Cited by 105Memory and Neural MechanismsNeural and Behavioral Psychology StudiesPrimate Behavior and Ecology

Neural architecture of the vertebrate brain: implications for the interaction between emotion and cognition

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Pessoa, Luiz, Medina, Loreta, Hof, Patrick R., Desfilis, Ester·2019·Neuroscience & Biobehavioral Reviews

Abstract

Cognition is considered a hallmark of the primate brain that requires a high degree of signal integration, such as achieved in the prefrontal cortex. Moreover, it is often assumed that cognitive capabilities imply "superior" computational mechanisms compared to those involved in emotion or motivation. In contrast to these ideas, we review data on the neural architecture across vertebrates that support the concept that association and integration are basic features of the vertebrate brain, which are needed to successfully adapt to a changing world. This property is not restricted to a few isolated brain centers, but rather resides in neuronal networks working collectively in a context-dependent manner. In different vertebrates, we identify shared large-scale connectional systems involving the midbrain, hypothalamus, thalamus, basal ganglia, and amygdala. The high degree of crosstalk and association between these systems at different levels supports the notion that cognition, emotion, and motivation cannot be separated - all of them involve a high degree of signal integration.

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Crossref · 10.1016/j.neubiorev.2019.09.021

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Research works printed but not linked: 2

  1. Medina, 2007, Theories, development, invertebrates, vol. 1, 73
  2. Reiner, 1990, An explanation of behavior, JSTOR.

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Authors
Pessoa, L., Medina, L., Hof, P. R., & Desfilis, E.
Affiliations
  • University of Maryland, College Park (US)
  • Universitat de Lleida (ES)
  • Icahn School of Medicine at Mount Sinai (US)
Corresponding author
Pessoa, Luiz
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
2019-12
Volume
107
Pages
296-312
ISSN
0149-7634 (ISSN-L)
OpenAlex
W2973866007
Cited by
105
References
174
Citations by year
2026: 14 · 2025: 18 · 2024: 13 · 2023: 16 · 2022: 14 · 2021: 18 · 2020: 11
FWCI
1.36
Type
journal article
Language
en
Open access
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Repositori ObertUDL (University of Lleida) (submittedVersion, cc-by-nc-nd)
Funders
  • National Institute of Mental Health (MH071589, MH112517)
  • Ministerio de Economía y Competitividad
  • European Regional Development Fund (BFU2015-68537-R)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
Keywords
neural architecture, vertebrate brain, emotion-cognition interaction, signal integration, large-scale brain networks, prefrontal cortex, midbrain, hypothalamus, thalamus, basal ganglia, amygdala, motivation
MeSH terms
Animals, Brain, Cognition, Emotions, Humans, Nerve Net, Neural Pathways, Vertebrates

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