Oligodendrocyte progenitor cells in Alzheimer's disease: from physiology to pathology

Lecanemab in early Alzheimer's disease

van Dyck, C. H., Swanson, C. J., Aisen, P., Bateman, R. J., Chen, C., Gee, M., Kanekiyo, M., Li, D., Reyderman, L., Cohen, S., et al. (2023) · New England Journal of Medicine · doi:10.1056/nejmoa2212948 · Cited by 5,678 · see citing works

A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease

Keren-Shaul, H., Spinrad, A., Weiner, A., Matcovitch-Natan, O., Dvir-Szternfeld, R., Ulland, T. K., David, E., Baruch, K., Lara-Astaiso, D., Toth, B., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.018 · Cited by 5,493 · see citing works

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089 · see citing works

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

Leng, F., & Edison, P. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-020-00435-y · Cited by 3,179 · see citing works

Single-cell transcriptomic analysis of Alzheimer’s disease

Mathys, H., Davila-Velderrain, J., Peng, Z., Gao, F., Mohammadi, S., Young, J. Z., Menon, M., He, L., Abdurrob, F., Jiang, X., et al. (2019) · Nature · doi:10.1038/s41586-019-1195-2 · Cited by 2,568 · see citing works

Senolytics improve physical function and increase lifespan in old age

Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0092-9 · Cited by 2,287 · cited 1× · see citing works

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

Di Micco, R., Krizhanovsky, V., Baker, D., & d’Adda di Fagagna, F. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00314-w · Cited by 2,277 · cited 1× · see citing works

Complex cell-state changes revealed by single cell RNA sequencing of 76,149 microglia throughout the mouse lifespan and in the injured brain

Hammond, T. R., Dufort, C., Dissing-Olesen, L., Giera, S., Young, A., Wysoker, A., Walker, A. J., Segel, M., Nemesh, J., Saunders, A., et al. (2018) · doi:10.1101/406140 · Cited by 2,225 · see citing works

Microglia states and nomenclature: A field at its crossroads

Paolicelli, R. C., Sierra, A., Stevens, B., Tremblay, M.-E., Aguzzi, A., Ajami, B., Amit, I., Audinat, E., Bechmann, I., Bennett, M., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.10.020 · Cited by 1,973 · see citing works

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

Salloway, S., Sperling, R., Fox, N. C., Blennow, K., Klunk, W., Raskind, M., Sabbagh, M., Honig, L. S., Porsteinsson, A. P., Ferris, S., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1304839 · Cited by 1,960 · see citing works

Concise review: MSC-derived exosomes for cell-free therapy

Phinney, D. G., & Pittenger, M. F. (2017) · Stem Cells · doi:10.1002/stem.2575 · Cited by 1,834 · see citing works

Biology of Oligodendrocyte and Myelin in the Mammalian Central Nervous System

Baumann, N., & Pham-Dinh, D. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.871 · Cited by 1,828 · see citing works

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

Zhang, B., Gaiteri, C., Bodea, L.-G., Wang, Z., McElwee, J., Podtelezhnikov, A. A., Zhang, C., Xie, T., Tran, L., Dobrin, R., et al. (2013) · Cell · doi:10.1016/j.cell.2013.03.030 · Cited by 1,657 · see citing works

Remyelination in the CNS: from biology to therapy

Franklin, R. J. M., & ffrench-Constant, C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2480 · Cited by 1,544 · see citing works

Microglial interactions with synapses are modulated by visual experience

Tremblay, M.-È., Lowery, R. L., & Majewska, A. K. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000527 · Cited by 1,542 · see citing works

Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain

Gibson, E. M., Purger, D., Mount, C. W., Goldstein, A. K., Lin, G. L., Wood, L. S., Inema, I., Miller, S. E., Bieri, G., Zuchero, J. B., et al. (2014) · Science · doi:10.1126/science.1252304 · Cited by 1,472 · see citing works

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

Yamazaki, Y., Zhao, N., Caulfield, T. R., Liu, C.-C., & Bu, G. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0228-7 · Cited by 1,425 · see citing works

Normal development of brain circuits

Tau, G. Z., & Peterson, B. S. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.115 · Cited by 1,391 · see citing works

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

Bussian, T. J., Aziz, A., Meyer, C. F., Swenson, B. L., van Deursen, J. M., & Baker, D. J. (2018) · Nature · doi:10.1038/s41586-018-0543-y · Cited by 1,289 · see citing works

Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: Recent advances.

Wang, W., Zhao, F., Ma, X., Perry, G., & Zhu, X. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00376-6 · Cited by 1,274 · see citing works

Cellular Senescence: Aging, Cancer, and Injury

Calcinotto, A., Kohli, J., Zagato, E., Pellegrini, L., Demaria, M., & Alimonti, A. (2019) · Physiological Reviews · doi:10.1152/physrev.00020.2018 · Cited by 1,270 · see citing works

Signal transduction via the MAP kinases: proceed at your own RSK.

Blenis, J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.13.5889 · Cited by 1,258 · see citing works

Normal aging induces A1-like astrocyte reactivity

Clarke, L. E., Liddelow, S. A., Chakraborty, C., Münch, A. E., Heiman, M., & Barres, B. A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1800165115 · Cited by 1,237 · see citing works

Senolytic drugs: from discovery to translation

Kirkland, J. L., & Tchkonia, T. (2020) · Journal of Internal Medicine · doi:10.1111/joim.13141 · Cited by 1,227 · see citing works

Motor skill learning requires active central myelination

McKenzie, I. A., Ohayon, D., Li, H., Paes de Faria, J., Emery, B., Tohyama, K., & Richardson, W. D. (2014) · Science · doi:10.1126/science.1254960 · Cited by 1,177 · see citing works

Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus

Bergles, D. E., Roberts, J. D. B., Somogyi, P., & Jahr, C. E. (2000) · Nature · doi:10.1038/35012083 · Cited by 1,062 · see citing works

Trial of Solanezumab for Mild Dementia Due to Alzheimer’s Disease

Honig, L. S., Vellas, B., Woodward, M., Boada, M., Bullock, R., Borrie, M., Hager, K., Andreasen, N., Scarpini, E., Liu-Seifert, H., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1705971 · Cited by 1,049 · cited 1× · see citing works

Disease-associated astrocytes in Alzheimer’s disease and aging

Habib, N., McCabe, C., Medina, S., Varshavsky, M., Kitsberg, D., Dvir-Szternfeld, R., Green, G., Dionne, D., Nguyen, L., Marshall, J. L., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0624-8 · Cited by 1,009 · see citing works

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

Zhang, P., Kishimoto, Y., Grammatikakis, I., Gottimukkala, K., Cutler, R. G., Zhang, S., Abdelmohsen, K., Bohr, V. A., Misra Sen, J., Gorospe, M., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0372-9 · Cited by 977 · see citing works

PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice

Rivers, L. E., Young, K. M., Rizzi, M., Jamen, F., Psachoulia, K., Wade, A., Kessaris, N., & Richardson, W. D. (2008) · Nature Neuroscience · doi:10.1038/nn.2220 · Cited by 961 · see citing works

A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation

Grubman, A., Chew, G., Ouyang, J. F., Sun, G., Choo, X. Y., McLean, C., Simmons, R. K., Buckberry, S., Vargas-Landin, D. B., Poppe, D., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0539-4 · Cited by 956 · see citing works

Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity

Nishiyama, A., Komitova, M., Suzuki, R., & Zhu, X. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2495 · Cited by 865 · see citing works

Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis

Kuhlmann, T., Miron, V., Cuo, Q., Wegner, C., Antel, J., & Bruck, W. (2008) · Brain · doi:10.1093/brain/awn096 · Cited by 864 · see citing works

Oxidative Stress and the Pathogenesis of Alzheimer's Disease

Zhao, Y., & Zhao, B. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/316523 · Cited by 855 · see citing works

A Review: Inflammatory Process in Alzheimer's Disease, Role of Cytokines

Rubio-Perez, J. M., & Morillas-Ruiz, J. M. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/756357 · Cited by 841 · see citing works

Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor ceil

Noble, M., Murray, K., Stroobant, P., Waterfield, M. D., & Riddle, P. (1988) · Nature · doi:10.1038/333560a0 · Cited by 830 · see citing works

Myelin Impairs CNS Remyelination by Inhibiting Oligodendrocyte Precursor Cell Differentiation

Kotter, M. R., Li, W.-W., Zhao, C., & Franklin, R. J. M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2615-05.2006 · Cited by 768 · see citing works

The blood-brain barrier in Alzheimer’s disease

Zenaro, E., Piacentino, G., & Constantin, G. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.07.007 · Cited by 767 · see citing works

White matter changes in Alzheimer’s disease: A focus on myelin and oligodendrocytes

Nasrabady, S. E., Rizvi, B., Goldman, J. E., & Brickman, A. M. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0515-3 · Cited by 723 · see citing works

NG2 cells generate both oligodendrocytes and gray matter astrocytes

Zhu, X., Bergles, D. E., & Nishiyama, A. (2007) · Development · doi:10.1242/dev.004895 · Cited by 678 · see citing works

Regulation of oligodendrocyte differentiation and myelination

Emery, B. (2010) · Science · doi:10.1126/science.1190927 · Cited by 653 · see citing works

