An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Shi, J., Zhao, Y., Wang, K., Shi, X., Wang, Y., Huang, H., Zhuang, Y., Cai, T., Wang, F., & Shao, F. (2015) · Nature · doi:10.1038/nature15514 · Cited by 6,659

The Inflammasome

Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Kayagaki, N., Stowe, I. B., Lee, B. L., O’Rourke, K., Anderson, K., Warming, S., Cuellar, T., Haley, B., Roose-Girma, M., Phung, Q. T., et al. (2015) · Nature · doi:10.1038/nature15541 · Cited by 3,686

Inflammatory caspases are innate immune receptors for intracellular LPS

Shi, J., Zhao, Y., Wang, Y., Gao, W., Ding, J., Li, P., Hu, L., & Shao, F. (2014) · Nature · doi:10.1038/nature13683 · Cited by 2,285

Control of adaptive immunity by the innate immune system

Iwasaki, A., & Medzhitov, R. (2015) · Nature Immunology · doi:10.1038/ni.3123 · Cited by 2,160

How dying cells alert the immune system to danger

Kono, H., & Rock, K. L. (2008) · Nature Reviews Immunology · doi:10.1038/nri2215 · Cited by 1,737

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

Kayagaki, N., Wong, M. T., Stowe, I. B., Ramani, S. R., Gonzalez, L. C., Akashi‐Takamura, S., Miyake, K., Zhang, J., Lee, W. P., Muszyński, A., et al. (2013) · Science · doi:10.1126/science.1240248 · Cited by 1,545

The IL-1 family: regulators of immunity

Sims, J. E., & Smith, D. E. (2010) · Nature reviews. Immunology · doi:10.1038/nri2691 · Cited by 1,459

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

Imai, Y., Kuba, K., Neely, G. G., Yaghubian-Malhami, R., Perkmann, T., van Loo, G., Ermolaeva, M., Veldhuizen, R., Leung, Y. H. C., Wang, H., et al. (2008) · Cell · doi:10.1016/j.cell.2008.02.043 · Cited by 1,356

Pyroptotic cell death defends against intracellular pathogens

Jorgensen, I., & Miao, E. A. (2015) · Immunological Reviews · doi:10.1111/imr.12287 · Cited by 1,021

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680

The NLRP3 inflammasome: molecular activation and regulation to therapeutics

Swanson, K. V., Deng, M., & Ting, J. P.-Y. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0165-0 · Cited by 4,884

Targeting the NLRP3 inflammasome in inflammatory diseases

Mangan, M. S. J., Olhava, E. J., Roush, W. R., Seidel, H. M., Glick, G. D., & Latz, E. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.97 · Cited by 1,885

DAMP-sensing receptors in sterile inflammation and inflammatory diseases

Gong, T., Liu, L., Jiang, W., & Zhou, R. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0215-7 · Cited by 1,672

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

Man, S. M., Karki, R., & Kanneganti, T. (2017) · Immunological Reviews · doi:10.1111/imr.12534 · Cited by 1,684

The gasdermins, a protein family executing cell death and inflammation

Broz, P., Pelegrín, P., & Shao, F. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0228-2 · Cited by 1,641

NLRP3 inflammasome activation and cell death

Huang, Y., Xu, W., & Zhou, R. (2021) · Cellular & Molecular Immunology · doi:10.1038/s41423-021-00740-6 · Cited by 1,527

TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling

Ciesielska, A., Matyjek, M., & Kwiatkowska, K. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03656-y · Cited by 1,420

FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

Hu, J. J., Liu, X., Xia, S., Zhang, Z., Zhang, Y., Zhao, J., Ruan, J., Luo, X., Lou, X., Bai, Y., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0669-6 · Cited by 1,145

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

Evavold, C. L., Ruan, J., Tan, Y., Xia, S., Wu, H., & Kagan, J. C. (2018) · Immunity · doi:10.1016/j.immuni.2017.11.013 · Cited by 1,115

Inflammasome activation and regulation: toward a better understanding of complex mechanisms

Zheng, D., Liwinski, T., & Elinav, E. (2020) · Cell Discovery · doi:10.1038/s41421-020-0167-x · Cited by 1,078

NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis

Grebe, A., Hoss, F., & Latz, E. (2018) · Circulation Research · doi:10.1161/circresaha.118.311362 · Cited by 926

Caspases in Cell Death, Inflammation, and Pyroptosis

Kesavardhana, S., Malireddi, R. K. S., & Kanneganti, T. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-073119-095439 · Cited by 954

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

Sarhan, J., Liu, B. C., Muendlein, H. I., Li, P., Nilson, R., Tang, A. Y., Rongvaux, A., Bunnell, S. C., Shao, F., Green, D. R., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1809548115 · Cited by 894

Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors

Xu, S., Chaudhary, O., Rodríguez-Morales, P., Sun, X., Chen, D., Zappasodi, R., Xu, Z. Z., Pinto, A. F. M., Williams, A. E., Schulze, I., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.05.003 · Cited by 834

Channelling inflammation: gasdermins in physiology and disease

Liu, X., Xia, S., Zhang, Z., Wu, H., & Lieberman, J. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00154-z · Cited by 779

Pattern Recognition Receptors and the Host Cell Death Molecular Machinery

Amarante-Mendes, G. P., Adjemian, S., Branco, L. M., Zanetti, L. C., Weinlich, R., & Bortoluci, K. R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02379 · Cited by 802

Gasdermin D in pyroptosis

Burdette, B. E., Esparza, A. N., Zhu, H., & Wang, S. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.02.006 · Cited by 721

Innate immunity to intracellular LPS

Rathinam, V. A. K., Zhao, Y., & Shao, F. (2019) · Nature Immunology · doi:10.1038/s41590-019-0368-3 · Cited by 622

Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis

Miao, R., Jiang, C., Chang, W. Y.-H., Zhang, H., An, J., Ho, F. Y., Chen, P., Zhang, H., Junqueira, C., Amgalan, D., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.10.004 · Cited by 589

IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines

Tahtinen, S., Tong, A.-J., Himmels, P., Oh, J., Paler-Martinez, A., Kim, L., Wichner, S., Oei, Y., McCarron, M. J., Freund, E. C., et al. (2022) · Nature Immunology · doi:10.1038/s41590-022-01160-y · Cited by 535

DAMPs and DAMP-sensing receptors in inflammation and diseases

Ma, M., Jiang, W., & Zhou, R. (2024) · Immunity · doi:10.1016/j.immuni.2024.03.002 · Cited by 575

Emerging Activators and Regulators of Inflammasomes and Pyroptosis

Xue, Y., Tuipulotu, D. E., Tan, W. H., Kay, C., & Man, S. M. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.09.005 · Cited by 517

The role of mitochondria in NLRP3 inflammasome activation

Liu, Q., Zhang, D., Hu, D., Zhou, X., & Zhou, Y. (2018) · Molecular Immunology · doi:10.1016/j.molimm.2018.09.010 · Cited by 475

Caspase-11–mediated endothelial pyroptosis underlies endotoxemia-induced lung injury

Cheng, K. T., Xiong, S., Ye, Z., Hong, Z., Di, A., Tsang, K. M., Gao, X., An, S., Mittal, M., Vogel, S. M., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci94495 · Cited by 478

Pyroptosis: a new paradigm of cell death for fighting against cancer

Tan, Y., Chen, Q., Li, X., Zeng, Z., Xiong, W., Li, G., Li, X., Yang, J., Xiang, B., & Yi, M. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-01959-x · Cited by 487

Homeostasis-altering molecular processes as mechanisms of inflammasome activation

Liston, A., & Masters, S. L. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.151 · Cited by 459

A 360° view of the inflammasome: Mechanisms of activation, cell death, and diseases

Barnett, K. C., Li, S., Liang, K., & Ting, J. P.-Y. (2023) · Cell · doi:10.1016/j.cell.2023.04.025 · Cited by 458

Dendritic cell biology and its role in tumor immunotherapy

Wang, Y., Xiang, Y., Xin, V. W., Wang, X.-W., Peng, X., Liu, X., Wang, D., Li, N., Cheng, J.-T., Lyv, Y.-N., et al. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00939-6 · Cited by 463

