Cited by 593Inflammasome and immune disordersImmune Response and InflammationImmunotherapy and Immune Responses

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

Open access

Zanoni, Ivan, Tan, Yunhao, Di Gioia, Marco, Broggi, Achille, Ruan, Jianbin, Shi, Jianjin, Donado, Carlos A., Shao, Feng, Wu, Hao, Springstead, James R., Kagan, Jonathan C.·2016·Science

DOI 10.1126/science.aaf3036PMC PMC5111085

Open this paper in CoChat — free account

Abstract

Immune activation in context: Dendritic cells (DCs) initiate protective immunity upon binding molecules derived from microbes or released from dying cells. Zanoni et al. examined how microbial and endogenous signals interact to shape the course of the ensuing immune response (see the Perspective by Napier and Monack). They found that oxPAPC, an oxidized phospholipid released from dying cells, binds to a protein called caspase-11 in DCs, activating an inflammatory program in these cells. Whereas caspase-11 binding to oxPAPC and bacterial lipopolysaccharide causes DCs to produce the cytokine interleukin-1 (IL-1) and undergo cell death, binding to oxPAPC alone triggers DCs to secrete IL-1 and induce strong adaptive immunity. Thus, context-dependent signals can shape the ensuing immune response. Science , this issue p. 1232 ; see also p. 1173

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1126/science.aaf3036

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
Shi, J., Zhao, Y., Wang, K., Shi, X., Wang, Y., Huang, H., Zhuang, Y., Cai, T., Wang, F., & Shao, F. (2015) · Nature · doi:10.1038/nature15514 · Cited by 6,659
Self-citation
The Inflammasome
Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Kayagaki, N., Stowe, I. B., Lee, B. L., O’Rourke, K., Anderson, K., Warming, S., Cuellar, T., Haley, B., Roose-Girma, M., Phung, Q. T., et al. (2015) · Nature · doi:10.1038/nature15541 · Cited by 3,686
Inflammatory caspases are innate immune receptors for intracellular LPS
Shi, J., Zhao, Y., Wang, Y., Gao, W., Ding, J., Li, P., Hu, L., & Shao, F. (2014) · Nature · doi:10.1038/nature13683 · Cited by 2,285
Self-citation
Control of adaptive immunity by the innate immune system
Iwasaki, A., & Medzhitov, R. (2015) · Nature Immunology · doi:10.1038/ni.3123 · Cited by 2,160
How dying cells alert the immune system to danger
Kono, H., & Rock, K. L. (2008) · Nature Reviews Immunology · doi:10.1038/nri2215 · Cited by 1,737
Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4
Kayagaki, N., Wong, M. T., Stowe, I. B., Ramani, S. R., Gonzalez, L. C., Akashi‐Takamura, S., Miyake, K., Zhang, J., Lee, W. P., Muszyński, A., et al. (2013) · Science · doi:10.1126/science.1240248 · Cited by 1,545
The IL-1 family: regulators of immunity
Sims, J. E., & Smith, D. E. (2010) · Nature reviews. Immunology · doi:10.1038/nri2691 · Cited by 1,459
Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury
Imai, Y., Kuba, K., Neely, G. G., Yaghubian-Malhami, R., Perkmann, T., van Loo, G., Ermolaeva, M., Veldhuizen, R., Leung, Y. H. C., Wang, H., et al. (2008) · Cell · doi:10.1016/j.cell.2008.02.043 · Cited by 1,356
Pyroptotic cell death defends against intracellular pathogens
Jorgensen, I., & Miao, E. A. (2015) · Immunological Reviews · doi:10.1111/imr.12287 · Cited by 1,021