Rejuvenation of Regeneration in the Aging Central Nervous System

Ruckh, J. M., Zhao, J.-W., Shadrach, J. L., van Wijngaarden, P., Rao, T. N., Wagers, A. J., & Franklin, R. J. M. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2011.11.019 · Cited by 649 · see citing works

Regenerating CNS myelin — from mechanisms to experimental medicines

Franklin, R. J. M., & ffrench-Constant, C. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.136 · Cited by 647 · cited 2× · see citing works

The Age-Related Decrease in CNS Remyelination Efficiency Is Attributable to an Impairment of Both Oligodendrocyte Progenitor Recruitment and Differentiation

Sim, F. J., Zhao, C., Penderis, J., & Franklin, R. J. M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02451.2002 · Cited by 625 · see citing works

Oligodendrocytes in development, myelin generation and beyond

Kuhn, S., Gritti, L., Crooks, D., & Dombrowski, Y. (2019) · Cells · doi:10.3390/cells8111424 · Cited by 625 · see citing works

Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders

Jucker, M., & Walker, L. C. (2011) · Annals of Neurology · doi:10.1002/ana.22615 · Cited by 622 · cited 1× · see citing works

Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation

Nistor, G. I., Totoiu, M. O., Haque, N. S. K., Carpenter, M. K., & Keirstead, H. S. (2004) · Glia · doi:10.1002/glia.20127 · Cited by 580 · see citing works

Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis

Falcão, A. M., van Bruggen, D., Marques, S., Meijer, M., Jäkel, S., Agirre, E., Samudyata, Floriddia, E. M., Vanichkina, D. P., ffrench-Constant, C., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0236-y · Cited by 579 · see citing works

Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease

Barage, S. H., & Sonawane, K. D. (2015) · Neuropeptides · doi:10.1016/j.npep.2015.06.008 · Cited by 579 · see citing works

Exosomes — beyond stem cells for restorative therapy in stroke and neurological injury

Zhang, Z. G., Buller, B., & Chopp, M. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-018-0126-4 · Cited by 549 · see citing works

Retinoid X receptor gamma signaling accelerates CNS remyelination

Huang, J. K., Jarjour, A. A., Nait Oumesmar, B., Kerninon, C., Williams, A., Krezel, W., Kagechika, H., Bauer, J., Zhao, C., Evercooren, A. B.-V., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2702 · Cited by 547 · see citing works

Niche stiffness underlies the ageing of central nervous system progenitor cells

Segel, M., Neumann, B., Hill, M. F. E., Weber, I. P., Viscomi, C., Zhao, C., Young, A., Agley, C. C., Thompson, A. J., Gonzalez, G. A., et al. (2019) · Nature · doi:10.1038/s41586-019-1484-9 · Cited by 532 · see citing works

A singularity of PDGF alpha-receptor expression in the dorsoventral axis of the neural tube may define the origin of the oligodendrocyte lineage

Pringle, N. P., & Richardson, W. D. (1993) · Development · doi:10.1242/dev.117.2.525 · Cited by 510 · see citing works

Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning

Xiao, L., Ohayon, D., McKenzie, I. A., Sinclair-Wilson, A., Wright, J. L., Fudge, A. D., Emery, B., Li, H., & Richardson, W. D. (2016) · Nature Neuroscience · doi:10.1038/nn.4351 · Cited by 507 · see citing works

Oligodendrocyte Population Dynamics and the Role of PDGF In Vivo

Calver, A. R., Hall, A. C., Yu, W., Walsh, F. S., Heath, J. K., Betsholtz, C., & Richardson, W. D. (1998) · Neuron · doi:10.1016/s0896-6273(00)80469-9 · Cited by 501 · see citing works

Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency

Shen, S., Sandoval, J., Swiss, V. A., Li, J., Dupree, J. L., Franklin, R. J. M., & Casaccia‐Bonnefil, P. (2008) · Nature Neuroscience · doi:10.1038/nn.2172 · Cited by 486 · see citing works

Oligodendrocyte precursors migrate along vasculature in the developing nervous system

Tsai, H.-H., Niu, J., Munji, R., Davalos, D., Chang, J., Zhang, H., Tien, A.-C., Kuo, C. J., Chan, J. R., Daneman, R., et al. (2016) · Science · doi:10.1126/science.aad3839 · Cited by 483 · see citing works

Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease

Depp, C., Sun, T., Sasmita, A. O., Spieth, L., Berghoff, S. A., Nazarenko, T., Overhoff, K., Steixner-Kumar, A. A., Subramanian, S., Arinrad, S., et al. (2023) · Nature · doi:10.1038/s41586-023-06120-6 · Cited by 476 · cited 3× · see citing works

The multifaceted exosome: Biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities

Pant, S., Hilton, H., & Burczynski, M. E. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.12.037 · Cited by 470 · see citing works

Diversity in function and regulation of MAP kinase pathways

BLUMER, K. J., & Johnson, G. L. (1994) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(94)90147-3 · Cited by 465 · see citing works

Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue

Snaidero, N., Möbius, W., Czopka, T., Hekking, L. H. P., Mathisen, C., Verkleij, D., Goebbels, S., Edgar, J. M., Merkler, D., Lyons, D. A., et al. (2014) · Cell · doi:10.1016/j.cell.2013.11.044 · Cited by 451 · see citing works

Metformin restores CNS remyelination capacity by rejuvenating aged stem cells

Neumann, B., Baror, R., Zhao, C., Segel, M., Dietmann, S., Rawji, K. S., Foerster, S., McClain, C. R., Chalut, K., van Wijngaarden, P., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.08.015 · Cited by 449 · see citing works

What Is the Optimal Value of the g-Ratio for Myelinated Fibers in the Rat CNS? A Theoretical Approach

Chomiak, T., & Hu, B. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007754 · Cited by 446 · see citing works

Oligodendrocyte, Astrocyte, and Microglia Crosstalk in Myelin Development, Damage, and Repair

Domingues, H. S., Portugal, C. C., Socodato, R., & Relvas, J. B. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00071 · Cited by 438 · see citing works

Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination

Kirby, L., Jin, J., Cardona, J. G., Smith, M. D., Martin, K. A., Wang, J., Strasburger, H., Herbst, L., Alexis, M., Karnell, J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11638-3 · Cited by 436 · cited 1× · see citing works

Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease

Rangaraju, S., Dammer, E. B., Raza, S. A., Rathakrishnan, P., Xiao, H., Gao, T., Duong, D. M., Pennington, M. W., Lah, J. J., Seyfried, N. T., et al. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0254-8 · Cited by 430 · see citing works

Disruption of oligodendrogenesis impairs memory consolidation in adult mice

Steadman, P. E., Xia, F., Ahmed, M., Mocle, A. J., Penning, A. R. A., Geraghty, A. C., Steenland, H. W., Monje, M., Josselyn, S. A., & Frankland, P. W. (2020) · Neuron · doi:10.1016/j.neuron.2019.10.013 · Cited by 426 · see citing works

Motor skill learning induces changes in white matter microstructure and myelination

Sampaio-Baptista, C., Khrapitchev, A. A., Foxley, S., Schlagheck, T., Scholz, J., Jbabdi, S., DeLuca, G. C., Miller, K. L., Taylor, A., Thomas, N., et al. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3048-13.2013 · Cited by 417 · see citing works

Proinflammatory cytokines IL-6 and TNF-α and the development of inflammation in obese subjects

Popko, K., Górska, E., Stelmaszczyk‐Emmel, A., Pływaczewski, R., Stokłosa, A., Górecka, D., Pyrżak, B., & Demkow, U. A. (2010) · European journal of medical research · doi:10.1186/2047-783x-15-s2-120 · Cited by 407 · see citing works

Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice

Ogrodnik, M., Evans, S. A., Fielder, E., Victorelli, S., Kruger, P., Salmonowicz, H., Weigand, B. M., Patel, A. D., Pirtskhalava, T., Inman, C. L., et al. (2021) · Aging Cell · doi:10.1111/acel.13296 · Cited by 405 · see citing works

Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines

Cheng, A., Wan, R., Yang, J.-L., Kamimura, N., Son, T. G., Ouyang, X., Luo, Y., Okun, E., & Mattson, M. P. (2012) · Nature Communications · doi:10.1038/ncomms2238 · Cited by 401 · see citing works

Microglia Priming with Aging and Stress

Niraula, A., Sheridan, J. F., & Godbout, J. P. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.185 · Cited by 398 · see citing works

Synaptic pathology in Alzheimer's disease: a review of ultrastructural studies

Scheff, S. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.08.002 · Cited by 391 · see citing works

The Chemokine Receptor CXCR2 Controls Positioning of Oligodendrocyte Precursors in Developing Spinal Cord by Arresting Their Migration

Tsai, H., Frost, E. E., To, V., Robinson, S., ffrench‐Constant, C., Geertman, R. T., Ransohoff, R. M., & Miller, R. H. (2002) · Cell · doi:10.1016/s0092-8674(02)00838-3 · Cited by 388 · see citing works

Oligodendrocyte wars

Richardson, W. D., Kessaris, N., & Pringle, N. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1826 · Cited by 385 · see citing works

Antioxidant Therapies for Alzheimer's Disease

Feng, Y., & Wang, X. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/472932 · Cited by 382 · see citing works

Preservation of a remote fear memory requires new myelin formation

Pan, S., Mayoral, S. R., Choi, H. S., Chan, J. R., & Kheirbek, M. A. (2020) · Nature Neuroscience · doi:10.1038/s41593-019-0582-1 · Cited by 366 · see citing works

PDGF A-chain gene is expressed by mammalian neurons during development and in maturity

Yeh, H.-J., Ruit, K. G., Wang, Y.-X., Parks, W. C., Snider, W. D., & Deuel, T. F. (1991) · Cell · doi:10.1016/0092-8674(91)90222-k · Cited by 364 · see citing works

Tau and neuroinflammation: what impact for Alzheimer's disease and tauopathies?

