Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches

The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease

Lamb, J., Crawford, E. D., Peck, D., Modell, J. W., Blat, I. C., Wrobel, M. J., Lerner, J., Brunet, J.-P., Subramanian, A., Ross, K. N., et al. (2006) · Science · doi:10.1126/science.1132939 · Cited by 5,257

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175

Macrophage biology in development, homeostasis and disease

Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature · doi:10.1038/nature12034 · Cited by 4,684 · cited 1×

Full-length RNA-seq from single cells using Smart-seq2

Picelli, S., Faridani, O. R., Björklund, Å. K., Winberg, G., Sagasser, S., & Sandberg, R. (2014) · Nature Protocols · doi:10.1038/nprot.2014.006 · Cited by 4,137

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

Yona, S., Kim, K.-W., Wolf, Y., Mildner, A., Varol, D., Breker, M., Strauss-Ayali, D., Viukov, S., Guilliams, M., Misharin, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.12.001 · Cited by 3,245

Analysis of Fractalkine Receptor CX3CR1 Function by Targeted Deletion and Green Fluorescent Protein Reporter Gene Insertion

Jung, S., Aliberti, J., Graemmel, P., Sunshine, M. J., Kreutzberg, G. W., Sher, A., & Littman, D. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.4106-4114.2000 · Cited by 2,632

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578

Smart-seq2 for sensitive full-length transcriptome profiling in single cells

Picelli, S., Björklund, Å. K., Faridani, O. R., Sagasser, S., Winberg, G., & Sandberg, R. (2013) · Nature Methods · doi:10.1038/nmeth.2639 · Cited by 2,358

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

Hashimoto, D., Chow, A., Noizat, C., Teo, P., Beasley, M. B., Leboeuf, M., Becker, C. D., See, P., Price, J., Lucas, D., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.004 · Cited by 2,311

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

Lavin, Y., Winter, D., Blecher-Gonen, R., David, E., Keren-Shaul, H., Merad, M., Jung, S., & Amit, I. (2014) · Cell · doi:10.1016/j.cell.2014.11.018 · Cited by 2,167

VEGFR2 signaling drives meningeal vascular regeneration upon head injury

Koh, B. I., Lee, H. J., Kwak, P. A., Yang, M. J., Kim, J., Kim, H.-S., Koh, G. Y., & Kim, I. (2020) · Nature Communications · doi:10.1038/s41467-020-17545-2 · Cited by 30

Bioinformatics and Immune Infiltration Analyses Reveal the Key Pathway and Immune Cells in the Pathogenesis of Hypertrophic Cardiomyopathy

Zhang, X., Zhang, S., Tang, T., & Cheng, X. C. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.696321 · Cited by 30

Complement protein C1q activates lung fibroblasts and exacerbates silica-induced pulmonary fibrosis in mice

Ogawa, T., Shichino, S., Ueha, S., Ogawa, S., & Matsushima, K. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.02.090 · Cited by 30

Age-Related Alterations in Macrophage Distribution and Function Are Associated With Delayed Cutaneous Wound Healing

Dube, C. T., Ong, Y. H. B., Wemyss, K., Krishnan, S., Tan, T. J., Janela, B., Grainger, J. R., Ronshaugen, M., Mace, K. A., & Lim, C. Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.943159 · Cited by 34

Obesity retunes turnover kinetics of tissue-resident macrophages in fat

Chen, Q., & Ruedl, C. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.1ma1219-275r · Cited by 31

The origin, fate and function of macrophages in the peripheral nervous system—an update

Amann, L., & Prinz, M. (2020) · International Immunology · doi:10.1093/intimm/dxaa030 · Cited by 34

Synovial macrophage diversity and activation of M-CSF signaling in post-traumatic osteoarthritisPreprint

Knights, A. J., Farrell, E. C., Ellis, O. M., Song, M. J., Appleton, C. T., & Maerz, T. (2023) · eLife · doi:10.7554/elife.93283 · Cited by 30

