Effects of microbiota-directed foods in gnotobiotic animals and undernourished children
Open accessAbstract
To examine the contributions of impaired gut microbial community development to childhood undernutrition, we combined metabolomic and proteomic analyses of plasma samples with metagenomic analyses of fecal samples to characterize the biological state of Bangladeshi children with severe acute malnutrition (SAM) as they transitioned, after standard treatment, to moderate acute malnutrition (MAM) with persistent microbiota immaturity. Host and microbial effects of microbiota-directed complementary food (MDCF) prototypes targeting weaning-phase bacterial taxa underrepresented in SAM and MAM microbiota were characterized in gnotobiotic mice and gnotobiotic piglets colonized with age- and growth-discriminatory bacteria. A randomized, double-blind controlled feeding study identified a lead MDCF that changes the abundances of targeted bacteria and increases plasma biomarkers and mediators of growth, bone formation, neurodevelopment, and immune function in children with MAM.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Supplementing children with moderate acute malnutrition with a microbiota-directed complementary food prototype shifted the microbiota as well as markers of neurodevelopment toward that of healthy children, indicating that the immature microbiota is causally linked to unhealthy growth and development, but can be rescued by microbiota-targeted food therapy.
“Supplementing children with moderate acute malnutrition with a microbiota-directed complementary food prototype shifted the microbiota as well as markers of neurodevelopment toward that of healthy children, indicating that the immature microbiota is causally linked to unhealthy growth and development, but can be rescued by microbiota-targeted food therapy (282).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [282]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works
limma powers differential expression analyses for RNA-sequencing and microarray studies
Ritchie, M. E., Phipson, B., Wu, D., Hu, Y., Law, C. W., Shi, W., & Smyth, G. K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv007 · Cited by 40,458 · see citing works
KEGG: Kyoto Encyclopedia of Genes and Genomes
Kanehisa, M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.1.27 · Cited by 37,077 · see citing works
clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
Yu, G., Wang, L.-G., Han, Y., & He, Q.-Y. (2012) · OMICS: A Journal of Integrative Biology · doi:10.1089/omi.2011.0118 · Cited by 36,259 · see citing works
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887 · see citing works
Cutadapt removes adapter sequences from high-throughput sequencing reads
Martin, M. (2011) · EMBnet.journal · doi:10.14806/ej.17.1.200 · Cited by 33,889 · see citing works
KEGG: Kyoto Encyclopedia of Genes and Genomes
Ogata, H., Goto, S., Sato, K., Fujibuchi, W., Bono, H., & Kanehisa, M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.1.29 · Cited by 31,232 · see citing works
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219 · see citing works
SPAdes: A New Genome Assembly Algorithm and Its Applications to Single-Cell Sequencing
Bankevich, A., Nurk, S., Antipov, D., Gurevich, A. A., Dvorkin, M. V., Kulikov, A. S., Lesin, V. M., Nikolenko, S., Pham, S., Prjibelski, A. D., et al. (2012) · Journal of Computational Biology · doi:10.1089/cmb.2012.0021 · Cited by 25,691 · see citing works
Search and clustering orders of magnitude faster than BLAST
Edgar, R. C. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq461 · Cited by 20,617 · see citing works
Prokka: rapid prokaryotic genome annotation
Seemann, T. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu153 · Cited by 18,512 · see citing works
Fast and sensitive protein alignment using DIAMOND
Buchfink, B., Xie, C., & Huson, D. H. (2015) · Nature Methods · doi:10.1038/nmeth.3176 · Cited by 14,201 · see citing works
The RAST Server: Rapid Annotations using Subsystems Technology
Aziz, R. K., Bartels, D., Best, A. A., DeJongh, M., Disz, T. L., Edwards, R. A., Formsma, K., Gerdes, S., Glass, E. M., Kubal, M., et al. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-75 · Cited by 11,777 · see citing works
mTOR Signaling in Growth, Metabolism, and Disease
Saxton, R. A., & Sabatini, D. M. (2017) · Cell · doi:10.1016/j.cell.2017.02.004 · Cited by 7,555 · see citing works
Versatile and open software for comparing large genomes
Kurtz, S., Phillippy, A., Delcher, A. L., Smoot, M., Shumway, M., Antonescu, C., & Salzberg, S. L. (2004) · Genome Biology · doi:10.1186/gb-2004-5-2-r12 · Cited by 5,254 · see citing works
MMseqs2 enables sensitive protein sequence searching for the analysis of massive data sets
Steinegger, M., & Söding, J. (2017) · Nature Biotechnology · doi:10.1038/nbt.3988 · Cited by 4,840 · see citing works
The SEED and the Rapid Annotation of microbial genomes using Subsystems Technology (RAST)
Overbeek, R., Olson, R., Pusch, G. D., Olsen, G. J., Davis, J. J., Disz, T. L., Edwards, R. A., Gerdes, S., Parrello, B., Shukla, M. P., et al. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1226 · Cited by 4,509 · see citing works
Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413 · see citing works
mTOR Signaling in Growth, Metabolism, and Disease.
Saxton, R., & Sabatini, D. (2017) · Cell · doi:10.1016/j.cell.2017.03.035 · Cited by 3,889 · see citing works
Newgard, C. B., An, J., Bain, J. R., Muehlbauer, M. J., Stevens, R. D., Lien, L. F., Haqq, A. M., Shah, S. H., Arlotto, M., Slentz, C. A., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.02.002 · Cited by 3,165 · see citing works
Peng, Y., Leung, H. C. M., Yiu, S., & Chin, F. Y. L. (2012) · Bioinformatics · doi:10.1093/bioinformatics/bts174 · Cited by 2,997 · see citing works
NF-κB, inflammation, immunity and cancer: coming of age
Taniguchi, K., & Karin, M. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.142 · Cited by 2,679 · see citing works
Bifidobacteria can protect from enteropathogenic infection through production of acetate
Fukuda, S., Toh, H., Hase, K., Oshima, K., Nakanishi, Y., Yoshimura, K., Tobe, T., Clarke, J. M., Topping, D. L., Suzuki, T., et al. (2011) · Nature · doi:10.1038/nature09646 · Cited by 2,387 · see citing works
The Subsystems Approach to Genome Annotation and its Use in the Project to Annotate 1000 Genomes
Overbeek, R. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki866 · Cited by 2,019 · see citing works
Kelly, C. J., Zheng, L., Campbell, E. L., Saeedi, B., Scholz, C. C., Bayless, A. J., Wilson, K. E., Glover, L. E., Kominsky, D. J., Magnuson, A., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.03.005 · Cited by 1,716 · see citing works
Turner, S. D., Pryer, K. M., Miao, V., & Palmer, J. D. (1999) · Journal of Eukaryotic Microbiology · doi:10.1111/j.1550-7408.1999.tb04612.x · Cited by 1,576 · see citing works