Flagged first, then by citations

Show all 30 references

Sorted by citations

Items 401–500 of 593

Mycobacterium tuberculosis Utilizes Serine/Threonine Kinase PknF to Evade NLRP3 Inflammasome-driven Caspase-1 and RIPK3/Caspase-8 Activation in Murine Dendritic Cells
Rastogi, S., Ganesh, A., & Briken, V. (2024) · The Journal of Immunology · doi:10.4049/jimmunol.2300753 · Cited by 11
Discovery of Lipoxygenase-Like Materials for Inducing Ferroptosis
Xie, Q., Li, W., Chen, C., Yang, Q. K., Jiang, J., Cai, X., & Li, R. (2024) · ACS Nano · doi:10.1021/acsnano.4c04741 · Cited by 11
Deep learning powered single-cell clustering framework with enhanced accuracy and stability
Zhang, Y., Feng, X., Wang, Y., & Shi, K. (2025) · Scientific Reports · doi:10.1038/s41598-025-87672-7 · Cited by 11
LPS binding caspase activation and recruitment domains (CARDs) are bipartite lipid binding modules
Cao, A., Devant, P., Wang, C., Sun, M., Kennedy, S. N., Ma, W., Ruan, J., & Kagan, J. C. (2025) · Science Advances · doi:10.1126/sciadv.adt9027 · Cited by 12
Self-citation
Targeting innate immune sensors for therapeutic strategies in infectious diseases
Shin, S., Choi, Y. K., & Lee, S. (2025) · The Journal of Microbiology · doi:10.71150/jm.2503009 · Cited by 11
Single-cell analysis reveals cell death as driver of NLRP3-mediated secretion of IL-1β in human monocytes
Walle, L. V., Kato, K., Yamagishi, M., Kamatani, T., Vervaeke, A., Martín‐Pérez, R., Shimizu, M., Takizawa, T., Takita, J., Nishikomori, R., et al. (2025) · Nature Immunology · doi:10.1038/s41590-025-02319-z · Cited by 12
G‐CSF induces CD15+ CD14+ cells from granulocytes early in the physiological environment of pregnancy and the cancer immunosuppressive microenvironment
Maneta, E., Fultang, L., Taylor, J. V., Pugh, M., Jenkinson, W. E., Anderson, G., Coomarasamy, A., Kilby, M. D., Lissauer, D. M., Mussai, F., et al. (2022) · Clinical & Translational Immunology · doi:10.1002/cti2.1395 · Cited by 11
Three decades of caspases and RIPKs in life and death
Malireddi, R. K. S., & Kanneganti, T. (2025) · Human Molecular Genetics · doi:10.1093/hmg/ddaf106 · Cited by 10
Inflammasome Activation and IL-1β Release Triggered by Nanosecond Pulsed Electric Fields in Murine Innate Immune Cells and Skin
Mazzarda, F., Chittams-Miles, A. E., Pittaluga, J., Sozer, E. B., Vernier, P. T., & Muratori, C. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2200881 · Cited by 10
A stress sensor, IRE1α, is required for bacterial-exotoxin-induced interleukin-1β production in tissue-resident macrophages
Sasaki, I., Fukuda‐Ohta, Y., Nakai, C., Wakaki-Nishiyama, N., Okamoto, C., Okuzaki, D., Morita, S., Kaji, S., Furuta, Y., Hemmi, H., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113981 · Cited by 9
The potential application of stroma modulation in targeting tumor cells: Focus on pancreatic cancer and breast cancer models
Roscigno, G., Jacobs, S., Toledo, B., Borea, R., Russo, G., Pepe, F., Serrano, M. J., Calabrò, V., Troncone, G., Giovannoni, R., et al. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.05.003 · Cited by 9
Gasdermin D is activated but does not drive neurodegeneration in SOD1G93A model of ALS: Implications for targeting pyroptosis
Gunner, G., Basu, H., Lu, Y., Bergstresser, M., Sun, L., Neel, D. V., Choi, S. Y., & Chiu, I. M. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107048 · Cited by 9
Pyroptosis: Turning Up the Heat on Cancer
Zhang, Z., & Lieberman, J. (2026) · Annual Review of Immunology · doi:10.1146/annurev-immunol-082423-041848 · Cited by 9
Collab or Cancel? Bacterial Influencers of Inflammasome Signaling
Herrmann, B. I., Grayczyk, J. P., & Brodsky, I. E. (2023) · Annual Review of Microbiology · doi:10.1146/annurev-micro-032521-024017 · Cited by 9
Inflammasomes as regulators of mechano-immunity
Bezbradica, J. S., & Bryant, C. E. (2023) · EMBO Reports · doi:10.1038/s44319-023-00008-2 · Cited by 9