Laurent, C., Buée, L., & Blum, D. (2018) · Biomedical Journal · doi:10.1016/j.bj.2018.01.003 · Cited by 348 · see citing works

Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer’s disease

Chen, J.-F., Liu, K., Hu, B., Li, R.-R., Xin, W., Chen, H., Wang, F., Chen, L., Li, R.-X., Ren, S.-Y., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.05.012 · Cited by 346 · see citing works

Mitochondrial Dysfunction, Oxidative Stress, Neuroinflammation, and Metabolic Alterations in the Progression of Alzheimer's Disease: A Meta-Analysis of In Vivo Magnetic Resonance Spectroscopy Studies

Song, T., Song, X., Zhu, C., Patrick, R., Skurla, M., Santangelo, I., Green, M., Harper, D., Ren, B., Forester, B. P., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101503 · Cited by 346 · see citing works

Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner

Mitew, S., Gobius, I., Fenlon, L. R., McDougall, S. J., Hawkes, D. J., Xing, Y. L., Bujalka, H., Gundlach, A. L., Richards, L. J., Kilpatrick, T. J., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02719-2 · Cited by 345 · see citing works

Microglia phagocytose myelin sheaths to modify developmental myelination

Hughes, A. N., & Appel, B. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0654-2 · Cited by 344 · see citing works

Nanoparticles as carriers for drug delivery in cancer

Dadwal, A., Baldi, A., & Narang, R. K. (2018) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2018.1457039 · Cited by 344 · see citing works

IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes

Hsieh, J., Aimone, J. B., Kaspar, B. K., Kuwabara, T., Nakashima, K., & Gage, F. H. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200308101 · Cited by 334 · see citing works

The clinical promise of biomarkers of synapse damage or loss in Alzheimer’s disease

the Synaptic Health Endpoints Working Group, Colom-Cadena, M., Spires-Jones, T., Zetterberg, H., Blennow, K., Caggiano, A., DeKosky, S. T., Fillit, H., Harrison, J. E., Schneider, L. S., et al. (2020) · Alzheimer's Research & Therapy · doi:10.1186/s13195-020-00588-4 · Cited by 328 · see citing works

Highly Stabilized Curcumin Nanoparticles Tested in an In Vitro Blood–Brain Barrier Model and in Alzheimer’s Disease Tg2576 Mice

Cheng, K. K., Yeung, C. F., Ho, S. W., Chow, S. F., Chow, A. H. L., & Baum, L. (2012) · The AAPS Journal · doi:10.1208/s12248-012-9444-4 · Cited by 315 · see citing works

Motor learning promotes remyelination via new and surviving oligodendrocytes

Bacmeister, C. M., Barr, H. J., McClain, C. R., Thornton, M. A., Nettles, D., Welle, C. G., & Hughes, E. G. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0637-3 · Cited by 310 · see citing works

The identity and function of microglia in neurodegeneration

Song, W. M., & Colonna, M. (2018) · Nature Immunology · doi:10.1038/s41590-018-0212-1 · Cited by 308 · see citing works

The pathology of multiple sclerosis is the result of focal inflammatory demyelination with axonal damage

Brück, W. (2005) · Journal of Neurology · doi:10.1007/s00415-005-5002-7 · Cited by 307 · see citing works

Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors

Gautier, H. O. B., Evans, K. A., Volbracht, K., James, R., Sitnikov, S., Lundgaard, I., James, F., Lao‐Peregrín, C., Reynolds, R., Franklin, R. J. M., et al. (2015) · Nature Communications · doi:10.1038/ncomms9518 · Cited by 305 · see citing works

Bapineuzumab for mild to moderate Alzheimer’s disease in two global, randomized, phase 3 trials

Vandenberghe, R., Rinne, J. O., Boada, M., Katayama, S., Scheltens, P., Vellas, B., Tuchman, M., Gass, A., Fiebach, J. B., Hill, D., et al. (2016) · Alzheimer's Research & Therapy · doi:10.1186/s13195-016-0189-7 · Cited by 304 · see citing works

Demyelination Causes Adult CNS Progenitors to Revert to an Immature State and Express Immune Cues That Support Their Migration

Moyon, S., Dubessy, A., Aigrot, M. S., Trotter, M. W. B., Huang, J. K., Dauphinot, L., Potier, M., Kerninon, C., Parsadaniantz, S. M., Franklin, R. J. M., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0849-14.2015 · Cited by 295 · see citing works

Transcriptional Convergence of Oligodendrocyte Lineage Progenitors during Development

Marques, S., van Bruggen, D., Vanichkina, D. P., Floriddia, E. M., Munguba, H., Väremo, L., Giacomello, S., Falcão, A. M., Meijer, M., Björklund, Å. K., et al. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.07.005 · Cited by 290 · see citing works

Tau Activation of Microglial cGAS–IFN Reduces MEF2C‐mediated Cognitive Resilience

Udeochu, J. C., Amin, S., Huang, Y., Fan, L., Torres, E. R. S., Carling, G. K., Liu, B., McGurran, H., Coronas-Samano, G., Kauwe, G., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01315-6 · Cited by 289 · see citing works

Loss of adaptive myelination contributes to methotrexate chemotherapy-related cognitive impairment

Geraghty, A. C., Gibson, E. M., Ghanem, R. A., Greene, J. J., Ocampo, A., Goldstein, A. K., Ni, L., Yang, T., Marton, R. M., Paşca, S. P., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.04.032 · Cited by 288 · see citing works

Insufficient OPC migration into demyelinated lesions is a cause of poor remyelination in MS and mouse models

Boyd, A. L., Zhang, H., & Williams, A. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1112-y · Cited by 284 · see citing works

Amyloid-β peptide induces oligodendrocyte death by activating the neutral sphingomyelinase–ceramide pathway

Lee, J.-T., Xu, J., Lee, J.-M., Ku, G., Han, X., Yang, D.-I., Chen, S., & Hsu, C. Y. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200307017 · Cited by 280 · see citing works

Glia: the fulcrum of brain diseases

Giaume, C., Kirchhoff, F., Matute, C., Reichenbach, A., & Verkhratsky, A. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402144 · Cited by 260 · see citing works

The adult oligodendrocyte can participate in remyelination

Duncan, I. D., Radcliff, A. B., Heidari, M., Kidd, G., August, B. K., & Wierenga, L. A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1808064115 · Cited by 259 · see citing works

Cellular senescence and Alzheimer disease: the egg and the chicken scenario

Saez-Atienzar, S., & Masliah, E. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-0325-z · Cited by 257 · see citing works

An Oligovascular Niche: Cerebral Endothelial Cells Promote the Survival and Proliferation of Oligodendrocyte Precursor Cells

Arai, K., & Lo, E. H. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0035-09.2009 · Cited by 246 · see citing works

Aberrant oligodendroglial–vascular interactions disrupt the blood–brain barrier, triggering CNS inflammation

Niu, J., Tsai, H., Hoi, K. K., Huang, N., Yu, G., Kim, K., Baranzini, S. E., Xiao, L., Chan, J. R., & Fancy, S. P. J. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0369-4 · Cited by 241 · see citing works

Multiple Cerebral Hemorrhages in a Patient Receiving Lecanemab and Treated with t-PA for Stroke

Reish, N. J., Jamshidi, P., Stamm, B. J., Flanagan, M. E., Sugg, E., Tang, M., Donohue, K. L., McCord, M., Krumpelman, C. S., Mesulam, M. M., et al. (2023) · New England Journal of Medicine · doi:10.1056/nejmc2215148 · Cited by 234 · see citing works

Cell Microenvironment Engineering and Monitoring for Tissue Engineering and Regenerative Medicine: The Recent Advances

Barthès, J., Özçelik, H., Hindié, M., Halili, A. N., Hasan, A., & Vrana, N. E. (2014) · BioMed Research International · doi:10.1155/2014/921905 · Cited by 229 · see citing works

The Chemokine Growth-Regulated Oncogene-α Promotes Spinal Cord Oligodendrocyte Precursor Proliferation

Robinson, S., Tani, M., Strieter, R. M., Ransohoff, R. M., & Miller, R. H. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-24-10457.1998 · Cited by 229 · see citing works

Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis

Nicaise, A. M., Wagstaff, L. J., Willis, C. M., Paisie, C. A., Chandok, H., Robson, P., Fossati, V., Williams, A., & Crocker, S. J. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1818348116 · Cited by 227 · see citing works

Dynamic changes in myelin aberrations and oligodendrocyte generation in chronic amyloidosis in mice and men

Behrendt, G., Baer, K., Buffo, A., Curtis, M. A., Faull, R. L., Rees, M. I., Götz, M., & Dimou, L. (2013) · Glia · doi:10.1002/glia.22432 · Cited by 219 · see citing works