GAGE: generally applicable gene set enrichment for pathway analysis
Luo, W., Friedman, M. S., Shedden, K., Hankenson, K. D., & Woolf, P. J. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-161 · Cited by 1,333 · see citing works
Basu, S., Binder, R. J., Suto, R., Anderson, K. M., & Srivastava, P. K. (2000) · International Immunology · doi:10.1093/intimm/12.11.1539 · Cited by 1,305 · see citing works
Persistent gut microbiota immaturity in malnourished Bangladeshi children
Subramanian, S., Huq, S., Yatsunenko, T., Haque, R., Mahfuz, M., Alam, M. A., Benezra, A., DeStefano, J., Meier, M. F., Muegge, B. D., et al. (2014) · Nature · doi:10.1038/nature13421 · Cited by 1,270 · see citing works
The first 1000 cultured species of the human gastrointestinal microbiota
Rajilić-Stojanović, M., & de Vos, W. M. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12075 · Cited by 1,182 · see citing works
Quantification of Bone Microarchitecture with the Structure Model Index
Hildebrand, T., & Ruegsegger, P. (1997) · Computer Methods in Biomechanics & Biomedical Engineering · doi:10.1080/01495739708936692 · Cited by 1,053 · see citing works
<i>Lactobacillus reuteri</i> induces gut intraepithelial CD4 <sup>+</sup> CD8αα <sup>+</sup> T cells
Cervantes-Barragan, L., Chai, J. N., Tianero, M. D., Di Luccia, B., Ahern, P. P., Merriman, J., Cortez, V. S., Caparon, M. G., Donia, M. S., Gilfillan, S., et al. (2017) · Science · doi:10.1126/science.aah5825 · Cited by 896 · see citing works
Sela, D. A., Chapman, J., Adeuya, A., Kim, J., Chen, F., Whitehead, T. R., Lapidus, A. L., Rokhsar, D. S., Lebrilla, C. B., German, J. B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809584105 · Cited by 884 · see citing works
Goodman, A. L., Kallstrom, G., Faith, J. J., Reyes, A., Moore, A. M., Dantas, G. A., & Gordon, J. I. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102938108 · Cited by 779 · see citing works
Inflammation Dampened by Gelatinase A Cleavage of Monocyte Chemoattractant Protein-3
McQuibban, G. A., Gong, J.-H., Tam, E. M., McCulloch, C. A., Clark‐Lewis, I., & Overall, C. M. (2000) · Science · doi:10.1126/science.289.5482.1202 · Cited by 772 · see citing works
Gut microbiota induce IGF-1 and promote bone formation and growth
Yan, J., Herzog, J. W., Tsang, K., Brennan, C. A., Bower, M. A., Garrett, W. S., Sartor, B. R., Aliprantis, A. O., & Charles, J. F. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607235113 · Cited by 750 · see citing works
Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children
Blanton, L. V., Charbonneau, M. R., Salih, T., Barratt, M. J., Venkatesh, S., Ilkaveya, O., Subramanian, S., Manary, M. J., Trehan, I., Jorgensen, J. M., et al. (2016) · Science · doi:10.1126/science.aad3311 · Cited by 735 · see citing works
Inexpensive Multiplexed Library Preparation for Megabase-Sized Genomes
Baym, M., Kryazhimskiy, S., Lieberman, T. D., Chung, H., Desai, M. M., & Kishony, R. (2015) · PLOS ONE · doi:10.1371/journal.pone.0128036 · Cited by 685 · see citing works
Phase Transfer Surfactant-Aided Trypsin Digestion for Membrane Proteome Analysis
Masuda, T., Tomita, M., & Ishihama, Y. (2008) · Journal of Proteome Research · doi:10.1021/pr700658q · Cited by 655 · see citing works
Charbonneau, M. R., O’Donnell, D., Blanton, L. V., Totten, S. M., Davis, J. C. C., Barratt, M. J., Cheng, J., Guruge, J., Talcott, M., Bain, J. R., et al. (2016) · Cell · doi:10.1016/j.cell.2016.01.024 · Cited by 606 · see citing works
Self-citationLactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition
Schwarzer, M., Makki, K., Storelli, G., Machuca‐Gayet, I., Šrůtková, D., Hermanová, P. P., Martino, M. E., Balmand, S., Hudcovic, T., Heddi, A., et al. (2016) · Science · doi:10.1126/science.aad8588 · Cited by 590 · see citing works
Tabb, D. L., Fernando, C., & Chambers, M. (2007) · Journal of Proteome Research · doi:10.1021/pr0604054 · Cited by 548 · see citing works
IGF-Binding Proteins: Why Do They Exist and Why Are There So Many?
Allard, J. B., & Duan, C. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00117 · Cited by 517 · see citing works
RegPrecise 3.0–a resource for genome-scale exploration of transcriptional regulation in bacteria
Novichkov, P. S., Kazakov, A. E., Ravcheev, D. A., Leyn, S. A., Kovaleva, G. Y., Sutormin, R. A., Kazanov, M. D., Riehl, W., Arkin, A. P., Dubchak, I., et al. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-745 · Cited by 451 · see citing works
Self-citationBifidobacterium longum subspecies infantis: champion colonizer of the infant gut
Underwood, M. A., German, J. B., Lebrilla, C. B., & Mills, D. A. (2015) · Pediatric Research · doi:10.1038/pr.2014.156 · Cited by 439 · see citing works
Russell, W. R., Duncan, S. H., Scobbie, L., Duncan, G., Cantlay, L., Calder, A. G., Anderson, S. E., & Flint, H. J. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200594 · Cited by 417 · see citing works
Assessment of Variability in the SOMAscan Assay
Candia, J., Cheung, F., Kotliarov, Y., Fantoni, G., Sellers, B. A., Griesman, T., Huang, J., Stuccio, S., Zingone, A., Ryan, B. M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-14755-5 · Cited by 399 · see citing works
Martín, R., Miquel, S., Benevides, L., Bridonneau, C., Robert, V., Hudault, S., Chain, F., Berteau, O., Azevedo, V., Chatel, J. M., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01226 · Cited by 398 · see citing works
A Laboratory-Developed TaqMan Array Card for Simultaneous Detection of 19 Enteropathogens
Liu, J., Gratz, J. C., Amour, C., Kibiki, G. S., Becker, S. M., Janaki, L., Verweij, J. J., Taniuchi, M., Sobuz, S. U., Haque, R., et al. (2012) · Journal of Clinical Microbiology · doi:10.1128/jcm.02658-12 · Cited by 393 · see citing works
The MAL-ED Network Investigators, Acosta, A. M., Chávez, C. B., Flores, J. T., Olotegui, M. P., Pinedo, S. R., Trigoso, D. R., Vasquez, A. O., Ahmed, I., Alam, D. S., et al. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu653 · Cited by 377 · see citing works
IDPicker 2.0: Improved Protein Assembly with High Discrimination Peptide Identification Filtering
Ma, Z.-Q., Dasari, S., Chambers, M., Litton, M. D., Sobecki, S. M., Zimmerman, L. J., Halvey, P. J., Schilling, B., Drake, P. M., Gibson, B. W., et al. (2009) · Journal of Proteome Research · doi:10.1021/pr900360j · Cited by 328 · see citing works
Miquel, S., Leclerc, M., Martín, R., Chain, F., Lenoir, M., Raguideau, S., Hudault, S., Bridonneau, C., Northen, T. R., Bowen, B. P., et al. (2015) · mBio · doi:10.1128/mbio.00300-15 · Cited by 320 · see citing works
Development of the gut microbiota and mucosal IgA responses in twins and gnotobiotic mice
Planer, J. D., Peng, Y., Kau, A. L., Blanton, L. V., Ndao, I. M., Tarr, P. I., Warner, B. B., & Gordon, J. I. (2016) · Nature · doi:10.1038/nature17940 · Cited by 320 · see citing works
Fatty acid synthesis configures the plasma membrane for inflammation in diabetes
