Adult neurogenesis in Humans
Open accessAbstract
Adult neurogenesis appears very well conserved among mammals.It was, however, not until recently that quantitative data on the extent of this process became available in humans, largely because of methodological challenges to study this process in man.There is substantial hippocampal neurogenesis in adult humans, but humans appear unique among mammals in that there is no detectable olfactory bulb neurogenesis but continuous addition of new neurons in the striatum.T here has been an enormous expansion in the knowledge regarding adult neurogenesis in experimental animals over the last two decades.A strong motivation in this research field has been that similar processes are likely to operate in humans, and that alterations in adult neurogenesis could underlie neurological or psychiatric diseases.Moreover, many have hoped that the potential of resident neural stem cells could be harnessed to promote the generation of new neurons for cell replacement in neurological diseases.A seminal study by Eriksson, Gage and colleagues (Eriksson et al. 1998), in which they were able to show the presence of 5-bromo-2-deoxyuridine (BrdU) in hippocampal neurons of cancer patients who had received the label for diagnostic purposes, established the presence of adult-born neurons in the human hippocampus.This study was exceptionally important in that it provided strong evidence for the presence of adult neurogenesis in humans.However, it did not enable any quantitative estimates, and a lingering question has been whether adult neurogenesis decreased with pri-mate evolution, and whether the extent of this process in humans is sufficient to have any functional impact (Rakic 1985;Kempermann 2012).
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In adulthood, neurogenesis is restricted to the hippocampus, rudimentarily present in the olfactory bulb, and possibly occurring in the striatum.
“According to current knowledge in adulthood neurogenesis is restricted to the hippocampus, rudimentarily present in the olfactory bulb and possibly occurring in the striatum (Bergmann et al., 2015;Ernst et al., 2014).”
From Serotonin and neuroplasticity – Links between molecular, functional and structural pathophysiology in depression (2017) · cites this paper as Bergmann et al., 2015
The Abstract supports adult hippocampal neurogenesis and the addition of new neurons in the striatum. But it says there is no detectable olfactory bulb neurogenesis in adult humans; the OLFACTORY BULB section likewise says the findings suggest it is absent, contrary to the claim that it is rudimentarily present. No page number is provided in our copy. (LLM, conf=0.88)
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- Authors
- Bergmann, O., Spalding, K. L., & Frisén, J.
- Affiliations
- Karolinska Institutet (SE)
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2015-07
- Volume
- 7
- Issue
- 7
- Pages
- a018994
- ISSN
- 1943-0264 (ISSN-L)
- PMC
- PMC4484963
- OpenAlex
- W2128527975
- Cited by
- 256
- References
- 76
- Citations by year
- 2026: 3 · 2025: 14 · 2024: 9 · 2023: 10 · 2022: 29 · 2021: 23 · 2020: 28 · 2019: 36 · 2018: 29 · 2017: 35 · 2016: 26 · 2015: 13 · 2014: 1
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cancerfonden
- Karolinska Institutet
- Knut och Alice Wallenbergs Stiftelse
- Vetenskapsrådet
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- adult neurogenesis, human hippocampus, olfactory bulb neurogenesis, striatal neurogenesis, neural stem cells, BrdU labeling, primate evolution, cell replacement therapy
- MeSH terms
- Adult, Cell Differentiation, Corpus Striatum, Hippocampus, Humans, Neurons, Olfactory Bulb, Time Factors, Cellular Senescence, Neurogenesis
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