Motor Function in Subjects with Mild Cognitive Impairment and Early Alzheimer’s Disease

Pettersson, A. F., Olsson, E., & Wahlund, L. (2005) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000084555 · Cited by 218 · see citing works

Act1 mediates IL-17-induced EAE pathogenesis selectively in NG2+ glial cells

Kang, Z., Wang, C., Zepp, J., Wu, L., Sun, K., Zhao, J., Chandrasekharan, U., DiCorleto, P. E., Trapp, B. D., Ransohoff, R. M., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3505 · Cited by 218 · see citing works

Oxidative stress and impaired oligodendrocyte precursor cell differentiation in neurological disorders

Spaas, J., van Veggel, L., Schepers, M., Tiane, A., van Horssen, J., Wilson, D. M., Moya, P. R., Piccart, E., Hellings, N., Eijnde, B. O., et al. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03802-0 · Cited by 217 · see citing works

Targeting the Synapse in Alzheimer’s Disease

Jackson, J., Jambrina, E., Li, J., Marston, H., Menzies, F., Phillips, K., & Gilmour, G. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00735 · Cited by 215 · see citing works

Long-Term Potentiation of Neuron-Glia Synapses Mediated by Ca 2+ -Permeable AMPA Receptors

Ge, W., Yang, X.-J., Zhang, Z., Wang, H.-K., Shen, W., Deng, Q.-D., & Duan, S. (2006) · Science · doi:10.1126/science.1124669 · Cited by 208 · see citing works

Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion

Plemel, J. R., Stratton, J. A., Michaels, N. J., Rawji, K. S., Zhang, E., Sinha, S., Baaklini, C. S., Dong, Y., Ho, M., Thorburn, K., et al. (2020) · Science Advances · doi:10.1126/sciadv.aay6324 · Cited by 208 · see citing works

A light and electron microscopic study of NG2 chondroitin sulfate proteoglycan-positive oligodendrocyte precursor cells in the normal and kainate-lesioned rat hippocampus

Ong, W., & Levine, J. M. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00751-9 · Cited by 206 · see citing works

Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis

Weng, Q., Wang, J., Wang, J., He, D., Cheng, Z., Zhang, F., Verma, R., Xu, L., Dong, X., Liao, Y., et al. (2019) · Cell stem cell · doi:10.1016/j.stem.2019.03.006 · Cited by 206 · see citing works

Safety of Mesenchymal Stem Cells for Clinical Application

Wang, Y., Han, Z., Song, Y., & Han, Z. (2012) · Stem Cells International · doi:10.1155/2012/652034 · Cited by 206 · see citing works

Cellular Senescence and Inflammaging in Age-Related Diseases

Olivieri, F., Prattichizzo, F., Grillari, J., & Balistreri, C. R. (2018) · Mediators of Inflammation · doi:10.1155/2018/9076485 · Cited by 200 · see citing works

Mitochondrial dynamics and transport in Alzheimer's disease

Flannery, P. J., & Trushina, E. V. (2019) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2019.06.009 · Cited by 198 · see citing works

Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17

Iram, T., Kern, F., Kaur, A., Myneni, S., Morningstar, A. R., Shin, H., García, M. Á., Yerra, L. P., Pálovics, R., Yang, A. C., et al. (2022) · Nature · doi:10.1038/s41586-022-04722-0 · Cited by 198 · see citing works

Exosomes derived from bone marrow mesenchymal stromal cells promote remyelination and reduce neuroinflammation in the demyelinating central nervous system

Zhang, J., Buller, B., Zhang, Z. G., Zhang, Y., Lü, M., Rosene, D. L., Medalla, M., Moore, T. L., & Chopp, M. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113895 · Cited by 195 · see citing works

Periods of synchronized myelin changes shape brain function and plasticity

de Faria, O., Pivoňková, H., Varga, B. V., Timmler, S., Evans, K. A., & Káradóttir, R. T. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00917-2 · Cited by 193 · see citing works

Life Extension Factor Klotho Prevents Mortality and Enhances Cognition in hAPP Transgenic Mice

Dubal, D. B., Zhu, L., Sanchez, P. E., Worden, K., Broestl, L., Johnson, E. C. B., Ho, K., Yu, G.-Q., Kim, D., Bétourné, A., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.5791-12.2015 · Cited by 192 · see citing works

Short-term learning induces white matter plasticity in the fornix

Hofstetter, S., Tavor, I., Tzur Moryosef, S., & Assaf, Y. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4520-12.2013 · Cited by 190 · see citing works

Double-blind, placebo-controlled, proof-of-concept trial of bexarotene in moderate Alzheimer’s disease

Cummings, J. L., Zhong, K., Kinney, J. W., Heaney, C., Moll-Tudla, J., Joshi, A., Pontecorvo, M., Devous, M., Tang, A., & Bena, J. (2016) · Alzheimer's Research & Therapy · doi:10.1186/s13195-016-0173-2 · Cited by 190 · see citing works

The role of myelin damage in Alzheimer’s disease pathology

Papuć, E., & Rejdak, K. (2020) · Archives of Medical Science · doi:10.5114/aoms.2018.76863 · Cited by 188 · see citing works

Focal demyelination in Alzheimer’s disease and transgenic mouse models

Mitew, S., Kirkcaldie, M. T. K., Halliday, G. M., Shepherd, C. E., Vickers, J. C., & Dickson, T. C. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0657-2 · Cited by 186 · see citing works

Mechanisms of Pathogenic Tau and Aβ Protein Spreading in Alzheimer’s Disease

d’Errico, P., & Meyer‐Luehmann, M. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00265 · Cited by 182 · see citing works

Pattern of remyelination in the CNS

BLAKEMORE, W. F. (1974) · Nature · doi:10.1038/249577a0 · Cited by 182 · see citing works

Oligodendrocyte Precursor Cells Support Blood-Brain Barrier Integrity via TGF-β Signaling

Seo, J. H., Maki, T., Maeda, M., Miyamoto, N., Liang, A. C., Hayakawa, K., Pham, L. D., Suwa, F., Taguchi, A., Matsuyama, T., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103174 · Cited by 181 · see citing works

Polydendrocytes: NG2 Cells with Many Roles in Development and Repair of the CNS

Nishiyama, A. (2007) · The Neuroscientist · doi:10.1177/1073858406295586 · Cited by 179 · see citing works

Oligodendrocyte precursor cells engulf synapses during circuit remodeling in mice

Auguste, Y. S. S., Ferro, A., Kahng, J. A., Xavier, A. M., Dixon, J. R., Vrudhula, U., Nichitiu, A.-S., Rosado, D., Wee, T.-L., Pedmale, U. V., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01170-x · Cited by 178 · see citing works

Quantitative profiling brain proteomes revealed mitochondrial dysfunction in Alzheimer’s disease

Adav, S. S., Park, J. E., & Sze, S. K. (2019) · Molecular Brain · doi:10.1186/s13041-019-0430-y · Cited by 175 · see citing works

High-intensity interval training ameliorates Alzheimer's disease-like pathology by regulating astrocyte phenotype-associated AQP4 polarization

Feng, S., Wu, C., Zou, P., Deng, Q., Chen, Z., Li, M., Zhu, L., Li, F., Liu, T. C., Duan, R., et al. (2023) · Theranostics · doi:10.7150/thno.81951 · Cited by 170 · see citing works

Photobiomodulation therapy promotes neurogenesis by improving post-stroke local microenvironment and stimulating neuroprogenitor cells

Yang, L., Tucker, D., Dong, Y., Wu, C., Lu, Y., Li, Y., Zhang, J., Liu, T. C., & Zhang, Q. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.10.013 · Cited by 168 · see citing works

Potential Effects of MSC-Derived Exosomes in Neuroplasticity in Alzheimer’s Disease

Reza-Zaldívar, E. E., Hernández-Sapiéns, M. A., Minjarez, B. D., Gutiérrez-Mercado, Y. K., Márquez-Aguirre, A. L., & Canales-Aguirre, A. A. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00317 · Cited by 168 · see citing works

An aging, pathology burden, and glial senescence build-up hypothesis for late onset Alzheimer’s disease

Lau, V. Z., Ramer, L. M., & Tremblay, M. (2023) · Nature Communications · doi:10.1038/s41467-023-37304-3 · Cited by 168 · see citing works

Innovative nano-carriers in anticancer drug delivery-a comprehensive review

Dong, P. W., Rakesh, K. P., Manukumar, H. M. G., Mohammed, Y. H. I., Karthik, C. S., Sumathi, S., Mallu, P., & Qin, H. (2019) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2019.01.019 · Cited by 166 · see citing works

The Antiaging Protein Klotho Enhances Oligodendrocyte Maturation and Myelination of the CNS

Chen, C.-D., Sloane, J. A., Li, H., Aytan, N., Giannaris, E. L., Zeldich, E., Hinman, J. D., Dedeoglu, A., Rosene, D. L., Bansal, R., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2080-12.2013 · Cited by 165 · see citing works

Effects of Exercise Training on Anxious–Depressive-like Behavior in Alzheimer Rat

Wu, C., Yang, L., Li, Y., Dong, Y., YANG, B., Tucker, L. D., Zong, X., & Zhang, Q. (2020) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002294 · Cited by 161 · see citing works

The Beneficial Effects of Mind-Body Exercises for People With Mild Cognitive Impairment: a Systematic Review With Meta-analysis

Zou, L., Loprinzi, P. D., Yeung, A., Zeng, N., & Huang, T. (2019) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2019.03.009 · Cited by 160 · see citing works

Oligodendrocyte precursor cells ingest axons in the mouse neocortex

Buchanan, J., Elabbady, L., Collman, F., Jorstad, N. L., Bakken, T. E., Ott, C. M., Glatzer, J. C., Bleckert, A., Bodor, Á. L., Brittain, D., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2202580119 · Cited by 154 · see citing works

Modulation of platelet-derived growth factor receptor expression in microvascular endothelial cells during in vitro angiogenesis.