Wei, X., Song, H., Yin, L., Rizzo, M. G., Sidhu, R., Covey, D. F., Ory, D. S., & Semenkovich, C. F. (2016) · Nature · doi:10.1038/nature20117 · Cited by 316 · see citing works
Eggs in Early Complementary Feeding and Child Growth: A Randomized Controlled Trial
Iannotti, L. L., Lutter, C. K., Stewart, C. P., Gallegos-Riofrío, C. A., Malo, C., Reinhart, G. A., Palacios, A. M., Karp, C. A., Chapnick, M., Cox, K. L., et al. (2017) · PEDIATRICS · doi:10.1542/peds.2016-3459 · Cited by 296 · see citing works
McNulty, N. P., Wu, M., Erickson, A. R., Pan, C., Erickson, B. K., Martens, E. C., Pudlo, N. A., Muegge, B. D., Henrissat, B., Hettich, R. L., et al. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001637 · Cited by 295 · see citing works
Stunting Is Characterized by Chronic Inflammation in Zimbabwean Infants
Prendergast, A. J., Rukobo, S., Chasekwa, B., Mutasa, K., Ntozini, R., Mbuya, M. N. N., Jones, A. D., Moulton, L. H., Stoltzfus, R. J., & Humphrey, J. H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086928 · Cited by 294 · see citing works
Ahmed, T., Ali, M., Ullah, M. M., Choudhury, I. A., Haque, M. E., Salam, M. A., Rabbani, G. H., Suskind, R. M., & Fuchs, G. J. (1999) · The Lancet · doi:10.1016/s0140-6736(98)07499-6 · Cited by 288 · see citing works
A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity
Marchant, D., Bellac, C. L., Moraes, T. J., Wadsworth, S. J., Dufour, A., Butler, G. S., Bilawchuk, L. M., Hendry, R. G., Robertson, A. G., Cheung, C., et al. (2014) · Nature Medicine · doi:10.1038/nm.3508 · Cited by 265 · see citing works
Advances in human proteomics at high scale with the SOMAscan proteomics platform
Gold, L., Walker, J. J., Wilcox, S. K., & Williams, S. A. (2011) · New Biotechnology · doi:10.1016/j.nbt.2011.11.016 · Cited by 263 · see citing works
Dean, R. A., Cox, J. H., Bellac, C. L., Doucet, A., Starr, A. E., & Overall, C. M. (2008) · Blood · doi:10.1182/blood-2007-12-129080 · Cited by 257 · see citing works
Fetuin B is a secreted hepatocyte factor linking steatosis to impaired glucose metabolism
Meex, R. C., Hoy, A. J., Morris, A., Brown, R. D., Lo, J. C. Y., Burke, M., Goode, R. J. A., Kingwell, B. A., Kraakman, M. J., Febbraio, M. A., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.023 · Cited by 255 · see citing works
White, P., Lapworth, A., An, J., Wang, L.-P., McGarrah, R., Stevens, R., Ilkayeva, O., George, T., Muehlbauer, M., Bain, J. R., et al. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.04.006 · Cited by 253 · see citing works
Sujino, T., London, M., Hoytema van Konijnenburg, D. P., Rendon, T., Buch, T., Silva, H. M., Lafaille, J. J., Reis, B. S., & Mucida, D. (2016) · Science · doi:10.1126/science.aaf3892 · Cited by 250 · see citing works
Genetic determinants of in vivo fitness and diet responsiveness in multiple human gut Bacteroides
Wu, M., McNulty, N. P., Rodionov, D. A., Khoroshkin, M., Griffin, N. W., Cheng, J., Latreille, P., Kerstetter, R. A., Terrapon, N., Henrissat, B., et al. (2015) · Science · doi:10.1126/science.aac5992 · Cited by 245 · see citing works
Breyner, N. M., Michon, C., de Sousa, C. S., Boas, P. C. B. V., Chain, F., Azevedo, V., Langella, P., & Chatel, J. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00114 · Cited by 238 · see citing works
The effects of micronutrient deficiencies on bacterial species from the human gut microbiota
Hibberd, M. C., Wu, M., Rodionov, D. A., Li, X., Cheng, J., Griffin, N. W., Barratt, M. J., Giannone, R. J., Hettich, R. L., Osterman, A. L., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aal4069 · Cited by 221 · see citing works
A sparse covarying unit that describes healthy and impaired human gut microbiota development
Raman, A. S., Gehrig, J. L., Venkatesh, S., Chang, H.-W., Hibberd, M. C., Subramanian, S., Kang, G., Bessong, P. O., Lima, A. Â. M., Kosek, M. N., et al. (2019) · Science · doi:10.1126/science.aau4735 · Cited by 214 · see citing works
Clavel, T., Henderson, G., Engst, W., Dore, J. M., & Blaut, M. (2006) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2005.00057.x · Cited by 209 · see citing works
Lerner, L., Hayes, T. G., Tao, N., Krieger, B., Feng, B., Wu, Z., Nicoletti, R., Chiu, M. I., Gyuris, J., & Garcia, J. M. (2015) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12033 · Cited by 208 · see citing works
Nutrition of Children and Women in Bangladesh: Trends and Directions for the Future
Ahmed, T., Ireen, S., Ahmed, A. M. S., Rahman, S., Islam, M. M., Alam, N., Hossain, M., Rahman, S. M. M., Ali, M. M., Choudhury, F. P., et al. (2012) · Journal of Health Population and Nutrition · doi:10.3329/jhpn.v30i1.11268 · Cited by 208 · see citing works
Ferrara, C. T., Wang, P., Neto, E. C., Stevens, R. D., Bain, J. R., Wenner, B. R., Ilkayeva, O., Keller, M. P., Blasiole, D. A., Kendziorski, C. M., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000034 · Cited by 204 · see citing works
The role of PAPP-A in the IGF system: location, location, location
Oxvig, C. (2015) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-015-0259-9 · Cited by 200 · see citing works
Bartz, S., Mody, A., Hornik, C. P. V., Bain, J. R., Muehlbauer, M. J., Kiyimba, T., Kiboneka, E., Stevens, R., Bartlett, J. A., Peter, J. V. S., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4018 · Cited by 198 · see citing works
Das, G., Augustine, M. M., Das, J., Bottomly, K., Ray, P., & Ray, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0831037100 · Cited by 197 · see citing works
Dey, N., Wagner, V. E., Blanton, L. V., Cheng, J., Fontana, L., Haque, R., Ahmed, T., & Gordon, J. I. (2015) · Cell · doi:10.1016/j.cell.2015.08.059 · Cited by 195 · see citing works
Krause, D., Suh, H.-S., Tarassishin, L., Cui, Q., Durafourt, B. A., Choi, N., Bauman, A., Cosenza-Nashat, M. A., Antel, J. P., Zhao, M., et al. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.05.048 · Cited by 176 · see citing works
Prehn, J., Mehdizadeh, S., Landers, C. J., Luo, X., Cha, S. C., Wei, P., & Targan, S. R. (2004) · Clinical Immunology · doi:10.1016/j.clim.2004.02.007 · Cited by 160 · see citing works
Lack of fibulin-3 causes early aging and herniation, but not macular degeneration in mice
McLaughlin, P. J., Bakall, B., Choi, J., Liu, Z., Sasaki, T., Davis, E. C., Marmorstein, A. D., & Marmorstein, L. Y. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm264 · Cited by 160 · see citing works
Sandige, H. L., Ndekha, M. J., Briend, A., Ashorn, P., & MANARY, M. J. (2004) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200408000-00003 · Cited by 151 · see citing works
Fernando, W., Hill, J., Zello, G., Tyler, R., Dahl, W., & Van Kessel, A. (2010) · Beneficial Microbes · doi:10.3920/bm2009.0027 · Cited by 151 · see citing works
Compensatory Responses to Pyruvate Carboxylase Suppression in Islet β-Cells
