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Cited by 1,069

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

Minden, Audrey, Lin, Anning, McMahon, Martin, Lange-Carter, Carol, Dérijard, Benoit, Davis, Roger J., Johnson, Gary L., Karin, Michael·1994·Science

Abstract

Growth factors activate mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinases (ERKs) and Jun kinases (JNKs). Although the signaling cascade from growth factor receptors to ERKs is relatively well understood, the pathway leading to JNK activation is more obscure. Activation of JNK by epidermal growth factor (EGF) or nerve growth factor (NGF) was dependent on H-Ras activation, whereas JNK activation by tumor necrosis factor α (TNF-α) was Ras-independent. Ras activates two protein kinases, Raf-1 and MEK (MAPK, or ERK, kinase) kinase (MEKK). Raf-1 contributes directly to ERK activation but not to JNK activation, whereas MEKK participated in JNK activation but caused ERK activation only after overexpression. These results demonstrate the existence of two distinct Ras-dependent MAPK cascades—one initiated by Raf-1 leading to ERK activation, and the other initiated by MEKK leading to JNK activation.

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Metadata

Authors
Minden, A., Lin, A., McMahon, M., Lange-Carter, C., Dérijard, B., Davis, R. J., Johnson, G. L., & Karin, M.
Venue
Science
Published
1994-12-09
Volume
266
Issue
5191
Pages
1719-1723
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2005900169
Cited by
1,069
References
2
FWCI
36.40
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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