Marx, M., Perlmutter, R. A., & Madri, J. A. (1994) · Journal of Clinical Investigation · doi:10.1172/jci116936 · Cited by 152 · see citing works

The role of glial cells in multiple sclerosis disease progression

Healy, L. M., Stratton, J. A., Kuhlmann, T., & Antel, J. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00624-x · Cited by 152 · cited 1× · see citing works

A small-molecule PI3Kα activator for cardioprotection and neuroregeneration

Gong, G. Q., Bilanges, B., Allsop, B., Masson, G. R., Roberton, V. H., Askwith, T., Oxenford, S. J., Madsen, R. R., Conduit, S. E., Bellini, D., et al. (2023) · Nature · doi:10.1038/s41586-023-05972-2 · Cited by 151 · see citing works

Oxidative Stress and Metabolic Syndrome: Cause or Consequence of Alzheimer's Disease?

Contreras, D. L., Carvajal, K., Toral-Ríos, D., Franco-Bocanegra, D., & Campos‐Peña, V. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/497802 · Cited by 148 · see citing works

Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune functionPreprint

Akay, L. A., Effenberger, A. H., & Tsai, L. (2021) · Genes & Development · doi:10.1101/gad.344218.120 · Cited by 142 · see citing works

Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice

Dumont, M., Stack, C., Elipenahli, C., Jainuddin, S., Gerges, M., Starkova, N. N., Yang, L., Starkov, A. A., & Beal, F. M. (2011) · The FASEB Journal · doi:10.1096/fj.11-186650 · Cited by 139 · see citing works

Current and emerging avenues for Alzheimer's disease drug targets

Loera‐Valencia, R., Cedazo-Mı́nguez, Á., Kenigsberg, P.-A., Page, G., Duarte, A. I., Giusti, P., Zusso, M., Robert, P. H., Frisoni, G. B., Cattaneo, A., et al. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12959 · Cited by 139 · see citing works

NG2 glia regulate brain innate immunity via TGF-β2/TGFBR2 axis

Zhang, S.-Z., Wang, Q., Yang, Q., Gu, H., Yin, Y., Li, Y., Hou, J., Chen, R., Sun, Q., Sun, Y., et al. (2019) · BMC Medicine · doi:10.1186/s12916-019-1439-x · Cited by 138 · see citing works

Differential cell proliferation in the cortex of the appsweps1de9 alzheimer's disease mouse model

Kamphuis, W., Orre, M., Kooijman, L., Dahmen, M., & Hol, E. M. (2012) · Glia · doi:10.1002/glia.22295 · Cited by 137 · see citing works

Non-invasive photobiomodulation treatment in an Alzheimer Disease-like transgenic rat model

Yang, L., Wu, C., Parker, E., Li, Y., Dong, Y., Tucker, L. D., Brann, D. W., Lin, H. W., & Zhang, Q. (2022) · Theranostics · doi:10.7150/thno.70756 · Cited by 137 · see citing works

Myelin repair in vivo is increased by targeting oligodendrocyte precursor cells with nanoparticles encapsulating leukaemia inhibitory factor (LIF)

Rittchen, S., Boyd, A. L., Burns, A., Park, J. Y., Fahmy, T. M., Metcalfe, S. M., & Williams, A. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.03.044 · Cited by 131 · see citing works

Disruption of oligodendrocyte progenitor cells is an early sign of pathology in the triple transgenic mouse model of Alzheimer's disease

Vanzulli, I., Papanikolaou, M., De-La-Rocha, I. C., Pieropan, F., Rivera, A. D., Gomez-Nicola, D., Verkhratsky, A., Rodríguez, J. J., & Butt, A. M. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.05.016 · Cited by 130 · see citing works

Integrin‐growth factor interactions as regulators of oligodendroglial development and function

Baron, W., Colognato, H., & ffrench-Constant, C. (2005) · Glia · doi:10.1002/glia.20132 · Cited by 129 · see citing works

The injury response of oligodendrocyte precursor cells is induced by platelets, macrophages and inflammation-associated cytokines

Rhodes, K. E., Raivich, G., & Fawcett, J. W. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.01.055 · Cited by 128 · see citing works

Cdk5 Phosphorylation of WAVE2 Regulates Oligodendrocyte Precursor Cell Migration through Nonreceptor Tyrosine Kinase Fyn

Miyamoto, Y., Yamauchi, J., & Tanoue, A. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1482-08.2008 · Cited by 126 · see citing works

The effect of glia-glia interactions on oligodendrocyte precursor cell biology during development and in demyelinating diseases

Clemente, D., Ortega, M. C., Melero‐Jerez, C., & de Castro, F. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00268 · Cited by 122 · see citing works

Acetylation changes tau interactome to degrade tau in Alzheimer’s disease animal and organoid models

Choi, H., Kim, H. J., Yang, J., Chae, S., Lee, W., Chung, S., Kim, J., Choi, H., Song, H., Lee, C. K., et al. (2019) · Aging Cell · doi:10.1111/acel.13081 · Cited by 122 · see citing works

Interplay Between Age and Neuroinflammation in Multiple Sclerosis: Effects on Motor and Cognitive Functions

Musella, A., Gentile, A., Rizzo, F. R., Vito, F. D., Fresegna, D., Bullitta, S., Vanni, V., Guadalupi, L., Bassi, M. S., Buttari, F., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00238 · Cited by 121 · see citing works

From OPC to Oligodendrocyte: An Epigenetic Journey

Tiane, A., Schepers, M., Rombaut, B., Hupperts, R., Prickaerts, J., Hellings, N., van den Hove, D., & Vanmierlo, T. (2019) · Cells · doi:10.3390/cells8101236 · Cited by 121 · see citing works

Alzheimer’s Disease, Inflammation, and the Role of Antioxidants

Sinyor, B., Mineo, J., & Ochner, C. (2020) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-200171 · Cited by 120 · cited 1× · see citing works

Microvesicles and intercellular communication in the context of parasitism

Barteneva, N. S., Maltsev, N., & Vorobjev, I. A. (2013) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2013.00049 · Cited by 120 · see citing works

Co-Localization of Glia Maturation Factor with NLRP3 Inflammasome and Autophagosome Markers in Human Alzheimer’s Disease Brain

Ahmed, M. E., Iyer, S. S., Thangavel, R., Kempuraj, D., Selvakumar, G. P., Raikwar, S. P., Zaheer, S. A., & Zaheer, A. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170634 · Cited by 120 · see citing works

The Therapeutic Potential of Mesenchymal Stem Cell–Derived Exosomes in Treatment of Neurodegenerative Diseases

Gorabi, A. M., Kiaie, N., Barreto, G. E., Read, M. I., Tafti, S. H. A., & Sahebkar, A. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01663-0 · Cited by 120 · see citing works

Beneficial Effects of Exercise Pretreatment in a Sporadic Alzheimer’s Rat Model

Wu, C., Yang, L., Tucker, D., Dong, Y., Zhu, L., Duan, R., Liu, T. C., & Zhang, Q. (2017) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001519 · Cited by 113 · see citing works

NG2 glia-derived GABA release tunes inhibitory synapses and contributes to stress-induced anxiety

Zhang, X., Liu, Y., Hong, X., Li, X., Meshul, C. K., Moore, C., Yang, Y., Han, Y., Li, W., Qi, X., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25956-y · Cited by 112 · see citing works

Oligodendrocyte progenitor cell recruitment and remyelination in multiple sclerosis: the more, the merrier?