Jensen, M. V., Joseph, J. W., Ilkayeva, O., Burgess, S. C., Lu, D., Ronnebaum, S. M., Odegaard, M. L., Becker, T. C., Sherry, A. D., & Newgard, C. B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604350200 · Cited by 144 · see citing works
Antonow‐Schlorke, I., Schwab, M. G., Cox, L. A., Li, C., Stuchlik, K. M., Witte, O. W., Nathanielsz, P. W., & McDonald, T. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009838108 · Cited by 143 · see citing works
TL1A Synergizes with IL-12 and IL-18 to Enhance IFN-γ Production in Human T Cells and NK Cells
Papadakis, K. A., Prehn, J., Landers, C. J., Han, Q., Luo, X., Cha, S. C., Wei, P., & Targan, S. R. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.11.7002 · Cited by 143 · see citing works
RibEx: a web server for locating riboswitches and other conserved bacterial regulatory elements
Abreu‐Goodger, C., & Merino, E. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki445 · Cited by 143 · see citing works
Amino acid scoring patterns for protein quality assessment
Millward, D. J. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512002462 · Cited by 139 · see citing works
Kosek, M. N., Guerrant, R. L., Kang, G., Bhutta, Z. A., Yori, P. P., Gratz, J. C., Gottlieb, M., Lang, D., Lee, G. O., Haque, R., et al. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu457 · Cited by 137 · see citing works
Avoiding the pitfalls of gene set enrichment analysis with SetRank
Simillion, C., Liechti, R., Lischer, H. E. L., Ioannidis, V., & Bruggmann, R. (2017) · BMC Bioinformatics · doi:10.1186/s12859-017-1571-6 · Cited by 131 · see citing works
Overexpression of Human Stanniocalcin Affects Growth and Reproduction in Transgenic Mice
Varghese, R., Gagliardi, A. D., Bialek, P., Yee, S., Wagner, G. F., & DiMattia, G. E. (2002) · Endocrinology · doi:10.1210/endo.143.3.8671 · Cited by 123 · see citing works
CD4 CTL: Living up to the challenge
Cheroutre, H., & Husain, M. M. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.10.022 · Cited by 119 · see citing works
Kløverpris, S., Mikkelsen, J. H., Pedersen, J. H., Jepsen, M. R., Laursen, L. S., Petersen, S. V., & Oxvig, C. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.650143 · Cited by 110 · see citing works
Beyond antibodies: New affinity reagents to unlock the proteome
Lollo, B. A., Steele, F. R., & Gold, L. (2014) · PROTEOMICS · doi:10.1002/pmic.201300187 · Cited by 110 · see citing works
Murshid, A., Gong, J., & Calderwood, S. K. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903635 · Cited by 108 · see citing works
Pinheiro, T. D. A., Barcala-Jorge, A. S., Andrade, J. M. O., Pinheiro, T. D. A., Ferreira, E. C. N., Crespo, T. S., Batista-Jorge, G. C., Vieira, C. A., Lelis, D. D. F., Paraíso, A. F., et al. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.06.008 · Cited by 103 · see citing works
WISP3 and RhoC guanosine triphosphatase cooperate in the development of inflammatory breast cancer
Kleer, C. G., Zhang, Y., Pan, Q., Gallagher, G., Wu, M., Wu, Z.-F., & Merajver, S. D. (2003) · Breast Cancer Research · doi:10.1186/bcr755 · Cited by 101 · see citing works
GDF15 is a heart‐derived hormone that regulates body growth
Wang, T., Liu, J., McDonald, C., Lupino, K., Zhai, X., Wilkins, B. J., Hakonarson, H. H., & Pei, L. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201707604 · Cited by 92 · see citing works
Qin, X., Wergedal, J. E., Rehage, M., Tran, K., Newton, J., Lam, P., Baylink, D. J., & Mohan, S. (2006) · Endocrinology · doi:10.1210/en.2006-1055 · Cited by 89 · see citing works
The MAL-ED Cohort Study in Mirpur, Bangladesh
Ahmed, T., Mahfuz, M., Islam, M. M., Mondal, D., Hossain, M. I., Ahmed, A. M. S., Tofail, F., Gaffar, S. M. A., Haque, R., Guerrant, R. L., et al. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu458 · Cited by 82 · see citing works
LC/MS/MS Method for Quantitative Determination of Long-Chain Fatty Acyl-CoAs
Magnes, C., Sinner, F. M., Regittnig, W., & Pieber, T. R. (2005) · Analytical Chemistry · doi:10.1021/ac048314i · Cited by 77 · see citing works
Fielder, P. J., Mortensen, D. L., Mallet, P., Carlsson, B., Baxter, R. C., & CLARK, R. G. (1996) · Endocrinology · doi:10.1210/endo.137.5.8612531 · Cited by 77 · see citing works
Yapo, B. M. (2009) · Biomacromolecules · doi:10.1021/bm801490e · Cited by 65 · see citing works
Hoeflich, A., & Russo, V. C. (2015) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2015.07.002 · Cited by 64 · see citing works
Clarkson, S. M., Giannone, R. J., Kridelbaugh, D. M., Elkins, J. G., Guss, A. M., & Michener, J. K. (2017) · Applied and Environmental Microbiology · doi:10.1128/aem.01313-17 · Cited by 64 · see citing works
Zhao, J., Li, M., Bradfield, J. P., Zhang, H., Mentch, F. D., Wang, K., Abou‐Sleiman, P. M., Kim, C. E., Glessner, J., Hou, C., et al. (2010) · BMC Medical Genetics · doi:10.1186/1471-2350-11-96 · Cited by 63 · see citing works
Growth hormone binding protein. The soluble growth hormone receptor.
Baumann, G. (2002) · PubMed · Cited by 60 · see citing works
Meng, L., Bai, Z., He, S., Mochizuki, K., Liu, Y., Purushe, J., Sun, H., Wang, J., Yagita∥, H., Mineishi, S., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1501310 · Cited by 59 · see citing works
Rasmussen, M. H., Ho, K. K. Y., Kjems, L., & Hilsted, J. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.4.8636361 · Cited by 56 · see citing works
Gyrup, C., & Oxvig, C. (2007) · Biochemistry · doi:10.1021/bi062229i · Cited by 54 · see citing works
Pabois, A., Pagie, S., Gérard, N., LABOISSE, C. L., Pattier, S., Hulin, P., Nédellec, S., Toquet, C. S., & Charreau, B. L. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.01.016 · Cited by 53 · see citing works
Plasma biomarker proteins for detection of human growth hormone administration in athletes
Tan, S. H., Lee, A., Pascovici, D., Care, N., Birzniece, V., Ho, K. K. Y., Molloy, M. P., & Khan, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-09968-7 · Cited by 41 · see citing works
Manikam, L., Robinson, A., Kuah, J. Y., Vaidya, H. J., Alexander, E. C., Miller, G. W., Singh, K. K., Dawe, V., Ahmed, S., Lingam, R., et al. (2017) · BMC Nutrition · doi:10.1186/s40795-017-0176-9 · Cited by 37 · see citing works
Rehage, M., Mohan, S., Wergedal, J. E., Bonafede, B., Tran, K., Hou, D., Phang, D., Kumar, A., & Qin, X. (2007) · Endocrinology · doi:10.1210/en.2007-0274 · Cited by 34 · see citing works
WISP-3 functions as a ligand and promotes superoxide dismutase activity
Davis, L., Chen, Y., & Sen, M. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.01.132 · Cited by 33 · see citing works
Choudhury, N., Ahmed, T., Hossain, M. I., Islam, M. M., Sarker, S. A., Zeilani, M., & Clemens, J. D. (2017) · Food and Nutrition Bulletin · doi:10.1177/0379572117743929 · Cited by 33 · see citing works
PAPP-A, IGFBP-4 and IGF-II are secreted by human adipose tissue cultures in a depot-specific manner