Pulmonary macrophages and SARS-Cov2 infection

Bain, C. C., Lucas, C. D., & Rossi, A. G. (2022) · International review of cytology · doi:10.1016/bs.ircmb.2022.01.001 · Cited by 31

Homologous recombination deficiency in triple-negative breast cancer: Multi-scale transcriptomics reveals distinct tumor microenvironments and limitations in predicting immunotherapy response

Kang, K., Wu, Y., Chang, H., Wang, L., Wang, Z., & Zhao, A. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2023.106836 · Cited by 30

The crosstalk between enteric nervous system and immune system in intestinal development, homeostasis and diseases

Wang, X., Ding, C., & Li, H. (2023) · Science China Life Sciences · doi:10.1007/s11427-023-2376-0 · Cited by 29

Endothelial metabolic control of insulin sensitivity through resident macrophages

Zhang, J., Sjøberg, K. A., Gong, S., Wang, T., Li, F., Kuo, A., Durot, S., Majcher, A., Ardicoglu, R., Desgeorges, T., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.08.008 · Cited by 30

The Integrated Pulmonary Immune Response to Pneumonia

Traber, K. E., & Mizgerd, J. P. (2025) · Annual Review of Immunology · doi:10.1146/annurev-immunol-082323-031642 · Cited by 33

Sensory neurons shape local macrophage identity via TGF-β signaling

Kolter, J., Döring, C.-L., Sarout, S., Baasch, S., Steele, L., Alsumati, R., da Silva, G. V. L., Silva, C. E. A., Paiva, I. M., Moghadam, Z. M., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.08.004 · Cited by 29

The Sphingosine Kinase 1 Inhibitor, PF543, Mitigates Pulmonary Fibrosis by Reducing Lung Epithelial Cell mtDNA Damage and Recruitment of Fibrogenic Monocytes

Cheresh, P., Kim, S.-J., Huang, L. S., Watanabe, S., Joshi, N., Williams, K. J. N., Chi, M., Lu, Z., Harijith, A. K., Yeldandi, A. V., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165595 · Cited by 29

Diverse Macrophage Populations Contribute to the Inflammatory Microenvironment in Premalignant Lesions During Localized Invasion

Ibrahim, A. M., Moss, M. A., Gray, Z., Rojo, M. D., Burke, C. M., Schwertfeger, K. L., dos Santos, C. O., & Machado, H. L. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.569985 · Cited by 29

Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice

Medina‐Ruiz, L., Bartolini, R., Wilson, G. J., Dyer, D. P., Vidler, F., Hughes, C. E., Schuette, F., Love, S., Pingen, M., Hayes, A. J., et al. (2022) · eLife · doi:10.7554/elife.72418 · Cited by 29

Immune phenotypes that are associated with subsequent COVID-19 severity inferred from post-recovery samples

Liechti, T., Iftikhar, Y., Mangino, M., Beddall, M. H., Goss, C. W., O’Halloran, J. A., Mudd, P. A., & Roederer, M. (2022) · Nature Communications · doi:10.1038/s41467-022-34638-2 · Cited by 32

Blockade of TREM2 ameliorates pulmonary inflammation and fibrosis by modulating sphingolipid metabolism

Gu, X., Kang, H., Cao, S., Tong, Z., & Song, N. (2025) · Translational Research · doi:10.1016/j.trsl.2024.10.002 · Cited by 28

Crystalline Silica-Induced Proinflammatory Interstitial Macrophage Recruitment through Notch3 Signaling Promotes the Pathogenesis of Silicosis

Yuan, H., You, Y., He, Y., Wei, Y., Zhang, Y., Min, H., Li, C. R., & Chen, J. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.3c03980 · Cited by 28

A dynamic and multimodal framework to define microglial states

Sankowski, R., & Prinz, M. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-01978-3 · Cited by 31

B cells modulate the expression of MHC-II on cardiac CCR2− macrophages

Resende, C. R., Pani, F., & Adamo, L. (2021) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2021.05.003 · Cited by 28

Immunosenescence and macrophages: From basics to therapeutics

Zhu, H., Shen, F., Liao, T., Qian, H., & Liu, Y. (2023) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2023.106479 · Cited by 30

