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Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches
Abstract
Tissue macrophages have a split personality: Resident tissue macrophages (RTMs) reside in various tissue-specific niches during development. They evince microenvironment-directed phenotypes that support host defense and tissue homeostasis. Chakarov et al. used single-cell RNA sequencing and fate-mapping of murine lung RTMs to interrogate RTM-subset heterogeneity, interrelationships, and ontogeny (see the Perspective by Mildner and Yona). In addition to alveolar macrophages, they identified two different interstitial macrophage populations. One population mostly abutted nerve fibers; the other population preferentially localized near blood vessels and appeared to support vessel integrity and inhibit inflammatory cell infiltration into tissues. Science , this issue p. eaau0964 ; see also p. 1154
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“Since CX3CR1 is a marker of the monocyte-to-macrophage transition and also of the lung interstitial macrophages 45”
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“macrophage-derived amphiregulin (an epidermal growth factor receptor ligand) has recently been shown to induce the differentiation of mesenchymal stromal cells into myofibroblasts via integrin αv-mediated activation of TGF-β79.”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [79]
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Metadata
- Authors
- Chakarov, S., Lim, H. Y., Tan, L., Lim, S. Y., See, P., Lum, J., Zhang, X.-M., Foo, S., Nakamizo, S., Duan, K., Kong, W. T., Gentek, R., Balachander, A., Carbajo, D., Bleriot, C., Malleret, B., Tam, J. K. C., Baig, S., Shabeer, M., Toh, S.-A. E. S., Schlitzer, A., Larbi, A., Marichal, T., Malissen, B., Chen, J., Poidinger, M., Kabashima, K., Bajenoff, M., Ng, L. G., Angeli, V., & Ginhoux, F.
- Affiliations
- Agency for Science, Technology and Research (SG)
- National University of Singapore (SG)
- Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building, Level 3, Singapore 138648, Singapore.
- Centre National de la Recherche Scientifique (FR)
- University of Bonn (DE)
- University of Liège (BE)
- Centre d’Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, 13288 Marseille, France.
- Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
- Corresponding author
- Ginhoux, Florent
- ORCID
- Chakarov, Svetoslav
- Lim, Hwee Ying
- Tan, Leonard
- Lim, Sheau Yng
- See, Peter
- Lum, Josephine
- Foo, Shihui
- Nakamizo, Satoshi
- Duan, Kaibo
- Kong, Wan Ting
- Gentek, Rebecca
- Balachander, Akhila
- Carbajo, Daniel
- Malleret, Benoit
- Tam, John Kit Chung
- Baig, Sonia
- Shabeer, Muhammad
- Toh, Sue-Anne Ee Shiow
- Schlitzer, Andreas
- Larbi, Anis
- Marichal, Thomas
- Malissen, Bernard
- Chen, Jinmiao
- Poidinger, Michael
- Kabashima, Kenji
- Ng, Lai Guan
- Angeli, Veronique
- Ginhoux, Florent
- Venue
- Science
- Published
- 2019-03-15
- Volume
- 363
- Issue
- 6432
- Pages
- eaau0964
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2921168633
- Cited by
- 1,114
- References
- 68
- Citations by year
- 2026: 140 · 2025: 173 · 2024: 176 · 2023: 175 · 2022: 157 · 2021: 123 · 2020: 115 · 2019: 54
- FWCI
- 44.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- HAL AMU (submittedVersion)
- ORBi (University of Liège) (submittedVersion)
- Funders
- AXA Research Fund
- Singapore Immunology Institute
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- interstitial macrophages, alveolar macrophages, macrophage heterogeneity, macrophage ontogeny, lung macrophages, single-cell RNA sequencing, fate mapping
- MeSH terms
- CX3C Chemokine Receptor 1, Animals, Histocompatibility Antigens Class II, Antigens, Ly, Disease Models, Animal, Fibrosis, Glycoproteins, Lung, Macrophages, Mice, Inbred C57BL, Monocytes, Myocardium, Sequence Analysis, RNA, Cell Lineage, Dermis, Membrane Transport Proteins, Organic Anion Transporters, Mice, Single-Cell Analysis, Transcriptome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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