The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Positional Syntenic Cloning and Functional Characterization of the Mammalian Circadian Mutation tau
Open accessAbstract
The tau mutation is a semidominant autosomal allele that dramatically shortens period length of circadian rhythms in Syrian hamsters. We report the molecular identification of the tau locus using genetically directed representational difference analysis to define a region of conserved synteny in hamsters with both the mouse and human genomes. The tau locus is encoded by casein kinase I epsilon (CKIɛ), a homolog of the Drosophila circadian gene double-time . In vitro expression and functional studies of wild-type and tau mutant CKIɛ enzyme reveal that the mutant enzyme has a markedly reduced maximal velocity and autophosphorylation state. In addition, in vitro CKIɛ can interact with mammalian PERIOD proteins, and the mutant enzyme is deficient in its ability to phosphorylate PERIOD. We conclude that tau is an allele of hamster CKIɛ and propose a mechanism by which the mutation leads to the observed aberrant circadian phenotype in mutant animals.
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Cites
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Mutagenesis and Mapping of a Mouse Gene, Clock , Essential for Circadian Behavior
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Cited by
Coordination of circadian timing in mammals
Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379
Resetting of circadian time in peripheral tissues by glucocorticoid signaling
Balsalobre, A., Brown, S. A., Marcacci, L., Tronche, F., Kellendonk, C., Reichardt, H. M., Schütz, G., & Schibler, U. (2000) · Science · doi:10.1126/science.289.5488.2344 · Cited by 1,859
Mop3 is an essential component of the master circadian pacemaker in mammals.
Bunger, M. K., Wilsbacher, L. D., Moran, S. M., Clendenin, C., Radcliffe, L. A., Hogenesch, J. B., Simon, M. C., Takahashi, J. S., & Bradfield, C. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00205-1 · Cited by 1,621
Self-citationThe genetics of mammalian circadian order and disorder: implications for physiology and disease
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Self-citationAn h Per2 Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome
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Metadata
- Authors
- Lowrey, P. L., Shimomura, K., Antoch, M. P., Yamazaki, S., Zemenides, P. D., Ralph, M. R., Menaker, M., & Takahashi, J. S.
- Venue
- Science
- Published
- 2000-04-21
- Volume
- 288
- Issue
- 5465
- Pages
- 483-491
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2160091872
- Cited by
- 862
- References
- 7
- FWCI
- 22.15
- Type
- journal article
- Language
- en
- Open access
- green
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- Lowrey, P. L., Shimomura, K., Antoch, M. P., Yamazaki, S., Zemenides, P. D., Ralph, M. R., Menaker, M., & Takahashi, J. S. (2000). Positional Syntenic Cloning and Functional Characterization of the Mammalian Circadian Mutation tau. Science. https://doi.org/10.1126/science.288.5465.483
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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