The Role of Immune Cells Driving Electropathology and Atrial Fibrillation

Huang, M., Huiskes, F. G., de Groot, N. M. S., & Brundel, B. J. J. M. (2024) · Cells · doi:10.3390/cells13040311 · Cited by 31

Journey of monocytes and macrophages upon influenza A virus infection

Ruscitti, C., Radermecker, C., & Marichal, T. (2024) · Current Opinion in Virology · doi:10.1016/j.coviro.2024.101409 · Cited by 27

TWEAK-Fn14 signaling protects mice from pulmonary fibrosis by inhibiting fibroblast activation and recruiting pro-regenerative macrophages

Li, L., Wu, P., Wei, Y., Lü, M., Ge, H., Wang, P., Sun, J., Horng, T., Liu, X., Shen, X., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2024.115220 · Cited by 32

The equine mononuclear phagocyte system: The relevance of the horse as a model for understanding human innate immunity

Karagianni, A. E., Lisowski, Z. M., Hume, D. A., & Pirie, R. S. (2020) · Equine Veterinary Journal · doi:10.1111/evj.13341 · Cited by 28

Cross-Talk Between Inflammation and Fibroblast Growth Factor 10 During Organogenesis and Pathogenesis: Lessons Learnt From the Lung and Other Organs

Marega, M., Chen, C., & Bellusci, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.656883 · Cited by 28

The roles of hydrogen sulfide in renal physiology and disease states

Feng, J., Lu, X., Li, H., & Wang, S. (2022) · Renal Failure · doi:10.1080/0886022x.2022.2107936 · Cited by 27

Adipocyte hypertrophy associates with in vivo postprandial fatty acid metabolism and adipose single-cell transcriptional dynamics

Ye, R. Z., Montastier, É., Frisch, F., Noll, C., Allard‐Chamard, H., Gévry, N. Y., Tchernof, A., & Carpentier, A. C. (2023) · iScience · doi:10.1016/j.isci.2023.108692 · Cited by 27

The Cellular Organization of the Mammary Gland: Insights From Microscopy

Dawson, C. A., & Visvader, J. E. (2021) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-021-09483-6 · Cited by 30

Genetic Factors Altering Immune Responses in Atrial Fibrillation

Ninni, S., Dombrowicz, D., de Winther, M. P. J., Staels, B., Montaigne, D., & Nattel, S. (2024) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2023.12.034 · Cited by 26

Neutrophils and galectin-3 defend mice from lethal bacterial infection and humans from acute respiratory failure

Das, S., Kaminski, T. W., Schlegel, B. T., Bain, W., Hu, S., Patel, A., Kale, S. L., Chen, K., Lee, J. S., Mallampalli, R. K., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48796-y · Cited by 28

LungVis 1.0: an automatic AI-powered 3D imaging ecosystem unveils spatial profiling of nanoparticle delivery and acinar migration of lung macrophages

Yang, L., Liu, Q., Kumar, P., Sengupta, A., Farnoud, A., Shen, R., Trofimova, D., Ziegler, S., Davoudi, N., Doryab, A., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-54267-1 · Cited by 29

The cellular and molecular cardiac tissue responses in human inflammatory cardiomyopathies after SARS-CoV-2 infection and COVID-19 vaccination

Maatz, H., Lindberg, E. L., Adami, E., López-Anguita, N., Perdomo-Sabogal, Á., Ortega, L. C., Patone, G., Reichart, D., Myronova, A., Schmidt, S., et al. (2025) · Nature Cardiovascular Research · doi:10.1038/s44161-025-00612-6 · Cited by 26

Role of Tristetraprolin in the Resolution of Inflammation

Rappl, P., Brüne, B., & Schmid, T. (2021) · Biology · doi:10.3390/biology10010066 · Cited by 26

Interleukin‐34 accelerates intrauterine adhesions progress related to CX3CR1 + monocytes/macrophages

Wang, J., Li, D., Pan, Y., Li, J., Jiang, Q., Liu, D., & Hou, Y. (2021) · European Journal of Immunology · doi:10.1002/eji.202149174 · Cited by 27

