The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse
Abstract
Neurogenesis is restricted in the adult mammalian brain; most neurons are neither exchanged during normal life nor replaced in pathological situations. We report that stroke elicits a latent neurogenic program in striatal astrocytes in mice. Notch1 signaling is reduced in astrocytes after stroke, and attenuated Notch1 signaling is necessary for neurogenesis by striatal astrocytes. Blocking Notch signaling triggers astrocytes in the striatum and the medial cortex to enter a neurogenic program, even in the absence of stroke, resulting in 850 ± 210 (mean ± SEM) new neurons in a mouse striatum. Thus, under Notch signaling regulation, astrocytes in the adult mouse brain parenchyma carry a latent neurogenic program that may potentially be useful for neuronal replacement strategies.
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Cites
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
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Neuronal replacement from endogenous precursors in the adult brain after stroke
Arvidsson, A., Collin, T., Kirik, D., Kokaia, Z., & Lindvall, O. (2002) · Nature Medicine · doi:10.1038/nm747 · Cited by 2,799
Self-citationSchaeren-Wiemers, N., & Gerfin-Moser, A. (1993) · Histochemistry · doi:10.1007/bf00267823 · Cited by 1,157
Rat forebrain neurogenesis and striatal neuron replacement after focal stroke
Parent, J. M., Vexler, Z. S., Gong, C., Derugin, N., & Ferriero, D. M. (2002) · Annals of Neurology · doi:10.1002/ana.10393 · Cited by 1,024
Neurogenesis in the striatum of the adult human brain
Ernst, A., Alkass, K., Bernard, S., Salehpour, M., Perl, S., Tisdale, J., Possnert, G., Druid, H., & Frisén, J. (2014) · Cell · doi:10.1016/j.cell.2014.01.044 · Cited by 937
Self-citationGuo, Z., Zhang, L., Wu, Z., Chen, Y., Wang, F., & Chen, G. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2013.12.001 · Cited by 832
Notch signaling controls multiple steps of pancreatic differentiation
Murtaugh, L. C., Stanger, B. Z., Kwan, K. M., & Melton, D. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2436557100 · Cited by 782
Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain
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In vivo reprogramming of astrocytes to neuroblasts in the adult brain
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Cited by
Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later
Bond, A. M., Ming, G.-L., & Song, H. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.09.003 · Cited by 791
“In the absence of exogenous reprogramming factors, striatal astrocytes turn on nestin expression and generate neurons in both an adult mouse stroke model (Magnusson et al., 2014) and an excitotoxic model of Huntington’s disease (Nato et al., 2015) via downregulation of Notch signaling.”
BackgroundQuiescence of Adult Mammalian Neural Stem Cells: A Highly Regulated Rest
Urbán, N., Blomfield, I. M., & Guillemot, F. (2019) · Neuron · doi:10.1016/j.neuron.2019.09.026 · Cited by 373
Chen, Y.-C., Ma, N.-X., Pei, Z.-F., Wu, Z., Do-Monte, F. H., Keefe, S., Yellin, E., Chen, M. S., Yin, J.-C., Lee, G., et al. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2019.09.003 · Cited by 312
Questions and (some) answers on reactive astrocytes
Escartin, C., Guillemaud, O., & Carrillo‐de Sauvage, M. (2019) · Glia · doi:10.1002/glia.23687 · Cited by 275
Bergmann, O., Spalding, K. L., & Frisén, J. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018994 · Cited by 256
Self-citation
Metadata
- Authors
- Magnusson, J. P., Göritz, C., Tatarishvili, J., Dias, D. O., Smith, E. M. K., Lindvall, O., Kokaia, Z., & Frisén, J.
- Venue
- Science
- Published
- 2014-10-10
- Volume
- 346
- Issue
- 6206
- Pages
- 237-241
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2036785515
- Cited by
- 431
- References
- 25
- FWCI
- 13.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- Magnusson, J. P., Göritz, C., Tatarishvili, J., Dias, D. O., Smith, E. M. K., Lindvall, O., Kokaia, Z., & Frisén, J. (2014). A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse. Science. https://doi.org/10.1126/science.346.6206.237
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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