Tepavčević, V., & Lubetzki, C. (2022) · Brain · doi:10.1093/brain/awac307 · Cited by 112 · see citing works

The Role of Mitochondrial Damage-Associated Molecular Patterns in Chronic Neuroinflammation

Bajwa, E., Pointer, C. B., & Klegeris, A. (2019) · Mediators of Inflammation · doi:10.1155/2019/4050796 · Cited by 111 · see citing works

Potential interactions between pericytes and oligodendrocyte precursor cells in perivascular regions of cerebral white matter

Maki, T., Maeda, M., Uemura, M. T., Lo, E. K., Terasaki, Y., Liang, A. C., Shindo, A., Choi, Y. K., Taguchi, A., Matsuyama, T., et al. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.04.047 · Cited by 110 · see citing works

Transcriptional control of myelination and remyelination

Sock, E., & Wegner, M. (2019) · Glia · doi:10.1002/glia.23636 · Cited by 109 · see citing works

Cellular Senescence and Iron Dyshomeostasis in Alzheimer’s Disease

Masaldan, S., Belaidi, A. A., Ayton, S., & Bush, A. I. (2019) · Pharmaceuticals · doi:10.3390/ph12020093 · Cited by 103 · see citing works

Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance

Zhang, X., Pearsall, V. M., Carver, C. M., Atkinson, E. J., Clarkson, B. D. S., Grund, E. M., Baez-Faria, M., Pavelko, K. D., Kachergus, J. M., White, T. A., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33226-8 · Cited by 102 · see citing works

Astrocytes protect oligodendrocyte precursor cells via MEK/ERK and PI3K/Akt signaling

Arai, K., & Lo, E. H. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22256 · Cited by 101 · see citing works

PACAP‐38 induces neuronal differentiation of human SH‐SY5Y neuroblastoma cells via cAMP‐mediated activation of ERK and p38 MAP kinases1

Monaghan, T. K., MacKenzie, C., Plevin, R. J., & Lutz, E. M. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05018.x · Cited by 101 · see citing works

Neuronally-directed effects of RXR activation in a mouse model of Alzheimer’s disease

Mariani, M. M., Malm, T., Lamb, R., Jay, T. R., Neilson, L., Casali, B., Medarametla, L., & Landreth, G. E. (2017) · Scientific Reports · doi:10.1038/srep42270 · Cited by 98 · cited 1× · see citing works

Iron Accumulation during Cellular Senescence

KILLILEA, D. W., WONG, S. L., CAHAYA, H. S., ATAMNA, H., & AMES, B. N. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1297.063 · Cited by 97 · see citing works

Adaptive and maladaptive myelination in health and disease

Knowles, J. K., Batra, A., Xu, H., & Monje, M. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00737-3 · Cited by 94 · see citing works

Long-term exercise pre-training attenuates Alzheimer’s disease–related pathology in a transgenic rat model of Alzheimer’s disease

Yang, L., Wu, C., Li, Y., Dong, Y., Wu, C. Y., Lee, R. H., Brann, D. W., Lin, H. W., & Zhang, Q. (2022) · GeroScience · doi:10.1007/s11357-022-00534-2 · Cited by 93 · see citing works

The impact of gamma transcranial alternating current stimulation (tACS) on cognitive and memory processes in patients with mild cognitive impairment or Alzheimer's disease: A literature review

Nissim, N. R., Pham, D. V., Poddar, T., Blutt, E., & Hamilton, R. H. (2023) · Brain stimulation · doi:10.1016/j.brs.2023.04.001 · Cited by 93 · see citing works

NG2 glial cells regulate neuroimmunological responses to maintain neuronal function and survival

Nakano, M., Tamura, Y., Yamato, M., Kume, S., Eguchi, A., Takata, K., Watanabe, Y., & Kataoka, Y. (2017) · Scientific Reports · doi:10.1038/srep42041 · Cited by 89 · see citing works

The active contribution of OPCs to neuroinflammation is mediated by LRP1

Fernández-Castañeda, A., Chappell, M. S., Rosen, D. A., Seki, S. M., Beiter, R. M., Johanson, D. M., Liskey, D., Farber, E., Önengüt-Gümüşcü, S., Overall, C. C., et al. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-02073-1 · Cited by 87 · see citing works

Microglial NMDA receptors drive pro‐inflammatory responses via PARP‐1/TRMP2 signaling

Raghunatha, P., Vosoughi, A. R., Kauppinen, T. M., & Jackson, M. F. (2020) · Glia · doi:10.1002/glia.23790 · Cited by 87 · see citing works

Oligodendrocyte Dysfunction in Amyotrophic Lateral Sclerosis: Mechanisms and Therapeutic Perspectives

Raffaele, S., Boccazzi, M., & Fumagalli, M. (2021) · Cells · doi:10.3390/cells10030565 · Cited by 86 · see citing works

α-Synuclein impairs oligodendrocyte progenitor maturation in multiple system atrophy

May, V. E. L., Ettle, B., Poehler, A.-M., Nuber, S., Ubhi, K. K., Rockenstein, E. M., Winner, B., Wegner, M., Masliah, E., & Winkler, J. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.02.028 · Cited by 84 · see citing works

Can Exercise-Induced Modulation of the Tumor Physiologic Microenvironment Improve Antitumor Immunity?

Zhang, X., Ashcraft, K. A., Warner, A. B., Nair, S. K., & Dewhirst, M. W. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-2468 · Cited by 84 · see citing works

Elevated microglial oxidative phosphorylation and phagocytosis stimulate post-stroke brain remodeling and cognitive function recovery in mice

Song, S., Yu, L., Hasan, M. N., Paruchuri, S. S., Mullett, S. J., Sullivan, M. L. G., Fiesler, V. M., Young, C. B., Stolz, D. B., Wendell, S. G., et al. (2022) · Communications Biology · doi:10.1038/s42003-021-02984-4 · Cited by 83 · see citing works

Astrocyte endfoot formation controls the termination of oligodendrocyte precursor cell perivascular migration during development

Su, Y., Wang, X., Yang, Y., Chen, L., Xia, W., Hoi, K. K., Li, H. Z., Wang, Q., Yu, G., Chen, X., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.10.032 · Cited by 83 · see citing works

Oligodendrocyte precursor cells transplantation protects blood–brain barrier in a mouse model of brain ischemia via Wnt/β-catenin signaling

Wang, L., Geng, J., Qu, M., Yuan, F., Wang, Y., Pan, J., Li, Y., Ma, Y., Zhou, P., Zhang, Z., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-019-2206-9 · Cited by 83 · see citing works

Aging, Cellular Senescence, and Progressive Multiple Sclerosis

Papadopoulos, D., Magliozzi, R., Mitsikostas, D. D., Gorgoulis, V. G., & Nicholas, R. S. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00178 · Cited by 83 · see citing works

Novel Treatment Strategies Targeting Myelin and Oligodendrocyte Dysfunction in Schizophrenia

Junqueira, D. G., Falvella, A. C. B., Antunes, A. S. L. M., Seabra, G., Brandão‐Teles, C., Martins‐de‐Souza, D., & Crunfli, F. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00379 · Cited by 80 · see citing works

Cross-Talk of the CNS With Immune Cells and Functions in Health and Disease

Matejuk, A., Vandenbark, A. A., & Offner, H. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.672455 · Cited by 79 · see citing works

Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development

Ehrnhoefer, D. E., Wong, B. K. Y., & Hayden, M. R. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3556 · Cited by 78 · see citing works

NG2 glia are required for maintaining microglia homeostatic state

Liu, Y., & Aguzzi, A. (2019) · Glia · doi:10.1002/glia.23721 · Cited by 78 · see citing works

Mesenchymal stem cell-derived extracellular vesicles promote microglial M2 polarization after subarachnoid hemorrhage in rats and involve the AMPK/NF-κB signaling pathway

Han, M., Cao, Y., Guo, X., Chu, X., Li, T., Xue, H., Xin, D., Yuan, L., Ke, H., Li, G., et al. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111048 · Cited by 77 · see citing works

Activation of hypothalamic-enhanced adult-born neurons restores cognitive and affective function in Alzheimer's disease

Li, Y.-D., Luo, Y., Xie, L., Tart, D. S., Sheehy, R. N., Zhang, L., Coleman, L. G., Chen, X., & Song, J. (2023) · Cell Stem Cell · doi:10.1016/j.stem.2023.02.006 · Cited by 77 · see citing works

Glial cells as integrators of peripheral and central signals in the regulation of energy homeostasis

Nampoothiri, S. S., Nogueiras, R., Schwaninger, M., & Prévot, V. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00610-z · Cited by 75 · see citing works

Metformin accelerates myelin recovery and ameliorates behavioral deficits in the animal model of multiple sclerosis via adjustment of AMPK/Nrf2/mTOR signaling and maintenance of endogenous oligodendrogenesis during brain self-repairing period

Sanadgol, N., Barati, M., Houshmand, F., Hassani, S., Clarner, T., Shahlaei, M., & Golab, F. (2019) · Pharmacological Reports · doi:10.1007/s43440-019-00019-8 · Cited by 74 · see citing works

Photobiomodulation as a treatment for neurodegenerative disorders: current and future trends

Hong, N. (2019) · Biomedical Engineering Letters · doi:10.1007/s13534-019-00115-x · Cited by 71 · see citing works

Aging compromises oligodendrocyte precursor cell maturation and efficient remyelination in the monkey brain

Dimovasili, C., Fair, A. E., Garza, I., Batterman, K. V., Mortazavi, F., Moore, T. L., & Rosene, D. L. (2022) · GeroScience · doi:10.1007/s11357-022-00621-4 · Cited by 71 · see citing works

Cellular senescence in Alzheimer’s disease: from physiology to pathology

Zhu, J., Wu, C., & Yang, L. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00447-4 · Cited by 70 · see citing works

From Genetics to Neuroinflammation: The Impact of ApoE4 on Microglial Function in Alzheimer’s Disease

Dias, D., Portugal, C. C., Relvas, J. B., & Socodato, R. (2025) · Cells · doi:10.3390/cells14040243 · Cited by 66 · see citing works

“Rewiring brain immunity: targeting microglial metabolism for neuroprotection in neurodegenerative disorders”

Shokr, M. M. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-025-01739-y · Cited by 62 · see citing works

The impact of physical exercise on neuroinflammation mechanism in Alzheimer’s disease

Hu, J., Huang, B., & Chen, K. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1444716 · Cited by 52 · see citing works

Myelin dysfunction in aging and brain disorders: mechanisms and therapeutic opportunities

Huang, Z., Zhang, Y., Zou, P., Zong, X., & Zhang, Q. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00861-w · Cited by 46 · see citing works

Navigating oligodendrocyte precursor cell aging in brain health

Leenders, F., Koole, L., Slaets, H., Tiane, A., van den Hove, D., & Vanmierlo, T. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111959 · Cited by 30 · see citing works

Neuroplasticity and Nervous System Recovery: Cellular Mechanisms, Therapeutic Advances, and Future Prospects

Tătăranu, L. G., & Rizea, R. E. (2025) · Brain Sciences · doi:10.3390/brainsci15040400 · Cited by 29 · see citing works

Does photobiomodulation alter mitochondrial dynamics?

Trajano, L. A. D. S. N., Siqueira, P. B., Rodrigues, M. M. D. S., Pires, B. R. B., da Fonseca, A. D. S., & Mencalha, A. L. (2024) · Photochemistry and Photobiology · doi:10.1111/php.13963 · Cited by 27 · see citing works

Alzheimer’s Disease: From Molecular Mechanisms to Promising Therapeutic Strategies

Ivanova, A. V., Kutuzova, A. D., Kuzmichev, I., & Abakumov, M. A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199444 · Cited by 32 · see citing works

Glial cell nutrient sensing: mechanisms of nutrients regulating Alzheimer’s pathogenesis and precision intervention

Yan, Q., Qin, Q., Zhang, S., Chen, F., Ru, Y., Zhong, Y., & Wu, G. (2025) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2025.2568606 · Cited by 27 · see citing works

Senescent brain cell types in Alzheimer's disease: Pathological mechanisms and therapeutic opportunities

Hudson, H. R., Sun, X., & Orr, M. E. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00519 · Cited by 26 · see citing works

The Role of Oligodendrocytes in Neurodegenerative Diseases: Unwrapping the Layers

Panichi, L. B., Stanca, S., Dolciotti, C., & Bongioanni, P. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104623 · Cited by 20 · see citing works

Integrated multi-omics analyses of synaptosomes revealed synapse-associated novel targets in Alzheimer’s disease

Kumar, S., Ramos, E., Hidalgo, A. M., Rodarte, D., Sharma, B., Torres, M. M., Devara, D., & Gadad, S. S. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03095-w · Cited by 21 · see citing works

Alzheimer’s Disease, Obesity, and Type 2 Diabetes: Focus on Common Neuroglial Dysfunctions (Critical Review and New Data on Human Brain and Models)

Tolédano, A., Rodríguez‐Casado, A., Álvarez, M., & Toledano‐Díaz, A. (2024) · Brain Sciences · doi:10.3390/brainsci14111101 · Cited by 19 · see citing works

Emerging Role of Oligodendrocytes Malfunction in the Progression of Alzheimer's Disease

Tylek, K., & Basta‐Kaim, A. (2025) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-025-10236-z · Cited by 18 · see citing works

Treadmill Exercise Mitigates Alzheimer’s Pathology by Modulating Glial Polarization and Reducing Oligodendrocyte Precursor Cell Perivascular Clustering

Wu, C., Zou, P., Zhu, L., Feng, S., Deng, Q., Liu, T. C., Duan, R., & YANG, L. (2025) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000003650 · Cited by 16 · see citing works

Oligodendrogenesis in Evolution, Development and Adulthood

Hu, H., Gao, T.-H., Zhao, J.-W., & Li, H. (2025) · Glia · doi:10.1002/glia.70033 · Cited by 13 · see citing works

Advances in the genetics and pathology of Lewy body dementia

Scholz, S. W., Okubadejo, N. U., Prakash, P., Liddelow, S. A., Ryten, M., & Halliday, G. M. (2025) · The Lancet Neurology · doi:10.1016/s1474-4422(25)00363-1 · Cited by 18 · see citing works

Diversity, Functional Complexity, and Translational Potential of Glial Cells in the Central Nervous System

Wawrzyniak, A., Krawczyk-Marć, I., Żuryń, A., Walocha, J. A., & Balawender, K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26189080 · Cited by 16 · see citing works

Serum/glucocorticoid regulated kinase 1 (SGK1) in neurological disorders: pain or gain

Howard, P. G., Zou, P., Zhang, Y., Huang, F., Tesic, V., Wu, C. Y.-C., & Lee, R. H.-C. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114973 · Cited by 13 · see citing works

Current Development of iPSC-Based Modeling in Neurodegenerative Diseases

Guo, X., Wang, X., Wang, J., Ma, M., & Ren, Q. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083774 · Cited by 14 · see citing works

Dynamic Intercellular Networks in the CNS: Mechanisms of Crosstalk from Homeostasis to Neurodegeneration

Zheng, Y., Huang, R., & Pan, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178155 · Cited by 11 · see citing works

Shifting Microglial Phenotypes: Targeting Disease-Associated Microglia in Neurodegeneration

Sasidharan, A., Somayaji, Y., & Fernandes, R. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00159 · Cited by 10 · see citing works

The Genomic Intersection of Oligodendrocyte Dynamics in Schizophrenia and Aging Unravels Novel Pathological Mechanisms and Therapeutic Potentials

Rivera, A. D., Normanton, J. R., Butt, A. M., & Azim, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084452 · Cited by 10 · see citing works

The Many Lives of an Oligodendrocyte Precursor Cell

Buchanan, J., & Cheadle, L. (2025) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-112723-025806 · Cited by 10 · see citing works

Is age-related myelinodegenerative change an initial risk factor of neurodegenerative diseases?

Wu, S., & Chen, J. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00848 · Cited by 9 · see citing works

From Organotypic Mouse Brain Slices to Human Alzheimer’s Plasma Biomarkers: A Focus on Nerve Fiber Outgrowth

Yilmaz, S. N., Steiner, K., Marksteiner, J., Faserl, K., Villunger, M., Sarg, B., & Humpel, C. (2024) · Biomolecules · doi:10.3390/biom14101326 · Cited by 9 · see citing works

The Role of Oligodendrocyte Lineage Cells in the Pathogenesis of Alzheimer’s Disease

Liu, X., Lv, Z., Huang, Q., Lei, Y., Liu, H., & Xu, P. (2025) · Neurochemical Research · doi:10.1007/s11064-024-04325-3 · Cited by 9 · see citing works

Neuropathological links between T2DM and LOAD: systematic review and meta-analysis

Lemche, E., Hortobágyi, T., Kiecker, C. M., & Turkheimer, F. (2025) · Physiological Reviews · doi:10.1152/physrev.00040.2024 · Cited by 8 · see citing works

Glial Cells in Alzheimer’s Disease: Pathogenic Mechanisms and Therapeutic Frontiers

Sil, M., Mukherjee, N., Chatterjee, I., Ghosh, A., & Goswami, A. (2025) · Journal of Molecular Neuroscience · doi:10.1007/s12031-025-02379-8 · Cited by 8 · see citing works

Toll-Like Receptor 4-Mediated Neuroinflammation: Updates on Pathological Roles and Therapeutic Strategies in Chronic Cerebral Hypoperfusion

Yawoot, N., Tocharus, J., & Tocharus, C. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04718-7 · Cited by 7 · see citing works

Analysis of changes in intercellular communications in Alzheimer’s disease reveals conserved changes in glutamatergic transmission in mice and humans

Bartas, K., Nguyen, M. H., Zhao, W., Hui, M., Nie, Q., & Beier, K. T. (2025) · Scientific Reports · doi:10.1038/s41598-025-10795-4 · Cited by 12 · see citing works

Voluntary running exercise promotes maturation differentiation and myelination of oligodendrocytes around Aβ plaques in the medial prefrontal cortex of APP/PS1 mice.

Pan, Q.-X., Jang, L., Xiong, Y., Chao, F.-L., Liu, S., Zhang, S.-S., Zhu, L., Luo, Y.-M., Xiao, Q., Tang, J., et al. (2024) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2024.111170 · Cited by 6 · see citing works

Ancestral genomic functional differences in oligodendroglia: implications for Alzheimer's disease

Ramírez, A. M., Nasciben, L. B., Moura, S., Coombs, L. E., Rajabli, F., DeRosa, B. A., Whitehead, P. L., Adams, L. D., Starks, T. D., Mena, P. R., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70593 · Cited by 6 · see citing works

Intercellular signaling and synaptic deconstruction uncovered by single-cell and spatial transcriptomics in an AD tauopathy model

Ji, J. X., Giles, B. L., Bhattacharjee, S., Kautzmann, M.-A. I., Masson, A. P., Carmo, S. D., Cuello, A. C., & Bazan, N. G. (2025) · Communications Biology · doi:10.1038/s42003-025-08959-z · Cited by 6 · see citing works

Myelin Lipid Reserves as a Conditional Metabolic Buffer: Implications for Alzheimer’s Disease and Ischemic Stroke

Zou, P., Huang, Z., Zhang, Y., Zong, X., & Zhang, Q. (2026) · NeuroMolecular Medicine · doi:10.1007/s12017-026-08905-0 · Cited by 6 · see citing works