Emerging role of exosomes in ulcerative colitis: Targeting NOD-like receptor family pyrin domain containing 3 inflammasome
Li, X., Ji, L.-J., Feng, K., Huang, H., Liang, M.-R., Cheng, S.-J., & Meng, X.-D. (2024) · World Journal of Gastroenterology · doi:10.3748/wjg.v30.i6.527 · Cited by 9
Demotion of canonical/non-canonical inflammasome and pyroptosis alleviates ischemia/reperfusion-induced acute kidney injury: Novel role of the D2/D3 receptor agonist ropinirole
Henedak, N. T., El-Abhar, H. S., Abdallah, D. M., Ahmed, K. A., & Soubh, A. A. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176460 · Cited by 9
Ganglioside GA2-mediated caspase-11 activation drives macrophage pyroptosis aggravating intimal hyperplasia after arterial injury
Shi, Y., He, T., Liu, H., Li, X., Li, Z., Wen, Q., Dai, Z.-H., Sun, X., Tan, Q., Yang, W., et al. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.97106 · Cited by 9
Trained Immunity-Based Vaccines: A Ready-to-Act Strategy to Tackle Viral Outbreaks
Conejero, L., Saz-Leal, P., & Subiza, J. L. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.95765 · Cited by 9
Reprogramming Metabolism of Macrophages as a Target for Kidney Dysfunction Treatment in Autoimmune Diseases
Tian, F., Chen, H., Zhang, J., & He, W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23148024 · Cited by 10
Pyroptosis in Skeleton Diseases: A Potential Therapeutic Target Based on Inflammatory Cell Death
Wu, Q., Du, J., Bae, E. J., & Choi, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25169068 · Cited by 8
Inflammasomes and idiopathic inflammatory myopathies
Sun, R., Chu, J., & Li, P. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1449969 · Cited by 8
Inflammasomopathies: mechanisms and disease signatures
Cahill, S. E., & Humphries, F. (2025) · Trends in Immunology · doi:10.1016/j.it.2025.03.008 · Cited by 8
Synthetic anticoagulant octaparin targets mitochondrial cardiolipin-GSDMD axis to rescue redox homeostasis in sepsis
Zhang, S., Feng, C., Yu, N., Fang, R., Zhang, Y., Chen, S., Cao, L., & Zhang, J. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103877 · Cited by 8
Oxidized phosphatidylcholines deposition drives chronic neurodegeneration in a mouse model of progressive multiple sclerosis via IL-1β signaling
Yu, R., Lozinski, B. M., Seifert, A., Ta, K., Zandee, S., Kaushik, D. K., Park, J., Klément, W., Larouche, S., Tsimikas, S., et al. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-02113-y · Cited by 10
Regulation of gasdermins in pyroptosis and cytokine release
Li, S., Bracey, S., Liu, Z., & Xiao, T. S. (2023) · Advances in immunology · doi:10.1016/bs.ai.2023.03.002 · Cited by 8
Recent advancement in the spatial immuno-oncology
To, A., Zou, Y., & Sugimura, R. (2024) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2024.12.003 · Cited by 8
Cooperative induction of CXCL chemokines by inflammatory cytokines and oxidized phospholipids
Hodzic, A., Gesslbauer, B., Bochkov, V. N., & Oskolkova, O. (2024) · Immunology · doi:10.1111/imm.13773 · Cited by 8
NLRP1 in Cutaneous SCCs: An Example of the Complex Roles of Inflammasomes in Cancer Development
Filippo, M. D., Hennig, P., Karakaya, T., Slaufova, M., & Beer, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012308 · Cited by 8
Circumventing pyroptosis via hyperactivation shapes superior immune responses of human type 2 dendritic cells compared to type 3 dendritic cells
Hatscher, L., Kaszubowski, T., Amon, L., Dudziak, D., & Heger, L. (2023) · European Journal of Immunology · doi:10.1002/eji.202250123 · Cited by 9
Transcriptomics and Targeted Metabolomics Reveal That CES1 Ablation in Macrophages Confers a Distinct Inflammatory Phenotype Involving Altered Interleukin‐1β, Citrate, and Lipid Levels
Adekanye, O., Borazjani, A., Phillips, M. E., & Ross, M. K. (2025) · The FASEB Journal · doi:10.1096/fj.202500753r · Cited by 7
