Myelin plasticity and nervous system function
Open accessAbstract
Structural plasticity in the myelinated infrastructure of the nervous system has come to light. Although an innate program of myelin development proceeds independent of nervous system activity, a second mode of myelination exists in which activity-dependent, plastic changes in myelin-forming cells influence myelin structure and neurological function. These complementary and possibly temporally overlapping activity-independent and activity-dependent modes of myelination crystallize in a model of experience-modulated myelin development and plasticity with broad implications for neurological function. In this article, I consider the contributions of myelin to neural circuit function, the dynamic influences of experience on myelin microstructure, and the role that plasticity of myelin may play in cognition.
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Myelination exhibits activity-dependent plasticity.
“Myelination process also exhibits activity-dependent plasticity (Monje, 2018).”
From What is a cell type and how to define it? (2022) · cites this paper as Monje, 2018
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What is a cell type and how to define it?
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- Authors
- Monje, M.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Monje, Michelle
- ORCID
- Monje, Michelle
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 2018-07-08
- Volume
- 41
- Issue
- 1
- Pages
- 61-76
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- OpenAlex
- W2827807866
- Cited by
- 274
- References
- 112
- Citations by year
- 2026: 28 · 2025: 43 · 2024: 43 · 2023: 30 · 2022: 37 · 2021: 39 · 2020: 32 · 2019: 17 · 2018: 3
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annual Review of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Defense (W81XWH1510131, W81XWH)
- California Institute for Regenerative Medicine (RN3-06510)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- myelin plasticity, myelination, activity-dependent myelination, myelinated axons, neural circuit function, cognition, myelinating cells
- MeSH terms
- Animals, Humans, Myelin Sheath, Nervous System, Nervous System Physiological Phenomena, Neuroglia, Neuronal Plasticity, Neurons
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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