The NLRP3 inflammasome: Mechanism of action, role in disease and therapies

Wang, L., & Hauenstein, A. V. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100889 · Cited by 426

Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis

Wu, C., Lu, W., Zhang, Y., Zhang, G., Shi, X., Hisada, Y., Grover, S. P., Zhang, X., Li, L., Xiang, B., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.04.003 · Cited by 422

Apoptosis, Pyroptosis, and Necroptosis—Oh My! The Many Ways a Cell Can Die

Ketelut-Carneiro, N., & Fitzgerald, K. A. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.167378 · Cited by 427

Pyroptosis-Induced Inflammation and Tissue Damage

Vasudevan, S. O., Behl, B., & Rathinam, V. A. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101781 · Cited by 412

The Gasdermin‐D pore acts as a conduit for IL‐1β secretion in mice

Heilig, R., Dick, M. S., Sborgi, L., Meunier, É., Hiller, S., & Brož, P. (2017) · European Journal of Immunology · doi:10.1002/eji.201747404 · Cited by 397

TIM-3 restrains anti-tumour immunity by regulating inflammasome activation

Dixon, K. O., Tabaka, M., Schramm, M. A., Xiao, S., Tang, R., Dionne, D. A., Anderson, A. C., Rozenblatt–Rosen, O., Regev, A., & Kuchroo, V. K. (2021) · Nature · doi:10.1038/s41586-021-03626-9 · Cited by 381

Inflammasome signaling and regulation of interleukin-1 family cytokines

Chan, A. H., & Schroder, K. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20190314 · Cited by 388

Mechanisms of Gasdermin Family Members in Inflammasome Signaling and Cell Death

Feng, S., Fox, D., & Man, S. M. (2018) · Journal of Molecular Biology · doi:10.1016/j.jmb.2018.07.002 · Cited by 362

Toll-like Receptors and Inflammatory Bowel Disease

Lu, Y., Li, X., Liu, S., Zhang, Y., & Zhang, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00072 · Cited by 355

Bacterial Endotoxin Activates the Coagulation Cascade through Gasdermin D-Dependent Phosphatidylserine Exposure

Yang, X., Cheng, X., Tang, Y., Qiu, X., Wang, Y., Kang, H., Wu, J., Wang, Z., Liu, Y., Chen, F., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.11.005 · Cited by 328

An overview of the non-canonical inflammasome

Downs, K. P., Nguyen, H., Dorfleutner, A., & Stehlik, C. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100924 · Cited by 338

Inflammasome activation at the crux of severe COVID-19

Vora, S. M., Lieberman, J., & Wu, H. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00588-x · Cited by 332

Cholesterol Homeostatic Regulator SCAP-SREBP2 Integrates NLRP3 Inflammasome Activation and Cholesterol Biosynthetic Signaling in Macrophages

Guo, C., Chi, Z., Jiang, D., Xu, T., Yu, W., Wang, Z., Chen, S., Zhang, L., Liu, Q., Guo, X., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.08.021 · Cited by 325

The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection

Hara, H., Seregin, S. S., Yang, D., Fukase, K., Chamaillard, M., Alnemri, E. S., Inohara, N., Chen, G., & Núñez, G. (2018) · Cell · doi:10.1016/j.cell.2018.09.047 · Cited by 315

Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion

Monteleone, M. M., Stanley, A. C., Chen, K. W., Brown, D. L., Bezbradica, J. S., von Pein, J. B., Holley, C. L., Boucher, D., Shakespear, M. R., Kapétanovic, R., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.027 · Cited by 309

The role of inflammasomes in kidney disease

Komada, T., & Muruve, D. A. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0158-z · Cited by 317

Inflammasomes on the Crossroads of Innate Immune Recognition and Metabolic Control

Próchnicki, T., & Latz, E. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.06.018 · Cited by 302

Roles of Caspases in Necrotic Cell Death

Yuan, J., Najafov, A., & Py, B. F. (2016) · Cell · doi:10.1016/j.cell.2016.11.047 · Cited by 299

cGAS drives noncanonical-inflammasome activation in age-related macular degeneration