Oxidized phospholipids in ferroptosis, immunity and inflammation
O’Donnell, V. B., & Bochkov, V. N. (2025) · Redox Biochemistry and Chemistry · doi:10.1016/j.rbc.2025.100061 · Cited by 7
Vitamin A Promotes the Fusion of Autophagolysosomes and Prevents Excessive Inflammasome Activation in Dextran Sulfate Sodium-Induced Colitis
Hiraga, H., Chinda, D., Maeda, T., Murai, Y., Ogasawara, K., Muramoto, R., Ota, S., Hasui, K., Sakuraba, H., Ishiguro, Y., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108684 · Cited by 7
Gasdermins in sepsis
Wang, W., & He, Z. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1203687 · Cited by 7
Lethal and sublethal effects of programmed cell death pathways on hematopoietic stem cells
Yamada, Y., Zheng, Z., Jad, A. K., & Yamashita, M. (2024) · Experimental Hematology · doi:10.1016/j.exphem.2024.104214 · Cited by 7
Plexin C1 influences immune response to intracellular LPS and survival in murine sepsis
Bernard, A. M., Eggstein, C., Tang, L., Keller, M., Körner, A., Mirakaj, V., & Rosenberger, P. (2024) · Journal of Biomedical Science · doi:10.1186/s12929-024-01074-x · Cited by 7
CD14—New Tricks of an Old Acquaintance
Schmidt, F. I., & Latz, E. (2017) · Immunity · doi:10.1016/j.immuni.2017.10.003 · Cited by 7
Caspase-11 Contributes to Oviduct Pathology during Genital Chlamydia Infection in Mice
Allen, J., Gyorke, C. E., Tripathy, M. K., Zhang, Y., Lovett, A., Montgomery, S. A., & Nagarajan, U. M. (2019) · Infection and Immunity · doi:10.1128/iai.00262-19 · Cited by 7
Białko CD14 jako modulator odpowiedzi zapalnej
Ciesielska, A., Amor, I. B., & Kwiatkowska, K. (2023) · Postępy Biochemii · doi:10.18388/pb.2021_501 · Cited by 6
Inflammasome Activation by RNA Respiratory Viruses: Mechanisms, Viral Manipulation, and Therapeutic Insights
Rodrigues, T. S., & Zamboni, D. S. (2025) · Immunological Reviews · doi:10.1111/imr.70003 · Cited by 6
Detection of Gasdermin Activation and Lytic Cell Death During Pyroptosis and Apoptosis
Demarco, B., Ramos, S., & Brož, P. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2449-4_14 · Cited by 6
Gasdermins assemble; recent developments in bacteriology and pharmacology
Greenwood, C. S., Wynosky-Dolfi, M. A., Beal, A. M., & Booty, L. M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1173519 · Cited by 6
Construction of a novel pyrotosis-related prognostic model of esophageal square cell carcinoma and determination of the anti-tumor effect of WFDC12
Yu, Z., Wang, L., Ji, C., Sun, Y., & Shao, F. (2023) · Functional & Integrative Genomics · doi:10.1007/s10142-023-01103-2 · Cited by 5
Self-citation
Tumor immunity: A brief overview of tumor‑infiltrating immune cells and research advances into tumor‑infiltrating lymphocytes in gynecological malignancies (Review)
Wang, Z., Deng, Z., Dai, F., Yuan, M., Liu, S., LI, B.-S., & Cheng, Y. (2024) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2024.12453 · Cited by 5
Inflammasomes and autophagy in cancer: unlocking targeted therapies
Gupta, J., Mohammed, M. H., Alghazali, T. A. H., Uthirapathy, S., Roopashree, R., Thakur, V., Kaur, M., Naidu, K. S., Kubaev, A., & AL-Mukhtar, M. M. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04184-x · Cited by 5
The Neglected Role of GSDMD C‐Terminal in Counteracting Type I Interferon Signaling
Xu, W., He, S., Shi, W., Xu, J., Liu, S., Yu, Z., Li, D., Jin, Q., Wang, Y., Zhang, Z., et al. (2025) · Advanced Science · doi:10.1002/advs.202505255 · Cited by 5
Pattern Recognition Receptors in Autoinflammation
Saavedra, V., Moghaddas, F., Latz, E., & Masters, S. L. (2019) · Springer eBooks · doi:10.1007/978-3-319-98605-0_4 · Cited by 5
Caspase-11 deficiency attenuates neutrophil recruitment into the atherosclerotic lesion in apolipoprotein E-deficient mice
Karasawa, T., Komada, T., Baatarjav, C., Aizawa, E., Mizushina, Y., Fujimura, K., Gunji, Y., Komori, S., Aizawa, H., Tao, C. B. J., et al. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.149158 · Cited by 5
