Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches

The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease

Lamb, J., Crawford, E. D., Peck, D., Modell, J. W., Blat, I. C., Wrobel, M. J., Lerner, J., Brunet, J.-P., Subramanian, A., Ross, K. N., et al. (2006) · Science · doi:10.1126/science.1132939 · Cited by 5,257

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175

Macrophage biology in development, homeostasis and disease

Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature · doi:10.1038/nature12034 · Cited by 4,684 · cited 1×

Full-length RNA-seq from single cells using Smart-seq2

Picelli, S., Faridani, O. R., Björklund, Å. K., Winberg, G., Sagasser, S., & Sandberg, R. (2014) · Nature Protocols · doi:10.1038/nprot.2014.006 · Cited by 4,137

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

Yona, S., Kim, K.-W., Wolf, Y., Mildner, A., Varol, D., Breker, M., Strauss-Ayali, D., Viukov, S., Guilliams, M., Misharin, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.12.001 · Cited by 3,245

Analysis of Fractalkine Receptor CX3CR1 Function by Targeted Deletion and Green Fluorescent Protein Reporter Gene Insertion

Jung, S., Aliberti, J., Graemmel, P., Sunshine, M. J., Kreutzberg, G. W., Sher, A., & Littman, D. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.4106-4114.2000 · Cited by 2,632

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578

Smart-seq2 for sensitive full-length transcriptome profiling in single cells

Picelli, S., Björklund, Å. K., Faridani, O. R., Sagasser, S., Winberg, G., & Sandberg, R. (2013) · Nature Methods · doi:10.1038/nmeth.2639 · Cited by 2,358

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

Hashimoto, D., Chow, A., Noizat, C., Teo, P., Beasley, M. B., Leboeuf, M., Becker, C. D., See, P., Price, J., Lucas, D., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.004 · Cited by 2,311

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

Lavin, Y., Winter, D., Blecher-Gonen, R., David, E., Keren-Shaul, H., Merad, M., Jung, S., & Amit, I. (2014) · Cell · doi:10.1016/j.cell.2014.11.018 · Cited by 2,167

Fibrosis: from mechanisms to medicines

Henderson, N. C., Rieder, F., & Wynn, T. A. (2020) · Nature · doi:10.1038/s41586-020-2938-9 · Cited by 1,868

A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells

Cheng, S., Li, Z., Gao, R., Xing, B., Gao, Y., Yang, Y., Qin, S., Zhang, L., Ouyang, H., Du, P., et al. (2021) · Cell · doi:10.1016/j.cell.2021.01.010 · Cited by 1,601

Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer

Zhang, L., Li, Z., Skrzypczynska, K. M., Fang, Q., Zhang, W., O’Brien, S. A., He, Y., Wang, L., Zhang, Q., Kim, A., et al. (2020) · Cell · doi:10.1016/j.cell.2020.03.048 · Cited by 1,620

Microglia Biology: One Century of Evolving Concepts

Prinz, M., Jung, S., & Priller, J. (2019) · Cell · doi:10.1016/j.cell.2019.08.053 · Cited by 1,525

Lipid-associated macrophages control metabolic homeostasis in a Trem2-dependent manner

Jaitin, D. A., Adlung, L., Thaiss, C. A., Weiner, A., Li, B., Descamps, H., Lundgren, P., Bleriot, C., Liu, Z., Deczkowska, A., et al. (2019) · Cell · doi:10.1016/j.cell.2019.05.054 · Cited by 1,377

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Cossarizza, A., Chang, H., Radbruch, A., Acs, A., Adam, D., Adam‐Klages, S., Agace, W. W., Aghaeepour, N., Akdiş, M., Allez, M., et al. (2019) · European Journal of Immunology · doi:10.1002/eji.201970107 · Cited by 1,007

The role of macrophages in the resolution of inflammation

Watanabe, S., Alexander, M., Misharin, A. V., & Budinger, G. R. S. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124615 · Cited by 925

The immunology of rheumatoid arthritis

Weyand, C. M., & Goronzy, J. J. (2020) · Nature Immunology · doi:10.1038/s41590-020-00816-x · Cited by 842

A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling

Qian, J., Olbrecht, S., Boeckx, B., Vos, H., Laoui, D., Etlioglu, E., Wauters, E., Pomella, V., Verbandt, S., Busschaert, P., et al. (2020) · Cell Research · doi:10.1038/s41422-020-0355-0 · Cited by 845

