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Superinduction of c- fos by Nerve Growth Factor in the Presence of Peripherally Active Benzodiazepines
Abstract
Alterations in proto-oncogene expression after stimulation of rat pheochromocytoma (PC12) cells by nerve growth factor (NGF) have been investigated. A specific stimulation of c- fos messenger RNA and protein was detected 30 minutes after treatment. This induction was enhanced more than 100-fold in the presence of peripherally active benzodiazepines. The effect was specific as very little change was observed in the levels of c- ras Ha , c- ras Ki , c- myc , and N- myc messenger RNA's. Under the conditions used here, NGF treatment ultimately results in neurite outgrowth, with a reduction or cessation of cell division. Thus, stimulation of the c- fos gene in this system appeared to be associated with differentiation and not with cellular proliferation. The effect of benzodiazepines was stereospecific and represents a novel action of these compounds at the level of gene expression.
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Cited by
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Metadata
- Authors
- Curran, T., & Morgan, J. I.
- Venue
- Science
- Published
- 1985-09-20
- Volume
- 229
- Issue
- 4719
- Pages
- 1265-1268
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2021235665
- Cited by
- 472
- References
- 0
- FWCI
- 14.10
- Type
- journal article
- Language
- en
- Open access
- closed
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