Identification of plasma proteins binding oxidized phospholipids using pull-down proteomics and OxLDL masking assay
Jokesch, P., Holzer, L., Jantscher, L., Guttzeit, S., Übelhart, R., Oskolkova, O., Bochkov, V. N., & Gesslbauer, B. (2024) · Journal of Lipid Research · doi:10.1016/j.jlr.2024.100704 · Cited by 5
CD14: Not Just Chaperone, But a Key-Player in Inflammation
Gioia, M. D., & Zanoni, I. (2020) · Progress in inflammation research · doi:10.1007/978-3-030-56319-6_4 · Cited by 5
Self-citation
Alendronate Augments Lipid A–Induced IL-1α Release via Activation of ASC but Not Caspase-11
Tamai, R., Mashima, I., & Kiyoura, Y. (2021) · Inflammation · doi:10.1007/s10753-021-01489-w · Cited by 5
A Smart DNA Hydrogel Enables Synergistic Immunotherapy and Photodynamic Therapy of Melanoma
Yang, S. Y., Wu, J., Wang, Z., Cheng, Y. S., Zhang, R., Yao, C., & Yang, D. (2024) · Angewandte Chemie · doi:10.1002/ange.202319073 · Cited by 5
Gain of function mechanisms triggering biological effects of oxidized phospholipids
Oskolkova, O., & Bochkov, V. N. (2020) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2020.08.002 · Cited by 5
Current Perspectives on Viral Disease Outbreaks - Epidemiology, Detection and Control
Claborn, D. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.92485 · Cited by 5
An unconventional mechanism of IL-1β secretion that requires Type I IFN in lupus monocytesPreprint
Caielli, S., Balasubramanian, P., Rodríguez-Alcázar, J. F., Balaji, U., Wan, Z., Baisch, J. M., Smitherman, C., Walters, L., Sparagana, P. R., Nehar-Belaid, D., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.03.551696 · Cited by 5
Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounterPreprint
Gioia, M. D., Poli, V., Tan, P. J., Spreafico, R., Chu, A., Cuenca, A. G., Gordts, P. L. S. M., Pandolfi, L., Meloni, F., Witztum, J. L., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.21.568047 · Cited by 5
Self-citation
An Intracellular Magnetic Micromotor Drives Spatiotemporal Mechano‐Immunotherapy
Gao, R., Xu, C., Liu, C., Zhu, Z., Wang, M., Wei, X., Ning, P., Zhang, W. Y., Li, Y., Zhang, Y., et al. (2025) · Advanced Materials · doi:10.1002/adma.202504404 · Cited by 4
Innate immunity in tumour immunoediting and immunosurveillance
Zhang, Z., Zhang, Y., & Lieberman, J. (2025) · The EMBO Journal · doi:10.1038/s44318-025-00650-7 · Cited by 4
Proinflammatory GSDMD activation in live macrophages and DLBCL cells marks cognate interactions and better prognosis
Kong, X., Xu-Monette, Z. Y., Xu, Z., Hsi, E. D., Zhao, X., Yan, H. M., Nunns, H., Au, K., Visco, C., Tzankov, A., et al. (2025) · Blood Advances · doi:10.1182/bloodadvances.2025017643 · Cited by 4
Cellular memory of sub-lethal stress
Tait, S. W. G., & Oberst, A. (2026) · Immunity · doi:10.1016/j.immuni.2026.02.017 · Cited by 5
Biting the hand that feeds: Metabolic determinants of cell fate during infection
Fraschilla, I. R., & Evavold, C. L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.923024 · Cited by 4
Contribution of Nucleotide-Binding Oligomerization Domain-like (NOD) Receptors to the Immune and Metabolic Health
Apaza, C. J., Días, M., García-Tejedor, A., Boscá, L., & Laparra, J. M. (2024) · Biomedicines · doi:10.3390/biomedicines12020341 · Cited by 4
A pyroptosis-enhanced leucocyte-hitchhiking liposomal nanoplatform for potentiated immunotherapy of hepatocellular carcinoma
Lu, Y., Lin, B., Chai, S., Wang, H., Zhou, J., Hu, J., Du, Y., Zhao, C., & Wu, L. (2024) · Materials Today Nano · doi:10.1016/j.mtnano.2024.100492 · Cited by 4
Maternal Serum Gasdermin D Concentrations in Pregnancies Complicated by Isolated Intrauterine Growth Restriction
Kobal, B. B., Kale, İ., Pektaş, A. M., Özel, A., & Muhçu, M. (2022) · Zeitschrift für Geburtshilfe und Neonatologie · doi:10.1055/a-1967-2274 · Cited by 4
Pyroptosis: the dawn of a new era in endometrial cancer treatment
