Cited by 1,114Immune cells in cancerPhagocytosis and Immune RegulationNeuroinflammation and Neurodegeneration Mechanisms

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Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches

Chakarov, Svetoslav, Lim, Hwee Ying, Tan, Leonard, Lim, Sheau Yng, See, Peter, Lum, Josephine, Zhang, Xiao-Meng, Foo, Shihui, Nakamizo, Satoshi, Duan, Kaibo, Kong, Wan Ting, Gentek, Rebecca, Balachander, Akhila, Carbajo, Daniel, Bleriot, Camille, Malleret, Benoit, Tam, John Kit Chung, Baig, Sonia, Shabeer, Muhammad, Toh, Sue-Anne Ee Shiow, Schlitzer, Andreas, Larbi, Anis, Marichal, Thomas, Malissen, Bernard, Chen, Jinmiao, Poidinger, Michael, Kabashima, Kenji, Bajenoff, Marc, Ng, Lai Guan, Angeli, Veronique, Ginhoux, Florent·2019·Science

DOI 10.1126/science.aau0964

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Abstract

Tissue macrophages have a split personality: Resident tissue macrophages (RTMs) reside in various tissue-specific niches during development. They evince microenvironment-directed phenotypes that support host defense and tissue homeostasis. Chakarov et al. used single-cell RNA sequencing and fate-mapping of murine lung RTMs to interrogate RTM-subset heterogeneity, interrelationships, and ontogeny (see the Perspective by Mildner and Yona). In addition to alveolar macrophages, they identified two different interstitial macrophage populations. One population mostly abutted nerve fibers; the other population preferentially localized near blood vessels and appeared to support vessel integrity and inhibit inflammatory cell infiltration into tissues. Science , this issue p. eaau0964 ; see also p. 1154

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Authors: Chakarov, S., Lim, H. Y., Tan, L., Lim, S. Y., See, P., Lum, J., Zhang, X.-M., Foo, S., Nakamizo, S., Duan, K., Kong, W. T., Gentek, R., Balachander, A., Carbajo, D., Bleriot, C., Malleret, B., Tam, J. K. C., Baig, S., Shabeer, M., Toh, S.-A. E. S., Schlitzer, A., Larbi, A., Marichal, T., Malissen, B., Chen, J., Poidinger, M., Kabashima, K., Bajenoff, M., Ng, L. G., Angeli, V., & Ginhoux, F.
Affiliations: Agency for Science, Technology and Research (SG)
National University of Singapore (SG)
Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building, Level 3, Singapore 138648, Singapore.
Centre National de la Recherche Scientifique (FR)
University of Bonn (DE)
University of Liège (BE)
Centre d’Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, 13288 Marseille, France.
Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
Corresponding author: Ginhoux, Florent
ORCID: Chakarov, Svetoslav
Lim, Hwee Ying
Tan, Leonard
Lim, Sheau Yng
See, Peter
Lum, Josephine
Foo, Shihui
Nakamizo, Satoshi
Duan, Kaibo
Kong, Wan Ting
Gentek, Rebecca
Balachander, Akhila
Carbajo, Daniel
Malleret, Benoit
Tam, John Kit Chung
Baig, Sonia
Shabeer, Muhammad
Toh, Sue-Anne Ee Shiow
Schlitzer, Andreas
Larbi, Anis
Marichal, Thomas
Malissen, Bernard
Chen, Jinmiao
Poidinger, Michael
Kabashima, Kenji
Ng, Lai Guan
Angeli, Veronique
Ginhoux, Florent
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2019-03-15
Volume: 363
Issue: 6432
Pages: eaau0964
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.aau0964
OpenAlex: W2921168633
Cited by: 1,114
References: 68
Citations by year: 2026: 140 · 2025: 173 · 2024: 176 · 2023: 175 · 2022: 157 · 2021: 123 · 2020: 115 · 2019: 54
FWCI: 44.55
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
National University of Singapore (submittedVersion)
HAL AMU (submittedVersion)
ORBi (University of Liège) (submittedVersion)
Funders: AXA Research Fund
Singapore Immunology Institute
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: interstitial macrophages, alveolar macrophages, macrophage heterogeneity, macrophage ontogeny, lung macrophages, single-cell RNA sequencing, fate mapping
MeSH terms: CX3C Chemokine Receptor 1, Animals, Histocompatibility Antigens Class II, Antigens, Ly, Disease Models, Animal, Fibrosis, Glycoproteins, Lung, Macrophages, Mice, Inbred C57BL, Monocytes, Myocardium, Sequence Analysis, RNA, Cell Lineage, Dermis, Membrane Transport Proteins, Organic Anion Transporters, Mice, Single-Cell Analysis, Transcriptome

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Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches

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