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DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway
Abstract
Viral oncogenes remove the host's STING: Cancer-causing viruses, such as the human papilloma virus (HPV) that causes cervical cancer, account for 12% of human cancers. One way they can cause cancer is by targeting tumor suppressor proteins in the host. Now Lau et al. report that DNA tumor viruses can also thwart the host's immune system. Oncogenes from HPV and human adenovirus bound to the protein STING, a key component of the cGAS-STING pathway that senses and defends against intracellular DNA. In this way, the viruses subvert the host's antiviral immunity and set up shop, which, for an unlucky few, eventually causes cancer. Science , this issue p. 568
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“High-risk HPV-18 E7 can directly bind to STING via the pRB binding motif, resulting in inhibition of the cGAS-STING pathway, involving recognition of foreign DNA [356].”
From The Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis (2021) · cites this paper as [356]
In the citing paper
“Host cell PRRs are major targets for immune evasion by HPV and HPV oncoproteins have been demonstrated to repress this innate immune response.”
From The Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis (2021) · cites this paper as [356]
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Metadata
- Authors
- Lau, L., Gray, E. E., Brunette, R. L., & Stetson, D. B.
- Affiliations
- Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA.
- Venue
- Science
- Published
- 2015-10-30
- Volume
- 350
- Issue
- 6260
- Pages
- 568-571
- ISSN
- 0036-8075
- 1095-9203
- PMC
- PMC12974531
- Cited by
- 453
- References
- 11
- Language
- en
- Funders
- Burroughs Wellcome Fund
- Cancer Research Institute
- Rita Allen Foundation
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