Branched-chain amino acid fortification does not restore muscle protein synthesis rates following ingestion of lower-compared with higher-dose mycoprotein

Monteyne, Alistair J; Coelho, Mariana OC; Porter, Craig; Abdelrahman, Doaa R; Jameson, Thomas SO; Finnigan, Tim JA; Stephens, Francis B; Dirks, Marlou L; Wall, Benjamin T

doi:10.1093/jn/nxaa251

Cited by 29Muscle metabolism and nutritionMuscle Physiology and DisordersNutrition and Health in Aging

Branched-chain amino acid fortification does not restore muscle protein synthesis rates following ingestion of lower-compared with higher-dose mycoprotein

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Monteyne, Alistair J, Coelho, Mariana OC, Porter, Craig, Abdelrahman, Doaa R, Jameson, Thomas SO, Finnigan, Tim JA, Stephens, Francis B, Dirks, Marlou L +1 more·2020·The Journal of Nutrition

DOI 10.1093/jn/nxaa251

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Abstract

Background We have shown that ingesting a large bolus (70 g) of the fungal-derived, whole food mycoprotein robustly stimulates muscle protein synthesis (MPS) rates.Objective The aim of this study was to determine if a lower dose (35 g) of mycoprotein enriched with branched-chain amino acids (BCAAs) stimulates MPS to the same extent as 70 g of mycoprotein in resistance-trained young men.Methods Nineteen men [aged 22 ± 1 y, BMI (kg/m2): 25 ± 1] took part in a randomized, double-blind, parallel-group study. Participants received primed, continuous infusions of l-[ring-2H5]phenylalanine and ingested either 70 g mycoprotein (31.5 g protein; MYCO; n = 10) or 35 g BCAA-enriched mycoprotein (18.7 g protein: matched on BCAA content; ENR; n = 9) following a bout of unilateral resistance exercise. Blood and bilateral quadriceps muscle samples were obtained before exercise and protein ingestion and during a 4-h postprandial period to assess MPS in rested and exercised muscle. Two- and 3-factor ANOVAs were used to detect differences in plasma amino acid kinetics and mixed muscle fractional synthetic rates, respectively.Results Postprandial plasma BCAA concentrations increased more rapidly and to a larger degree in ENR compared with MYCO. MPS increased with protein ingestion (P ≤ 0.05) but to a greater extent following MYCO (from 0.025% ± 0.006% to 0.057% ± 0.004% · h-1 in rested muscle, and from 0.024% ± 0.007% to 0.072% ± 0.005% · h-1 in exercised muscle; P < 0.0001) compared with ENR (from 0.031% ± 0.003% to 0.043% ± 0.005% · h-1 in rested muscle, and 0.027% ± 0.005% to 0.052% ± 0.005% · h-1 in exercised muscle; P < 0.01) ingestion. Postprandial MPS rates were greater in MYCO compared with ENR (P < 0.01).Conclusions The ingestion of lower-dose BCAA-enriched mycoprotein stimulates resting and postexercise MPS rates, but to a lesser extent compared with the ingestion of a BCAA-matched 70-g mycoprotein bolus in healthy young men. This trial was registered at clinicaltrials.gov as 660065600.

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Evidence to date shows no benefit of fortifying non-animal-derived protein sources with leucine or branch chain amino acids, suggesting that other amino acids may be limiting to the MPS response.
“However, evidence to date shows no benefit of fortifying non–animal-derived protein sources with leucine [100] or branch chain amino acids [101], suggesting that other amino acids may be limiting to the MPS response.”
From Nutritional Considerations for the Vegan Athlete (2023) · cites this paper as [101]

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Branched-Chain Amino Acid Ingestion Stimulates Muscle Myofibrillar Protein Synthesis following Resistance Exercise in Humans
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Co-Ingestion of Branched-Chain Amino Acids and Carbohydrate Stimulates Myofibrillar Protein Synthesis Following Resistance Exercise in Trained Young Men
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Authors: Monteyne, A. J., Coelho, M. O., Porter, C., Abdelrahman, D. R., Jameson, T. S., Finnigan, T. J., Stephens, F. B., Dirks, M. L., & Wall, B. T.
Affiliations: University of Exeter (GB)
The University of Texas Medical Branch at Galveston (US)
Quorn (United Kingdom) (GB)
Corresponding author: Wall, Benjamin T
ORCID: Monteyne, Alistair J
Porter, Craig
Abdelrahman, Doaa R
Finnigan, Tim JA
Stephens, Francis B
Dirks, Marlou L
Wall, Benjamin T
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2020-11
Volume: 150
Issue: 11
Pages: 2931-2941
ISSN: 0022-3166 (ISSN-L)
DOI: 10.1093/jn/nxaa251
OpenAlex: W3083261556
Cited by: 29
References: 51
Citations by year: 2026: 2 · 2025: 6 · 2024: 3 · 2023: 5 · 2022: 10 · 2021: 2 · 2020: 1
FWCI: 2.25
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 807 d)
Locations: Journal of Nutrition (publishedVersion)
PubMed (publishedVersion)
Socio-Environmental Systems Modeling (submittedVersion)
Funders: Shriners Hospitals for Children (84090)
University of Exeter
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Keywords: branched-chain amino acids, mycoprotein, muscle protein synthesis, protein supplementation, resistance training, dose-response relationship, resistance-trained men, quadriceps
MeSH terms: Beverages, Double-Blind Method, Fungal Proteins, Gene Expression Regulation, Humans, Male, Muscle Proteins, Phenylalanine, Muscle, Skeletal, Young Adult

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Branched-chain amino acid fortification does not restore muscle protein synthesis rates following ingestion of lower-compared with higher-dose mycoprotein

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