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Single-particle cryo-EM—How did it get here and where will it go
Open accessAbstract
Cryo–electron microscopy, or simply cryo-EM, refers mainly to three very different yet closely related techniques: electron crystallography, single-particle cryo-EM, and electron cryotomography. In the past few years, single-particle cryo-EM in particular has triggered a revolution in structural biology and has become a newly dominant discipline. This Review examines the fascinating story of its start and evolution over the past 40-plus years, delves into how and why the recent technological advances have been so groundbreaking, and briefly considers where the technique may be headed in the future.
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Metadata
- Authors
- Cheng, Y.
- Venue
- Science
- Published
- 2018-08-31
- Volume
- 361
- Issue
- 6405
- Pages
- 876-880
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2889085087
- Cited by
- 448
- References
- 2
- FWCI
- 19.24
- Type
- journal article
- Language
- en
- Open access
- green
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