Gude, M. F., Hjortebjerg, R., Oxvig, C., Thyø, A. A., Magnusson, N. E., Bjerre, M., Pedersen, S. B., & Frystyk, J. (2016) · European Journal of Endocrinology · doi:10.1530/eje-16-0569 · Cited by 31 · see citing works
Choi, J., Liu, H., Mukherjee, R., & Yun, J. W. (2012) · Cellular Physiology and Biochemistry · doi:10.1159/000339065 · Cited by 28 · see citing works
Distinct structural requirements for CDON and BOC in the promotion of Hedgehog signaling
Song, J. Y., Holtz, A. M., Pinskey, J. M., & Allen, B. L. (2015) · Developmental Biology · doi:10.1016/j.ydbio.2015.03.015 · Cited by 25 · see citing works
Spatiotemporal Regulation of Hsp90–Ligand Complex Leads to Immune Activation
Tamura, Y., Yoneda, A., Takei, N., & Sawada, K. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00201 · Cited by 21 · see citing works
Physiological role of bone morphogenetic proteins in osteogenesis
Kugimiya, F., Ohba, S., Nakamura, K., Kawaguchi, H., & Chung, U. (2006) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-005-0653-0 · Cited by 20 · see citing works
Vassilyadi, P., Harding, S., Hazell, T. J., Weiler, H. A., & Wykes, L. (2016) · Pediatric Research · doi:10.1038/pr.2016.135 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Gut microbiota in human metabolic health and disease
Fan, Y., & Pedersen, O. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-0433-9 · Cited by 4,724 · see citing works
The maternal microbiome modulates fetal neurodevelopment in mice
Vuong, H. E., Pronovost, G. N., Williams, D. W., Coley, E. J. L., Siegler, E. L., Qiu, A., Kazantsev, M., Wilson, C. J., Rendon, T., & Hsiao, E. Y. (2020) · Nature · doi:10.1038/s41586-020-2745-3 · Cited by 564 · see citing works
Developmental origins of metabolic diseases
Hoffman, D. J., Powell, T. L., Barrett, E. S., & Hardy, D. B. (2020) · Physiological Reviews · doi:10.1152/physrev.00002.2020 · Cited by 483 · see citing works
Developmental trajectory of the healthy human gut microbiota during the first 5 years of life
Roswall, J., Olsson, L. M., Kovatcheva‐Datchary, P., Nilsson, S., Tremaroli, V., Simon, M., Kiilerich, P., Akrami, R., Kramer, M. M., Uhlén, M., et al. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.02.021 · Cited by 473 · see citing works
Sorbara, M. T., & Pamer, E. G. (2022) · Nature Reviews Microbiology · doi:10.1038/s41579-021-00667-9 · Cited by 468 · see citing works
Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
Berding, K., Vlckova, K., Marx, W., Schellekens, H., Stanton, C., Clarke, G., Jacka, F., Dinan, T. G., & Cryan, J. F. (2021) · Advances in Nutrition · doi:10.1093/advances/nmaa181 · Cited by 451 · see citing works
Zhu, H., Bi, D., Zhang, Y., Kong, C., Du, J., Wu, X., Wei, Q., & Qin, H. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00831-w · Cited by 412 · see citing works
Winkler, E. S., Gilchuk, P., Yu, J., Bailey, A. L., Chen, R. E., Chong, Z., Zost, S. J., Jang, H., Huang, Y., Allen, J. D., et al. (2021) · Cell · doi:10.1016/j.cell.2021.02.026 · Cited by 366 · see citing works
Self-citationThe Healthy Microbiome—What Is the Definition of a Healthy Gut Microbiome?
Shanahan, F., Ghosh, T. S., & O’Toole, P. W. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.09.057 · Cited by 383 · see citing works
Vulnerability of the industrialized microbiota
Sonnenburg, J. L., & Sonnenburg, E. D. (2019) · Science · doi:10.1126/science.aaw9255 · Cited by 330 · see citing works
A Microbiota-Directed Food Intervention for Undernourished Children
Chen, R. Y., Mostafa, I., Hibberd, M. C., Das, S., Mahfuz, M., Naila, N. N., Islam, M. M., Huq, S., Alam, M. A., Zaman, M. U., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2023294 · Cited by 306 · see citing works
Vitamins, the gut microbiome and gastrointestinal health in humans
Pham, V. T., Dold, S., Rehman, A., Bird, J. K., & Steinert, R. E. (2021) · Nutrition Research · doi:10.1016/j.nutres.2021.09.001 · Cited by 286 · see citing works
Problems with the concept of gut microbiota dysbiosis
Brüssow, H. (2020) · Microbial Biotechnology · doi:10.1111/1751-7915.13479 · Cited by 250 · see citing works
Gut Microbial Dysbiosis in the Pathogenesis of Gastrointestinal Dysmotility and Metabolic Disorders
Singh, R., Zogg, H., Wei, L., Bartlett, A., Ghoshal, U. C., Rajender, S., & Ro, S. (2020) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm20149 · Cited by 266 · see citing works
Rethinking healthy eating in light of the gut microbiome
Armet, A. M., Deehan, E. C., O’Sullivan, A. F., Mota, J. F., Field, C. J., Prado, C. M., Lucey, A. J., & Walter, J. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2022.04.016 · Cited by 252 · see citing works
Microbiome-based interventions to modulate gut ecology and the immune system
Hitch, T. C. A., Hall, L. J., Walsh, S. K., Leventhal, G. E., Slack, E. M. C., de Wouters, T., Walter, J., & Clavel, T. (2022) · Mucosal Immunology · doi:10.1038/s41385-022-00564-1 · Cited by 250 · see citing works
A collection of bacterial isolates from the pig intestine reveals functional and taxonomic diversity
Wylensek, D., Hitch, T. C. A., Riedel, T., Afrizal, A., Kumar, N., Wortmann, E., Liu, T., Devendran, S., Lesker, T. R., Hernández, S. B., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19929-w · Cited by 232 · see citing works
Ni, Y., Qian, L., Siliceo, S. L., Long, X., Nychas, E., Liu, Y., Ismaiah, M. J., Leung, H., Zhang, L., Gao, Q., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.08.002 · Cited by 231 · see citing works
A sparse covarying unit that describes healthy and impaired human gut microbiota development
Raman, A. S., Gehrig, J. L., Venkatesh, S., Chang, H.-W., Hibberd, M. C., Subramanian, S., Kang, G., Bessong, P. O., Lima, A. Â. M., Kosek, M. N., et al. (2019) · Science · doi:10.1126/science.aau4735 · Cited by 214 · see citing works
Park, J. C., & Im, S. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0473-2 · Cited by 217 · see citing works
Western diets and chronic diseases
Adolph, T. E., & Tilg, H. (2024) · Nature Medicine · doi:10.1038/s41591-024-03165-6 · Cited by 203 · see citing works
Priming for Life: Early Life Nutrition and the Microbiota-Gut-Brain Axis
Ratsika, A., Codagnone, M. G., O’Mahony, S. M., Stanton, C., & Cryan, J. F. (2021) · Nutrients · doi:10.3390/nu13020423 · Cited by 184 · see citing works
Micronutrient Requirements and Sharing Capabilities of the Human Gut Microbiome
Rodionov, D. A., Arzamasov, A. A., Khoroshkin, M., Iablokov, S. N., Leyn, S. A., Peterson, S. N., Novichkov, P. S., & Osterman, A. L. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01316 · Cited by 177 · see citing works
Cowan, C. S. M., Dinan, T. G., & Cryan, J. F. (2020) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13156 · Cited by 176 · see citing works
Liu, T., Kern, J. T., Jain, U., Sonnek, N. M., Xiong, S., Simpson, K. F., VanDussen, K. L., Winkler, E. S., Haritunians, T., Malique, A., et al. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.04.004 · Cited by 173 · see citing works
