Cited by 399Autophagy in Disease and TherapyCellular transport and secretionImmune Response and Inflammation

Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine

Open access
Bel, Shai, Pendse, Mihir, Wang, Yuhao, Li, Yun, Ruhn, Kelly A., Hassell, Brian, Leal, Tess, Winter, Sebastian E. +2 more·2017·Science

Abstract

Foiling bad bugs' sneaky tricks: Intestinal pathogens can invade host cells and disrupt critical cellular functions, including secretion. Secretion is necessary for the delivery of antimicrobial proteins that kill pathogenic bacteria. Bel et al. show that when intestinal epithelial cells sense an invading bacterial pathogen, they “reroute” the antimicrobial protein lysozyme through an alternative autophagy-based secretion pathway (see the Perspective by Kaser and Blumberg). This ensures lysozyme delivery to the gut lumen, which protects against further bacterial invasion. Secretory autophagy was triggered by endoplasmic reticulum stress and required signals from type 3 innate lymphoid cells. Thus, the innate immune response to gut pathogens co-opts autophagy in intestinal immune defense. Science , this issue p. 1047 ; see also p. 976

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1126/science.aal4677

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Bel, S., Pendse, M., Wang, Y., Li, Y., Ruhn, K. A., Hassell, B., Leal, T., Winter, S. E., Xavier, R. J., & Hooper, L. V.
Affiliations
  • The University of Texas Southwestern Medical Center (US)
  • Broad Institute (US)
  • Howard Hughes Medical Institute (US)
Corresponding author
Hooper, Lora V.
Venue
Science
Published
2017-09-08
Volume
357
Issue
6355
Pages
1047-1052
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2740220090
Cited by
396
References
27
Citations by year
2026: 28 · 2025: 46 · 2024: 42 · 2023: 43 · 2022: 70 · 2021: 41 · 2020: 37 · 2019: 46 · 2018: 30 · 2017: 13
FWCI
27.00
Type
journal article
Language
en
Open access
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • National Institutes of Health (award310630, DK070855, award339066, AI118807, award339067, AI128151)
  • Howard Hughes Medical Institute (award310633, N/A)
  • Welch Foundation (award310632, I-1874, award339068, I-1858)
  • Burroughs Wellcome Foundation (award310631, 1007035)
  • Gruss-Lipper Foundation (award310634, N/A)
Topics
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
Paneth cells, lysozyme secretion, secretory autophagy, intestinal epithelial cells, bacterial intestinal infections, endoplasmic reticulum stress, ILC3, antimicrobial proteins, innate immune response
MeSH terms
Autophagy-Related Proteins, Animals, Autophagy, Carrier Proteins, Crohn Disease, Mice, Inbred C57BL, Microtubule-Associated Proteins, Muramidase, Mutation, Salmonella Infections, Salmonella enterica, Paneth Cells, Mice, Endoplasmic Reticulum Stress

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review