Single-cell transcriptome analysis reveals the dynamics of human immune cells during early fetal skin development

Xu, Y., Zhang, J., Hu, Y., Li, X., Sun, L., Yu, P., Sun, Y., Liu, B., Bian, Z., & Rong, Z. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109524 · Cited by 27

A cardioimmunologist’s toolkit: genetic tools to dissect immune cells in cardiac disease

Wong, A., Hamidzada, H., & Epelman, S. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00701-0 · Cited by 26

Perspective on direction of control: Cellular metabolism and macrophage polarization

Thibaut, R., Orliaguet, L., Ejlalmanesh, T., Venteclef, N., & Alzaïd, F. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.918747 · Cited by 27

Interstitial Macrophages Lead Early Stages of Bleomycin-Induced Lung Fibrosis and Induce Fibroblasts Activation

Libório‐Ramos, S., Barbosa-Matos, C., Fernandes, R., Borges-Pereira, C., & Costa, S. (2023) · Cells · doi:10.3390/cells12030402 · Cited by 28

Emerging Role of Macrophage-Fibroblast Interactions in Cardiac Homeostasis and Remodeling

Zhang, X., Li, Q.-L., Tang, T., & Cheng, X. R. (2024) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2024.06.003 · Cited by 26

Mouse and human macrophages and their roles in cardiovascular health and disease

Gallerand, A., Han, J., Ivanov, S., & Randolph, G. J. (2024) · Nature Cardiovascular Research · doi:10.1038/s44161-024-00580-3 · Cited by 26

Intestinal macrophages modulate synucleinopathy along the gut–brain axis

Schepper, S. D., Konstantellos, V., Conway, J. A., Sokolova, D., Zaccagnini, L., Cowley, M. V., Sierksma, A. S. R., Yudina, M. M., Edmonds, M. J., Gavriouchkina, D., et al. (2026) · Nature · doi:10.1038/s41586-025-09984-y · Cited by 29

Macrophage NOX2 NADPH oxidase maintains alveolar homeostasis in mice

Bhattacharya, S., Idol, R. A., Yang, W., Márquez, J. D. R., Li, Y., Huang, G., Beatty, W. L., Atkinson, J. J., Brumell, J. H., Bagaitkar, J., et al. (2022) · Blood · doi:10.1182/blood.2021015365 · Cited by 25

Lung type II alveolar epithelial cells collaborate with CCR2+ inflammatory monocytes in host defense against poxvirus infection

Yang, N., Luna, J. M., Dai, P., Wang, Y., Rice, C. M., & Deng, L. (2022) · Nature Communications · doi:10.1038/s41467-022-29308-2 · Cited by 25

Single cell transcriptomic analyses reveal diverse and dynamic changes of distinct populations of lung interstitial macrophages in hypoxia-induced pulmonary hypertension

Kumar, S., Mickael, C. S., Kumar, R., Prasad, R. R., Campbell, N. V., Zhang, H., Li, M., McKeon, B. A., Allen, T. E., Graham, B. B., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1372959 · Cited by 27

Cytomegaloviruses and Macrophages—Friends and Foes From Early on?

Baasch, S., Ruzsics, Z., & Henneke, P. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00793 · Cited by 27

The role of macrophage plasticity in neurodegenerative diseases

Ma, H., Zhu, M., Chen, M., Li, X., & Feng, X. (2024) · Biomarker Research · doi:10.1186/s40364-024-00624-7 · Cited by 24

Innate immunity champions: The diverse functions of macrophages

Biscu, F., Zouzaf, A., Cicia, D., Pridans, C., & Matteoli, G. (2024) · European Journal of Immunology · doi:10.1002/eji.202451139 · Cited by 25

The Role of Macrophages During Mammalian Tissue Remodeling and Regeneration Under Infectious and Non-Infectious Conditions

Bohaud, C., Johansen, M. D., Jørgensen, C., Kremer, L., Ipseiz, N., & Djouad, F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.707856 · Cited by 25

