yoo, S.-H., Huang, H.-C., Kumar, V., Lee, C., Kim, T.-K., & Takahashi, J. S. (2012) · Science · doi:10.1126/science.1226339 · Cited by 1,464
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Metadata
- Authors
- Griffin, E. A., Staknis, D., & Weitz, C. J.
- Venue
- Science
- Published
- 1999-10-22
- Volume
- 286
- Issue
- 5440
- Pages
- 768-771
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2084887961
- Cited by
- 646
- References
- 8
- FWCI
- 12.94
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
