CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

Chen, Janice S., Ma, Enbo, Harrington, Lucas B., Da Costa, Maria, Tian, Xinran, Palefsky, Joel M., Doudna, Jennifer A.·2018·Science

DOI 10.1126/science.aar6245

Cited by (1,003)

Items 401–500 of 1,003

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Jiyun Chen, Ying Chen, Linglong Huang, Xiaofeng Lin, Hong Chen, Wenwen Xiang, Liang Liu · 2024 · Nature Biotechnology
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RNA targeting unleashes indiscriminate nuclease activity of CRISPR–Cas12a2
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SCOPE enables type III CRISPR-Cas diagnostics using flexible targeting and stringent CARF ribonuclease activation
Jurre A. Steens, Yifan Zhu, David Ward Taylor, Jack P. K. Bravo, Stijn H. P. Prinsen, Cor D. Schoen, Bart J. F. Keijser, Michel Ossendrijver, Laura Marije Hofstra, Stan J. J. Brouns et al. · 2021 · Nature Communications
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Jiajie Qian, Di Huang, Desheng Ni, Jiarun Zhao, Zhuwei Shi, Mengjun Fang, Zhinan Xu · 2021 · Food Control
PAM-independent ultra-specific activation of CRISPR-Cas12a via sticky-end dsDNA
Wei Zhang, Yaoqin Mu, Kejun Dong, Lei Zhang, Bei Yan, Hao Hu, Yangwei Liao, Rong Zhao, Wan Shu, Zhengxin Ye et al. · 2022 · Nucleic Acids Research
Cas12a2 elicits abortive infection through RNA-triggered destruction of dsDNA
Oleg Dmytrenko, Gina C. Neumann, Thomson Hallmark, Dylan Keiser, Valerie M. Crowley, Elena Vialetto, Ioannis Mougiakos, Katharina G. Wandera, Hannah Domgaard, Johannes Weber et al. · 2023 · Nature
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Xiaohong Xiang, Keli Qian, Zhen Zhang, Fengyun Lin, Yang Xie, Yang Liu, Zongfa Yang · 2020 · Journal of drug targeting
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Everardo Gonzalez‐González, Itzel Montserrat Lara-Mayorga, Iram Pablo Rodriguez-Sanchez, Felipe Yee-de León, Andrés García-Rubio, Carlos Ezio Garciamendez‐Mijares, Gilberto Emilio Guerra-Alvarez, Germán García-Martínez, Juan Andrés Aguayo-Hernández, Eduardo Márquez-García et al. · 2020 · Analytical Methods
A novel CRISPR/Cas14a system integrated with 2D porphyrin metal-organic framework for microcystin-LR determination through a homogeneous competitive reaction
Pian Wu, Xiaosheng Ye, Danqi Wang, Fangjie Gong, Xiaoqian Wei, Shan Xiang, Ge Zhang, Tianhan Kai, Ping Ding · 2021 · Journal of Hazardous Materials
Universally Stable and Precise CRISPR-LAMP Detection Platform for Precise Multiple Respiratory Tract Virus Diagnosis Including Mutant SARS-CoV-2 Spike N501Y
Tong Zhang, Wei Zhao, Wang Zhao, Yuying Si, Nianzhen Chen, Xi Chen, Xinlian Zhang, Lieying Fan, Guodong Sui · 2021 · Analytical Chemistry
Mechanistic insights of CRISPR/Cas nucleases for programmable targeting and early-stage diagnosis: A review
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Yuqing Ke, Behafarid Ghalandari, Shiyi Huang, Sijie Li, Chengjie Huang, Xiao Zhi, Daxiang Cui, Xianting Ding · 2022 · Chemical Science
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CRISPR/Cas Systems‐Inspired Nano/Biosensors for Detecting Infectious Viruses and Pathogenic Bacteria
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Advanced Nanotheranostics of CRISPR/Cas for Viral Hepatitis and Hepatocellular Carcinoma
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Microfluidic Ruler-Readout and CRISPR Cas12a-Responded Hydrogel-Integrated Paper-Based Analytical Devices (μReaCH-PAD) for Visible Quantitative Point-of-Care Testing of Invasive Fungi
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Cas12n nucleases, early evolutionary intermediates of type V CRISPR, comprise a distinct family of miniature genome editors
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Universal smartphone-assisted label-free CRISPR/Cas12a-DNAzyme chemiluminescence biosensing platform for on-site detection of nucleic acid and non-nucleic acid targets
Hui Chen, Ying Feng, Feng Liu, Chunyan Tan, Naihan Xu, Yuyang Jiang, Ying Ching Tan · 2023 · Biosensors and Bioelectronics
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