Gut Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and Pathogens
Open accessAbstract
The gut microbiota is compartmentalized in the intestinal lumen and induces local immune responses, but it remains unknown whether the gut microbiota can induce systemic response and contribute to systemic immunity. We report that selective gut symbiotic gram-negative bacteria were able to disseminate systemically to induce immunoglobulin G (IgG) response, which primarily targeted gram-negative bacterial antigens and conferred protection against systemic infections by E. coli and Salmonella by directly coating bacteria to promote killing by phagocytes. T cells and Toll-like receptor 4 on B cells were important in the generation of microbiota-specific IgG. We identified murein lipoprotein (MLP), a highly conserved gram-negative outer membrane protein, as a major antigen that induced systemic IgG homeostatically in both mice and humans. Administration of anti-MLP IgG conferred crucial protection against systemic Salmonella infection. Thus, our findings reveal an important function for the gut microbiota in combating systemic infection through the induction of protective IgG.
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Successful implantation and mucosal translocation of transplanted bacteria may occur preferentially in responders.
“suggesting that successful implantation and mucosal trans-location of the transplanted bacteria, known to induce an IgG response against commensal bacteria, may preferentially occur in Rs (18).”
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From Impact of the ONCOBIOME network in cancer microbiome research (2025) · cites this paper as [43]
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- Authors
- Zeng, M. Y., Cisalpino, D., Varadarajan, S., Hellman, J., Warren, H. S., Cascalho, M., Inohara, N., & Núñez, G.
- Affiliations
- University of Michigan (US)
- Universidade Federal de Minas Gerais (BR)
- University of California, San Francisco (US)
- Massachusetts General Hospital (US)
- Corresponding author
- Núñez, Gabriel
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 44
- Issue
- 3
- Pages
- 647-658
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC4794373
- OpenAlex
- W2289780567
- Cited by
- 417
- References
- 49
- Citations by year
- 2026: 26 · 2025: 41 · 2024: 39 · 2023: 49 · 2022: 43 · 2021: 59 · 2020: 33 · 2019: 44 · 2018: 31 · 2017: 38 · 2016: 13
- FWCI
- 21.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- University of Michigan
- National Heart, Lung, and Blood Institute (T32HL007517)
- National Institute of General Medical Sciences (R01 GM59694, R01GM059694)
- National Institute of Allergy and Infectious Diseases (R21AI117561)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK034933, NIH 5P30DK034933, DK095782, DK091191, R01DK095782, R01DK091191, T32DK094775)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- gut microbiota, IgG, systemic immunity, Gram-negative bacteria, salmonellosis, Escherichia coli infection, TLR4, B cells, T cells, phagocyte killing, systemic dissemination
- MeSH terms
- Animals, Gram-Negative Bacteria, Homeostasis, Immunoglobulin G, Intestines, Mice, Inbred C57BL, Peptidoglycan, Gram-Negative Bacterial Infections, Mice, Knockout, Toll-Like Receptor 2, Toll-Like Receptor 4, Mice, Host-Pathogen Interactions, Bacterial Load, Microbiota
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