Tian, P., Zhang, C., Chen, W., Zhao, X., Wu, W., Yang, W., & Liang, R. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1277639 · Cited by 4
TTP-mediated regulation of mRNA stability in immune cells contributes to adaptive immunity, immune tolerance and clinical applications
Zhang, Y., Zhou, J., Wei, Z., Dong, H. F., Yang, D., Deng, Y., Li, J., Shi, S., Sun, Y., Lu, H., et al. (2021) · RNA Biology · doi:10.1080/15476286.2021.1917185 · Cited by 4
Chlamydia trachomatis impairs T cell priming by inducing dendritic cell death
Mao, H., Dumas, E. K., & Starnbach, M. N. (2025) · Infection and Immunity · doi:10.1128/iai.00402-24 · Cited by 3
Regulatory Roles of Noncanonical Inflammasomes in Diabetes Mellitus and Diabetes-Associated Complications
Yi, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26188893 · Cited by 3
β-glucan combined with PD-1/PD-L1 checkpoint blockade suppresses pancreatic tumor growth after ablation therapy
Wu, S., Sun, X., Wang, H., Chai, J., & Huang, B. (2025) · Clinics · doi:10.1016/j.clinsp.2025.100805 · Cited by 3
Pan-membrane pyroptosis of liver induced by gasdermin-encoding mRNAs
Huang, Y.-J., Lin, L., Yang, G., Ma, W., Wang, Q., Yan, X., Ye, Q., Huang, X., Li, K., Lv, L., et al. (2025) · National Science Review · doi:10.1093/nsr/nwaf452 · Cited by 3
Cytosolic receptors and signaling in antifungal immunity
Khau, S., Désoubeaux, G., Si‐Tahar, M., Biquand, É., & Briard, B. (2025) · The EMBO Journal · doi:10.1038/s44318-025-00627-6 · Cited by 3
Modulation function of sphingomyelin molecular species in TLR4 signaling and cell death
Huang, X., Kanoh, H., Ueno, J., Ishikawa, U., Nitta, T., Takamatsu, M., Shimoyama, A., Taniguchi, M., Hanashima, S., Inamori, K., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116568 · Cited by 3
Regulatory roles of noncanonical inflammasomes in kidney diseases
Yi, Y. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114787 · Cited by 3
Boosting Dendritic Cell Function in Cancer
Giampazolias, E. (2025) · Cancer Medicine · doi:10.1002/cam4.71062 · Cited by 3
Does Dysregulation of Redox State Underpin the Decline of Innate Immunity with Aging?
Griffiths, H. R., Rooney, M. C. O., & Perrie, Y. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8021 · Cited by 3
Shikonin from Chinese herbal medicine induces GSDME-controlled pyroptosis in tumor cells
Cui, D., Wang, S., Guo, J., Yang, M., Li, Y., Zhang, Y., & Ma, W. (2022) · Journal of Traditional Chinese Medical Sciences · doi:10.1016/j.jtcms.2022.07.002 · Cited by 3
Noncanonical NLRP3 Inflammasome Activation: Standard Protocols
Leite-Aguiar, R., Savio, L. E. B., & Coutinho‐Silva, R. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-3350-2_9 · Cited by 3
Role of TLR4 activation and signaling in bone remodeling, and afferent sprouting in serum transfer arthritis
dos Santos, G. G., Jiménez‐Andrade, J. M., Muñoz‐Islas, E., Candanedo-Quiroz, M. E., Cardenas, A. G., Drummond, B., Pham, P., Stilson, G., Hsu, C., Delay, L., et al. (2024) · Arthritis Research & Therapy · doi:10.1186/s13075-024-03424-4 · Cited by 3
Inflammasomes in Myeloid Cells: Warriors Within
Jha, S., Brickey, W. J., & Ting, J. P.-Y. (2017) · ASM Press eBooks · doi:10.1128/9781555819194.ch17 · Cited by 3
Defusing inflammasomes
Sandstrom, A., & Vance, R. E. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20180241 · Cited by 3
Intestinal edema induced by LPS-induced endotoxemia is associated with an inflammasome adaptor ASC
Yamamoto, T., Kurata, M., Kaneko, N., & Masumoto, J. (2023) · PLoS ONE · doi:10.1371/journal.pone.0281746 · Cited by 3
A lipid arsenal to control inflammation
Napier, B. A., & Monack, D. M. (2016) · Science · doi:10.1126/science.aag0366 · Cited by 3
To die or not to die
Minton, K. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.73 · Cited by 3
Hyperactive Dendritc Cells Redirect Aged Antitumor Immunity
