Cited by 274Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research StudiesNeuroscience and Neuropharmacology Research

Myelin plasticity and nervous system function

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Monje, Michelle·2018·Annual Review of Neuroscience

Abstract

Structural plasticity in the myelinated infrastructure of the nervous system has come to light. Although an innate program of myelin development proceeds independent of nervous system activity, a second mode of myelination exists in which activity-dependent, plastic changes in myelin-forming cells influence myelin structure and neurological function. These complementary and possibly temporally overlapping activity-independent and activity-dependent modes of myelination crystallize in a model of experience-modulated myelin development and plasticity with broad implications for neurological function. In this article, I consider the contributions of myelin to neural circuit function, the dynamic influences of experience on myelin microstructure, and the role that plasticity of myelin may play in cognition.

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  • Myelination exhibits activity-dependent plasticity.

    “Myelination process also exhibits activity-dependent plasticity (Monje, 2018).”

    From What is a cell type and how to define it? (2022) · cites this paper as Monje, 2018

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Authors
Monje, M.
Affiliations
Stanford Medicine (US)
Corresponding author
Monje, Michelle
Venue
Annual Review of Neuroscience
Published
2018-07-08
Volume
41
Issue
1
Pages
61-76
ISSN
  • 0147-006X (ISSN-L)
  • 1545-4126
OpenAlex
W2827807866
Cited by
274
References
112
Citations by year
2026: 28 · 2025: 43 · 2024: 43 · 2023: 30 · 2022: 37 · 2021: 39 · 2020: 32 · 2019: 17 · 2018: 3
FWCI
2.86
Type
journal article
Language
en
Open access
Locations
  • Annual Review of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Department of Defense (W81XWH1510131, W81XWH)
  • California Institute for Regenerative Medicine (RN3-06510)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
myelin plasticity, myelination, activity-dependent myelination, myelinated axons, neural circuit function, cognition, myelinating cells
MeSH terms
Animals, Humans, Myelin Sheath, Nervous System, Nervous System Physiological Phenomena, Neuroglia, Neuronal Plasticity, Neurons

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