Up-regulation of myelin-associated glycoprotein is associated with the ameliorating effect of omega-3 polyunsaturated fatty acids on Alzheimer's disease progression in APP–PS1 transgenic mice

Shao, Y. H., Li, F., Zou, B., Jin, Y., Wang, X., Wang, L.-T., Huang, Y., Xie, Y., Sun, W., Kang, J. X., et al. (2024) · Food & Function · doi:10.1039/d4fo03355h · Cited by 6 · see citing works

Roles of Ion Channels in Oligodendrocyte Precursor Cells: From Physiology to Pathology

Wang, J., Shen, Y., Liao, P. S., Yang, B., & Jiang, R. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157336 · Cited by 6 · see citing works

Regulatory T cells in stroke inflammation: Therapeutic perspectives

Sun, Z., Zhou, H., Wang, Y.-J., & Li, Z.-X. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01424 · Cited by 6 · see citing works

Early life adversity and adult attention-deficit/hyperactivity disorder (ADHD): Pathways to persistence and adult susceptibility

Zou, P., Huang, Z., Zong, X., & Zhang, Q. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106436 · Cited by 5 · see citing works

Cellular senescence in brain aging and neurodegeneration: from molecular mechanisms to translational opportunities

Cantero‐Fortiz, Y., Butler, C., Montalbán, X., & Boada, M. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1805691 · Cited by 5 · see citing works

Identifying the Role of Oligodendrocyte Genes in the Diagnosis of Alzheimer's Disease through Machine Learning and Bioinformatics Analysis

Chen, Y., Li, C., Yao, Y., & Yazhen, S. (2024) · Current Alzheimer Research · doi:10.2174/0115672050338777241028071955 · Cited by 5 · see citing works

Clemastine enhances myelin formation in the striatum and medial prefrontal cortex and improves sociability in a neonatal rat hypoxic-ischemic model

Feng, Y., Ma, X., Zong, X., Jordan, J. D., Wu, C. Y., Tešić, V., Lee, R. H., & Zhang, Q. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.117916 · Cited by 5 · see citing works

The Role of Oligodendrocytes in Alzheimer’s Disease Pathogenesis and Therapy

Guo, S., Yu, X., & Zhang, H. (2025) · Neuroglia · doi:10.3390/neuroglia6040046 · Cited by 5 · see citing works

Gut microbiota and myelination: Crosstalk across the lifespan and microbiota-based modulation strategies

Li, Q., Wang, G., Zhao, J., Chen, W., & Tian, P. (2025) · Microbiological Research · doi:10.1016/j.micres.2025.128286 · Cited by 5 · see citing works

Research progress of cell senescence in Alzheimer's disease: mechanisms and therapy.

Cai, J., Yang, L., Xu, Y., Wang, L., Zhang, M., Qiao, J.-W., Xu, Q., Zhu, H., & Cai, M. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177697 · Cited by 6 · see citing works

Mechanistic correlation of potassium channel sensing and nitric oxide activity in neuroinflammation

Mannan, A., & Singh, T. G. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10954-w · Cited by 3 · see citing works

Targeting Oligodendrocyte Dysfunction in Alzheimer’s Disease: a New Frontier for Drug Repurposing with Antihistamines and Serotonin Receptor Agonists

Gurikar, S., Ahmed, S. S., & Raghunatahanaidu, B. D. (2025) · Journal of Molecular Neuroscience · doi:10.1007/s12031-025-02433-5 · Cited by 3 · see citing works

Exploring the Therapeutic Potential of Piezo1 in Ageing-Related Neurodegenerative Diseases

Kaur, A., Singh, S., Vishwas, S., & Singh, T. (2026) · Journal of Molecular Neuroscience · doi:10.1007/s12031-025-02449-x · Cited by 3 · see citing works

ACSS2 maintains oligodendrocyte progenitor cell pool and is required for myelination during development and aging

Gao, W., Chen, S., Huang, Y., (10164), X. W., Zhuang, L., Zheng, Y., Dai, X., Fu, Y., Chen, W., Ye, Q., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01071-9 · Cited by 3 · see citing works

The impact of kidney dysfunction on blood-brain barrier integrity and neurological conditions

Aderinto, N., Olatunji, G. D., Kokori, E., Ogieuhi, I., Ayodeji, K. B., Ajekiigbe, V. O., Bisola, M.-A. I., Ajayi, J. O., Agbo, C. E., Omoworare, O. T., et al. (2026) · The Egyptian Journal of Neurology Psychiatry and Neurosurgery · doi:10.1186/s41983-026-01132-1 · Cited by 3 · see citing works

Senescence as a Central Node in Alzheimer’s Disease: Molecular Triggers, Cellular Effectors, and RNA-Based Interventions

Some, A., Naskar, N., Thomas, D. M., Jeengar, M. K., & Nassar, A. (2026) · Neurochemical Research · doi:10.1007/s11064-026-04737-3 · Cited by 3 · see citing works

Extracellular Vesicles in Alzheimer’s Disease: Mechanisms, Biomarkers, and Therapeutic Engineering

Wang, L., Mao, L., & Zong, X. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27093974 · Cited by 4 · see citing works

Agarwood as a potential therapeutic for Alzheimer's disease: Mechanistic insights and target identification

Ma, Y., Hu, X., Karako, K., Song, P., Tang, W., & Xia, Y. (2024) · Drug Discoveries & Therapeutics · doi:10.5582/ddt.2024.01085 · Cited by 3 · see citing works

Isoliquiritigenin ameliorates abnormal oligodendrocyte development and behavior disorders induced by white matter injury

Wu, D., Zhou, W., Du, J., Zhao, T., Li, N., Fan, P., Li, A., Zhang, X., Zhang, M., & Hao, A. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1473019 · Cited by 2 · see citing works

Oligodendroglia in Ageing and Age-Dependent Neurodegenerative Diseases

Niu, J., Verkhratsky, A., Butt, A. M., & Yi, C. (2025) · Advances in neurobiology · doi:10.1007/978-3-031-87919-7_13 · Cited by 3 · see citing works

Encapsulated mesenchymal stem cell-derived exosomes promote optic nerve regeneration and functional recovery in a mouse model of optic nerve crush injury

Shoae‐Hassani, A., Niknam, P., Ahmadirad, N., Aghdam, K. A., Javan, M., Mirshahi, R., Naseripour, M., & Dehghan, S. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.124013 · Cited by 2 · see citing works

White matter degeneration precedes tau aggregation in rats with Alzheimer's-like tauopathy

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Hsieh, K., Zhang, K., Chu, Y., Yu, L., Li, X., Hu, N., Kawosa, I., Pilie, P. G., Bhattacharya, P. K., Zhi, D., et al. (2025) · Briefings in Bioinformatics · doi:10.1093/bib/bbaf296 · Cited by 2 · see citing works

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SIRT1 decreases Aβ-induced IL-1β production by suppressing NLRP3 inflammasome activation and M1 microglial polarization

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The 1920s and 1930s

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Gene Expression in the Hippocampus

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van Tellingen, O., Tolboom, Z. J., Leter, Y. M., Tsouri, E., Burylo, A. M., Heijningen, C. L. V., Schagen, S. B., de Gooijer, M. C., & Kuil, L. E. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.11.681780

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Liu, T., Hao, M., Sun, E., Markov, Y., Zhang, L., Zou, J., & Zhao, H. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.03.692255

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Feng, S., & Yang, L. (2026) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-025-01939-0

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Iman, T., Akram, R., Tehreem, A., Asghar, A., Mustafa, M., & Iqbal, J. (2026) · IGI Global eBooks · doi:10.4018/979-8-3373-4139-2.ch001

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Zhou, X., Zhang, Y., Sun, L., Kwok, C. K., & Zhang, J. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.20.700564

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Ju, M., Shen, H., Zhang, X., Tian, M., & Zhang, L. (2026) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2026.102475

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Zafar, S., Rasheed, U., & Zerr, I. (2026) · IntechOpen eBooks · doi:10.5772/intechopen.1013648

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Translational stem cell therapy for neurodegeneration and CNS trauma: a focused review

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Lü, K., Lu, Y., Tang, R., Dong, X., Zhuang, P., Gao, Y., Cheng, M., Wang, Y., & Wang, Y. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261460879

Characterizing the impact of plasma protein levels on human brain structure and disorders leveraging integrative multi-omics analysisPreprint

Ayubcha, C., Dennis, E., Bhattacharyya, U., John, J., Lam, M., Lencz, T., Ge, T., & Chen, C. (2026) · medRxiv · doi:10.64898/2026.07.13.26358006 · Cited by 1 · see citing works

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Clusterin regulates microglial inflammation and cognitive function independent of amyloid pathology in Alzheimer’s diseasePreprint

Rawal, P., Moon, H.-J., Nguyen, V., Khatri, S., Larson, M. A., Vivian, J. C., Saido, T. C., & Zhao, L. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.30.741791

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Non-invasive visual theta entrainment modulates myelin-related and functional outcomes in an LPC-induced demyelination model

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Emerging Role of Oligodendrocytes Malfunction in the Progression of Alzheimer's Disease

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The Role of Oligodendrocytes in Alzheimer’s Disease Pathogenesis and Therapy

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Evidence for oligodendrocyte progenitor cell heterogeneity and their role in Alzheimer's disease

Beiter, R. M. (2022) · Libra · doi:10.18130/7aja-as23

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