Contribution of Adiponectin/Carnitine Palmityl Transferase 1A‐Mediated Fatty Acid Metabolism during the Development of Idiopathic Pulmonary Fibrosis

Wu, W., Zhang, G., Qiu, L., Liu, X., Zhou, S. F., & Wu, J. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/5265616 · Cited by 24

Communication is key: Innate immune cells regulate host protection to helminths

Jianya, P., Federman, H. G., Hernandez, C. M., & Siracusa, M. C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.995432 · Cited by 24

Explaining the polarized macrophage pool during murine allergic lung inflammation

Draijer, C., Florez‐Sampedro, L., Reker‐Smit, C., Post, E., van Dijk, F., & Melgert, B. N. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1056477 · Cited by 24

Analysis of the heterogeneity and complexity of murine extraorbital lacrimal gland via single-cell RNA sequencing

Huang, D., Jiao, X., Huang, S., Liu, J., Si, H., Qi, D., Pei, X., Lu, D., Wang, Y., & Li, Z. (2024) · The Ocular Surface · doi:10.1016/j.jtos.2024.06.005 · Cited by 23

Classical monocyte ontogeny dictates their functions and fates as tissue macrophages

Trzebanski, S., Kim, J.-S., Larossi, N., Raanan, A., Kancheva, D., Bastos, J., Haddad, M., Solomon, A., Sivan, E., Aizik, D., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.06.011 · Cited by 23

Diverse Functions of Macrophages in Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease: Bridging Inflammation and Metabolism

Jang, J. H., Sung, J. H., & Huh, J. Y. (2025) · Immune Network · doi:10.4110/in.2025.25.e12 · Cited by 25

Using High-Dimensional Approaches to Probe Monocytes and Macrophages in Cardiovascular Disease

Dick, S. A., Zaman, R., & Epelman, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02146 · Cited by 25

Mapping Macrophage Polarization and Origin during the Progression of the Foreign Body Response to a Poly(ethylene glycol) Hydrogel Implant

Saleh, L. S., Amer, L. D., Thompson, B. J., Danhorn, T., Knapp, J. R., Gibbings, S. L., Thomas, S. M., Barthel, L., O’Connor, B. P., Janssen, W. J., et al. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202102209 · Cited by 24

Insights from Transcriptomics: CD163+ Profibrotic Lung Macrophages in COVID-19

Bhattacharya, M. (2022) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2022-0107tr · Cited by 24

MHCII expression on gut macrophages supports T cell homeostasis and is regulated by microbiota and ontogeny

Guillaume, J., Leufgen, A., Hager, F. T., Pabst, O., & Cerovic, V. (2023) · Scientific Reports · doi:10.1038/s41598-023-28554-8 · Cited by 25

Cardiac resident macrophages: key regulatory mediators in the aftermath of myocardial infarction

Chen, C., Wang, J., Liu, C., & Hu, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1207100 · Cited by 23

Molecular Markers of Early Immune Response in Tuberculosis: Prospects of Application in Predictive Medicine

Diatlova, A., Linkova, N. S., Lavrova, A. I., Zinchenko, Y. S., Медведев, Д. С., Krasichkov, A. S., Polyakova, V. O., & Yаblonskiy, P. K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713261 · Cited by 23

Non-genetic Heterogeneity of Macrophages in Diseases—A Medical Perspective

Gessain, G., Blériot, C., & Ginhoux, F. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.613116 · Cited by 24

Novel Cell-to-Cell Communications Between Macrophages and Fibroblasts Regulate Obesity-Induced Adipose Tissue Fibrosis

Kohda, H., Tanaka, M., Shichino, S., Arakawa, S., Komori, T., Ito, A., Wada, E., Ochi, K., Yuan, X., Takeda, T., et al. (2025) · Diabetes · doi:10.2337/db24-0762 · Cited by 22

Macrophage Subpopulation Promotes Skeletal Muscle Regeneration Through HGF / MET Signaling‐Mediated Skeletal Muscle Stem Cell Proliferation

