Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice

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An unbiased method for evaluating the genome-wide specificity of base editors in rice

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Implications of the EFSA Scientific Opinion on Site Directed Nucleases 1 and 2 for Risk Assessment of Genome-Edited Plants in the EU

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TadA orthologs enable both cytosine and adenine editing of base editors

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How to start your monocot CRISPR/Cas project: plasmid design, efficiency detection, and offspring analysis

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Will Plant Genome Editing Play a Decisive Role in “Quantum-Leap” Improvements in Crop Yield to Feed an Increasing Global Human Population?

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Prime editing-mediated correction of the CFTR W1282X mutation in iPSCs and derived airway epithelial cells

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Research progress of base editing and prime editing tools based on the CRISPR/Cas system

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Development of a DNA double-strand break-free base editing tool in Corynebacterium glutamicum for genome editing and metabolic engineering

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Progress and challenges in CRISPR-mediated therapeutic genome editing for monogenic diseases

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Challenges of Gene Editing Therapies for Genodermatoses

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Genome Editing Technology: A New Frontier for the Treatment and Prevention of Cardiovascular Diseases

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Genome- and transcriptome-wide off-target analyses of a high-efficiency adenine base editor in tomato

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Current therapies for osteoarthritis and prospects of CRISPR-based genome, epigenome, and RNA editing in osteoarthritis treatment

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Engineered cytosine base editor enabling broad-scope and high-fidelity gene editing in Streptomyces

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sgBE: a structure-guided design of sgRNA architecture specifies base editing window and enables simultaneous conversion of cytosine and adenosine

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Highly elevated base excision repair pathway in primordial germ cells causes low base editing activity in chickens

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Advancements in genome editing tools for genetic studies and crop improvement

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Sophisticated CRISPR/Cas tools for fine-tuning plant performance

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Simultaneous high-efficiency base editing and reprogramming of patient fibroblasts

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CRISPR-Cas technology in corn: a new key to unlock genetic knowledge and create novel products

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Modeling Niemann–Pick disease type C in a human haploid cell line allows for patient variant characterization and clinical interpretationPreprint

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High-precision cytosine base editors by evolving nucleic-acid-recognition hotspots in deaminase

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Application of the Safe-by-Design Concept in Crop Breeding Innovation

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Base Editing in Human Cells to Produce Single‐Nucleotide‐Variant Clonal Cell Lines

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Inhibition of base editors with anti-deaminases derived from viruses

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Internally inlaid SaCas9 base editors enable window specific base editing

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On- and Off-Target Analyses of CRISPR-Cas12b Genome Editing Systems in Rice

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Characterizing off-target effects of genome editors

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Genome editing based trait improvement in crops: current perspective, challenges and opportunities

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The Expanding Class 2 CRISPR Toolbox: Diversity, Applicability, and Targeting Drawbacks

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Cytosine base editing in cyanobacteria by repressing archaic Type IV uracil‐DNA glycosylase

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Genome assembly of two allotetraploid cotton germplasms reveals mechanisms of somatic embryogenesis and enables precise genome editing

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Application of the modified cytosine base-editing in the cultured cells of bama minipig

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High-Fidelity Cytosine Base Editing in a GC-Rich Corynebacterium glutamicum with Reduced DNA Off-Target Editing Effects

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Base editing-mediated one-step inactivation of the Dnmt gene family reveals critical roles of DNA methylation during mouse gastrulation

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Engineered deaminases as a key component of DNA and RNA editing tools

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Genetic and functional correction of argininosuccinate lyase deficiency using CRISPR adenine base editors

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Precise editing of plant genomes – Prospects and challenges

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Genome editing technologies to treat rare liver diseases

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CRISPR, animals, and FDA oversight: Building a path to success

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Perfecting Targeting in CRISPR

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Base-edited cynomolgus monkeys mimic core symptoms of STXBP1 encephalopathy

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Off-target effects and the solution

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CRISPR/Cas system-mediated transgene-free or DNA-free genome editing in plants

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Advances and Applications of Plant Base Editing Technologies

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Natural Variation in Vitamin B1 and Vitamin B6 Contents in Rice Germplasm

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Improving crops through transgenic breeding—Technological advances and prospects

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A novel base editor SpRY-ABE8eF148A mediates efficient A-to-G base editing with a reduced off-target effect

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Comparison of TRIBE and STAMP for identifying targets of RNA binding proteins in human and Drosophila cells

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The Dawn of In Vivo Gene Editing Era: A Revolution in the Making

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Web-Based Base Editing Toolkits: BE-Designer and BE-Analyzer

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Regulatory Assessment of Off-Target Changes and Spurious DNA Insertions in Gene-Edited Organisms for Agri-Food Use

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Rewriting CFTR to cure cystic fibrosis

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SARS-CoV-2 Infection and Disease Modelling Using Stem Cell Technology and Organoids

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Rescue of STAT3 Function in Hyper-IgE Syndrome Using Adenine Base Editing

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Versatile and multifaceted CRISPR/Cas gene editing tool for plant research

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Correction of the pathogenic mutation in TGM1 gene by adenine base editing in mutant embryos