A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart

Nicolás-Ávila, J. A., Lechuga-Vieco, A. V., Esteban-Martínez, L., Sánchez-Díaz, M., Díaz-García, E., Santiago, D. J., Rubio-Ponce, A., Li, J. L., Balachander, A., Quintana, J. A., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.031 · Cited by 762

The pathogenesis of rheumatoid arthritis

Alivernini, S., Firestein, G. S., & McInnes, I. B. (2022) · Immunity · doi:10.1016/j.immuni.2022.11.009 · Cited by 765

Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells

Liu, Z., Gu, Y., Chakarov, S., Bleriot, C., Kwok, I., Chen, X., Shin, A., Huang, W., Dress, R. J., Dutertre, C.-A., et al. (2019) · Cell · doi:10.1016/j.cell.2019.08.009 · Cited by 719

Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma

Sharma, A., Seow, J. J. W., Dutertre, C.-A., Pai, R., Blériot, C., Mishra, A., Wong, R. M. M., Singh, G. S. N., Sudhagar, S., Khalilnezhad, S., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.040 · Cited by 677

Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease

Mulder, K., Patel, A. A., Kong, W. T., Piot, C., Halitzki, E., Dunsmore, G., Khalilnezhad, S., Irac, S. E., Dubuisson, A., Chevrier, M., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.07.007 · Cited by 678

Cells of the human intestinal tract mapped across space and time

Elmentaite, R., Kumasaka, N., Roberts, K., Fleming, A., Dann, E., King, H. W., Kleshchevnikov, V., Dabrowska, M. H., Pritchard, S., Bolt, L., et al. (2021) · Nature · doi:10.1038/s41586-021-03852-1 · Cited by 706

Macrophages in health and disease

Park, M. D., Silvin, A., Ginhoux, F., & Merad, M. (2022) · Cell · doi:10.1016/j.cell.2022.10.007 · Cited by 644

Locally renewing resident synovial macrophages provide a protective barrier for the joint

Culemann, S., Grüneboom, A., Nicolás-Ávila, J. Á., Weidner, D., Lämmle, K. F., Rothe, T., Quintana, J. A., Kirchner, P., Krljanac, B., Eberhardt, M., et al. (2019) · Nature · doi:10.1038/s41586-019-1471-1 · Cited by 656

Biology of lung macrophages in health and disease

Aegerter, H., Lambrecht, B. N., & Jakubzick, C. (2022) · Immunity · doi:10.1016/j.immuni.2022.08.010 · Cited by 656

Tissue-specific macrophages: how they develop and choreograph tissue biology

Mass, E., Nimmerjahn, F., Kierdorf, K., & Schlitzer, A. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-023-00848-y · Cited by 621

Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer

Ramos, R. N., Missolo-Koussou, Y., Gerber-Ferder, Y., Bromley, C. P., Bugatti, M., Núñez, N. G., Tosello, J., Richer, W., Menger, L., Denizeau, J., et al. (2022) · Cell · doi:10.1016/j.cell.2022.02.021 · Cited by 627

Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles

Dick, S. A., Wong, A., Hamidzada, H., Nejat, S., Nechanitzky, R., Vohra, S., Mueller, B., Zaman, R., Kantores, C., Aronoff, L., et al. (2022) · Science Immunology · doi:10.1126/sciimmunol.abf7777 · Cited by 538

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531

Determinants of resident tissue macrophage identity and function

Blériot, C., Chakarov, S., & Ginhoux, F. (2020) · Immunity · doi:10.1016/j.immuni.2020.05.014 · Cited by 507

Fibroblast-macrophage reciprocal interactions in health, fibrosis, and cancer

Buechler, M. B., Fu, W., & Turley, S. J. (2021) · Immunity · doi:10.1016/j.immuni.2021.04.021 · Cited by 494

Single-cell transcriptomics reveals cell-type-specific diversification in human heart failure

Koenig, A. L., Shchukina, I., Amrute, J., Andhey, P. S., Zaitsev, K., Lai, L., Bajpai, G., Bredemeyer, A., Smith, G., Jones, C., et al. (2022) · Nature Cardiovascular Research · doi:10.1038/s44161-022-00028-6 · Cited by 482

Macrophages in Lung Injury, Repair, and Fibrosis

Cheng, P., Li, S., & Chen, H. (2021) · Cells · doi:10.3390/cells10020436 · Cited by 457

Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages

Covarrubias, A. J., Kale, A., Perrone, R., Lopez-Dominguez, J. A., Pisco, A. O., Kasler, H. G., Schmidt, M. S., Heckenbach, I., Kwok, R., Wiley, C. D., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00305-3 · Cited by 420

Role of Cardiac Macrophages on Cardiac Inflammation, Fibrosis and Tissue Repair

Lafuse, W. P., Wozniak, D. J., & Rajaram, M. V. S. (2020) · Cells · doi:10.3390/cells10010051 · Cited by 413

Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function

Eraslan, G., Drokhlyansky, E., Anand, S. K., Fiškin, E., Subramanian, A., Slyper, M., Wang, J., Wittenberghe, N. V., Rouhana, J. M., Waldman, J., et al. (2022) · Science · doi:10.1126/science.abl4290 · Cited by 406

Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets

Chen, R., Zhang, H., Tang, B., Luo, Y., Yang, Y., Zhong, X., Chen, S., Xu, X., Huang, S., & Liu, C. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01840-1 · Cited by 418

Inflammation and Skeletal Muscle Regeneration: Leave It to the Macrophages!

Chazaud, B. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.04.006 · Cited by 397

Macrophage phenotypes in tissue repair and the foreign body response: Implications for biomaterial-based regenerative medicine strategies

Martin, K. E., & Garcı́a, A. J. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.03.038 · Cited by 384

Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas

Zernecke, A., Winkels, H., Cochain, C., Williams, J. W., Wolf, D., Soehnlein, O., Robbins, C. S., Monaco, C. G., Park, I., McNamara, C. A., et al. (2020) · Circulation Research · doi:10.1161/circresaha.120.316903 · Cited by 387

Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets

Guan, F., Wang, R., Yi, Z., Luo, P., Liu, W., Xie, Y., Liu, Z., Xia, Z., Zhang, H., & Cheng, Q. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02124-y · Cited by 371

Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations

Rojo, R., Raper, A., Ozdemir, D. D., Lefèvre, L., Grabert, K., Wollscheid-Lengeling, E., Bradford, B. M., Caruso, M., Gažová, I., Sánchez, A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11053-8 · Cited by 390

Plasticity of Epididymal Adipose Tissue in Response to Diet-Induced Obesity at Single-Nucleus Resolution

Sárvári, A. K., Hauwaert, E. L. V., Markussen, L. K., Gammelmark, E., Marcher, A.-B., Ebbesen, M. F., Nielsen, R., Brewer, J. R., Madsen, J. G. S., & Mandrup, S. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.12.004 · Cited by 377

Roles of macrophages in tumor development: a spatiotemporal perspective

Bied, M., Ho, W. W., Ginhoux, F., & Blériot, C. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01061-6 · Cited by 381

Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity

Hildreth, A. D., Ma, F., Wong, Y. Y., Sun, R., Pellegrini, M. A., & O’Sullivan, T. E. (2021) · Nature Immunology · doi:10.1038/s41590-021-00922-4 · Cited by 377

Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification

Leader, A. M., Grout, J. A., Maier, B. B., Nabet, B. Y., Park, M. D., Tabachnikova, A., Chang, C., Walker, L. A., Lansky, A., Bérichel, J. L., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.10.009 · Cited by 370

A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF/M-CSFR signalling in monocyte-derived alveolar macrophages

Joshi, N., Watanabe, S., Verma, R., Jablonski, R. P., Chen, C.-I., Cheresh, P., Markov, N. S., Reyfman, P. A., McQuattie-Pimentel, A. C., Sichizya, L., et al. (2020) · European Respiratory Journal · doi:10.1183/13993003.00646-2019 · Cited by 344

Macrophage phenotypes and functions: resolving inflammation and restoring homeostasis

Rodríguez-Morales, P., & Franklin, R. A. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.10.004 · Cited by 341

CSF1R inhibition by a small-molecule inhibitor is not microglia specific; affecting hematopoiesis and the function of macrophages

Lei, F., Cui, N., Zhou, C., Chodosh, J., Vavvas, D. G., & Paschalis, E. I. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1922788117 · Cited by 322

Non-classical tissue monocytes and two functionally distinct populations of interstitial macrophages populate the mouse lung