Koike, H., Sugimura, M., Ouchi, R., Yoshimoto, Y., Manabe, I., & Oishi, Y. (2025) · Aging Cell · doi:10.1111/acel.70042 · Cited by 22

Spatially resolved transcriptomic analysis of the adult human prostate

Hu, J., Liu, F., Zhang, J., Yin, L., Cao, W., Xu, W., Chang, Y., Wang, Y., Wang, J., Hou, Y., et al. (2025) · Nature Genetics · doi:10.1038/s41588-025-02139-9 · Cited by 23

Spatial Profiling Identifies Regionally Distinct Microenvironments and Targetable Immunosuppressive Mechanisms in Pediatric Osteosarcoma Pulmonary Metastases

Eigenbrood, J., Wong, N. W., Mallory, P. W., Pereira, J. S., Williams, D., Morris-II, D. W., Beck, J. A., Cronk, J. C., Sayers, C. M., Mendez, M., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-24-3723 · Cited by 24

Recent Insights into Cellular Crosstalk in Respiratory and Gastrointestinal Mucosal Immune Systems

Kim, S., & Jang, Y. (2020) · Immune Network · doi:10.4110/in.2020.20.e44 · Cited by 22

Phenotypic and Functional Heterogeneity of Low-Density and High-Density Human Lung Macrophages

Balestrieri, B., Granata, F., Loffredo, S., Petraroli, A., Scalia, G., Morabito, P., Cardamone, C., Varricchi, G., & Triggiani, M. (2021) · Biomedicines · doi:10.3390/biomedicines9050505 · Cited by 23

MAP Kinase Phosphatase-5 Deficiency Protects Against Pressure Overload-Induced Cardiac Fibrosis

Zhong, C., Min, K., Zhao, Z., Zhang, C., Gao, E., Huang, Y., Zhang, X., Baldini, M., Roy, R., Yang, X., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.790511 · Cited by 22

Profibrotic properties of C1q+ interstitial macrophages in silica-induced pulmonary fibrosis in mice

Ogawa, T., Shichino, S., Ueha, S., Bando, K., & Matsushima, K. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.02.037 · Cited by 22

CX3CR1 + Macrophage Facilitates the Resolution of Allergic Lung Inflammation via Interacting CCL26

Moon, H., Kim, S.-J., Kim, K.-H., Kim, Y.-M., Rehman, J., Lee, H., Wu, Y.-C., Lee, S. Y., Christman, J. W., Ackerman, S. J., et al. (2023) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202209-1670oc · Cited by 22

CX3CR1hi macrophages sustain metabolic adaptation by relieving adipose-derived stem cell senescence in visceral adipose tissue

Zhou, Z., Zhang, H., Tao, Y., Jie, H., Zhao, J., Zang, J., Li, H., Wang, Y., Wang, T., Zhao, H., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112424 · Cited by 24

The contribution of the meningeal immune interface to neuroinflammation in traumatic brain injury

Mokbel, A. Y., Burns, M. P., & Main, B. S. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03122-7 · Cited by 25

Simple propagation method for resident macrophages by co-culture and subculture, and their isolation from various organs

Ogawa, K., Tsurutani, M., Hashimoto, A., & Soeda, M. (2019) · BMC Immunology · doi:10.1186/s12865-019-0314-z · Cited by 22

Reduction of host cell mitochondrial activity as Mycobacterium leprae’s strategy to evade host innate immunity

de Oliveira, M. F., Medeiros, R. C. A., Mietto, B. S., Leal-Calvo, T., Mendonça, A. P. M., Rosa, T. L. S. A., da Silva, D. S., Girardi, K. D. C. D. V., Pereira, A. M. R., de Macedo, C. S., et al. (2021) · Immunological Reviews · doi:10.1111/imr.12962 · Cited by 24

Immune mechanisms in fibrotic pulmonary sarcoidosis

Weeratunga, P. N., Möller, D. R., & Ho, L. (2022) · European Respiratory Review · doi:10.1183/16000617.0178-2022 · Cited by 22

Defining and targeting macrophage heterogeneity in the mammary gland and breast cancer

