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Cited by 49Neural dynamics and brain functionNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Sustained attention and apical dendrite activity in recurrent circuits.

LaBerge, David·2005·Brain Research Reviews
DOI 10.1016/j.brainresrev.2005.04.004
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Abstract

Recurrent neural activity is a pervasive mode of cortical operations and is believed to underlie cognitive functions of working memory, attention, and the generation of spontaneous activity during sleep . It is proposed here that activity in corticothalamic recurrent circuits underlies the sustaining of attention, and that extended durations of attention are made possible by the stabilizing effects of electrical activity in long apical dendrites of pyramidal neurons. Using the cue-target delay task as a framework, the present paper describes sustained attention during the cue-target delay as activity in recurrent circuits involving layer 5/6 pyramidal neurons. At target onset, persistent activity in apical dendrites of layer 2/3 pyramidal neurons (projected from the recurrent circuits) can enhance the processing of incoming pulse trains at basal dendrites. Apical dendrite activity is assumed to modulate the soma processing of layer 2/3 and layer 5/6 pyramidal neurons at subthreshold voltage levels. The variability of successive soma depolarizations from the apical dendrite strongly influences the stability of activity in the corticothalamic recurrent circuit. Lower variability promotes higher stability. According to the present model of apical dendrite function, soma depolarizations can be reduced in variability and maintained within subthreshold levels by increasing the distance that EPSPs propagate along the apical dendrite. The close relationship between sustained attention and the electrical field potentials produced by repeated EPSP propagations in apical dendrites is supported in a brief review of sustained attention experiments that have employed measures of EEG, ERS/ERD, ERP, and LFP.

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  • LaBerge's research provides a summary of arguments for the hypothesis that a recurrent cortico-thalamo-cortical circuit as proposed here can provide stable levels of modulatory activity at the soma of cortical pyramidal neurons that can persist over extended periods of time.

    “LaBerge's research [55] provides a summary of arguments for the hypothesis that a recurrent cortico-thalamo-cortical circuit as proposed here can provide stable levels of modulatory activity at the soma of cortical pyramidal neurons that can persist over extended periods of time.”

    From Towards a mathematical theory of cortical micro-circuits (2009) · cites this paper as [55]

  • LaBerge's research has identified the recurrent connection from layer-5 to the matrix thalamus to the apical dendrites of layer 2/3 and layer 5 neurons as the circuit responsible for sustaining activity for extended durations to support cue-target delay tasks.

    “LaBerge's [55] research has identified the recurrent connection from layer-5 to the matrix thalamus to the apical dendrites of layer 2/3 and layer 5 neurons as the circuit responsible for sustaining activity for extended durations to support cue-target delay tasks.”

    From Towards a mathematical theory of cortical micro-circuits (2009) · cites this paper as [55]

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Authors
LaBerge, D.
Affiliations
Bard College at Simon's Rock (US)
Corresponding author
LaBerge, David
Venue
Brain Research Reviews
Publisher
Elsevier BV
Published
2005-12
Volume
50
Issue
1
Pages
86-99
ISSN
0165-0173 (ISSN-L)
DOI
10.1016/j.brainresrev.2005.04.004
OpenAlex
W1976380425
Cited by
49
References
114
Citations by year
2023: 1 · 2022: 1 · 2021: 11 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 5 · 2012: 2
FWCI
0.23
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
sustained attention, apical dendrites, recurrent circuits, corticothalamic circuits, pyramidal neurons, layer 2/3 neurons, persistent activity, neural variability, attention stability, EEG, event-related potentials, local field potentials
MeSH terms
Animals, Attention, Dendrites, Electroencephalography, Evoked Potentials, Humans, Models, Biological, Nerve Net, Neural Conduction, Neurons

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