Malnutrition and Gut Microbiota in Children
Iddrisu, I., Monteagudo-Mera, A., Poveda, C. G., Pyle, S., Shahzad, M. A., Andrews, S. C., & Walton, G. (2021) · Nutrients · doi:10.3390/nu13082727 · Cited by 170 · see citing works
Barratt, M. J., Nuzhat, S., Ahsan, K., Frese, S. A., Arzamasov, A. A., Sarker, S. A., Islam, M. M., Palit, P., Islam, M. R., Hibberd, M. C., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abk1107 · Cited by 169 · see citing works
Duodenal Microbiota in Stunted Undernourished Children with Enteropathy
Chen, R. Y., Kung, V. L., Das, S., Hossain, M. S., Hibberd, M. C., Guruge, J. L., Mahfuz, M., Begum, S., Rahman, M., Fahim, S. M., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa1916004 · Cited by 167 · see citing works
The human gut microbiome and health inequities
Amato, K. R., Arrieta, M., Azad, M. B., Bailey, M. T., Broussard, J. L., Bruggeling, C. E., Claud, E. C., Costello, E. K., Davenport, E., Dutilh, B. E., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2017947118 · Cited by 167 · see citing works
Pursuing Human-Relevant Gut Microbiota-Immune Interactions
Spencer, S. P., Fragiadakis, G. K., & Sonnenburg, J. L. (2019) · Immunity · doi:10.1016/j.immuni.2019.08.002 · Cited by 160 · see citing works
Pham, V. T., Fehlbaum, S., Seifert, N., Richard, N., Bruins, M. J., Sybesma, W., Rehman, A., & Steinert, R. E. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1875774 · Cited by 158 · see citing works
Deconstructing Mechanisms of Diet-Microbiome-Immune Interactions
Alexander, M., & Turnbaugh, P. J. (2020) · Immunity · doi:10.1016/j.immuni.2020.07.015 · Cited by 150 · see citing works
Control of immunity via nutritional interventions
Collins, N., & Belkaid, Y. (2022) · Immunity · doi:10.1016/j.immuni.2022.01.004 · Cited by 130 · see citing works
Role of Bifidobacteria on Infant Health
Saturio, S., Nogacka, A. M., Alvarado-Jasso, G. M., Salazar, N., Reyes‐Gavilán, C. G. D. L., Gueimonde, M., & Arboleya, S. (2021) · Microorganisms · doi:10.3390/microorganisms9122415 · Cited by 140 · see citing works
The neurovascular unit and systemic biology in stroke — implications for translation and treatment
Tiedt, S., Buchan, A. M., Dichgans, M., Lizasoaín, I., Moro, M. Á., & Lo, E. H. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00703-z · Cited by 130 · see citing works
Enhanced cultured diversity of the mouse gut microbiota enables custom-made synthetic communities
Afrizal, A., Jennings, S. A. V., Hitch, T. C. A., Riedel, T., Basic, M., Panyot, A., Treichel, N. S., Hager, F. T., Wong, E. O.-Y., Wolter, B., et al. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2022.09.011 · Cited by 125 · see citing works
Nonalcoholic Fatty Liver Disease and the Gut-Liver Axis: Exploring an Undernutrition Perspective
Bauer, K. C., Littlejohn, P. T., Ayala, V., Creus-Cuadros, A., & Finlay, B. B. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.01.058 · Cited by 124 · see citing works
Dietary protein and the intestinal microbiota: An understudied relationship
Bartlett, A., & Kleiner, M. (2022) · iScience · doi:10.1016/j.isci.2022.105313 · Cited by 124 · see citing works
Consuegra, J., Grenier, T., Bâa-Puyoulet, P., Rahioui, I., Akherraz, H., Gervais, H., Parisot, N., Silva, P. D., Charles, H., Calevro, F., et al. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000681 · Cited by 121 · see citing works
Understanding the mother-breastmilk-infant “triad”
Bode, L., Raman, A. S., MURCH, S. H., Rollins, N. C., & Gordon, J. I. (2020) · Science · doi:10.1126/science.aaw6147 · Cited by 120 · see citing works
Genomic reconstruction of short-chain fatty acid production by the human gut microbiota
Frolova, M. S., Suvorova, I. A., Iablokov, S. N., Petrov, S. N., & Rodionov, D. A. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.949563 · Cited by 119 · see citing works
Vitamins for the Gut Microbiome
Steinert, R. E., Lee, Y. K., & Sybesma, W. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.11.005 · Cited by 115 · see citing works
Microbe-mediated intestinal NOD2 stimulation improves linear growth of undernourished infant mice
Schwarzer, M., Gautam, U. K., Makki, K., Lambert, A., Brabec, T., Joly, A., Šrůtková, D., Poinsot, P., Novotná, T., Geoffroy, S., et al. (2023) · Science · doi:10.1126/science.ade9767 · Cited by 117 · see citing works
Immune-Microbiota Interplay and Colonization Resistance in Infection
Leshem, A., Liwinski, T., & Elinav, E. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.03.001 · Cited by 113 · see citing works
Microbiota-brain interactions: Moving toward mechanisms in model organisms
Nagpal, J. K., & Cryan, J. F. (2021) · Neuron · doi:10.1016/j.neuron.2021.09.036 · Cited by 107 · see citing works
Mother–infant transmission of human microbiota
Browne, H. P., Shao, Y., & Lawley, T. D. (2022) · Current Opinion in Microbiology · doi:10.1016/j.mib.2022.102173 · Cited by 112 · see citing works
A nonenzymatic method for cleaving polysaccharides to yield oligosaccharides for structural analysis
Amicucci, M. J., Nandita, E., Galermo, A. G., Castillo, J. J., Chen, S., Park, D., Smilowitz, J. T., German, J. B., Mills, D. A., & Lebrilla, C. B. (2020) · Nature Communications · doi:10.1038/s41467-020-17778-1 · Cited by 107 · see citing works
Huang, G., Wang, L., Li, J., Hou, R., Wang, M., Wang, Z., Qu, Q., Zhou, W., Nie, Y., Hu, Y., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2021.110203 · Cited by 104 · see citing works
Nurturing the Early Life Gut Microbiome and Immune Maturation for Long Term Health
Dogra, S. K., Chung, C. K. C. K., Wang, D., Sakwińska, O., Mottaz, S. C., & Sprenger, N. (2021) · Microorganisms · doi:10.3390/microorganisms9102110 · Cited by 103 · see citing works
Going with the grain: Fiber, cognition, and the microbiota-gut-brain-axis
Berding, K., Carbia, C., & Cryan, J. F. (2021) · Experimental Biology and Medicine · doi:10.1177/1535370221995785 · Cited by 100 · see citing works
Roles of the gut microbiome in weight management
Carmody, R. N., & Bisanz, J. E. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-023-00888-0 · Cited by 103 · see citing works
Reframing anorexia nervosa as a metabo-psychiatric disorder
Bulik, C. M., Carroll, I. M., & Mehler, P. (2021) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2021.07.010 · Cited by 96 · see citing works
A distinct clade of Bifidobacterium longum in the gut of Bangladeshi children thrives during weaning
Vatanen, T., Ang, Q. Y., Siegwald, L., Sarker, S. A., Roy, C. I. L., Duboux, S., Delannoy-Bruno, O., Ngom‐Bru, C., Boulangé, C. L., Stražar, M., et al. (2022) · Cell · doi:10.1016/j.cell.2022.10.011 · Cited by 92 · see citing works
The gut microbiome and early-life growth in a population with high prevalence of stunting
Robertson, R. C., Edens, T. J., Carr, L., Mutasa, K., Gough, E. K., Evans, C., Geum, H. M., Baharmand, I., Gill, S. K., Ntozini, R., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36135-6 · Cited by 98 · see citing works