Elfstrum, A. K., Bapat, A. S., & Schwertfeger, K. L. (2024) · Cancer Medicine · doi:10.1002/cam4.7053 · Cited by 22

Injury and obesity differentially and synergistically induce dysregulation of synovial immune cells in osteoarthritis

Harasymowicz, N. S., Harissa, Z., Rashidi, N., Lenz, K. L., Tang, R., & Guilak, F. (2025) · Annals of the Rheumatic Diseases · doi:10.1016/j.ard.2025.03.001 · Cited by 21

Nerve-associated macrophages control adipose homeostasis across lifespan and restrain age-related inflammation

Gonzalez-Hurtado, E., Leveau, C., Li, K., Mishra, M., Qu, R., Goldberg, E. L., Sidorov, S., Damani‐Yokota, P., Yeung, S. T., Khairallah, C. F., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-00952-9 · Cited by 22

Innate immune memory: The evolving role of macrophages in therapy

Damani‐Yokota, P., & Khanna, K. M. (2025) · eLife · doi:10.7554/elife.108276 · Cited by 22

OIT3 mediates macrophage polarization and facilitates hepatocellular carcinoma progression

Yang, S., Zhang, J., Xu, Y., Wang, J., Zhao, H., Lei, J., Zhou, Y. J., Chen, Y., Wu, L., Zhou, M., et al. (2022) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-022-03188-3 · Cited by 21

Identification of Potential Diagnostic Biomarkers and Biological Pathways in Hypertrophic Cardiomyopathy Based on Bioinformatics Analysis

Yu, T.-Y., Huang, Z., & Pu, Z. (2022) · Genes · doi:10.3390/genes13030530 · Cited by 21

The liver contains distinct interconnected networks of CX3CR1 + macrophages, XCR1 + type 1 and CD301a + type 2 conventional dendritic cells embedded within portal tracts

English, K., Tan, S. Y., Kwan, R. Y. Q., Holz, L. E., Sierro, F., McGuffog, C., Kaisho, T., Heath, W. R., MacDonald, K. P. A., McCaughan, G. W., et al. (2022) · Immunology and Cell Biology · doi:10.1111/imcb.12559 · Cited by 21

Tongue immune compartment analysis reveals spatial macrophage heterogeneity

Lyras, E. M., Zimmermann, K., Wagner, L. K., Dörr, D., Klose, C. S. N., Fischer, C., Jung, S., Yona, S., Hovav, A., Stenzel, W., et al. (2022) · eLife · doi:10.7554/elife.77490 · Cited by 21

Heterogeneity of tumor-infiltrating myeloid cells in era of single-cell genomics

Chu, X., Zhang, Y., & Cheng, S. (2022) · Chinese Journal of Cancer Research · doi:10.21147/j.issn.1000-9604.2022.06.01 · Cited by 21

CD206+ tendon resident macrophages and their potential crosstalk with fibroblasts and the ECM during tendon growth and maturation

Bautista, C. A., Srikumar, A., Tichy, E. D., Qian, G., Jiang, X., Qin, L., Mourkioti, F., & Dyment, N. A. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1122348 · Cited by 22

Immunity‐on‐a‐Chip: Integration of Immune Components into the Scheme of Organ‐on‐a‐Chip Systems

Ramadan, Q., Hazaymeh, R., & Zourob, M. M. (2023) · Advanced Biology · doi:10.1002/adbi.202200312 · Cited by 21

Cx3cr1 controls kidney resident macrophage heterogeneity

Yashchenko, A., Bland, S. J., Song, C. J., Ahmed, U. K. B., Sharp, R. R., Darby, I. G., Cordova, A. M., Smith, M. E., Lever, J. M., Li, Z., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1082078 · Cited by 22

Single-cell RNA sequencing-guided fate-mapping toolkit delineates the contribution of yolk sac erythro-myeloid progenitors

Zhao, Y. X., Song, J., Bao, X. W., Zhang, J., Wu, J. C., Wang, L. Y., He, C., Shao, W., Bai, X. L., Liang, T., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113364 · Cited by 21