Schyns, J., Bai, Q., Ruscitti, C., Radermecker, C., Schepper, S. D., Chakarov, S., Farnir, F., Pirottin, D., Ginhoux, F., Boeckxstaens, G. E., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11843-0 · Cited by 346

Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer

Etzerodt, A., Moulin, M., Doktor, T. K., Delfini, M., Mossadegh‐Keller, N., Bajénoff, M., Sieweke, M. H., Moestrup, S. K., Auphan‐Anezin, N., & Lawrence, T. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20191869 · Cited by 321

Macrophages in cardiac remodelling after myocardial infarction

Yap, J., Irei, J. S., Lozano-Gerona, J., Vanapruks, S., Bishop, T., & Boisvert, W. A. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00823-5 · Cited by 329

Cross-tissue human fibroblast atlas reveals myofibroblast subtypes with distinct roles in immune modulation

Gao, Y., Li, J., Cheng, W., Diao, T., Liu, H., Bo, Y., Liu, C., Zhou, W., Chen, M., Zhang, Y., et al. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.08.020 · Cited by 320

Distinct microbial and immune niches of the human colon

James, K. R., Gomes, T., Elmentaite, R., Kumar, N., Gulliver, E. L., King, H. W., Stares, M., Bareham, B. R., Ferdinand, J. R., Petrova, V. N., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0602-z · Cited by 312

Lipid-Associated Macrophages Are Induced by Cancer-Associated Fibroblasts and Mediate Immune Suppression in Breast Cancer

Timperi, E., Gueguen, P., Molgora, M., Magagna, I., Kieffer, Y., Lopez‐Lastra, S., Sirven, P., Baudrin, L. G., Baulande, S., Nicolas, A., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-22-1427 · Cited by 323

Identification of a nerve-associated, lung-resident interstitial macrophage subset with distinct localization and immunoregulatory properties

Ural, B. B., Yeung, S. T., Damani‐Yokota, P., Devlin, J. C., de Vries, M., Vera‐Licona, P., Samji, T., Sawai, C. M., Jang, G., Perez, O. A., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.aax8756 · Cited by 298

Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states

Song, H., Weinstein, H. N. W., Allegakoen, P., Wadsworth, M. H., Xie, J., Yang, H., Castro, E. A., Lu, K. L., Stohr, B. A., Feng, F. Y.-C., et al. (2022) · Nature Communications · doi:10.1038/s41467-021-27322-4 · Cited by 294

Macrophages, Chronic Inflammation, and Insulin Resistance

He, L., Meng, Y., He, S., Tan, X., Zhang, Y., Zhang, X., Wang, L., & Zheng, W. (2022) · Cells · doi:10.3390/cells11193001 · Cited by 286

Mucosal immune responses to infection and vaccination in the respiratory tract

Mettelman, R. C., Allen, E. K., & Thomas, P. G. (2022) · Immunity · doi:10.1016/j.immuni.2022.04.013 · Cited by 283

Synovial tissue macrophages in joint homeostasis, rheumatoid arthritis and disease remission

Kurowska‐Stolarska, M., & Alivernini, S. (2022) · Nature Reviews Rheumatology · doi:10.1038/s41584-022-00790-8 · Cited by 279

Macrophage function in adipose tissue homeostasis and metabolic inflammation

Chavakis, T., Alexaki, V. I., & Ferrante, A. W. (2023) · Nature Immunology · doi:10.1038/s41590-023-01479-0 · Cited by 279

TREM2+ macrophages suppress CD8+ T-cell infiltration after transarterial chemoembolisation in hepatocellular carcinoma

Tan, J., Fan, W., Liu, T., Zhu, B., Liu, Y., Wang, S., Wu, J. H., Liu, J., Zou, F., Wei, J., et al. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.02.032 · Cited by 261

The impact of the lung environment on macrophage development, activation and function: diversity in the face of adversity

Bain, C. C., & MacDonald, A. S. (2022) · Mucosal Immunology · doi:10.1038/s41385-021-00480-w · Cited by 266

Profiling peripheral nerve macrophages reveals two macrophage subsets with distinct localization, transcriptome and response to injury

Ydens, E., Amann, L., Asselbergh, B., Scott, C. L., Martens, L., Sichien, D., Mossad, O., Blank, T., Prijck, S. D., Low, D., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0618-6 · Cited by 251

Ontogeny of Tumor-Associated Macrophages

Laviron, M., & Boissonnas, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01799 · Cited by 249

A subset of Kupffer cells regulates metabolism through the expression of CD36

Blériot, C., Barreby, E., Dunsmore, G., Ballaire, R., Chakarov, S., Ficht, X., De Simone, G., Andreata, F., Fumagalli, V., Guo, W., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.08.006 · Cited by 236

Does tissue imprinting restrict macrophage plasticity?