Kerur, N., Fukuda, S., Banerjee, D., Kim, Y., Fu, D., Apicella, I., Varshney, A., Yasuma, R., Fowler, B. J., Baghdasaryan, E., et al. (2017) · Nature Medicine · doi:10.1038/nm.4450 · Cited by 290

Role of the Inflammasome in Liver Disease

Ribeiro, M. D. C., & Szabó, G. (2021) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-032521-102529 · Cited by 286

Gasdermins and their role in immunity and inflammation

Ørning, P., Lien, E., & Fitzgerald, K. A. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20190545 · Cited by 277

Molecular mechanisms of gasdermin D pore-forming activity

Devant, P., & Kagan, J. C. (2023) · Nature Immunology · doi:10.1038/s41590-023-01526-w · Cited by 280

Trained Immunity-Based Vaccines: A New Paradigm for the Development of Broad-Spectrum Anti-infectious Formulations

Sánchez‐Ramón, S., Conejero, L., Netea, M. G., Sancho, D., Palomares, Ó., & Subiza, J. L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02936 · Cited by 271

Switching from Apoptosis to Pyroptosis: Gasdermin-Elicited Inflammation and Antitumor Immunity

Tsuchiya, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22010426 · Cited by 258

Pharmacological Inhibition of the NLRP3 Inflammasome: Structure, Molecular Activation, and Inhibitor-NLRP3 Interaction

Ma, Q. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000629 · Cited by 260

Inflammasome‐associated cell death: Pyroptosis, apoptosis, and physiological implications

Tsuchiya, K. (2020) · Microbiology and Immunology · doi:10.1111/1348-0421.12771 · Cited by 245

Inflammasomes and adaptive immune responses

Deets, K. A., & Vance, R. E. (2021) · Nature Immunology · doi:10.1038/s41590-021-00869-6 · Cited by 243

Inflammasome Priming in Sterile Inflammatory Disease

Patel, M. N., Carroll, R. G., Galván-Peña, S., Mills, E. L., Olden, R., Triantafilou, M., Wolf, A. I., Bryant, C. E., Triantafilou, K., & Masters, S. L. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.12.007 · Cited by 241

CD14: Biology and role in the pathogenesis of disease

Wu, Z., Zhang, Z., Lei, Z., & Lei, P. (2019) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2019.06.003 · Cited by 244

Targeting innate immune pathways for cancer immunotherapy

Cao, L. L., & Kagan, J. C. (2023) · Immunity · doi:10.1016/j.immuni.2023.07.018 · Cited by 234

By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation

Zanoni, I., Tan, Y., Di Gioia, M., Springstead, J. R., & Kagan, J. C. (2017) · Immunity · doi:10.1016/j.immuni.2017.09.010 · Cited by 221

Interleukin-1 as Innate Mediator of T Cell Immunity

Eeckhout, B. V. D., Tavernier, J. H., & Gerlo, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.621931 · Cited by 227

Mechanistic insights from inflammasome structures

Fu, J., Schroder, K., & Wu, H. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-00995-w · Cited by 223

Inflammasomes in Alveolar Bone Loss

Li, Y., Ling, J., & Jiang, Q. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.691013 · Cited by 219

Mitochondria and the NLRP3 inflammasome: physiological and pathological relevance

Yu, J., & Lee, M. (2016) · Archives of Pharmacal Research · doi:10.1007/s12272-016-0827-4 · Cited by 209

Cutting Edge: Mitochondrial Assembly of the NLRP3 Inflammasome Complex Is Initiated at Priming

Elliott, E. I., Miller, A. N., Banoth, B., Iyer, S. S., Stotland, A., Weiss, J. P., Gottlieb, R. A., Sutterwala, F. S., & Cassel, S. L. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701723 · Cited by 195

Gasdermins and pyroptosis in the kidney

Elias, E. E., Lyons, B., & Muruve, D. A. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-022-00662-0 · Cited by 206

The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages

Chu, L. H., Indramohan, M., Ratsimandresy, R. A., Gangopadhyay, A., Morris, E. P., Monack, D. M., Dorfleutner, A., & Stehlik, C. (2018) · Nature Communications · doi:10.1038/s41467-018-03409-3 · Cited by 200

Mechanisms and Therapeutic Regulation of Pyroptosis in Inflammatory Diseases and Cancer

Zheng, Z., & Li, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041456 · Cited by 194

Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11

Lagrange, B., Benaoudia, S., Wallet, P., Magnotti, F., Provost, A., Michal, F., Martin, A., Lorenzo, F. D., Py, B. F., Molinaro, A., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02682-y · Cited by 211

Inflammasome, Inflammation, and Tissue Homeostasis

Rathinam, V. A. K., & Chan, F. K.-M. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.01.004 · Cited by 199

Molecular mechanisms of inflammasome signaling

Mathur, A., Hayward, J. A., & Man, S. M. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.3mr0617-250r · Cited by 192

NLRP3 inflammasome as a key driver of vascular disease

Takahashi, M. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab010 · Cited by 193

Pore formation in regulated cell death

Flores‐Romero, H., Ros, U., & García‐Sáez, A. J. (2020) · The EMBO Journal · doi:10.15252/embj.2020105753 · Cited by 191

The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors

Zhan, X., Li, Q., Xu, G., Xiao, X., & Bai, Z. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1109938 · Cited by 203

Adaptation and memory in immune responses

Natoli, G., & Ostuni, R. (2019) · Nature Immunology · doi:10.1038/s41590-019-0399-9 · Cited by 203

Mechanistic insights into gasdermin-mediated pyroptosis

Bai, Y., Pan, Y., & Liu, X. (2025) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-025-00837-0 · Cited by 218

Gasdermin D activity in inflammation and host defense

Lieberman, J., Wu, H., & Kagan, J. C. (2019) · Science Immunology · doi:10.1126/sciimmunol.aav1447 · Cited by 189

Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia

Dong, Y., D’Mello, C., Pinsky, W., Lozinski, B. M., Kaushik, D. K., Ghorbani, S., Moezzi, D., Brown, D., Melo, F. C., Zandee, S., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00801-z · Cited by 181

Cell biology of inflammasome activation

Pandey, A., Shen, C. X., Feng, S., & Man, S. M. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.06.010 · Cited by 183

Multi-receptor detection of individual bacterial products by the innate immune system

Kieser, K. J., & Kagan, J. C. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.25 · Cited by 184

STING-dependent translation inhibition restricts RNA virus replication

Franz, K. M., Neidermyer, W. J., Tan, Y., Whelan, S. P. J., & Kagan, J. C. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1716937115 · Cited by 183

DAMP sensing and sterile inflammation: intracellular, intercellular and inter-organ pathways

Huang, Y., Jiang, W., & Zhou, R. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01027-3 · Cited by 208

Function and Regulation of Noncanonical Caspase-4/5/11 Inflammasome

Matikainen, S., Nyman, T. A., & Cypryk, W. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000373 · Cited by 179

Mechanism and Regulation of Gasdermin-Mediated Cell DeathPreprint

Xia, S., Hollingsworth, L. R., & Wu, H. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a036400 · Cited by 177

Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation

Gioia, M. D., Spreafico, R., Springstead, J. R., Mendelson, M., Joehanes, R., Levy, D. A., & Zanoni, I. (2019) · Nature Immunology · doi:10.1038/s41590-019-0539-2 · Cited by 176

Apaf-1 Pyroptosome Senses Mitochondrial Permeability Transition

Xu, W., Che, Y., Zhang, Q., Huang, H., Ding, C., Wang, Y., Wang, G., Cao, L., & Hao, H. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.11.018 · Cited by 172

Mitochondria-Targeting Polymer Micelle of Dichloroacetate Induced Pyroptosis to Enhance Osteosarcoma Immunotherapy

Jin, J., Yuan, P., Yu, W., Lin, J., Xu, A., Xu, X., Lou, J., Yu, T., Qian, C., Liu, B., et al. (2022) · ACS Nano · doi:10.1021/acsnano.2c00192 · Cited by 173

The role of inflammasomes in vascular cognitive impairment

Poh, L., Sim, W. L., Jo, D., Dinh, Q. N., Drummond, G. R., Sobey, C. G., Chen, C., Lai, M. K. P., Fann, D. Y., & Arumugam, T. V. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00506-8 · Cited by 167

Structure, Activation and Regulation of NLRP3 and AIM2 Inflammasomes

Sharma, M., & de Alba, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020872 · Cited by 173

IL1 Receptor Antagonist Controls Transcriptional Signature of Inflammation in Patients with Metastatic Breast Cancer

Wu, T.-C., Xu, K., Martínek, J., Young, R. R., Banchereau, R., George, J., Turner, J., Kim, K. I., Zurawski, S., Wang, X., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-0413 · Cited by 168

Cytosolic Recognition of Microbes and Pathogens: Inflammasomes in Action

Hayward, J. A., Mathur, A., Ngo, C., & Man, S. M. (2018) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00015-18 · Cited by 168

Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity

Zhivaki, D., Borriello, F., Chow, O. A., Doran, B. A., Fleming, I., Theisen, D. J., Pallis, P., Shalek, A. K., Sokol, C. L., Zanoni, I., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108381 · Cited by 170

Epithelial-derived gasdermin D mediates nonlytic IL-1β release during experimental colitis

Bulek, K., Zhao, J., Liao, Y., Rana, N., Corridoni, D., Antanaviciute, A., Chen, X., Wang, H., Wen, Q., Miller-Little, W. A., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci138103 · Cited by 163

Nonalcoholic Steatohepatitis

Suzuki, A., & Diehl, A. M. (2016) · Annual Review of Medicine · doi:10.1146/annurev-med-051215-031109 · Cited by 163

Cardiolipin in Immune Signaling and Cell Death

Pizzuto, M., & Pelegrı́n, P. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.09.004 · Cited by 157

Inflammasomes: Threat-Assessment Organelles of the Innate Immune System

Evavold, C. L., & Kagan, J. C. (2019) · Immunity · doi:10.1016/j.immuni.2019.08.005 · Cited by 159

Differential roles of caspase-1 and caspase-11 in infection and inflammation

Man, S. M., Karki, R., Briard, B., Burton, A. R., Gingras, S., Pelletier, S. W., & Kanneganti, T. (2017) · Scientific Reports · doi:10.1038/srep45126 · Cited by 155

A noncanonical function of cGAMP in inflammasome priming and activation

Swanson, K. V., Junkins, R. D., Kurkjian, C. J., Holley-Guthrie, E., Pendse, A. A., Morabiti, R. E., Petrucelli, A., Barber, G. N., Benedict, C. A., & Ting, J. P. ‐. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20171749 · Cited by 148

Heparin prevents caspase-11-dependent septic lethality independent of anticoagulant properties

Tang, Y., Wang, X., Li, Z., He, Z., Yang, X., Cheng, X., Peng, Y., Xue, Q., Bai, Y., Zhang, R., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.01.007 · Cited by 153

Pore formation by GSDMD is the effector mechanism of pyroptosis

Gaidt, M. M., & Hornung, V. (2016) · The EMBO Journal · doi:10.15252/embj.201695415 · Cited by 152

Immune activation in context

Mueller, K. L. (2016) · Science · doi:10.1126/science.352.6290.1185-o

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Zanoni, I., Tan, Y., Di Gioia, M., Springstead, J. R., & Kagan, J. C. (2017) · Immunity · doi:10.1016/j.immuni.2017.09.010 · Cited by 221

A caspaselike activity is triggered by LPS and is required for survival of human dendritic cells

Franchi, L., Condò, I., Tomassini, B., Nicolò, C., & Testi, R. (2003) · Blood · doi:10.1182/blood-2003-03-0967 · Cited by 30

Distinct Licensing of IL-18 and IL-1b Secretion in Response to NLRP3 Inflammasome Activation

Schmidt, R. L. (2012)

Inflammatory caspases are innate immune receptors for intracellular LPS

Shi, J., Zhao, Y., Wang, Y., Gao, W., Ding, J., Li, P., Hu, L., & Shao, F. (2014) · Nature · doi:10.1038/nature13683 · Cited by 2,285