Neural architecture of the vertebrate brain: implications for the interaction between emotion and cognition
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Cognition is considered a hallmark of the primate brain that requires a high degree of signal integration, such as achieved in the prefrontal cortex. Moreover, it is often assumed that cognitive capabilities imply "superior" computational mechanisms compared to those involved in emotion or motivation. In contrast to these ideas, we review data on the neural architecture across vertebrates that support the concept that association and integration are basic features of the vertebrate brain, which are needed to successfully adapt to a changing world. This property is not restricted to a few isolated brain centers, but rather resides in neuronal networks working collectively in a context-dependent manner. In different vertebrates, we identify shared large-scale connectional systems involving the midbrain, hypothalamus, thalamus, basal ganglia, and amygdala. The high degree of crosstalk and association between these systems at different levels supports the notion that cognition, emotion, and motivation cannot be separated - all of them involve a high degree of signal integration.
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Developmentally, cortex originates from pallium, a main part of the telencephalon, which can be divided into several parts.
“Developmentally, cortex originates from pallium, a main part of the telencephalon, which can be divided into several parts”
From A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation (2021) · cites this paper as Pessoa et al., 2019
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- Authors
- Pessoa, L., Medina, L., Hof, P. R., & Desfilis, E.
- Affiliations
- University of Maryland, College Park (US)
- Universitat de Lleida (ES)
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Pessoa, Luiz
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 107
- Pages
- 296-312
- ISSN
- 0149-7634 (ISSN-L)
- PMC
- PMC6996540
- OpenAlex
- W2973866007
- Cited by
- 105
- References
- 174
- Citations by year
- 2026: 14 · 2025: 18 · 2024: 13 · 2023: 16 · 2022: 14 · 2021: 18 · 2020: 11
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Repositori ObertUDL (University of Lleida) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institute of Mental Health (MH071589, MH112517)
- Ministerio de Economía y Competitividad
- European Regional Development Fund (BFU2015-68537-R)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
- Keywords
- neural architecture, vertebrate brain, emotion-cognition interaction, signal integration, large-scale brain networks, prefrontal cortex, midbrain, hypothalamus, thalamus, basal ganglia, amygdala, motivation
- MeSH terms
- Animals, Brain, Cognition, Emotions, Humans, Nerve Net, Neural Pathways, Vertebrates
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