Chen, C.-Y., & Sen, D. R. (2024) · Cancer Research · doi:10.1158/0008-5472.can-24-2650 · Cited by 2
Active ingredients of traditional Chinese medicine inhibit NOD-like receptor protein 3 inflammasome: a novel strategy for preventing and treating heart failure
Lin, R., Yu, Y., Du, L., Ding, Z., Wang, Z., Wei, J., & Guo, Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1520482 · Cited by 2
Caspase-11 regulates systemic inflammation and cell death in a cell-specific manner after trauma with shock
Mulla, J., Gregory, A. D., Liao, H., Matour, B. A., Li, Y., Abdullah, A., Billiar, T. R., & Scott, M. J. (2025) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiaf121 · Cited by 2
An NLRP3-stimulatory adjuvant improves the immunogenicity of influenza virus vaccines in mice and non-human primates
Finn, K. K., Chow, J., Zhivaki, D., Sengupta, D., Concepcion, H. A., Komoroski, V., MacFarlane, C., Coblentz, P. D., Chokshi, M., Matissek, S. J., et al. (2025) · mBio · doi:10.1128/mbio.02343-25 · Cited by 2
Self-citation
NLRPs and tumor: research progress from molecular mechanisms to clinical applications
Song, L., Cao, Y., & Tao, Y. (2025) · Oncogene · doi:10.1038/s41388-025-03642-3 · Cited by 2
NLRP3 activation by lipopolysaccharide (LPS) mediates the pyroptosis of human spermatogonial stem cells via GBP4 regulation
Jin, W.-C., Zhang, D., Cui, Y.-H., Du, L., & He, Z. (2026) · Asian Journal of Andrology · doi:10.4103/aja202564 · Cited by 2
A Biomimetic Nanovesicle‐Based Synthetic Vaccine Platform Through Co‐Anchoring Oxidized Phospholipid and CpG for Rejuvenating Antitumor Immunity in Aged Mice
Miao, F., Lu, J., Zhao, Y., Wang, W., Zhang, T., Liu, J., Zhang, X., Wu, L., Yan, H., Wang, R., et al. (2026) · Angewandte Chemie International Edition · doi:10.1002/anie.202522249 · Cited by 2
Targeting the NLRP3 Inflammasome: Novel Inhibitors for Cardiovascular Diseases Management — A Narrative Review
Momen, Y. S. (2026) · Drug Development Research · doi:10.1002/ddr.70283 · Cited by 2
Noncanonical inflammasomes: New insights into their roles in inflammation and immunopathology
Yi, Y. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.153991 · Cited by 2
Targeting the NLRP3 inflammasome in Alzheimer’s disease: Mechanistic insights and therapeutic advances
廉文文, Zhou, F., Tong, Z., 夏聪媛, Yu, Y., He, J., Jiekun, X., & Zhang, W. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103273 · Cited by 2
Structural and molecular principles of DAMP biology
Chen, R., Zou, J., Li, J., Chen, J., Zhong, X., Liu, J., Kang, R., Zhou, H., & Tang, D. (2026) · Nature Structural & Molecular Biology · doi:10.1038/s41594-026-01858-9 · Cited by 2
Innate immune sensors of inflammasomes and PANoptosomes: structural–mechanistic insights and therapeutic implications
Upadhyay, S., Nagampalli, R., Resende, S., & Kanneganti, T. (2026) · Cell Research · doi:10.1038/s41422-026-01287-9 · Cited by 2
Progress in the Cross-Organ Biomarker oxLDL in Promoting Pathological Neovascular Diseases
Wu, Y., Lao, X., Su, X., Chen, H., Fu, C., & Liu, Q. (2026) · Antioxidants · doi:10.3390/antiox15020182 · Cited by 2
Characterization of the Structural Diversity and Structure-Specific Behavior of Oxidized Phospholipids by LC-MS/MS
Aoyagi, R., Yamamoto, T. S., Furukawa, Y., & Arita, M. (2021) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.c21-00274 · Cited by 2
Patterns of bacterial viability governing noncanonical inflammasome activation
Shi, Y., & Blander, J. M. (2024) · Current Opinion in Immunology · doi:10.1016/j.coi.2024.102512 · Cited by 2
Immune Sensors, Regulators, and Effectors of Brain Health
Acıoğlu, Ç., & Elkabes, S. (2024) · Springer eBooks · doi:10.1007/978-3-031-68237-7_3 · Cited by 2
Damage-associated molecular patterns as metabolic regulators of innate immunity
Ryan, T. A. J., Zanoni, I., & Gioia, M. D. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-15447-8.00007-6 · Cited by 2
Self-citation