Yeoh, Y. K., Sun, Y., Ip, L., Wang, L., Chan, F. K. L., Miao, Y., & Ng, S. C. (2022) · Scientific Reports · doi:10.1038/s41598-022-12721-4 · Cited by 98 · see citing works
The influence of nutrition on clinical outcomes in children with cancer
Barr, R. D., & Stevens, M. C. G. (2020) · Pediatric Blood & Cancer · doi:10.1002/pbc.28117 · Cited by 92 · see citing works
A systematic review on the role of microbiota in the pathogenesis and treatment of eating disorders
Carbone, E. A., D'Amato, P., Vicchio, G., Fazio, P. D., & Segura‐Garcìa, C. (2020) · European Psychiatry · doi:10.1192/j.eurpsy.2020.109 · Cited by 90 · see citing works
Benezra, A. (2020) · Science Technology & Human Values · doi:10.1177/0162243920911998 · Cited by 90 · see citing works
A framework for microbiome science in public health
Wilkinson, J. E., Franzosa, E. A., Everett, C., Li, C., trainees, H. R. A., Bae, S., Berzansky, I., Bhosle, A., Bjørnevik, K., Brennan, C. A., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01258-0 · Cited by 89 · see citing works
Jašarević, E., Hill, E. M., Kane, P. J., Rutt, L., Gyles, T. M., Folts, L. M., Rock, K. D., Howard, C. D., Morrison, K. E., Ravel, J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26634-9 · Cited by 85 · see citing works
The gut microbiota mediates protective immunity against tuberculosis via modulation of lncRNA
Yang, F., Yang, Y., Chen, L., Zhang, Z., Liu, L., Zhang, C., Mai, Q., Chen, Z., Chen, Z., Lin, T., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2029997 · Cited by 84 · see citing works
Underwood, M. A., Mukhopadhyay, S., Lakshminrusimha, S., & Bevins, C. L. (2020) · Journal of Perinatology · doi:10.1038/s41372-020-00829-2 · Cited by 81 · see citing works
Geographic Differences in Gut Microbiota Composition Impact Susceptibility to Enteric Infection
Porras, A. M., Shi, Q., Zhou, H., Callahan, R., Montenegro-Bethancourt, G., Solomons, N., & Brito, I. L. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109457 · Cited by 74 · see citing works
Gehrig, J. L., Portik, D. M., Driscoll, M. D., Jackson, E., Chakraborty, S., Gratalo, D., Ashby, M., & Valladares, R. B. (2022) · Microbial Genomics · doi:10.1099/mgen.0.000794 · Cited by 78 · see citing works
The future of human malnutrition: rebalancing agency for better nutritional health
Wells, J. C. K., Marphatia, A. A., Amable, G. S., Siervo, M., Friis, H., Miranda, J. J., Haisma, H. H., & Raubenheimer, D. (2021) · Globalization and Health · doi:10.1186/s12992-021-00767-4 · Cited by 94 · see citing works
Dynamic of the human gut microbiome under infectious diarrhea
The, H. C., & Le, S.-N. H. (2022) · Current Opinion in Microbiology · doi:10.1016/j.mib.2022.01.006 · Cited by 78 · see citing works
Clinical evidence of the role of Methanobrevibacter smithii in severe acute malnutrition
Camara, A., Konaté, S., Alou, M. T., Kodio, A., Togo, A. H., Cortaredona, S., Henrissat, B., Thera, M. A., Doumbo, O. K., Raoult, D., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-84641-8 · Cited by 73 · see citing works
The intersection of undernutrition, microbiome, and child development in the first years of life
Fontaine, F., Turjeman, S. C., Callens, K., & Koren, O. (2023) · Nature Communications · doi:10.1038/s41467-023-39285-9 · Cited by 79 · see citing works
Haberman, Y., Iqbal, N. T., Ghandikota, S. K., Mallawaarachchi, I. V., Braun, T., Dexheimer, P. J., Rahman, N., Hadar, R., Sadiq, K., Ahmad, Z., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.01.221 · Cited by 73 · see citing works
Health Benefits of Dietary Fiber for the Management of Inflammatory Bowel Disease
Yusuf, K., Saha, S., & Umar, S. (2022) · Biomedicines · doi:10.3390/biomedicines10061242 · Cited by 73 · see citing works
Microbiome as an immune regulator in health, disease, and therapeutics
Juarez, V. M., Montalbine, A. N., & Singh, A. K. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114400 · Cited by 76 · see citing works
Dietary Selection Pressures and Their Impact on the Gut Microbiome
Ecklu-Mensah, G., Gilbert, J. A., & Devkota, S. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.07.009 · Cited by 76 · see citing works
Parker, E. P. K., Bronowski, C., Sindhu, K. N., Babji, S., Benny, B., Carmona‐Vicente, N., Chasweka, N., Chinyama, E., Cunliffe, N. A., Dube, Q., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27074-1 · Cited by 72 · see citing works
Food Insecurity, Malnutrition, and the Microbiome
Christian, V. J., Miller, K. R., & Martindale, R. G. (2020) · Current Nutrition Reports · doi:10.1007/s13668-020-00342-0 · Cited by 71 · see citing works
Microbial liberation of N-methylserotonin from orange fiber in gnotobiotic mice and humans
Han, N. D., Cheng, J., Delannoy-Bruno, O., Webber, D. M., Terrapon, N., Henrissat, B., Rodionov, D. A., Arzamasov, A. A., Osterman, A. L., Hayashi, D. K., et al. (2022) · Cell · doi:10.1016/j.cell.2022.06.004 · Cited by 71 · see citing works
Keller, L. J., Babin, B. M., Lakemeyer, M., & Bogyo, M. S. (2019) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2019.10.007 · Cited by 70 · see citing works
Bioactive glycans in a microbiome-directed food for children with malnutrition
Hibberd, M. C., Webber, D. M., Rodionov, D. A., Henrissat, S., Chen, R. Y., Zhou, C., Lynn, H. M., Wang, Y., Chang, H.-W., Lee, E. M., et al. (2023) · Nature · doi:10.1038/s41586-023-06838-3 · Cited by 68 · see citing works
Greathouse, K. L., Wyatt, M., Johnson, A. J., Toy, E. P., Khan, J., Dunn, K., Clegg, D. J., & Reddy, S. (2022) · Neoplasia · doi:10.1016/j.neo.2022.100800 · Cited by 65 · see citing works
Environmental enteric dysfunction: gut and microbiota adaptation in pregnancy and infancy
Cowardin, C. A., Syed, S., Iqbal, N. T., Jamil, Z., Sadiq, K., Iqbal, J., Ali, A., & Moore, S. R. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00714-7 · Cited by 67 · see citing works
Rankin, L. C., Kaiser, K. A., Santos, K. D. L., Park, H., Uhlemann, A., Gray, D. H. D., & Arpaia, N. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112135 · Cited by 63 · see citing works
Laursen, M. F., & Roager, H. M. (2023) · The ISME Journal · doi:10.1038/s41396-023-01525-7 · Cited by 63 · see citing works
Gut Microbiota Regulate Astrocytic Functions in the Brain: Possible Therapeutic Consequences
Zhao, Y.-F., Wei, D., & Tang, Y. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210215123239 · Cited by 60 · see citing works
Gut microbiome development and childhood undernutrition
Barratt, M. J., Ahmed, T., & Gordon, J. I. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2022.04.002 · Cited by 60 · see citing works
Ang, Q. Y., Alba, D., Upadhyay, V., Bisanz, J. E., Cai, J., Lee, H. L., Barajas, E., Wei, G., Noecker, C. A., Patterson, A. D., et al. (2021) · eLife · doi:10.7554/elife.70349 · Cited by 60 · see citing works
