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Linkage of Plasma Aβ42 to a Quantitative Locus on Chromosome 10 in Late-Onset Alzheimer's Disease Pedigrees
Abstract
Plasma Aβ42 (amyloid β42 peptide) is invariably elevated in early-onset familial Alzheimer's disease (AD), and it is also increased in the first-degree relatives of patients with typical late-onset AD (LOAD). To detect LOAD loci that increase Aβ42, we used plasma Aβ42 as a surrogate trait and performed linkage analysis on extended AD pedigrees identified through a LOAD patient with extremely high plasma Aβ. Here, we report linkage to chromosome 10 with a maximal lod score of 3.93 at 81 centimorgans close to D10S1225. Remarkably, linkage to the same region was obtained independently in a genome-wide screen of LOAD sibling pairs. These results provide strong evidence for a novel LOAD locus on chromosome 10 that acts to increase Aβ.
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Metadata
- Authors
- Ertekin-Taner, N., Graff-Radford, N., Younkin, L. H., Eckman, C., Baker, M., Adamson, J., Ronald, J., Blangero, J., Hutton, M., & Younkin, S. G.
- Venue
- Science
- Published
- 2000-12-22
- Volume
- 290
- Issue
- 5500
- Pages
- 2303-2304
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2011617651
- Cited by
- 373
- References
- 3
- FWCI
- 21.54
- Type
- journal article
- Language
- en
- Open access
- closed
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