Immune System of Dental Pulp in Inflamed and Normal Tissue

Sarfi, S., Azaryan, E., & Naseri, M. (2024) · DNA and Cell Biology · doi:10.1089/dna.2024.0044 · Cited by 21

Myeloid‐specific blockade of Notch signaling alleviates murine pulmonary fibrosis through regulating monocyte‐derived Ly6c lo MHCII hi alveolar macrophages recruitment and TGF‐β secretion

Zhang, N., Yang, K., Bai, J., Yi, J., Gao, C.-C., Zhao, J., Liang, S.-Q., Wei, T., Feng, L., Song, L., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201903086rr · Cited by 21

The role of macrophages in asthma-related fibrosis and remodelling

Yang, X., Li, F., Zhang, G., Foster, P. S., & Yang, M. (2025) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2025.108820 · Cited by 20

Differences in glycolytic metabolism between tissue-resident alveolar macrophages and recruited lung macrophages

Woods, P. S., & Mutlu, G. M. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1535796 · Cited by 21

FOLR2+ macrophages in cancer: allies or enemies

Jiang, D., Xiao, R., Bai, J., Wang, X., Fang, Y., Liu, J., Wang, X., Cui, M., You, L., & Zhao, Y. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02257-1 · Cited by 22

Monocyte‐Derived Macrophages‐Synovial Fibroblasts Crosstalk Unravels Oncostatin Signaling Network as a Driver of Synovitis in Osteoarthritis

Laouteouet, D., Bortolotti, O., Marinèche, L., Hannemann, N., Chambon, M., Glasson, Y., Dumé, A., Lima, J. D., Fournial, M., Touchet, D., et al. (2025) · Arthritis & Rheumatology · doi:10.1002/art.43299 · Cited by 20

Cross-Talk Between Neutrophils and Macrophages Post-Myocardial Infarction: From Inflammatory Drivers to Therapeutic Targets

Ciortan, L., Macarie, R. D., Barbu, E., Naie, M. L., Mihaila, A. C., Serbanescu, M. A., & Butoi, E. D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110575 · Cited by 21

Neuroinflammation-Driven Lymphangiogenesis in CNS Diseases

Hsu, M., Laaker, C. J., Sándor, M., & Fábry, Z. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.683676 · Cited by 20

Intratracheal administration of mesenchymal stem cells modulates lung macrophage polarization and exerts anti-asthmatic effects

Mo, Y., Kang, H., Bang, J.-Y., Shin, J. W., Kim, H. Y., Cho, S., & Kang, H. (2022) · Scientific Reports · doi:10.1038/s41598-022-14846-y · Cited by 20

Guidelines for DC preparation and flow cytometry analysis of mouse nonlymphoid tissues

Probst, H. C., Stoitzner, P., Amon, L., Backer, R. A., Brand, A., Chen, J., Clausen, B. E., Dieckmann, S. M., Dudziak, D., Heger, L., et al. (2022) · European Journal of Immunology · doi:10.1002/eji.202249819 · Cited by 22

Tissue macrophages have a split personality

Scanlon, S. T. (2019) · Science · doi:10.1126/science.363.6432.1187-j

Non-classical tissue monocytes and two functionally distinct populations of interstitial macrophages populate the mouse lung

Schyns, J., Bai, Q., Ruscitti, C., Radermecker, C., Schepper, S. D., Chakarov, S., Farnir, F., Pirottin, D., Ginhoux, F., Boeckxstaens, G. E., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11843-0 · Cited by 346

Resident tissue macrophages: Key coordinators of tissue homeostasis beyond immunity

Zhao, J., Andreev, I., & Silva, H. M. (2024) · Science Immunology · doi:10.1126/sciimmunol.add1967 · Cited by 109

The hidden functional diversity of macrophages

(2024) · Nature Immunology · doi:10.1038/s41590-024-01832-x · Cited by 5

Biology of lung macrophages in health and disease

Aegerter, H., Lambrecht, B. N., & Jakubzick, C. (2022) · Immunity · doi:10.1016/j.immuni.2022.08.010 · Cited by 656