Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis
Open accessAbstract
Context shapes anticommensal immunity: The gut bacterium Akkermansia muciniphila is associated with protection from obesity, enhanced wound healing, and augmented antitumor responses. Ansaldo et al. found that this microbe induces antigen-specific immunoglobulin G1 (IgG1) antibodies generated by B cells with CD4 + T cell help. This is in contrast to most anticommensal responses, which involve the T cell–independent production of IgA antibodies. In a gnotobiotic setting in which all components of the microbiome are defined, A. muciniphila –specific T cells expanded only when A. muciniphila was present. The T cells primarily displayed a phenotype associated with B cell help. However, in mice with a conventional gut microbiota, other proinflammatory A. muciniphila –specific T cell populations also expanded. Thus, anti– A. muciniphila immunity is context dependent, which may explain the variable immune responses to this microbe reported in patients. Science , this issue p. 1179
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A. muciniphila activates intestinal immune responses by recruiting local TFH cells or systemic TH1 cells in an IL-12-dependent manner.
“A. muciniphila activates intestinal immune responses under homeostatic or immunostimulatory conditions by recruiting local follicular T helper (TFH) cells104 or systemic TH1 cells in an IL-12-dependent manner, respectively42.”
From Gut OncoMicrobiome Signatures (GOMS) as next-generation biomarkers for cancer immunotherapy (2023) · cites this paper as [104]
A. muciniphila induces antigen-specific T cell responses to modulate host immune function during homeostasis.
“A. muciniphila induced antigen-specific T cell responses to modulate host immune function during homeostasis.17”
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- Authors
- Ansaldo, E., Slayden, L. C., Ching, K. L., Koch, M. A., Wolf, N. K., Plichta, D. R., Brown, E. M., Graham, D. B., Xavier, R. J., Moon, J. J., & Barton, G. M.
- Affiliations
- University of California, Berkeley (US)
- Broad Institute (US)
- Harvard University (US)
- Corresponding author
- Barton, Gregory M.
- ORCID
- Venue
- Science
- Published
- 2019-06-21
- Volume
- 364
- Issue
- 6446
- Pages
- 1179-1184
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC6645389
- OpenAlex
- W2952093130
- Cited by
- 566
- References
- 42
- Citations by year
- 2026: 71 · 2025: 89 · 2024: 84 · 2023: 87 · 2022: 88 · 2021: 85 · 2020: 54 · 2019: 8
- FWCI
- 19.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI063302, AI124143, R01AI142926)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK043351)
- Burroughs Wellcome Fund (N/A)
- Crohn's and Colitis Foundation of America (252507)
- Fundación Bancaria Caixa dâEstalvis i Pensions de Barcelona (N/A)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- Akkermansia muciniphila, IgG1 antibodies, B cells, CD4+ T cell help, T cell expansion, gnotobiotic mice, gut microbiota, proinflammatory T cells
- MeSH terms
- Gastrointestinal Microbiome, Animals, Cell Movement, Female, Germ-Free Life, T-Lymphocytes, Helper-Inducer, Homeostasis, Immunoglobulin G, Intestinal Mucosa, Intestines, Male, Mice, Inbred C57BL, Immunity, Mucosal, Mice, Adaptive Immunity, Verrucomicrobia
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