Authors: Zanoni, I., Tan, Y., Di Gioia, M., Broggi, A., Ruan, J., Shi, J., Donado, C. A., Shao, F., Wu, H., Springstead, J. R., & Kagan, J. C.
Affiliations: Boston Children's Hospital (US)
Harvard Medical School and Division of Gastroenterology, Boston Children’s Hospital, Boston, MA, USA.
Harvard University (US)
National Institute of Biological Sciences, Beijing (CN)
Western Michigan University (US)
Corresponding author: Kagan, Jonathan C.
ORCID: Zanoni, Ivan
Tan, Yunhao
Broggi, Achille
Ruan, Jianbin
Shi, Jianjin
Shao, Feng
Wu, Hao
Springstead, James R.
Kagan, Jonathan C.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2016-06-03
Volume: 352
Issue: 6290
Pages: 1232-1236
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.aaf3036
PMC: PMC5111085
OpenAlex: W2340046691
Cited by: 583
References: 30
Citations by year: 2026: 34 · 2025: 69 · 2024: 58 · 2023: 76 · 2022: 69 · 2021: 62 · 2020: 61 · 2019: 51 · 2018: 49 · 2017: 38 · 2016: 14
FWCI: 26.34
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
BOA (University of Milano-Bicocca) (submittedVersion)
Funders: Mead Johnson & Company
Burroughs Wellcome Fund
Harvard Digestive Diseases Center (P30 DK34854)
Cariplo Foundation
Jane Coffin Childs Fund
NIH (AI093589, AI072955, P30 DK34854, 1R01AI121066-01A1, 1R15HL121770-01A1)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: caspase-11, dendritic cells, OxPAPC, lipopolysaccharide, pyroptosis, inflammasome, dendritic cell activation, pattern recognition receptors, innate immunity, adaptive immune response
MeSH terms: NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Carrier Proteins, Dendritic Cells, Immunity, Innate, Lipopolysaccharides, Phospholipids, Cell Death, Mice, Knockout, Caspases, Receptors, Pattern Recognition, Toll-Like Receptor 4, Mice, Caspases, Initiator, Interleukin-1beta, Adaptive Immunity, Inflammasomes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks