The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8 + T cells
Open accessAbstract
Dying to impress the immune system: Besides reacting to microbes, T cells can also mount immune responses to fragments of dying cells, which they encounter displayed on dendritic cells. Not all dying cells activate T cells, however, so what differentiates the dying cells that do? Yatim et al. studied two forms of programmed cells death: apoptosis and necroptosis. Using mouse cells in culture and mouse models of inflammatory cell death and anti-tumor immunity, they found that programmed cell death initiated T cell immunity only when the dying cells signaled through the enzyme RIPK1 and the transcription factor NF-κB. Science , this issue p. 328
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221
Calreticulin exposure dictates the immunogenicity of cancer cell death
Obeid, M., Tesniere, A., Ghiringhelli, F., Fimia, G. M., Apetoh, L., Perfettini, J.-L., Castedo, M., Mignot, G., Panaretakis, T., Casares, N., et al. (2007) · Nature Medicine · doi:10.1038/nm1523 · Cited by 3,216
Batf3 Deficiency Reveals a Critical Role for CD8α + Dendritic Cells in Cytotoxic T Cell Immunity
Hildner, K., Edelson, B. T., Purtha, W. E., Diamond, M., Matsushita, H., Kohyama, M., Calderon, B., Schraml, B. U., Unanue, E. R., Diamond, M. S., et al. (2008) · Science · doi:10.1126/science.1164206 · Cited by 2,081
Ghiringhelli, F., Apetoh, L., Tesniere, A., Aymeric, L., Ma, Y., Ortiz, C., Vermaelen, K., Panaretakis, T., Mignot, G., Ullrich, E., et al. (2009) · Nature Medicine · doi:10.1038/nm.2028 · Cited by 1,898
Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death
Casares, N., Pequignot, M. O., Tesniere, A., Ghiringhelli, F., Roux, S., Chaput, N., Schmitt, E., Hamai, A., Hervas-Stubbs, S., Obeid, M., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050915 · Cited by 1,512
Identification of a dendritic cell receptor that couples sensing of necrosis to immunity
Sancho, D., Joffre, O. P., Keller, A. M., Rogers, N. C., Martínez, D., Hernanz-Falcón, P., Rosewell, I., & Sousa, C. R. E. (2009) · Nature · doi:10.1038/nature07750 · Cited by 750
Self-citationKazama, H., Ricci, J.-E., Herndon, J. M., Hoppe, G., Green, D. R., & Ferguson, T. A. (2008) · Immunity · doi:10.1016/j.immuni.2008.05.013 · Cited by 627
Self-citationRIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3
Dillon, C. P., Weinlich, R., Rodriguez, D. A., Cripps, J. G., Quarato, G., Gurung, P., Verbist, K. C., Brewer, T. L., Llambi, F., Gong, Y.-N., et al. (2014) · Cell · doi:10.1016/j.cell.2014.04.018 · Cited by 562
Self-citationWidespread Mitochondrial Depletion via Mitophagy Does Not Compromise Necroptosis
Tait, S. W. G., Oberst, A., Quarato, G., Milasta, S., Haller, M., Wang, R., Karvela, M., Ichim, G., Yatim, N., Albert, M. L., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.10.034 · Cited by 303
Self-citationOberst, A., Pop, C., Tremblay, A. G., Blais, V., Denault, J.-B., Salvesen, G. S., & Green, D. R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.095083 · Cited by 214
Self-citation
Research works printed but not linked: 38
- 10.1038/32183 · DOI · Paper page
- 10.1038/3315 · DOI · Paper page
- 10.1084/jem.143.5.1283 · DOI · Paper page
- 10.1084/jem.20030966 · DOI · Paper page
- 10.1073/pnas.0908698106 · DOI · Paper page
- 10.1038/nature01991 · DOI · Paper page
- 10.1084/jem.191.3.423 · DOI · Paper page
- 10.1002/ijc.10777 · DOI · Paper page
- 10.1073/pnas.96.5.2233 · DOI · Paper page
- 10.1172/JCI65698 · DOI
- 10.1038/nri11308 · DOI · Paper page
- 10.1016/j.molcel.2011.06.011 · DOI · Paper page
- 10.1016/j.molcel.2011.06.006 · DOI · Paper page
- 10.1038/nri3720 · DOI
- 10.1016/j.molcel.2012.04.026 · DOI · Paper page
- 10.1038/cdd.2014.76 · DOI · Paper page
- 10.1038/onc.2009.356 · DOI · Paper page
- 10.1126/science.1208347 · DOI · Paper page
- 10.1046/j.1365-2567.2002.01513.x · DOI · Paper page
- 10.1038/nri2780 · DOI · Paper page
- 10.1016/j.immuni.2008.03.013 · DOI · Paper page
- Besch R., Poeck H., Hohenauer T., Senft D., Häcker G., Berking C., Hornung V., Endres S., Ruzicka T., Rothenfusser S., Hartmann G., Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells. J. Clin. Invest. 119, 2399–2411 (2009).19620789
- 10.1038/nature03326 · DOI · Paper page
- 10.1146/annurev.iy.12.040194.005015 · DOI · Paper page
- 10.1038/15200 · DOI · Paper page
- 10.1038/nrmicro2539 · DOI · Paper page
- 10.1016/j.chom.2010.06.007 · DOI · Paper page
- 10.1016/j.immuni.2011.10.010 · DOI
- 10.1016/j.molcel.2014.11.001 · DOI
- 10.3389/fimmu.2012.00331 · DOI · Paper page
- 10.1016/j.molcel.2013.01.025 · DOI · Paper page
- 10.1038/cdd.2014.222 · DOI
- 10.1016/j.immuni.2012.09.015 · DOI · Paper page
- 10.1016/j.molcel.2006.03.026 · DOI · Paper page
- 10.1016/S1074-7613(00)80535-X · DOI · Paper page
- 10.1038/cdd.2009.178 · DOI
- 10.1038/ni1061 · DOI · Paper page
- 10.1038/embor.2009.109 · DOI · Paper page
Cited by
Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680
Self-citationElements of cancer immunity and the cancer–immune set point
Chen, D. S., & Mellman, I. (2017) · Nature · doi:10.1038/nature21349 · Cited by 5,352
Immunogenic cell stress and death
Kroemer, G., Galassi, C., Zitvogel, L., & Galluzzi, L. (2022) · Nature Immunology · doi:10.1038/s41590-022-01132-2 · Cited by 1,353
Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors
Galluzzi, L., Humeau, J., Buqué, A., Zitvogel, L., & Kroemer, G. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0413-z · Cited by 1,349
Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion
Friedmann Angeli, J. P., Krysko, D. V., & Conrad, M. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0149-1 · Cited by 1,259
Metadata
- Authors
- Yatim, N., Jusforgues-Saklani, H., Orozco, S., Schulz, O., Barreira da Silva, R., Reis e Sousa, C., Green, D. R., Oberst, A., & Albert, M. L.
- Venue
- Science
- Published
- 2015-10-16
- Volume
- 350
- Issue
- 6258
- Pages
- 328-334
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2146810078
- Cited by
- 622
- References
- 10
- FWCI
- 15.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- Funders
- NIH (R21CA185681, R01AI108685, AI44848, 5R01AI108685-02)
- Francis Crick Institute
- European Research Council
- Cancer Research UK
- Agence Nationale de Recherches sur le Sida et les Hepatitis
- Agence Nationale de la Recherche (ANR-12-BSV3-0011-01)
- French National Cancer Institute (INCa)
- Laboratories of Excellence Immuno-Onco (ANR-11-IDEX-0005-02)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8 + T cells. https://app.cochat.ai/papers/10.1126/science.aad0395
- The paper
- Yatim, N., Jusforgues-Saklani, H., Orozco, S., Schulz, O., Barreira da Silva, R., Reis e Sousa, C., Green, D. R., Oberst, A., & Albert, M. L. (2015). RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8 + T cells. Science. https://doi.org/10.1126/science.aad0395
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