Darnaud, M., Vadder, F. D., Bogeat, P., Boucinha, L., Bulteau, A., Bunescu, A., Couturier, C., Delgado, A., Dugua, H., Elie, C., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26963-9 · Cited by 54 · see citing works
Whelan, K., Alexander, M., Gaïani, C., Lunken, G., Holmes, A. J., Staudacher, H. M., Theis, S., & Marco, M. L. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01831-6 · Cited by 63 · see citing works
Luccia, B. D., Ahern, P. P., Griffin, N. W., Cheng, J., Guruge, J. L., Byrne, A. E., Rodionov, D. A., Leyn, S. A., Osterman, A. L., Ahmed, T., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.04.008 · Cited by 58 · see citing works
Chang, H.-W., Lee, E. M., Wang, Y., Zhou, C., Pruss, K. M., Henrissat, S., Chen, R. Y., Kao, C.-Y., Hibberd, M. C., Lynn, H. M., et al. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01628-7 · Cited by 60 · see citing works
The roles and potential of lentil prebiotic carbohydrates in human and plant health
Johnson, N., Johnson, C. R., Thavarajah, P., Kumar, S., & Thavarajah, D. (2020) · Plants People Planet · doi:10.1002/ppp3.10103 · Cited by 57 · see citing works
Studies of xenobiotic-induced gut microbiota dysbiosis: from correlation to mechanisms
Chi, L., Tu, P., Ru, H., & Lü, K. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1921912 · Cited by 58 · see citing works
The impact of maternal and early life malnutrition on health: a diet-microbe perspective
Forgie, A. J., Drall, K. M., Bourque, S. L., Field, C. J., Kozyrskyj, A. L., & Willing, B. P. (2020) · BMC Medicine · doi:10.1186/s12916-020-01584-z · Cited by 59 · see citing works
Moustafa, M. A. M., Chel, H. M., Thu, M. J., Bawm, S., Htun, L. L., Win, M. M., Oo, Z. M., Ohsawa, N., Lahdenperä, M., Mohamed, W. M. A., et al. (2021) · Scientific Reports · doi:10.1038/s41598-020-80537-1 · Cited by 56 · see citing works
Di Luccia, B., Molgora, M., Khantakova, D., Jaeger, N., Chang, H.-W., Czepielewski, R. S., Helmink, B. A., Onufer, E. J., Fachi, J. L., Bhattarai, B., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.adi5374 · Cited by 59 · see citing works
Self-citationWong, C. B., Huang, H., Ning, Y., & Xiao, J. (2024) · Microorganisms · doi:10.3390/microorganisms12051014 · Cited by 56 · see citing works
MASI: microbiota—active substance interactions database
Zeng, X. L., Yang, X., Fan, J., Tan, Y. C., Ju, L., Shen, W. X., Wang, Y., Wang, X., Chen, W., Ju, D., et al. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa924 · Cited by 54 · see citing works
Human Milk Oligosaccharide Compositions Illustrate Global Variations in Early Nutrition
Vinjamuri, A., Davis, J. C. C., Totten, S. M., Wu, L. D., Klein, L. D., Martin, M., Quinn, E. A., Scelza, B., Breakey, A., Gurven, M., et al. (2022) · The Journal of Nutrition · doi:10.1093/jn/nxac027 · Cited by 53 · see citing works
Identifying determinants of bacterial fitness in a model of human gut microbial succession
Feng, L., Raman, A. S., Hibberd, M. C., Cheng, J., Griffin, N. W., Peng, Y., Leyn, S. A., Rodionov, D. A., Osterman, A. L., & Gordon, J. I. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1918951117 · Cited by 53 · see citing works
Littlejohn, P. T., & Finlay, B. B. (2021) · BMC Medicine · doi:10.1186/s12916-021-01910-z · Cited by 53 · see citing works
Li, S., Feng, X., Hao, X., Zhu, Y., Zou, L., Chen, X., & Yao, Y. (2023) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.13183 · Cited by 52 · see citing works
Impact of international travel and diarrhea on gut microbiome and resistome dynamics
Boolchandani, M., Blake, K. S., Tilley, D. H., Cabada, M. M., Schwartz, D. J., Patel, S., Morales, M. L., Meza, R. A., Soto, G. M., Isidean, S. D., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34862-w · Cited by 52 · see citing works
- Authors
- Gehrig, J. L., Venkatesh, S., Chang, H.-W., Hibberd, M. C., Kung, V. L., Cheng, J., Chen, R. Y., Subramanian, S., Cowardin, C. A., Meier, M. F., O’Donnell, D., Talcott, M., Spears, L. D., Semenkovich, C. F., Henrissat, B., Giannone, R. J., Hettich, R. L., Ilkayeva, O., Muehlbauer, M., Newgard, C. B., Sawyer, C., Head, R. D., Rodionov, D. A., Arzamasov, A. A., Leyn, S. A., Osterman, A. L., Hossain, M. I., Islam, M., Choudhury, N., Sarker, S. A., Huq, S., Mahmud, I., Mostafa, I., Mahfuz, M., Barratt, M. J., Ahmed, T., & Gordon, J. I.
- Affiliations
- Washington University in St. Louis (US)
- Centre National de la Recherche Scientifique (FR)
- Oak Ridge National Laboratory (US)
- Duke Medical Center (US)
- Russian Academy of Sciences (RU)
- Sanford Burnham Prebys Medical Discovery Institute (US)
- International Centre for Diarrhoeal Disease Research (BD)
- Corresponding author
- Gehrig, Jeanette L.
- Venkatesh, Siddarth
- Chang, Hao-Wei
- Gordon, Jeffrey I.
- ORCID
- Gehrig, Jeanette L.
- Venkatesh, Siddarth
- Chang, Hao-Wei
- Hibberd, Matthew C.
- Kung, Vanderlene L.
- Cheng, Jiye
- Chen, Robert Y.
- Subramanian, Sathish
- Cowardin, Carrie A.
- O’Donnell, David
- Talcott, Michael
- Spears, Larry D.
- Semenkovich, Clay F.
- Henrissat, Bernard
- Giannone, Richard J.
- Hettich, Robert L.
- Ilkayeva, Olga
- Muehlbauer, Michael
- Newgard, Christopher B.
- Sawyer, Christopher
- Head, Richard D.
- Rodionov, Dmitry A.
- Arzamasov, Aleksandr A.
- Leyn, Semen A.
- Osterman, Andrei L.
- Hossain, Md Iqbal
- Islam, Munirul
- Choudhury, Nuzhat
- Sarker, Shafiqul Alam
- Huq, Sayeeda
- Mahmud, Imteaz
- Mostafa, Ishita
- Mahfuz, Mustafa
- Barratt, Michael J.
- Ahmed, Tahmeed
- Gordon, Jeffrey I.
- Venue
- Science
- Published
- 2019-07-12
- Volume
- 365
- Issue
- 6449
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC6683325
- OpenAlex
- W2959398154
- Cited by
- 431
- References
- 120
- Citations by year
- 2026: 38 · 2025: 51 · 2024: 56 · 2023: 57 · 2022: 72 · 2021: 82 · 2020: 56 · 2019: 16 · 2018: 2
- FWCI
- 18.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Science (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Commons@Becker (Washington University School of Medicine) (submittedVersion, cc-by)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion, cc-by)
- HAL (submittedVersion, cc-by)
- Bristol Research (University of Bristol) (submittedVersion, other-oa)
- Greater South Information System
- Funders
- National Institutes of Health (GM007200, P30AR057235)
- Bill and Melinda Gates Foundation (OPP1134649)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Child Nutrition and Water Access
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- gut microbiota, child undernutrition, severe acute malnutrition, moderate acute malnutrition, gnotobiotic mice, gnotobiotic pigs, plasma biomarkers, bone formation, brain development, immune function, Bangladeshi children
- MeSH terms
- Gastrointestinal Microbiome, Host Microbial Interactions, Animals, Bangladesh, Blood Proteins, Child, Preschool, Germ-Free Life, Humans, Infant, Infant Nutritional Physiological Phenomena, Child Nutrition Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review