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Enhancing the productivity and resilience of rice (Oryza sativa) under environmental stress conditions using clustered regularly interspaced short palindromic repeats (CRISPR) technology

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Improving plant C-to-G base editors with a cold-adapted glycosylase and TadA-8e variants

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A streamlined base editor engineering strategy to reduce bystander editing

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In vivo application of base and prime editing to treat inherited retinal diseases

Jo, D. H., Bae, S., Kim, S., Kim, J., & Kim, J. H. (2022) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2022.101132 · Cited by 15

Site-specific genome editing in treatment of inherited diseases: possibility, progress, and perspectives

Huang, C., Li, Q., & Li, J. (2022) · Medical Review · doi:10.1515/mr-2022-0029 · Cited by 20

Bacterial-Artificial-Chromosome-Based Genome Editing Methods and the Applications in Herpesvirus Research

Hao, M., Tang, J., Ge, S., Li, T., & Xia, N. (2023) · Microorganisms · doi:10.3390/microorganisms11030589 · Cited by 15

Highly efficient CRISPR‐mediated base editing for the gut Bacteroides spp. with pnCasBS‐CBE

Liang, J., & Tan, Y. (2023) · Biotechnology Journal · doi:10.1002/biot.202200504 · Cited by 16

Genome editing in grass plants

Char, S. N., & Yang, B. (2019) · aBIOTECH · doi:10.1007/s42994-019-00005-x · Cited by 15

CRISPR/Cas9-mediated correction of MITF homozygous point mutation in a Waardenburg syndrome 2A pig model

Yao, J. T., Wang, Y., Cao, C., Song, R., Bi, D., Zhang, H., Li, Y., Qin, G., Hou, N., Zhang, J., et al. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.04.009 · Cited by 16

Modified Gene Editing Systems: Diverse Bioengineering Tools and Crop Improvement

Zhu, G., & Zhu, H. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.847169 · Cited by 16

Eliminating predictable DNA off-target effects of cytosine base editor by using dual guiders including sgRNA and TALE

Zhou, J., Liu, Y., Wei, Y., Zheng, S., Gou, S., Chen, T., Yang, Y., Lan, T., Chen, M., Liao, Y. C., et al. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.04.010 · Cited by 14

To BE or not to BE, that is the question

Chen, J., Yang, B., & Yang, L. C. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0119-x · Cited by 15

Improving Editing Efficiency for the Sequences with NGH PAM Using xCas9-Derived Base Editors

Liu, X., Li, G., Zhou, X., Qiao, Y., Wang, R., Tang, S., Liu, J., Wang, L., & Huang, X. (2019) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2019.06.024 · Cited by 15

Off-target challenge for base editor-mediated genome editing

Liang, P., & Huang, J. (2019) · Cell Biology and Toxicology · doi:10.1007/s10565-019-09474-8 · Cited by 15

Development of a base editor for convenient and multiplex genome editing in cyanobacteria

Li, X.-D., Liu, L.-M., Xi, Y.-C., Sun, Q.-W., Luo, Z., Huang, H.-L., Wang, X.-W., Jiang, H.-B., & Chen, W. (2024) · Communications Biology · doi:10.1038/s42003-024-06696-3 · Cited by 14

Selict-seq profiles genome-wide off-target effects in adenosine base editing

Yuan, K., Xin, X., Han, S., Han, J., Zhao, B., Wei, Q., & Zhou, X. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf281 · Cited by 18

The application of CRISPR-Cas system in Staphylococcus aureus infection

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Cell-Penetrating Peptides and CRISPR-Cas9: A Combined Strategy for Human Genetic Disease Therapy

de Morais, C. C. P. D. L., Correia, E. M., Bonamino, M., & de Vasconcelos, Z. F. M. (2024) · Human Gene Therapy · doi:10.1089/hum.2024.020 · Cited by 15

Amelioration of metabolic and behavioral defects through base editing in the PahR408W phenylketonuria mouse model

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Recent advances in CRISPR research

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A split cytosine deaminase architecture enables robust inducible base editing

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Adenine base-editing-mediated exon skipping induces gene knockout in cultured pig cells

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Developing high-efficiency base editors by combining optimized synergistic core components with new types of nuclear localization signal peptide

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Beyond Seek and Destroy: how to Generate Allelic Series Using Genome Editing Tools

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Development of plant cytosine base editors with the Cas12a system

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Design and application of the transformer base editor in mammalian cells and mice

Han, W., Gao, B., Zhu, J., He, Z., Li, J., Yang, L. C., & Chen, J. (2023) · Nature Protocols · doi:10.1038/s41596-023-00877-w · Cited by 15

Base Editors-Mediated Gene Therapy in Hematopoietic Stem Cells for Hematologic Diseases

Zhang, C., Xu, J., Wu, Y., Xu, C., & Xu, P. (2024) · Stem Cell Reviews and Reports · doi:10.1007/s12015-024-10715-5 · Cited by 16

Technological advancements in the CRISPR toolbox for improving plant salt tolerance

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CRISPR Gene-Editing Models Geared Toward Therapy for Hereditary and Developmental Neurological Disorders

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Using precision phenotyping to inform de novo domestication

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Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos

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Cytosine base editors go off-target

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