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Cited by 1,146

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G 1

Olson, Michael F., Ashworth, Alan, Hall, Alan·1995·Science
DOI 10.1126/science.7652575
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Abstract

Members of the Rho family of small guanosine triphosphatases (GTPases) regulate the organization of the actin cytoskeleton; Rho controls the assembly of actin stress fibers and focal adhesion complexes, Rac regulates actin filament accumulation at the plasma membrane to produce lamellipodia and membrane ruffles, and Cdc42 stimulates the formation of filopodia. When microinjected into quiescent fibroblasts, Rho, Rac, and Cdc42 stimulated cell cycle progression through G1 and subsequent DNA synthesis. Furthermore, microinjection of dominant negative forms of Rac and Cdc42 or of the Rho inhibitor C3 transferase blocked serum-induced DNA synthesis. Unlike Ras, none of the Rho GTPases activated the mitogen-activated protein kinase (MAPK) cascade that contains the protein kinases c-Raf1, MEK (MAPK or ERK kinase), and ERK (extracellular signal-regulated kinase). Instead, Rac and Cdc42, but not Rho, stimulated a distinct MAP kinase, the c-Jun kinase JNK/SAPK (Jun NH 2 -terminal kinase or stress-activated protein kinase). Rho, Rac, and Cdc42 control signal transduction pathways that are essential for cell growth.

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Metadata

Authors
Olson, M. F., Ashworth, A., & Hall, A.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1995-09
Volume
269
Issue
5228
Pages
1270-1272
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.7652575
OpenAlex
W2087172814
Cited by
1,146
References
2
FWCI
32.21
Type
journal article
Language
en
Open access
closed

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