Guilliams, M., & Svedberg, F. R. (2021) · Nature Immunology · doi:10.1038/s41590-020-00849-2 · Cited by 232

Myeloid cells in liver and bone marrow acquire a functionally distinct inflammatory phenotype during obesity-related steatohepatitis

Krenkel, O., Hundertmark, J., Abdallah, A. T., Kohlhepp, M., Puengel, T., Roth, T., Branco, D. P. P., Mossanen, J. C., Luedde, T., Trautwein, C., et al. (2020) · Gut · doi:10.1136/gutjnl-2019-318382 · Cited by 220

A spatially resolved atlas of the human lung characterizes a gland-associated immune niche

Madissoon, E., Oliver, A. J., Kleshchevnikov, V., Wilbrey-Clark, A., Polanski, K., Richoz, N., Ribeiro Orsi, A., Mamanova, L., Bolt, L., Elmentaite, R., et al. (2023) · Nature Genetics · doi:10.1038/s41588-022-01243-4 · Cited by 219

Human skeletal muscle aging atlas

Kedlian, V. R., Wang, Y., Liu, T., Chen, X., Bolt, L., Tudor, C., Shen, Z., Fasouli, E. S., Prigmore, E., Kleshchevnikov, V., et al. (2024) · Nature Aging · doi:10.1038/s43587-024-00613-3 · Cited by 218

Diversity of Macrophages in Lung Homeostasis and Diseases

Hou, F., Xiao, K., Tang, L., & Xie, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.753940 · Cited by 226

Inducing trained immunity in pro-metastatic macrophages to control tumor metastasis

Ding, C., Shrestha, R., Zhu, X., Geller, A. E., Wu, S., Woeste, M. R., Li, W., Wang, H., Yuan, F., Xu, R., et al. (2023) · Nature Immunology · doi:10.1038/s41590-022-01388-8 · Cited by 222

Single-cell analysis of endometriosis reveals a coordinated transcriptional programme driving immunotolerance and angiogenesis across eutopic and ectopic tissues

Tan, Y., Flynn, W. F., Sivajothi, S. K., Luo, D., Bozal, S. B., Davé, M., Luciano, A. A., Robson, P., Luciano, D. E., & Courtois, E. T. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00961-5 · Cited by 223

Adipose tissue at single-cell resolution

Maniyadath, B., Zhang, Q., Gupta, R. K., & Mandrup, S. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.02.002 · Cited by 218

The Ontogeny of Monocyte Subsets

Wolf, A. A., Yáñez, A., Barman, P. K., & Goodridge, H. S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01642 · Cited by 223

Macrophage: A Cell With Many Faces and Functions in Tuberculosis

Ahmad, F., Rani, A., Alam, A., Zarin, S., Pandey, S., Singh, H., Hasnain, S. E., & Ehtesham, N. Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.747799 · Cited by 207

Repair of the Infarcted Heart: Cellular Effectors, Molecular Mechanisms and Therapeutic Opportunities

Hilgendorf, I., Frantz, S., & Frangogiannis, N. G. (2024) · Circulation Research · doi:10.1161/circresaha.124.323658 · Cited by 208

Single cell analysis of M. tuberculosis phenotype and macrophage lineages in the infected lung

Pisu, D., Huang, L., Narang, V., Theriault, M. E., Lê-Bury, G., Lee, B. T. K., Lakudzala, A. E., Mzinza, D. T., Mhango, D. V., Mitini-Nkhoma, S. C., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20210615 · Cited by 199

Immune biology of glioma associated macrophages and microglia: Functional and therapeutic implications

Wei, J., Chen, P., Gupta, P., Ott, M., Zamler, D. B., Kassab, C., Bhat, K., Curran, M. A., de Groot, J., & Heimberger, A. B. (2019) · Neuro-Oncology · doi:10.1093/neuonc/noz212 · Cited by 192

Single-cell, single-nucleus, and spatial transcriptomics characterization of the immunological landscape in the healthy and PSC human liver

Andrews, T. S., Nakib, D., Perciani, C. T., Zhong, X. Y., Liu, L. Y., Winter, E., Camat, D., Chung, S., Lumanto, P., Manuel, J., et al. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2023.12.023 · Cited by 197

Transformer for one stop interpretable cell type annotation

Chen, J., Xu, H., Tao, W., Chen, Z., Zhao, Y., & Han, J.-D. J. (2023) · Nature Communications · doi:10.1038/s41467-023-35923-4 · Cited by 189

Single-Cell Transcriptomics Reveals the Complexity of the Tumor Microenvironment of Treatment-Naive Osteosarcoma

Liu, Y., Feng, W., Dai, Y., Bao, M., Yuan, Z., He, M., Qin, Z., Liao, S., He, J., Huang, Q., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.709210 · Cited by 190

Distinct developmental pathways from blood monocytes generate human lung macrophage diversity

Evren, E., Ringqvist, E. E., Tripathi, K. P., Sleiers, N., Rives, I. C., Alisjahbana, A., Gao, Y., Sarhan, D., Halle, T., Sorini, C., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.12.003 · Cited by 194

Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

Matusiak, M., Hickey, J. W., van IJzendoorn, D. G. P., Lu, G., Kidziński, Ł., Zhu, S., Colburg, D. R. C., Luca, B. A., Phillips, D. J., Brubaker, S. W., et al. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-23-1300 · Cited by 190

Sentinel p16 INK4a+ cells in the basement membrane form a reparative niche in the lung

Reyes, N. S., Krasilnikov, M., Allen, N. C., Lee, J. Y., Hyams, B., Zhou, M., Ravishankar, S., Cassandras, M., Wang, C., Khan, I., et al. (2022) · Science · doi:10.1126/science.abf3326 · Cited by 181

A Binary Cre Transgenic Approach Dissects Microglia and CNS Border-Associated Macrophages

Kim, J.-S., Kolesnikov, M., Peled-Hajaj, S., Scheyltjens, I., Xia, Y., Trzebanski, S., Haimon, Z., Shemer, A., Lubart, A., Van Hove, H., et al. (2021) · Immunity · doi:10.1016/j.immuni.2020.11.007 · Cited by 176

Single-cell analyses implicate ascites in remodeling the ecosystems of primary and metastatic tumors in ovarian cancer

Zheng, X., Wang, X., Cheng, X., Liu, Z., Yin, Y., Li, X., Huang, Z., Wang, Z., Guo, W., Ginhoux, F., et al. (2023) · Nature Cancer · doi:10.1038/s43018-023-00599-8 · Cited by 172

Tissue-resident macrophages: guardians of organ homeostasis

Nobs, S. P., & Köpf, M. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.04.007 · Cited by 180

Origin and ontogeny of lung macrophages: from mice to humans

Evren, E., Ringqvist, E. E., & Willinger, T. (2019) · Immunology · doi:10.1111/imm.13154 · Cited by 185

Tissue-Specific Macrophage Responses to Remote Injury Impact the Outcome of Subsequent Local Immune Challenge

Hoyer, F. F., Naxerova, K., Schloss, M. J., Hulsmans, M., Nair, A. V., Dutta, P., Calcagno, D. M., Hérisson, F., Anzai, A., Sun, Y., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.10.010 · Cited by 177

Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling

Dawson, C. A., Pal, B., Vaillant, F., Gandolfo, L. C., Liu, Z., Blériot, C., Ginhoux, F., Smyth, G. K., Lindeman, G. J., Mueller, S. N., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0505-0 · Cited by 177

Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia

Wang, P. L., Yim, A. K., Kim, K.-W., Avey, D. R., Czepielewski, R. S., Colonna, M., Milbrandt, J., Randolph, G. J., & The Immunological Genome Project (2020) · Nature Communications · doi:10.1038/s41467-020-16355-w · Cited by 168

Tet2-mediated clonal hematopoiesis in nonconditioned mice accelerates age-associated cardiac dysfunction

Wang, Y., Sano, S., Yura, Y., Ke, Z., Sano, M., Oshima, K., Ogawa, H., Horitani, K., Min, K.-D., Miura-Yura, E., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.135204 · Cited by 167

Airway remodelling in asthma and the epithelium: on the edge of a new era

Varricchi, G., Brightling, C. E., Grainge, C., Lambrecht, B. N., & Chanez, P. (2024) · European Respiratory Journal · doi:10.1183/13993003.01619-2023 · Cited by 166

Dynamics of monocyte-derived macrophage diversity in experimental myocardial infarction

Rizzo, G., Gropper, J., Piollet, M., Vafadarnejad, E., Rizakou, A., Bandi, S. R., Arampatzi, P., Krammer, T., DiFabion, N., Dietrich, O., et al. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvac113 · Cited by 165

Inducible antibacterial responses in macrophages

Sweet, M. J., Ramnath, D., Singhal, A., & Kapétanovic, R. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01080-y · Cited by 171

Immune responses during COVID-19 infection

Melenotte, C., Silvin, A., Goubet, A., Lahmar, I., Dubuisson, A., Zumla, A. I., Raoult, D., Merad-Boudia, M., Gachot, B., Henon, C., et al. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1807836 · Cited by 167

Inflammation in Myocardial Ischemia/Reperfusion Injury: Underlying Mechanisms and Therapeutic Potential

Francisco, J. J., & Re, D. P. D. (2023) · Antioxidants · doi:10.3390/antiox12111944 · Cited by 165

A census of the lung: CellCards from LungMAP

Sun, X., Perl, A. T., Li, R., Bell, S. M., Sajti, E., Kalinichenko, V. V., Kalin, T. V., Misra, R. S., Deshmukh, H. S., Clair, G., et al. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.11.007 · Cited by 169

pH sensing at the intersection of tissue homeostasis and inflammation

Hajjar, S., & Zhou, X. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.08.008 · Cited by 165

Immune Cell Subtypes and Their Function in the Testis

Bhushan, S., Theas, M. S., Guazzone, V. A., Jacobo, P. V., Wang, M., Fijak, M., Meinhardt, A., & Lustig, L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.583304 · Cited by 153

An immune cell atlas reveals the dynamics of human macrophage specification during prenatal development

Wang, Z., Wu, Z., Wang, H., Feng, R., Wang, G., Li, M., Wang, S.-Y., Chen, X., Su, Y., Wang, J., et al. (2023) · Cell · doi:10.1016/j.cell.2023.08.019 · Cited by 158

Immune and non-immune functions of adipose tissue leukocytes

Trim, W. V., & Lynch, L. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00635-7 · Cited by 155

Tissue‐resident innate immunity in the lung

Ardain, A., Marakalala, M. J., & Leslie, A. J. (2019) · Immunology · doi:10.1111/imm.13143 · Cited by 142

Resident cardiac macrophages: Heterogeneity and function in health and disease

Zaman, R., & Epelman, S. (2022) · Immunity · doi:10.1016/j.immuni.2022.08.009 · Cited by 145

Single cell atlas identifies lipid-processing and immunomodulatory endothelial cells in healthy and malignant breast

Geldhof, V., de Rooij, L. P. M. H., Sokol, L., Amersfoort, J., Schepper, M. D., Rohlenová, K., Hoste, G., Vanderstichele, A., Delsupehe, A.-M., Isnaldi, E., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33052-y · Cited by 145

Recruited macrophages that colonize the post-inflammatory peritoneal niche convert into functionally divergent resident cells

Louwe, P. A., Gomez, L. B., Webster, H. C., Perona‐Wright, G., Bain, C. C., Forbes, S. J., & Jenkins, S. J. (2021) · Nature Communications · doi:10.1038/s41467-021-21778-0 · Cited by 148

Tissue macrophages have a split personality

Scanlon, S. T. (2019) · Science · doi:10.1126/science.363.6432.1187-j

Non-classical tissue monocytes and two functionally distinct populations of interstitial macrophages populate the mouse lung

Schyns, J., Bai, Q., Ruscitti, C., Radermecker, C., Schepper, S. D., Chakarov, S., Farnir, F., Pirottin, D., Ginhoux, F., Boeckxstaens, G. E., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11843-0 · Cited by 346

Resident tissue macrophages: Key coordinators of tissue homeostasis beyond immunity

Zhao, J., Andreev, I., & Silva, H. M. (2024) · Science Immunology · doi:10.1126/sciimmunol.add1967 · Cited by 109

The hidden functional diversity of macrophages

(2024) · Nature Immunology · doi:10.1038/s41590-024-01832-x · Cited by 5

Biology of lung macrophages in health and disease

Aegerter, H., Lambrecht, B. N., & Jakubzick, C. (2022) · Immunity · doi:10.1016/j.immuni.2022.08.010 · Cited by 656